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Neuroprotective Effect and Mechanism of Tanreqing Injection on Ischemic Stroke:Insights from Network Pharmacology and in vivo Experiments

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Chinese Journal of Integrative Medicine 2024年第8期30卷 713-720页

作者： LI Zhong-hao PU Xiao-qi LI Sha-sha DONG Xiao-ke zhang guo-qiang WANG Yu LIU Jin-min Department of Emergency China-Japan Friendship HospitalBeijing100029China Department of Neurology Beijing University of Chinese Medicine Dongfang HospitalBeijing100078China Department of Radiology China-Japan Friendship HospitalBeijing100029China Graduate School Beijing University of Chinese MedicineBeijing100029China

Objective To explore the neuroprotective effects and mechanism of Tanreqing Injection(TRQ)on treating ischemic stroke based on network pharmacology and in vivo experimental *** The chemical compounds of TRQ were retrieved based on published data,with targets retrieved from PubChem,Therapeutic Target Database and *** visualization and analysis were performed using Cytoscape,with protein-protein interaction networks derived from the STRING *** analysis was performed using Kyoto Encyclopedia of Genes Genomes pathway and Gene Ontology *** in vivo experiments,the middle cerebral artery occlusion(MCAO)model was *** volume was determined by 2,3,5-triphenyltetrazolium hydrochloride staining and protein expressions were analyzed by Western *** docking was performed to predict ligand-receptor *** We screened 81 chemical compounds in TRQ and retrieved their therapeutic *** the targets,116 were therapeutic targets for *** enrichment analysis showed that the apelin signaling pathway was a key pathway for ischemic ***,in in vivo experiment we found that administering with intraperitoneal injection of 2.5 mL/kg TRQ every 6 h could significantly reduce the infarct volume of MCAO rats(P<0.05).In addition,protein levels of the apelin receptor(APJ)/phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)pathway were increased by TRQ(P<0.05).In addition,41 chemical compounds in TRQ could bind to *** The neuroprotective effect of TRQ may be related to the APJ/PI3K/AKT signaling ***,further studies are needed to confirm the findings.

关键词： Tanreqing Injection Chinese medicine ischemic stroke middle cerebral artery occlusion quantitative estimate of drug-likeness

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六元氮杂芳环构建方法及含能材料合成研究

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火炸药学报 2024年第2期47卷 97-113,I0001页

作者：周静段秉蕙刘宁张俊林王伯周张国强北京理工大学化学与化工学院北京102488 西安近代化学研究所陕西西安710065 陆军某部陕西西安710065

综述了吡啶,哒嗪、嘧啶、吡嗪环、三嗪以及四嗪等六元氮杂芳环骨架构建方法,探讨了相应的六元氮杂芳环环化反应机理,概述了典型含能材料的物化与爆轰性能;重点从合成角度总结了缩合反应与环加成反应在构建六元氮杂芳环结构中的应用,讨... 详细信息

综述了吡啶,哒嗪、嘧啶、吡嗪环、三嗪以及四嗪等六元氮杂芳环骨架构建方法,探讨了相应的六元氮杂芳环环化反应机理,概述了典型含能材料的物化与爆轰性能;重点从合成角度总结了缩合反应与环加成反应在构建六元氮杂芳环结构中的应用,讨论了在相应氮原子中心位点实现氮氧化或氮氨化反应的方式。其中,六元氮杂芳环氮氧化片段的引入主要包括两类途径:一是以氧化剂与氮杂芳环中氮原子中心发生反应,形成N-氧化物片段;另一类是利用环化反应,将相应的氮氧双键等结构转化为N-氧化物片段。附参考文献91篇。

关键词：有机化学六元氮杂芳环骨架构建方法反应机理含能材料爆轰性能。

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Preparation and photocatalytic activity of Cu^(2+)-doped TiO_2/SiO_2

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International Journal of Minerals,Metallurgy and Materials 2009年第2期16卷 220-225页

作者： Ru-fen Chen Cui-xuan zhang Juan Deng guo-qiang Song College of Chemistry and Material Science Hebei Normal University Shijiazhuang 050016 China

Cu^2＋-doped nanostructured TiO2-coated SiO2 （TiO2/SiO2） particles were prepared by the layer-by-layer assembly technique and their photocatalytic property was studied. TiO2 colloids were synthesized by the sol-gel method using TiOSO4 as a precursor. The experimental results showed that TiO2 nanopowders on the surface of SiO2 particles were well distributed and compact. The amount of TiO2 increased with the increase in coating layers. The shell structure appeared to be composed of anatase titania nanocrystals at 550℃. The 2-layer coated TiO2 particles on the surface showed a higher degradation rate compared with all the different-layer samples. The photocatalytic activity of Cu^2＋-doped TiO2/SiO2 was higher than that ofundoped TiO2/SiO2. The optimum dopant content was about 0.10wt%.

关键词： nanostructured TiO2 SiO2 particles layer-byqayer assembly Cu^2+ -doped photocatalytic activity

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引江补汉雾渡河段深埋隧洞渗流与稳定性分析

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中国农村水利水电 2024年第4期 175-181页

作者：于松颜天佑张国强李典庆荣冠水资源工程与调度全国重点实验室湖北武汉430072 长江勘测规划设计研究有限责任公司湖北武汉430010

深埋隧洞往往会穿越复杂的地质结构,隧洞在穿越富水断层面临严重的涌水突泥问题,其中围岩内的渗流过程以及应力状态是隧洞围岩稳定的关键影响因素。以雾渡河段为研究对象,基于数值模拟方法研究了富水断层内隧洞开挖过程中的渗流过程以... 详细信息

深埋隧洞往往会穿越复杂的地质结构,隧洞在穿越富水断层面临严重的涌水突泥问题,其中围岩内的渗流过程以及应力状态是隧洞围岩稳定的关键影响因素。以雾渡河段为研究对象,基于数值模拟方法研究了富水断层内隧洞开挖过程中的渗流过程以及隧洞围岩的稳定性。结果表明,隧洞开挖会导致隧洞围岩内渗流过程改变,隧洞衬砌会承受较大的外水压力;灌浆圈有效地阻隔了地下水,水流通过排水孔流出,二者组合能降低衬砌70%的外水压力;断层围岩物理力学性质较差,开挖后变形明显,水平向的位移大于铅直向;采用超前灌浆与超前支护处理后,围岩位移降低50%~60%,衬砌应力显著降低;综合比选后,推荐使用长4.5 m、搭接长度1 m、外插角为15°的小导管和长30 m、搭接长度3 m、外插角3°的管棚进行超前支护。

关键词：深埋隧洞渗流分析围岩稳定超前支护数值模拟

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Role of Ultrasound Lung Comets in the Diagnosis of Acute Heart Failure in Emergency Department: A Systematic Review and Meta-analysis

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Biomedical and Environmental Sciences 2018年第8期31卷 596-607页

作者： LIAN Rui zhang guo Chao YAN Sheng Tao SUN Li Chao zhang Su Qiao zhang guo qiang Department of Emergency Medicine China-Japan Friendship Hospital Department of General Surgery China-Japan Friendship Hospital

Objective A new technique of transthoracic lung ultrasonography(TLS) has emerged and demonstrated promising results in acute heart failure diagnosis at an early stage. However, the diagnostic value of ultrasound lung comets(ULCs) for acute heart failure(AHF) performed in busy emergency department(ED) is uncertain. The present meta-analysis aimed to assess the diagnostic efficiency of ULCs in AHF. Methods We conducted a search on online journal databases to collect the data on TLS performed for diagnosing AHF published up to the end of July 2017. The sensitivity, specificity, positive likelihood ratio(PLR), negative likelihood ratio(NLR), and summary receiver operating characteristic(SROC) curve were calculated. The post-test probability of AHF was calculated by using Bayes analysis. Results We enrolled a total of 15 studies involving 3,309 patients. The value of sensitivity, specificity, PLR, NLR, DOR, area under the SROC curve, and Q* index was 85%, 91%, 8.94, 0.14, 67.24, 0.9587, and 0.9026, respectively. We detected significant heterogeneity among included studies, and therefore, all these results were analyzed under the random-effect model. We also explored possible sources of heterogeneity among the studies by using meta-regression analysis. Results suggest that the time interval between patient’s admission to bedside TLS examination was closely related to TLS accuracy. Conclusion This meta-analysis demonstrated that detecting ULCs is a convenient bedside tool and has high accuracy for early AHF diagnosis in ED. TLS could be recommended to be applied for early diagnosis of AHF in ED.

关键词： Transthoracic lung ultrasonography Lung comets sign Dyspnea Acute heart failure Diagnostic test Meta-analysis

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The Role of Endoplasmic Reticulum Stress-related Apoptosis in Vascular Endothelium Pathogenesis

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Biomedical and Environmental Sciences 2018年第7期31卷 555-559页

作者： TAO Yong Kang SHI Jing YU Pu Lin zhang guo qiang Departments of Emergency China-Japan Friendship Hospital Department of Deriatric Medicine Beijing Hospital National Center of Gerontology

Vascular endothelium refers to a single layer of endothelial cells that line the inner surface of blood vessels,serving as barriers and transducers between the circulating blood in the lumen and the rest of the vessel *** cells play essential roles in many aspects of vascular biology,such as barrier functions,thrombosis/fibrinolysis,inflammation,angiogenesis,vasoconstriction and vasodilation.

关键词： ER UPR GRP The Role of Endoplasmic Reticulum Stress-related Apoptosis in Vascular Endothelium Pathogenesis HUVECs

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Inhibitory Effects of Simvastatin on Oxidized Low-Density Lipoprotein-lnduced Endoplasmic Reticulum Stress and Apoptosis in Vascular Endothelial Cells

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Chinese Medical Journal 2018年第8期131卷 950-955页

作者： guo-qiang zhang Yong-Kang Tao Yong-Ping Bai Sheng-Tao Yan Shui-Ping Zhao Department of Emergency China-Japan Friendship Hospital Beijing 100029 China Department of Geriatric Medicine Xiangya Hospital Central South University Changsha Hunan 410008 China Department of Cardiology The Second Xiangya Hospital Central South University Changsha Hunan 410011 China

Background：Oxidized low-density lipoprotein （ox-LDL）-induced oxidative stress and endothelial apoptosis are essential for atherosclerosis. Our previous study has shown that ox-LDL-induced apoptosis is mediated by the protein kinase RNA-like endoplasmic reticulum kinase （PERK）/eukaryotic translation initiation factor 2α-subunit （eIF2α）/CCAAT/enhancer-binding protein homologous protein （CHOP） endoplasmic reticulum （ER） stress pathway in endothelial cells. Statins are cholesterol-lowering drugs that exert pleiotropic effects including suppression of oxidative stress. This study aimed to explore the roles of simvastatin on ox-LDL-induced ER stress and apoptosis in endothelial ***：Human umbilical vein endothelial cells （HUVECs） were treated with simvastatin （0.1, 0.5, or 2.5 μmol/L） or DEVD-CHO （selective inhibitor of caspase-3, 100 μmol/L） for 1 h before the addition of ox-LDL （100 μg/ml） and then incubated for 24 h, and untreated cells were used as a control group. Apoptosis, expression of PERK, phosphorylation of eIF2α, CHOP mRNA level, and caspase-3 activity were measured. Comparisons among multiple groups were performed with one-way analysis of variance （ANOVA） followed by post hoc pairwise comparisons using Tukey’s tests. A value of P 〈 0.05 was considered statistically ***：Exposure of HUVECs to ox-LDL resulted in a significant increase in apoptosis （31.9% vs. 4.9%, P 〈 0.05）. Simvastatin （0.1, 0.5, and 2.5 μmol/L） led to a suppression of ox-LDL-induced apoptosis （28.0%, 24.7%, and 13.8%, F = 15.039, all P 〈 0.05, compared with control group）. Ox-LDL significantly increased the expression of PERK （499.5%, P 〈 0.05） and phosphorylation of eIF2α （451.6%, P 〈 0.05）, if both of which in the control groups were considered as 100%. Simvastatin treatment （0.1, 0.5, and 2.5 μmol/L） blunted ox-LDL-induced expression of PERK （407.8%, 339.1%, and 187.5%, F = 10.121, all P 〈 0.05, compared with control group） and phosphorylation of eIF2α （407.8%, 339.

关键词： Apoptosis Endoplasmic Reticulum Stress Endothelial Cells Oxidized Low-Density Lipoprotein Simvastatin

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Protective Effects of Phellodendron Species on Bone Health: A Novel Perspective on Their Potentials in Treating Osteoporosis and Osteoarthritis

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Chinese Journal of Integrative Medicine 2024年第4期30卷 379-384页

作者： XIN Li TAN guo-yao zhang qiang zhang Qun Good Clinical Practice Development Guangdong Provincial Key Laboratory of Bone and Joint Degeneration DiseasesThe Third Affiliated Hospital of Southern Medical UniversityGuangzhou(510630)China Department of Pharmacy Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou(510120)China

Phellodendron(PN)species,traditionally used in Chinese medicine for centuries,hold promise as a potential treatment for osteoporosis(OP)and osteoarthritis(OA)due to their bioactive *** bioactive compounds,including berberine and palmatine,exhibit anti-inflammatory,antioxidant,and bone-protective properties,contributing to their potential therapeutic benefits in promoting bone health and preventing bone ***,challenges such as the need for standardized preparation and dosing,limited clinical studies,and potential interactions with other medications hinder their clinical ***,the rich history of PN species in Chinese medicine provides a promising foundation for future investigation into their potential as alternative treatments for OP and *** research is needed to fully understand the underlying mechanisms of action and explore the clinical implications of PN for bone health.

关键词： Phellodendron species bone health osteoporosis osteoarthritis review

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光纤法珀传感器的改进型相位生成载波法解调

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中国光学（中英文） 2024年第2期17卷 312-323页

作者：周朕蕊张国强邱宗甲郭少朋李群邵剑吴鹏陆云才中国科学院电工研究所北京100190 中国科学院大学北京100049 国网江苏省电力有限公司电力科学研究院江苏南京211102

为解决相位生成载波-反正切解调算法(PGC-Atan)的非线性失真问题,搭建了基于改进型PGC-Atan算法的非本征型法珀传感器(EFPI)解调系统。首先,理论分析了载波相位调制深度(C)偏离最优值、伴生调幅、载波相位延迟等非线性因素对经典PGC-Ata... 详细信息

为解决相位生成载波-反正切解调算法(PGC-Atan)的非线性失真问题,搭建了基于改进型PGC-Atan算法的非本征型法珀传感器(EFPI)解调系统。首先,理论分析了载波相位调制深度(C)偏离最优值、伴生调幅、载波相位延迟等非线性因素对经典PGC-Atan算法中参与反正切运算的正弦与余弦两路信号的影响。然后,针对外调制或伴生调幅较小的情况,提出了一种基于系数补偿的改进型PGC-Atan算法(PGC-CC-Atan)。该算法通过构造与C值和载波相位延迟有关的系数,消除反正切运算中的非线性参数。针对内调制情况,提出了一种基于椭圆拟合的改进型PGC-Atan算法(PGCEF-Atan)。该算法通过基于分块矩阵的最小二乘法拟合椭圆并提取3个椭圆参数,进而将受非线性因素影响的正弦与余弦两路信号校正为正交信号。最后,通过仿真验证了改进型算法的正确性,并采用高调制特性的垂直腔面发射激光器(VCSEL)和常规腔长的EFPI等搭建PGC解调系统,对比经典PGC-Atan算法与两种改进型算法的解调性能,证实了改进型算法非线性失真抑制的有效性。实验结果表明:一定C值范围内,两种改进型算法可在非线性因素影响下有效解调。PGC-EF-Atan算法相较于PGC-CC-Atan算法,解调信纳比提升了11.602 dB,总谐波失真降低了10.951%。两种改进型算法中,PGC-EF-Atan算法对非线性失真的抑制效果更好,且解调线性度良好,准确度高。

关键词：相位生成载波解调非线性失真椭圆拟合光纤法珀传感器

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Dermoscopy of papular elastorrhexis

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Chinese Medical Journal 2021年第12期134卷 1503-1504页

作者： Jia-Qing Zhao Zhe Xu Bin Wang Yan-Jia Li guo-qiang zhang Department of Dermatology The First Hospital of Hebei Medical UniversityShijiazhuangHebei 050031China Department of Dermatology Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China

To the Editor:Papular elastorrhexis(PE)is a rare acquired elastic tissue *** etiology and pathogenesis remain *** is predisposed to the trunk and limbs and clinically presented as multiple asymptomatic,3-to 5-mm non-follicular flesh-colored papules on children and adolescents,mainly in *** presents only cutaneous involvement,and most of the patients are asymptomatic and often misdiagnosed and ***,we present a case of PE and describe its dermoscopic features that have not been previously reported.

关键词： involvement limbs pathogenesis

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