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PD-L1 targeted iron oxide SERS bioprobe for accurately detecting circulating tumor cells and delineating tumor boundary

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Chinese Chemical Letters 2025年第1期36卷 408-414页

作者： Ting Pan Dinghu zhang Guomei You Xiaoxia Wu chenguang zhang Xinyu Miao Wenzhi Ren Yiwei He Lulu He Yuanchuan Gong Jie Lin Aiguo Wu Guoliang Shao Department of Interventional Radiology Zhejiang Cancer HospitalInstitute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Cixi Institute of Biomedical EngineeringInternational Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Science(CAS)Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringCASNingbo 315201China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China

Early diagnosis and accurate boundary delineation are the key steps of tumor precision *** tumor cells(CTCs)detection of liquid biopsy can provide abundant information for early diagnosis of *** detection specificity and good enrichment features are two key factors for CTCs accurate identification in peripheral blood *** this purpose,iron oxide(IO)-based surface-enhanced Raman scattering(SERS)bioprobes with good biocompatibility,high detection sensitivity,remarkable detection specificity,and good enrichment efficiency,were developed for detecting different types of *** SERS bioprobes combined with programmed death ligand-1(PD-L1)antibody are regarded as an effective way to boost the targeting ability and detection specificity,benefiting for accurately capturing and identifying rare *** types of CTCs with different PD-L1 expression were accurately distinguished among white blood cells via high-resolution SERS mapping images and stable Raman ***,CTCs blood samples obtained from the triple negative breast cancer patients were also successfully recognized compared to that of health people,indicating IO@AR@PDA-a PD-L1 SERS bioprobe possessed great potential for CTCs detection in liquid ***,IO-based bioprobe exhibited excellent dual-modal imaging abilities of high-resolution SERS imaging mode and microimaging magnetic resonance imaging *** two highly complementary imaging modes endowed IO-based bioprobes unrivalled capacity in tumor boundary differentiation,supporting tumor accurate resection and precise *** our best knowledge,this is the first time that biocompatible IO-based SERS bioprobes without noble metal element were reported not only for CTCs accurate detection,but also for precise tumor boundary delineation,showing great advantages in tumor diagnosis and treatment.

关键词： Circulating tumor cells Surface-enhanced Raman scattering PD-L1 Iron oxide bioprobe Dual-modal imaging Tumor boundaries delineation

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Susceptible Windows of Prenatal Ozone Exposure and Preterm Birth:A Hospital-Based Observational Study

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Biomedical and Environmental Sciences 2025年第2期38卷 255-260,I0001-I0004页

作者： Rongrong Qu Dongqin zhang Hanying Li Jiayin Zhi Yanxi Chen Ling Chao Zhenzhen Liang chenguang zhang Weidong Wu Jie Song Henan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution School of Public HealthXinxiang Medical UniversityXinxiang 453003HenanChina School of Medical Technology Xinxiang Medical UniversityXinxiang 453003HenanChina

Preterm birth(PTB)is defined as delivery before 37 weeks of *** is associated with increased cardiovascular risk,neurodevelopmental disorders,and other diseases in infancy,childhood,and adulthood[1].Globally,approximately 15 million PTB cases are reported annually,posing a huge burden on individual families and the community economy[2].In the context of climate warming,O_(3) pollution has continuously increased in many countries in recent years,including China;therefore,scientific communities and government agencies must strive to mitigate ozone pollution.

关键词： Windows individual annually

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轻度贫血对玻璃体切割手术治疗增生型糖尿病视网膜病变视力预后的影响

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中华眼底病杂志 2025年第1期41卷 32-38页

作者：仲奇奇张晨光林铁柱沈阳何氏眼科医院沈阳110002 浙江省人民医院眼科杭州310014

目的观察轻度贫血对玻璃体切割手术(PPV)治疗增生型糖尿病视网膜病变(PDR)视力预后的影响。方法回顾性病例对照研究。2021年1月至2022年12月于沈阳何氏眼科医院接受PPV治疗的PDR患者147例147只眼纳入研究。其中,男性82例82只眼,女性65... 详细信息

目的观察轻度贫血对玻璃体切割手术(PPV)治疗增生型糖尿病视网膜病变(PDR)视力预后的影响。方法回顾性病例对照研究。2021年1月至2022年12月于沈阳何氏眼科医院接受PPV治疗的PDR患者147例147只眼纳入研究。其中,男性82例82只眼,女性65例65只眼;年龄25~79(53.54±12.74)岁。男性、女性血红蛋白(Hb)水平分别为90~120、90~110 g/L定义为轻度贫血。根据Hb结果,将患者分为轻度贫血组、非贫血组,分别为39例39只眼、108例108只眼。手术前后患者均采用国际标准对数视力表行最佳矫正视力(BCVA)检查,统计时换算为最小分辨对数(logMAR)视力。手术前患眼logMAR BCVA为0.2~2.5(1.60±0.62)。根据手术后6个月BCVA较手术前提高是否≥3行,将患眼分为BCVA提高≥3行组、BCVA提高<3行组,分别为117、30只眼。记录患者身体质量指数(BMI)、手术后6个月时BCVA以及新生血管性青光眼(NVG)、玻璃体再积血(RVH)发生情况。组间比较采用独立样本t检验;logistic多因素回归分析手术后BCVA提高≥3行的影响因素。结果手术后6个月,轻度贫血组、非贫血组患眼logMAR BCVA分别为0.97±0.87、0.68±0.63;BCVA提高≥3行者分别为26(66.7%,26/39)、91(84.3%,91/108)只眼;两组患眼logMAR BCVA(t=2.234)、BCVA提高≥3行眼数(χ^(2)=5.460)比较,差异均有统计学意义(P=0.027、0.019)。logistic回归分析结果显示,基线logMAR BCVA[比值比(OR)=4.291,95%可信区间(CI)1.918~9.600,P<0.001]、BMI(OR=1.248,95%CI 1.057~1.472,P=0.009)、手术中视网膜激光光凝斑数量(OR=1.001,95%CI 1.000~1.002,P=0.038)、轻度贫血(OR=0.360,95%CI 0.131~0.993,P=0.048)、手术后NVG(OR=0.156,95%CI 0.033~0.726,P=0.018)、RVH(OR=0.264,95%CI 0.086~0.808,P=0.020)是PPV后BCVA提高≥3行的独立影响因素。结论轻度贫血对PDR患眼PPV后BCVA的改善有一定影响;轻度贫血、手术后NVG和RVH是影响PDR患眼PPV后BCVA提高≥3行的独立危险因素。

关键词：玻璃体切除术轻度贫血增生型糖尿病视网膜病变视力预后

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Effects of hurricane forward speed and approach angle on storm surges: an idealized numerical experiment

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Acta Oceanologica Sinica 2019年第7期38卷 48-56页

作者： chenguang zhang Chunyan Li Department of Oceanography and Coastal Sciences Louisiana State University

The effects of hurricane forward speed(V)and approach angle(θ)on storm surge are important and a systematic investigation covering possible and continuous ranges of these parameters has not been done *** we present such a study with a numerical experiment using the Finite Volume Community Ocean Model(FVCOM).The hurricane track is simplified as a straight line,such that V andθfully define the motion of the *** maximum surge is contributed by both free waves and a forced storm surge wave moving with the *** the free waves,Kelvin-type waves can only propagate in the down-coast *** show that those waves can only have a significant positive storm surge when the hurricane velocity has a down-coast *** optimal values of V andθthat maximize the storm surge in an idealized semi-circular ocean basin are functions of the *** a constant bathymetry,the maximum surge occurs when the hurricane approaches the coast from the normal direction when the free wave generation is minimal;for a stepped bathymetry,the maximum surge occurs at a certain acute approach angle which maximizes the duration of persistent wind forcing;a step-like bathymetry with a sloped shelf is similar to the stepped bathymetry,with the added possibility of landfall resonance when the free and forced waves are moving at about the same *** other cases,the storm surge is smaller,given other parameters(hurricane size,maximum wind speed,etc.)unchanged.

关键词： storm surge experiments FVCOM hurricane forward speed approach angle Kelvin waves forced and free surge interactions

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Polypyrrole-based hybrid nanostructures grown on textile for wearable supercapacitors

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Nano Research 2019年第5期12卷 1129-1137页

作者： Lingchang Wang chenguang zhang Xin Jiao Zhihao Yuan School of Materials Science and Engineering Tianjin University of TechnologyTianjin 300384China Tianjin Key Laboratory for Photoelectric Materials & Devices Tianjin University of TechnologyTianjin 300384China Key Laboratory of Display Materials and Photoelectric Devices Ministry of EducationTianjin University of TechnologyTianjin 300384China

In the development of wearable energy devices,polypyrrole (PPy) is considered as a promising electrode material owing to its high capacitance and good mechanical ***,we report a PPy-based hybrid structure consisting of vertical PPy nanotube arrays and carbon nano-onions (CNOs) grown on textile for wearable *** this hybrid nanostructure,the vertical PPy nanotubes provide straight and superhighways for electron and ion transport,boosting the energy storage;while the CNOs mainly act as a conductivity retainer for the underlayered PPy film during stretching.A facile template-degrading method is developed for the large-area growth of the PPy-based hybrid nanostructures on the textile through one-step polymerization *** fabricated stretchable supercapacitor exhibits superior energy storage capacitance with the specific capacitance of 64 F·g^-***,it presents the high capacitance retention of 99% at a strain of 50% after 500 stretching ***,we demonstrate that the textile-based stretchable supercapacitor device can provide a stable energy storage performance in different wearable situations for practical *** use of the PPy-based hybrid nanostructures as the supercapacitor electrode offers a novel structure design and a promising opportunity for wearable power supply in real applications.

关键词： wearable supercapacitor polypyrrole nanotube carbon nano-onion template-degrading method stretchable electrode

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A metric normalization of tree edit distance

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Frontiers of Computer Science 2011年第1期5卷 119-125页

作者： Yujian Li (1) liyujian@*** zhang chenguang (12) Beijing Univ Technol Coll Comp Sci & Technol Beijing 100124 Peoples R China Hainan Univ Coll Informat Sci & Technol Haikou 570228 Peoples R China

Traditional normalized tree edit distances do not satisfy the triangle inequality. We present a metric normalization method for tree edit distance, which results in a new normalized tree edit distance fulfilling the triangle inequality, under the condition that the weight function is a metric over the set of elementary edit operations with all costs of insertions/deletions having the same weight. We prove that the new distance, in the range [0, 1], is a genuine metric as a simple function of the sizes of two ordered labeled trees and the tree edit distance between them, which can be directly computed through tree edit distance with the same complexity. Based on an efficient algorithm to represent digits as ordered labeled trees, we show that the normalized tree edit metric can provide slightly better results than other existing methods in handwritten digit recognition experiments using the approximating and eliminating search algorithm （AESA） algorithm.

关键词： metric normalization tree edit distance,triangle inequality approximating and eliminating searchalgorithm (AESA)

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Graphene quantum dots derived from hollow carbon nano-onions

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Nano Research 2018年第1期11卷 174-184页

作者： chenguang zhang Jiajun LI Xianshun Zeng Zhihao Yuan Naiqin Zhao [1School of Materials Science and Engineering Tianjin University of Technology Tianjin 300384 China [2School of Materials Science and Engineering Tianin University Tianin 300072 China [3Tianjin Key Lab for Photoelectric Materials & Devices Tianjin 300384 China [4Collaborative Innovation Center of Chemical Science and Engineering Tianjin University Tianjin 300072 China

Herein, carbon nano-onions （CNOs） with different structures have been investigated as precursors for the synthesis of graphene quantum dots （GQDs）. It was found that hollow CNOs yield GQDs with a uniform size distribution, whereas metal encapsulation in the CNO structure is disadvantageous for the same. Furthermore, the hollow CNOs are also advantageous for the synthesis of GQDs with a yellow-green hybrid luminescence and long-ranged excitation wavelength （λex）-independent photoluminescent （PL） behavior, in which the λex upper limit was 480 nm. These features enable safe sensing and cell tracking applications with a longer excitation wavelength in the visible light region. The potential applications of the synthesized GQDs as fluorescent sensing probes for detecting Cu（II） ions and non-toxic cell imaging under visible light excitation have been demonstrated. This means that sensing and bioimaging can be accomplished in the natural environment with no need for UV excitation. This work provides a reference to researchers in tailoring CNO structures in terms of their inner space to synthesize GQDs with the desired luminescence behavior.

关键词： graphene quantum dots carbon nano-onions fluorescent quenching bioimaging

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Experimental and numerical simulation of bird-strike performance of lattice-material-infilled curved plate

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Chinese Journal of Aeronautics 2021年第8期34卷 245-257页

作者： Jun YAN chenguang zhang Sixu HUO Xianghai CHAI Zhihui LIU Kun YAN State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering MechanicsDalian University of TechnologyDalian 116024China Ningbo Institute of Dalian University of Technology Ningbo 315016China Department of Discipline Engineering AVIC Commercial Aircraft Engine Co.LTDShanghai 200241China Shanghai Engineering Research Center of Civil Aero Engine Shanghai 200241China School of Chemical Engineering Dalian University of TechnologyDalianLiaoning 116024China

The anti-bird-strike performance of a lattice-material-infilled curved plate is investigated *** automatically filling the curved structure by classical lattice material filling methods will cause a large number of manufacturing defects,a space-dependent lattice material filling method for the curved plate is firstly proposed in this paper Next,using a face-centered cubic lattice,a lattice-material-infilled test piece with a hollow ratio of 40.8%is *** test pieces are manufactured via additive manufacturing using titanium *** bird-strike experimental tests,the test pieces are crashed against gelatin birds at an impact velocity of 200 m/*** strain gauges are used to record the crash history and the results are ***,a numerical analysis to simulate the bird-strike experiment is *** results from the experimental tests and numerical simulation agree *** work shows that the lattice-material-infilled curved plate yields promising bird-strike ***,lattice-infilled materials are feasible for protecting aerospace components against bird-strike as well as for reducing the component weight.

关键词： Bird-strike test Face-centered cubic lattice Infilled curved plate Lattice material Numerical simulation

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Self-anchored catalysts for substrate-free synthesis of metal-encapsulated carbon nano-onions and study of their magnetic properties

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Nano Research 2016年第4期9卷 1159-1172页

作者： chenguang zhang Jiajun Li Chunsheng Shi Chunnian He Enzuo Liu Naiqin Zhao School of Materials Science and Engineering Tianjin University Tianjin 300072 China Collaborative Innovation Center of Chemical Science and Engineering Tianjin University Tianjin 300072 China

We demonstrate the synthesis of a novel self-anchored catalyst structure containing a Fe-Ni alloy nanosheet generated by phase separation for the substrate-free synthesis of carbon nanostructures. Fast Fourier transform analysis was carried out in order to investigate both the phase and structural evolution of the alloy nanosheet during reduction and chemical vapor deposition （CVD） growth. y-Fe-Ni （Feo.64Nio.36） and a-Fe-Ni （kamacite） phases were formed and separated on the NiFe204 nanosheet catalyst precursor during H2 reduction, forming selfanchored mono-dispersed y-Fe-Ni nanocrystals on a a-Fe-Ni matrix. The Fe-Ni alloy nanosheet serves both as a catalyst for growing metal-encapsulated carbon nano-onions （CNOs）, and as a support for anchoring these preformed nano- particles, yielding mono-dispersed catalyst nanoparticles with no requirement of additional substrates for the CVD growth. This synthesis is capable of mitigating the coalescence and Ostwald ripening without the assistance of an additional substrate. This structure allows for the growth of uniform-sized CNOs despite the aggregation, crumbling, and stacking of the alloy sheet. This study provides a promising design for novel catalyst structures by phase separation towards the substrate-free synthesis of carbon nanostructures in large scale. Finally, the ferromagnetic Feo.64Ni0.36@#CNOs particles demonstrate their application in both magnetic storage and water purification, as a non-toxic water treatment material.

关键词： carbon nano-onion self-anchored catalyst phase separation y-Fe-Ni a-Fe-Ni chemical vapor deposition

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Dietary fat and carbohydrate-balancing the lactation performance and methane emissions in the dairy cow industry:A meta-analysis

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Animal Nutrition 2024年第2期17卷 347-357页

作者： chenguang zhang Xingwei Jiang Shengru Wu Jun zhang Yue Wang Zongjun Li Junhu Yao College of Animal Science and Technology Northwest A&F UniversityYangling 712100ShaanxiChina

For the agroecosystems of the dairy cow industry,dietary carbohydrate(starch,neutral detergent fiber[NDF])and fat could directly affect rumen methane emissions and host energy ***,the relationships among diet,lactation performance,and methane emissions need to be further determined to assist dairy farms to adjust diet formulations and feeding strategies for environmental and production management.A meta-analysis was conducted in the current study to explore quantitative patterns of dietary fat and carbohydrate at different levels in balancing lactation performance and environment sustainability of dairy cows,and to establish a methane emission prediction model using the artificial neural network(ANN)*** results showed that the regression relationship between dietary fat,carbohydrate and methane emissions could be shown by the following models:methane=106.78+(14.86 × DMI),R2=0.80;methane=443.17-(46.41 × starch/NDF),R2=0.76;and methane=388.91+(31.40 × fat)-(5.42 × fat2),R2=*** regression relationships between dietary fat,carbohydrate and lactation performance could be shown by the following models:milk fat yield=1.08+(0.43 × starch/NDF)-[0.34 ×(starch/NDF)2],R2=0.79;milk protein yield=0.68+(0.15 × fat)-(0.016 × fat2),R2=*** the structural equation model,we found that when formulating dietary carbohydrates and fats,it was necessary to balance the relationship between methane emissions and lactation ***,dietary starch/NDF was lower than 0.63(extremum point)and dietary fat was between 2.89%and 4.69%(extremum point),it could ensure that the aim of methane emission reduction(methane emissions decrease with increasing dietary starch/NDF and fat)was achieved without losing lactation performance of dairy cows(lactation performance increase with increasing dietary starch/NDF and fat).Finally,we established the ANN model to predict methane emissions(training set:R2=0.62;validation set:R2=0.61).

关键词： Dietary fat and carbohydrate Environment sustainability Lactation performance Dairy cow Meta-analysis

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