检索结果-南通市图书馆

Upfront Alternate Donor HSCT for Children with Severe Aplastic Anemia:A Single Center Prospective Clinical Trail Outcome

在线全文

学校读者我要写书评

暂无评论

Upfront Alternate Donor HSCT for Children with Severe Aplast...

老年阻塞性睡眠呼吸暂停综合征与心血管疾病的研究进展

第十三届江浙沪儿科学术会议暨2016年浙江省医学会儿科学学术年会

作者： LUO CJ LUO CY WANG JM QIN X XU KL zhang bh CHEN J Shanghai Jiao Tong University School of MedicineShanghai Children’s Medical Center

Background:Alternate donor(AD)hematopoietic stem cell transplantation(HSCT)for children with severe aplastic anemia(SAA)remains challenges mainly associated with graft failure and Graft versus Host Disease(GVHD).So it has been considered in the second choice of treatment *** the survival outcomes from AD HSCT in childhood SAA have improved steadily over the past *** answer the question whether the AD HSCT can be

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

第四军医大学学报 2008年第4期29卷 376-378页

作者：黄颖张丙芳王晓明范风云黄晨张琦第四军医大学西京医院老年病二科陕西西安710033 第四军医大学西京医院放疗科陕西西安710033

睡眠呼吸暂停综合征（sleep apnea syndrome，SAS）是指每晚7h睡眠中出现持续10S以上的呼吸暂停大于30次或睡眠呼吸暂停／低通气指数（AHI，即平均每小时呼吸暂停次数＋低通气次数）≥5，60岁以上老年人AHI≥***分为三型，即阻塞性（obs... 详细信息

睡眠呼吸暂停综合征（sleep apnea syndrome，SAS）是指每晚7h睡眠中出现持续10S以上的呼吸暂停大于30次或睡眠呼吸暂停／低通气指数（AHI，即平均每小时呼吸暂停次数＋低通气次数）≥5，60岁以上老年人AHI≥***分为三型，即阻塞性（obstructive sleep apnea，OSA）、中枢性（central aleep apnea，CSA）和混合性（mixed sleep apnea，MSA）．阻塞性睡眠呼吸暂停综合征（obstructive sleep apnea syndrome，OS-AS）是临床最常见类型，其特点是睡眠期间反复发生部分或完全上气道闭塞，导致气流减少或完全停止，甚至窒息.

关键词：睡眠呼吸暂停,阻塞性心血管疾病老年人

Joint Beam Scheduling and Power Optimization for Beam Hopping LEO Satellite Systems

在线全文

学校读者我要写书评

暂无评论

China Communications 2024年第10期21卷 226-239页

作者： Zheng Shuang zhang Xing Wang Peng Wang Wenbo Key Laboratory of Universal Wireless Communication Ministry of EducationSchool of Information and Communication EngineeringBeijing University of Posts and TelecommunicationsBeijing 100876China

Low earth orbit(LEO) satellite communications can provide ubiquitous and reliable services,making it an essential part of the Internet of Everything network. Beam hopping(bh) is an emerging technology for effectively addressing the issue of low resource utilization caused by the non-uniform spatio-temporal distribution of traffic demands. However, how to allocate multi-dimensional resources in a timely and efficient way for the highly dynamic LEO satellite systems remains a challenge. This paper proposes a joint beam scheduling and power optimization beam hopping(JBSPO-bh) algorithm considering the differences in the geographic distribution of sink nodes. The JBSPO-bh algorithm decouples the original problem into two sub-problems. The beam scheduling problem is modelled as a potential game,and the Nash equilibrium(NE) point is obtained as the beam scheduling strategy. Moreover, the penalty function interior point method is applied to optimize the power allocation. Simulation results show that the JBSPO-bh algorithm has low time complexity and fast convergence and achieves better performance both in throughput and fairness. Compared with greedybased bh, greedy-based bh with the power optimization, round-robin bh, Max-SINR bh and satellite resource allocation algorithm, the throughput of the proposed algorithm is improved by 44.99%, 20.79%,156.06%, 15.39% and 8.17%, respectively.

关键词： beam hopping interior point method potential game resource allocation

Facile construction of Mxene-supported niobium hydride nanoparticles toward reversible hydrogen storage in magnesium borohydride

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第9期43卷 4387-4400页

作者： Ao Xia Jia-Guang Zheng Qing-Bo zhang Yu-Gang Shu Cheng-Guo Yan Liu-Ting zhang Zhan-Liang Tao Li-Xin Chen School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071China State Key Laboratory of Silicon and Advanced Semiconductor Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China

The facile construction of nanoscale Nbh_(x)supported by Ti_(3)C_(2)(Nbh_(x)@Ti_(3)C_(2))was achieved using facile ball milling strategy to improve the hydrogen desorption kinetics and reversibility of magnesium borohydride(Mg(bh_(4))_(2)).The doping of 30 wt%Nbh_(x)@Ti_(3)C_(2)catalyst reduced the onset dehydrogenation temperature of Mg(bh_(4))_(2)to 71.2℃.Additionally,the Mg(bh_(4))_(2)+30Nbh_(x)@Ti_(3)C_(2)composite achieved remarkable hydrogen release of over 9.2 wt%at a temperature as low as 230℃,indicating unexpected dehydrogenation ***,the reversibility of Nbh_(x)@Ti_(3)C_(2)doped Mg(bh_(4))_(2)was retained to more than 4.2 wt%after four cycles,which was increased by 68%compared to that of undoped Mg(bh_(4))_(2).The strong catalysis of Nbh_(x)@Ti_(3)C_(2)catalyst could be attributed to the synergistic effect of Nbh_(x)and Ti_(3)C_(2)in hydrogen spillover and ***_(x)acted as a"hydrogen pump"for effective hydrogen spillover,while Ti_(3)C_(2)created numerous diffusion channels for hydrogen dissolution and provided the active catalytic site to facilitate the re/dehydrogenation of Mg(bh_(4))_(2).

关键词： Hydrogen storage Magnesium borohydride Catalysts Mxene

Coercivity mechanism of high-performance anisotropic heterostructure SmCo_(5)magnets

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2024年第10期42卷 1882-1888页

作者： Yuan Teng Yuqing Li Weiqiang Liu Xiaochang Xu Zhanjia Wang Jianjun Yang Dongtao zhang Hongguo zhang Qingmei Lu Qiong Wu Weixing Xia Ming Yue Faculty of Materials and Manufacturing Key Laboratory of Advanced Functional MaterialsMinistry of Education of ChinaBeijing University of TechnologyBeijing100124China School of Mechanical and Electrical Engineering Henan Institute of Science and TechnologyXinxiang453000China School of Mechanical Engineering Anyang Institute of TechnologyAnyang455000China Key Laboratory of Magnetic Materials and Devices Ningbo Institute of Material Technology and EngineeringChinese Academy of SciencesNingbo315201China

Due to its large magnetocrystalline anisotropy field and high Curie temperature,SmCo-based magnets are irreplaceable in high-temperature applications,The hot-deformed SmCo-based magnets are especially attractive for their excellent corrosion resistance,making them more suitable for harsh ***,it is still challenging for hot-deformed SmCo-based magnets to obtain high magnetization and high coercivity ***,it is necessary to analyze the relationship between its microstructure and magnetic properties and explore its magnetic hardening mechanism to guide the further improvement of magnetic *** this paper,the anisotropic heterostructure SmCo_(5)magnet was prepared by combining large height-reduction and introducing a nano-grained Smrich *** c-axis texture,(bh)m of 16.1 MGOe,and H_(ci)of 9.6 kOe were obtained via the heterostructure with SmCo_(5)micron-grain and Sm-rich nano-scale *** magnetic domain observation and technical magnetization analysis demonstrate that the coe rcivity mechanism is dominated by *** results also show that the smooth and Sm-rich precipitated grain boundary provides weak pinning *** provides a reference for the development of high-pe rformance nanocrystalline SmCo_(5)magnets.

关键词： Permanent magnet Heterostructure Rare earths Coercivity mechanism Hot-deformed SmCo magnet

C反应蛋白诱导肾小管上皮细胞TGFβ1表达的受体途径

在线全文

学校读者我要写书评

暂无评论

中华医学杂志 2012年第18期92卷 1281-1284页

作者：谢恺庆史伟李东风章斌刘双信周红卫广东省医学科学院广东省人民医院肾内科广州510080 广东省医学科学院医学研究中心广州510080 广西医科大学第一附属医院肾内科暨血液净化部

目的观察C反应蛋白（CRP）对肾小管上皮细胞Fcγ受体表达的影响，并探讨Fcγ受体在CRP诱导转化生长因子β1（TGFβ1）表达中的作用。方法以CRP干预人肾小管上皮细胞株（HK-2细胞），实时定量PCR检测FcγRI（CD64）、FcγRIIa（CD32a）... 详细信息

目的观察C反应蛋白（CRP）对肾小管上皮细胞Fcγ受体表达的影响，并探讨Fcγ受体在CRP诱导转化生长因子β1（TGFβ1）表达中的作用。方法以CRP干预人肾小管上皮细胞株（HK-2细胞），实时定量PCR检测FcγRI（CD64）、FcγRIIa（CD32a）、FcγRⅢ（CDl6）3种Fcγ受体mRNA表达。根据实验结果，采用流式细胞术和Western印迹法检测CD32a蛋白的表达。以抗CD32a抗体封闭CD32a受体，实时定量PCR检测TGFβ1mRNA表达，酶联免疫吸附试验（ELISA）检测TGFβ1蛋白和I型胶原蛋白、Ⅳ型胶原蛋白的分泌水平。结果HK-2细胞无CD64和CDl6mRNA表达，有CD32amRNA表达。CD32amRNA表达呈剂量依赖性增高（P〈0．01），CRP10mg／L刺激达到高峰。流式细胞术示CRP10mg／L刺激HK-2细胞24hCD32a平均表达量为23．35％±7．43％，未刺激组为1．66％±0．28％，差异有统计学意义（P〈0．01）。Western印迹显示CRP以剂量依赖方式上调CD32a表达，CRP10mg／L显著性上调CD32a表达（P〈0．01）。抗CD32a抗体封闭CD32a受体后，CRP作用减弱，TGFIMmRNA表达下调（P〈0．01），TGFβ1、I型胶原蛋白、Ⅳ型胶原蛋白的分泌下降（均P〈0．05）。结论CRP刺激可上调肾小管上皮细胞表面的CD32a受体的表达，CRP通过肾小管上皮细胞CD32a受体介导促纤维化因子TGFβ1表达上调。

关键词： C反应蛋白质肾小管上皮细胞受体 IgG 转化生长因子β1

Microbiologically influenced corrosion resistance enhancement of coppercontaining high entropy alloy Fe_(x)Cu_(1−x)CoNiCrMn against Pseudomonas aeruginosa

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2024年第11期31卷 2488-2497页

作者： Yuntian Lou Weiwei Chang Yu zhang Shengyu He Xudong Chen Hongchang Qian Dawei zhang Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China National Materials Corrosion and Protection Data Center University of Science and Technology BeijingBeijing 100083China BRI Southeast Asia Network for Corrosion and Protection(MOE) Shunde Innovation SchoolUniversity of Science and Technology BeijingFoshan 528399China School of Materials Science and Energy Foshan UniversityFoshan 528000China

To enhance the microbiologically influenced corrosion(MIC)resistance of FeCoNiCrMn high entropy alloy(HEAs),a series of Fe_(x)Cu_((1−x))CoNiCrMn(x=1,0.75,0.5,and 0.25)HEAs were *** characteristics,corrosion behavior(morphology observation and electrochemical properties),and antimicrobial performance of Fe_(x)Cu_((1−x))CoNiCrMn HEAs were evaluated in a medium inoculated with typical corrosive microorganism Pseudomonas *** aim was to identify copper-containing FeCoNiCrMn HEAs that balance corrosion resistance and antimicrobial *** revealed that all Fe_(x)Cu_((1−x))CoNiCrMn(x=1,0.75,0.5,and 0.25)HEAs exhibited an FCC(face centered cubic)phase,with significant grain refinement observed in Fe_(0.75)Cu_(0.25)CoNiCrMn *** tests indicated that Fe_(0.75)Cu_(0.25)CoNiCrMn HEA demonstrated lower corrosion current density(i_(corr))and pitting potential(E_(pit))compared to other Fe_(x)Cu_((1−x))CoNiCrMn HEAs in ***-inoculated medium,exhibiting superior resistance to ***-microbial tests showed that after 14 d of immersion,Fe_(0.75)Cu_(0.25)CoNiCrMn achieved an antibacterial rate of 89.5%,effectively inhibiting the adhesion and biofilm formation of ***,thereby achieving resistance to MIC.

关键词： microbiologically influenced corrosion Pseudomonas aeruginosa high entropy alloys antibacterial property

Development of surrogate-optimization models for a novel transcritical power cycle integrated with a small modular reactor

在线全文

学校读者我要写书评

暂无评论

Energy and AI 2024年第1期15卷 15-25页

作者： Yili zhang Jacob Bryan Geordie Richards Hailei Wang Department of Mechanical&Aerospace Engineering Utah State UniversityLoganUT 84322USA

In recent years,various types of surrogate optimization models have been proposed to reduce the computational time and to improve the emulation *** this study,by leveraging an ANN surrogate model developed earlier,a comprehensive and efficient optimization algorithm is conceived for the global optimal design of an integrated regenerative methanol transcritical *** combines a unique converging/diverging classifier model into the surrogate model to form a surrogate-based model,which significantly improves the prediction accuracy of the objective *** binary classifiers are explored and the multi-layer feed-forward(MLF)neural network classifier is *** addition,within the five global optimizers being explored,the basinhopping(bh)and dual-annealing(DA)are *** optimal surrogate-based model and global optimizers are then combined to form a unique surrogate-optimizer *** surrogate-optimizer model is slightly outperformed by the physics-based model in terms of the optimization results,the time consumption of the surrogate-optimizer model during the optimization searching process is 99%less than that of the physicsbased *** the results,the surrogate-optimizer model is slightly outperformed by the physics-based model in terms of the optimization results,where the Levelized Cost of Energy(LCOE)of the Surrogate-DA and Surrogate-bh models are 77.912 and 78.876$/MWh,respectively,compared to the 77.190$/MWh of the Baseline model with fairly close penalties between *** the meantime,the time consumption of the surrogate-optimizer model during the optimization searching process is 99%less than that of the physics-based model.

关键词： Surrogate model Optimization Binary classifier model Global optimizer Thermodynamic model Transcritical cycle Small modular reactors

Directly targeting BAX for drug discovery:Therapeutic opportunities and challenges

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第6期14卷 2378-2401页

作者： Zhenwei zhang Linghui Hou Dan Liu Shenglin Luan Min Huang Linxiang Zhao Key Laboratory of Structure-Based Drugs Design&Discovery of Ministry of Education Shenyang Pharmaceutical UniversityShenyang 110016China China Resources Sanjiu Medical&Pharmaceutical Co. Ltd.Shenzhen 518000China

For over two decades,the development of B-cell lymphoma-2(Bcl-2)family therapeutics has primarily focused on anti-apoptotic proteins,resulting in the first-in-class drugs called bh3 mimetics,especially for Bcl-2 inhibitor *** pro-apoptotic protein Bcl-2-associated X protein(BAX)plays a crucial role as the executioner protein of the mitochondrial regulated cell death,contributing to organismal development,tissue homeostasis,and *** dysregulation of BAX is closely associated with the onset and progression of diseases characterized by pathologic cell survival or death,such as cancer,neurodegeneration,and heart *** addition to conducting thorough investigations into the physiological modulation of BAX,research on the regulatory mechanisms of small molecules identified through biochemical screening approaches has prompted the identification of functional and potentially druggable binding sites on BAX,as well as diverse all-molecule BAX *** review presents recent advancements in elucidating the physiological and pharmacological modulation of BAX and in identifying potentially druggable binding sites on ***,it highlights the structural and mechanistic insights into small-molecule modulators targeting diverse binding surfaces or conformations of BAX,offering a promising avenue for developing next-generation apoptosis modulators to treat a wide range of diseases associated with dysregulated cell death by directly targeting BAX.

关键词： Apoptosis Pro-apoptotic protein BAX Dynamic conformational activation Small-molecule apoptosis modulators