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Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping zhang Ying Zhu pu Chen Tong Zhou Zhe-Yi Han jun xiao Jian-Feng Ma Wen Ma Peng Zang Ying Chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway

Spontaneous Orientation Polarization of Anisotropic Equivalent Dipoles Harnessed by Entropy Engineering for Ultra‑Thin Electromagnetic Wave Absorber

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Nano-Micro Letters 2025年第1期17卷 424-438页

作者： Honghan Wang Xinyu xiao Shangru Zhai Chuang Xue Guangping Zheng Deqing zhang Renchao Che junye cheng Liaoning Key Lab of Lignocellulose Chemistry and BioMaterials Liaoning Collaborative Innovation Center for Lignocellulosic BiorefinerySchool of Light Industry and Chemical EngineeringDalian Polytechnic UniversityDalian 116034People’s Republic of China School of Life Science and Biotechnology Dalian University of TechnologyDalian 116024People’s Republic of China Department of Mechanical Engineering Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 999077People’s Republic of China School of Materials Science and Engineering Qiqihar UniversityQiqihar 161006People’s Republic of China Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai 200438People’s Republic of China Department of Materials Science Shenzhen MSU-BIT UniversityShenzhen 517182People’s Republic of China

The synthesis of carbon supporter/nanoscale high-entropy alloys(HEAs)electromagnetic response composites by carbothermal shock method has been identified as an advanced strategy for the collaborative competition engineering of conductive/dielectric *** migration modes within HEAs as manipulated by the electronegativity,valence electron configurations and molar proportions of constituent elements determine the steady state and efficiency of equivalent ***,enlightened by skin-like effect,a reformative carbothermal shock method using carbonized cellulose paper(CCP)as carbon supporter is used to preserve the oxygencontaining functional groups(O·)of carbonized cellulose fibers(CCF).Nucleation of HEAs and construction of emblematic shell-core CCF/HEAs heterointerfaces are inextricably linked to carbon metabolism induced by O·.Meanwhile,the electron migration mode of switchable electronrich sites promotes the orientation polarization of anisotropic equivalent *** virtue of the reinforcement strategy,CCP/HEAs composite prepared by 35%molar ratio of Mn element(CCP/HEAs-Mn_(2.15))achieves efficient electromagnetic wave(EMW)absorption of−51.35 dB at an ultra-thin thickness of 1.03 *** mechanisms of the resulting dielectric properties of HEAs-based EMW absorbing materials are elucidated by combining theoretical calculations with experimental characterizations,which provide theoretical bases and feasible strategies for the simulation and practical application of electromagnetic functional devices(e.g.,ultra-wideband bandpass filter).

关键词： High-entropy alloys Carbothermal shock Switchable electron migration modes Emblematic shell-core heterointerfaces Ultra-thin thickness

Trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development

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World Journal of Gastroenterology 2025年第2期31卷 42-51页

作者： Wen-Chong Zhen Jing Sun Xue-Ting Bai Qian zhang Zi-Han Li Yi-Xin zhang Rong-Xuan Xu Wei Wu Zhi-Han Yao Chun-Wen pu xiao-Feng Li School of public Health Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Dalian public Health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116001Liaoning ProvinceChina Department of Epidemiology and Health Statistics Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Chronic hepatitis B often progresses silently toward hepatocellular carcinoma(HCC),a leading cause of mortality *** detection of HCC is crucial,yet *** To investigate the role of dynamic changes in alkaline phosphatase to prealbumin ratio(APR)in hepatitis B progression to *** Data from 4843 patients with hepatitis B(January 2015 to January 2024)were *** incidence rates in males and females were compared using the log-rank *** were evaluated using Kaplan–Meier *** Linear Mixed-Effects Model was applied to track the fluctuation of APR levels over ***,Joint Modeling of Longitudinal and Survival data was employed to investigate the temporal relationship between APR and HCC *** The incidence of HCC was higher in *** ensure the model’s normality assumption,this study applied a logarithmic transformation to APR,yielding *** levels were higher in females(t=5.26,P<0.01).A 1-unit increase in ratio correlated with a 2.005-fold higher risk of HCC in males(95%CI:1.653-2.431)and a 2.273-fold higher risk in females(95%CI:1.620-3.190).CONCLUSION Males are more prone to HCC,while females have higher APR *** no baseline APR link,rising APR indicates a higher HCC risk.

关键词： Alkaline phosphatase to prealbumin ratio Chronic hepatitis B patients Hepatocellular carcinoma Retrospective cohort study Linear Mixed-Effect Mode Joint Modelling of Longitudinal and Survival data

Reliable approach for bistatic scattering of three-dimensional targets from underlying rough surface based on parabolic equation

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Chinese Physics B 2018年第7期27卷 314-320页

作者： Dong-Min zhang cheng Liao liang Zhou xiao-Chuan Deng ju Feng Institute of Electromagnetics Southwest Jiaotong University Chengdu 610031 China Science and Technology on Electronic Information Control Laboratory Chengdu 610031 China

A parabolic equation （PE） based method for analyzing composite scattering under an electromagnetic wave incidence at low grazing angle, which composes of three-dimensional （3-D） electrically large targets and rough surface, is presented and discussed. A superior high-order PE version is used to improve the accuracy at wider paraxial angles, and along with the alternating direction implicit （ADI） differential technique, the computational efficiency is further improved. The formula of bistatic normalized radar cross section is derived by definition and near-far field transformation. Numerical examples are given to show the validity and accuracy of the proposed approach, in which the results are compared with those of Kirchhoff approximation （KA） and moment of method （MoM）. Furthermore, the bistatic scattering properties of composite model in which the 3-D PEC targets on or above the two-dimensional Gaussian rough surfaces under the tapered wave incidence are analyzed.

关键词： parabolic equation rough surface alternating direction implicit (ADI) difference normalizedradar cross section

不同强度运动干预2型糖尿病大鼠骨骼肌羧酸酯酶1及炎症因子的变化

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中国组织工程研究 2025年第2期29卷 269-278页

作者：胡淑娟程平张啸丁一庭刘璇蒲锐汪献旺长江大学教育与体育学院湖北省荆州市423000 吉首大学体育科学学院湖南省吉首市416000 长江大学医学部湖北省荆州市423000

背景:羧酸酯酶1及炎症因子在调节脂质代谢以及葡萄糖稳态方面起着至关重要的作用,然而有关不同强度运动干预对2型糖尿病大鼠骨骼肌羧酸酯酶1及炎症因子的影响尚待揭示。目的:探究不同强度运动干预对2型糖尿病大鼠骨骼肌羧酸酯酶1及炎症... 详细信息

背景:羧酸酯酶1及炎症因子在调节脂质代谢以及葡萄糖稳态方面起着至关重要的作用,然而有关不同强度运动干预对2型糖尿病大鼠骨骼肌羧酸酯酶1及炎症因子的影响尚待揭示。目的:探究不同强度运动干预对2型糖尿病大鼠骨骼肌羧酸酯酶1及炎症因子的影响。方法:取32只8周龄雄性SD大鼠,适应性喂养1周后随机分为正常对照组(n=12)和造模组(n=20),造模组大鼠利用高脂膳食和一次性注射链脲佐菌素制备2型糖尿病模型,建模成功后随机分为糖尿病对照组(n=6)、中等强度运动组(n=6)和高强度间歇运动组(n=6),后2组适应性跑台运动5 d后分别进行对应强度的跑台运动,每天1次,每次50 min,每周训练5 d。连续运动6周后,检测大鼠血糖与血脂相关指标,苏木精-伊红染色观察骨骼肌组织形态学变化,qRT-PCR检测骨骼肌羧酸酯酶1与炎症因子的mRNA表达,Western-blotting及免疫荧光染色检测骨骼肌中羧酸酯酶1与炎症因子的蛋白表达。结果与结论:①与正常对照组相比,糖尿病对照组大鼠空腹血糖、三酰甘油、低密度脂蛋白胆固醇、胰岛素抵抗指数均升高(P<0.05),胰岛素活性降低(P<0.05),骨骼肌中的羧酸酯酶1、NEK7、白细胞介素18的mRNA与蛋白表达均升高(P<0.05)。②与糖尿病对照组相比,中等强度运动组和高强度间歇运动组大鼠空腹血糖、三酰甘油、低密度脂蛋白胆固醇、胰岛素抵抗指数均降低(P<0.05),胰岛素活性升高(P<0.05);中等强度运动组大鼠骨骼肌中的NEK7 mRNA表达降低(P<0.01),羧酸酯酶1、NEK7、白细胞介素18蛋白表达降低(P<0.05);高强度间歇运动组大鼠骨骼肌中的羧酸酯酶1、NEK7、NLRP3、白细胞介素18 mRNA表达降低(P<0.05),羧酸酯酶1、白细胞介素18蛋白表达降低(P<0.05)。③苏木精-伊红染色显示,相较于糖尿病对照组,中等强度运动组大鼠肌纤维间隙变小,内部空洞减少,细胞结构趋于完整;高强度间歇运动组大鼠肌细胞排列松散,组织形态不规则,肌纤维内部空洞较多。④结果表明,中等强度运动和高强度间歇运动均可降低2型糖尿病大鼠的血糖、血脂、胰岛素抵抗与骨骼肌羧酸酯酶1水平,中等强度运动可明显降低骨骼肌NEK7表达,高强度间歇运动可降低骨骼肌白细胞介素18表达,并且羧酸酯酶1与NEK7、白细胞介素18关系密切。

关键词：中等强度有氧运动高强度间歇运动 2型糖尿病羧酸酯酶1 炎症因子

Non-Impact Origin of the Baisha Structure in Hainan Province, China

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Journal of Earth Science 2020年第2期31卷 385-392页

作者： Jiang pu Zhiyong xiao Long xiao cheng Huang Planetary Science Institute School of Earth SciencesChina University of GeosciencesWuhan 430074China Space Science Institute Macao University of Science and TechnologyMacaoChina College of Hydraulic and Ecological Engineering Nanchang Institute of Technology Nanchang 330099China

The Baisha Structure,with a rim-to-rim diameter of^3.7 km,in the center of the Hainan Province,southern China has been considered to be an impact *** investigation and petrological study are presented in this paper to investigate the impact hypothesis for this ***^600-m-thick Lower Cretaceous feldspathic quartz sandstones from the Lumuwan Formation are the major outcrops both within and outside of the *** amphitheater-shaped rim of the structure is composed of granite porphyries that are intruded in the Lumuwan *** interpreted impact breccia and impact melt rocks are actually granite porphyries different cooling rates and weathering *** from locations that most likely have recorded shock metamorphic signatures are sampled,but petrographic analyses reveal no indications of shock *** subtle structural deformation occurs at the contact boundary between the granite porphyries and the feldspathic quartz sandstones,the feldspathic quartz sandstones exhibit uniformed dipping strata across the crater floor and *** the evidence suggests that the Baisha Structure was not formed by impact *** most likely has been shaped by a combination of magmatic intrusion and long-term differential erosion.

关键词： impact crater shock metamorphism differential erosion

Study on crab-cavity-based longitudinal injection scheme and prototype realization of C-band crab cavity for electron storage rings

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Nuclear Science and Techniques 2023年第7期34卷 137-147页

作者： Guan-Hua Wang Bo-cheng Jiang Jian-Hao Tan Qing-Lei zhang Wen-cheng Fang Chang-liang Li Kun Wang xiao-Xia Huang Sheng-Li pu University of Shanghai for Science and Technology Shanghai 200093China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Laboratory for Ultrafast Transient Facility Chongqing UniversityChongqing 401331China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China

A diffraction-limited storage ring with a multi-bend achromat lattice suffers from a small dynamic aperture for conventional off-axis ***,a longitudinal on-axis injection scheme based on a new type of crab cavity is proposed in this *** tracking simulations were performed to study the disturbance of the stored beam and the motion of the injected beam during the injection *** possibility of multi-bunch injections was *** addition,the effect of the long-range wake field induced by the stored beam was analyzed.A C-band standing-wave crab cavity was designed and produced as requested,and its field distribution was *** corresponding results are consistent with the simulation results.

关键词： On-axis injection Crab cavity Bump orbit Wakefield

Model Tests Research on A Float-Over Barge in Shallow Water Under the Undocking Conditions

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China Ocean Engineering 2021年第6期35卷 933-942页

作者： QIN Li-cheng DING Hong-yan zhang pu-yang LI Huai-liang YU Wen-tai State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China China Offshore Oil Engineering Company Limited Tianjin 300461China

In this study,the Jinzhou 9-3 CEPD float-over installation project was *** the undocking condition,the water depth of the motion path of the working barge gradually changed from 10.31 m to 9.41 *** undocking clearance of the HYSY 228 is smaller than 1 m;therefore,the barge shows highly nonlinear hydrodynamic characteristics,and it is difficult to be accurately simulated by numerical ***,it is necessary to obtain the hydrodynamic characteristics and laws of the float-over barge at different water depths by using tank model test,to provide some reference and guidance for float-over operations in shallow water.

关键词： float-over installation shallow water effect undocking conditions model test

A Monotonic Algorithm for Eigenvalue Optimization in Shape Design Problems of Multi-Density Inhomogeneous Materials

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Communications in Computational Physics 2010年第8期8卷 565-584页

作者： Zheng-fang zhang Ke-wei liang xiao-liang cheng Department of Mathematics Zhejiang UniversityHangzhou 310027China

Many problems in engineering shape design involve eigenvalue *** relevant difficulty is that the eigenvalues are not continuously differentiable with respect to the *** this paper,we are interested in the case of multi-density inhomogeneous materials which minimizes the least *** the finite element discretization,we propose a monotonically decreasing algorithm to solve the minimization *** numerical examples are provided to illustrate the efficiency of the present algorithm as well as to demonstrate its availability for the case of more than two *** the computations are sensitive to the choice of the discretization mesh sizes,we adopt the refined mesh strategy,whose mesh grids are 25-times of the amount used in[*** and ***,***.,171(2001),pp.272-288].We also show the significant reduction in computational cost with the fast convergence of this algorithm.

关键词： Multi-density inhomogeneous materials the least eigenvalue optimization problem finite element method monotonic algorithm