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Scorpiones,Scolopendra and Gekko Inhibit Lung Cancer Growth and Metastasis by Ameliorating Hypoxic Tumor Microenvironment via PI3K/AKT/mTOR/HIF-1αSignaling Pathway

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Chinese Journal of Integrative Medicine 2024年第9期30卷 799-808页

作者： MAO Qi-yuan WANG Xue-qian LIN Fei YU Ming-wei FAN Hui-ting ZHENG Qi LIU Lan-chun zhang chu-chu LI Dao-rui LIN Hong-sheng Department of Oncology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing100053China Department of Oncology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing100010China Department of Cardiology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing100053China Institute of Traditional Chinese Medicine Information China Academy of Chinese Medical SciencesBeijing100700China

Objective:To investigate whether Buthus martensii karsch(Scorpiones),Scolopendra subspinipes mutilans ***(Scolopendra)and Gekko gecko Linnaeus(Gekko)could ameliorate the hypoxic tumor microenvironment and inhibit lung cancer growth and metastasis by regulating phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin/hypoxia-inducible factor-1α(PI3K/AKT/mTOR/HIF-1α)signaling ***:Male C57BL/6J mice were inoculated with luciferase labeled LL/2-luc-M38 cell suspension to develop lung cancer models,with rapamycin and cyclophosphamide as positive *** methyl cellulose solutions of Scorpiones,Scolopendra and Gekko were administered intragastrically as 0.33,0.33,and 0.83 g/kg,respectively once daily for 21 *** expression were detected every 7 days after inoculation,and tumor growth curves were *** was performed to determine CD31 and HIF-1αexpressions in tumor tissue and microvessel density(MVD)was *** blot was performed to detect the expression of PI3K/AKT/mTOR/HIF-1αsignaling pathway-related ***-linked immunosorbent assay was performed to detect serum basic fibroblast growth factor(bFGF),transforming growth factor-β1(TGF-β1)and vascular endothelial growth factor(VEGF)in ***:Scorpiones,Scolopendra and Gekko prolonged the survival time and inhibited lung cancer metastasis and expression of HIF-1α(all P<0.01).Moreover,Scorpiones,Scolopendra and Gekko inhibited the phosphorylation of AKT and ribosomal protein S6 kinase(p70S6K)(P<0.05 or P<0.01).In addition,they also decreased the expression of CD31,MVD,bFGF,TGF-β1 and VEGF compared with the model group(P<0.05 or P<0.01).Conclusion:Scorpiones,Scolopendra and Gekko all showed beneficial effects on lung cancer by ameliorating the hypoxic tumor microenvironment via PI3K/AKT/mTOR/HIF-1αsignaling pathway.

关键词： Scorpiones Scolopendra Gekko dredging collaterals and activating blood Chinese medicine of worms lung cancer hypoxic tumor microenvironment phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin/hypoxia-inducible factor-1α signaling pathway

Prediction and optimization of flue pressure in sintering process based on SHAP

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 346-359页

作者： Mingyu Wang Jue Tang Mansheng chu Quan Shi Zhen zhang School of Metallurgy Northeastern UniversityShenyang 110819China Liaoning Low-Carbon Steelmaking Technology Engineering Research Center Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-Carbon Steelmaking(Ministry of Education) Shenyang 110819China

Sinter is the core raw material for blast *** pressure,which is an important state parameter,affects sinter *** this paper,flue pressure prediction and optimization were studied based on the shapley additive explanation(SHAP)to predict the flue pressure and take targeted adjustment ***,the sintering process data were collected and processed.A flue pressure prediction model was then constructed after comparing different feature selection methods and model algorithms using SHAP+extremely random-ized trees(ET).The prediction accuracy of the model within the error range of±0.25 kPa was 92.63%.SHAP analysis was employed to improve the interpretability of the prediction *** effects of various sintering operation parameters on flue pressure,the relation-ship between the numerical range of key operation parameters and flue pressure,the effect of operation parameter combinations on flue pressure,and the prediction process of the flue pressure prediction model on a single sample were analyzed.A flue pressure optimization module was also constructed and analyzed when the prediction satisfied the judgment *** operating parameter combination was then *** flue pressure was increased by 5.87%during the verification process,achieving a good optimization effect.

关键词： sintering process flue pressure shapley additive explanation prediction optimization

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论英语情态动词道义情态的主现性

外国语 2007年第5期30卷 23-30页

作者：张楚楚长沙理工大学外国语学院湖南410076

英语情态动词的意义是主观的还是中立的(主观或客观取决于语境)?对于这个问题,语言学家的回答不尽相同。本文试图通过论证英语情态动词道义情态的主观性来证明情态动词内在隐含的主现性。本文认为:情态动词的意义并不与归一性直接相连,... 详细信息

英语情态动词的意义是主观的还是中立的(主观或客观取决于语境)?对于这个问题,语言学家的回答不尽相同。本文试图通过论证英语情态动词道义情态的主观性来证明情态动词内在隐含的主现性。本文认为:情态动词的意义并不与归一性直接相连,中间还隔着非情态动词情态表达式表示的客观情态和所谓的评价情态。与这些客观意义相比,尤其是与实义动词表示的零情态断言或陈述相比,情态动词总是主观的。本文还对6位学者有关情态动词主/客观情态的观点进行了评析,并从不同的语法视角时情态动词的意义进行分析,在肯定了功能语法和认知语法情态阐释力长处的同时,也指出了它们各自的不足。

关键词：主观性主观/客观情态判断/断言

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预制菜产业的食品安全风险及其治理对策

粮油食品科技 2024年第1期32卷 201-208页

作者：张莉莉张楚楚河海大学法学院江苏南京211100

预制菜产业在生产许可、加工经营、贮存与运输、销售等环节均存在食品安全风险,而当前我国应对预制菜产业食品安全风险的法律法规及行业规范尚不完善,对预制菜产业的监管存在不足之处。需要以保障消费者权益为核心,以健全预制菜产业有... 详细信息

预制菜产业在生产许可、加工经营、贮存与运输、销售等环节均存在食品安全风险,而当前我国应对预制菜产业食品安全风险的法律法规及行业规范尚不完善,对预制菜产业的监管存在不足之处。需要以保障消费者权益为核心,以健全预制菜产业有关标准体系、构建预制菜产业监管的基本制度为具体对策,以数字技术赋能预制菜产业治理,推动预制菜产业规范健康发展。

关键词：预制菜食品安全消费者权益治理对策

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Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang chu Zhicheng Lin Tianyuan Fang Yuyu Zhou chuxia zhang Jianghui Shan Shiyu Chen Liping Li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

文学接受史视角下的公共阐释论略议——以东晋陶渊明的诗文接受史为例

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求是学刊 2018年第5期45卷 134-141页

作者：张楚楚李淑岩中国社会科学院马克思主义学院哈尔滨师范大学文学院

"公共阐释论"致力于对阐释学的元理论做出理性的分析,找出阐释行为本身所包含的公共理性本质,在自我与他人之间开辟可共享的精神场域,以在面对疏异性文本时给予清晰且有说服力的解释和说明,给确当的阐释以合法身份。纵观东晋隐士陶渊明... 详细信息

"公共阐释论"致力于对阐释学的元理论做出理性的分析,找出阐释行为本身所包含的公共理性本质,在自我与他人之间开辟可共享的精神场域,以在面对疏异性文本时给予清晰且有说服力的解释和说明,给确当的阐释以合法身份。纵观东晋隐士陶渊明的诗文接受史,可以发现公共阐释得以构建的历程和基石,即以公共语境的边界约束为存在前提,以杰出个体的理性洞见为原生动力,以公共理性的审阅修正为选择机制,以研究方法的积淀提升为构建支点,对此的梳理和重视可对文本阐释的理性原则、实证原则和确当性原则加以重申,捍卫人类的公共理性和认知的真理性。

关键词：公共阐释公共理性个体阐释陶渊明诗文接受史

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试探张仲景对背部诸症的辨证论治

中华中医药杂志 2020年第7期35卷 3326-3328页

作者：张楚楚陈明北京中医药大学中医学院北京100029

文章论述《伤寒杂病论》对背部诸症之辨治,通过分析认为,背部诸症可见于太阳病、阳明病、少阴病、痉病、湿病、血痹、胸痹、痰饮病等诸多疾病中,其治法有解表、通经、散寒、化饮、祛痰、活血之不同,可分别使用桂枝加葛根汤、葛根汤、白... 详细信息

文章论述《伤寒杂病论》对背部诸症之辨治,通过分析认为,背部诸症可见于太阳病、阳明病、少阴病、痉病、湿病、血痹、胸痹、痰饮病等诸多疾病中,其治法有解表、通经、散寒、化饮、祛痰、活血之不同,可分别使用桂枝加葛根汤、葛根汤、白虎加人参汤、附子汤、黄芪桂枝五物汤、栝楼薤白白酒汤、乌头赤石脂丸、小青龙汤、苓桂术甘汤等方剂治疗,充分反映了中医辨证论治之特点。

关键词：背强背寒背痛背麻经方运用张仲景伤寒杂病论

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翻译课及其他——爱荷华大学作家工作坊见闻

当代文坛 2025年第1期 103-109页

作者：张楚天津市作家协会

通过作者参加爱荷华大学作家工作坊(Iowa Writers’Workshop)两堂英语翻译课的经历,真实、细致地记录了该校作家工作坊的授课方式和特点,进而延宕到作家工作坊的创办历史、招生方式、教学内容等具体情况。通过工作坊的课程安排与国内高... 详细信息

通过作者参加爱荷华大学作家工作坊(Iowa Writers’Workshop)两堂英语翻译课的经历,真实、细致地记录了该校作家工作坊的授课方式和特点,进而延宕到作家工作坊的创办历史、招生方式、教学内容等具体情况。通过工作坊的课程安排与国内高校创写专业课程的比较,从小切口反思了中外创意写作教学中存在的一些共性问题和个性问题,并对中外地域性写作做了剖析,一方面地域性写作的共性叙事主题与美学风格在不断彰显中呈现出新的气象,超越了个体表达的局限性。另外一方面,对写作者按地域分类忽略了小说作为一种艺术表达方式的个性。

关键词：作家工作坊创意写作地域性写作

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Carbon-supported CeNCl as an efficient catalyst for CO_(2)cycloaddition

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Nano Research 2025年第1期18卷 157-163页

作者： Li Liu Lingling zhang Xiang chu Baokang Geng Huilin Wang Zongxiang Li Xiao Wang Shuyan Song Hongjie zhang School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Sinocare Incorporation Changsha 410221China Department of Chemistry Tsinghua UniversityBeijing 100084China

The cycloaddition reaction of CO_(2)with epoxide not only effectively reduces the concentration of CO_(2)in the atmosphere,but also has excellent industrial application value and up to 100%atom utilization,but there are difficulties in separation and recovery of traditional homogeneous catalysts,harsh reaction conditions of traditional heterogeneous catalysts,and activation of CO_(2)*** this paper,an easily synthesized heterogeneous catalyst CeNCl/C was used to catalyze the cycloaddition reaction of CO_(2)with styrene oxide,with a high yield of 92.7%,a high selectivity of 96.7%,a turnover numbers(TON)value of 349,and a good stability demonstrated in six cycle tests(equivalent to 216 h of testing).Through comprehensive studies,it was shown that CeNCl/C contains Lewis acid-base centers as active centers,which can effectively reduce the energy barrier required for ring opening of the reaction substrate,enhance the adsorption and activation of CO_(2),and promote the formation of intermediates,which led to the acquisition of excellent catalytic activity.

关键词： CO_(2)cycloaddition heterogeneous catalysis CeNCl Lewis acid/base