检索结果-南通市图书馆

Blockade of integrin signaling reduces chemotherapy-induced premature senescence in collagen cultured bladder cancer cells

在线全文

学校读者我要写书评

暂无评论

Precision Clinical Medicine 2022年第2期5卷 63-71页

作者： Linghui Deng Kun Jin Xianghong Zhou zilong zhang Liming Ge Xingyu Xiong Xingyang Su Di Jin Qiming Yuan Chichen zhang Yifan Li Haochen Zhao Qiang Wei Lu Yang Shi Qiu National Clinical Research Center of Geriatrics the Center of Gerontology and GeriatricsWest China HospitalSichuan UniversityChengdu 610041China Department of Urology Institute of Urology and National Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610041China West China School of Medicine Sichuan UniversityChengdu 610041China Department of Pharmaceutical and Bioengineering School of Chemical EngineeringSichuan UniversityChengdu 610065China Department of Molecular Oncology Institute of Oncology Research(IOR)Oncology Institute of Southern Switzerland(IOSI)Bellinzona 6500Switzerland

Background:Diminished sensitivity towards chemotherapy remains the major impediment to the clinical treatment of bladder ***,the critical elements in control of chemotherapy resistance remain ***:We adopted improved collagen gels and performed cytotoxicity analysis of doxorubicin(DOX)and mitomycin C(MMC)of bladder cancer cells in a 3D culture *** then detected the expression of multidrug resistant gene ABCB1,dormancy-associated functional protein chicken ovalbumin upstream-transcription factor 1(COUPTF1),cell proliferation marker Ki-67,and cellular senescence marker senescence-associatedβ-galactosidase(SA-β-Gal)in these *** further tested the effects of integrin blockade or protein kinase B(AKT)inhibitor on the senescent state of bladder ***,we examined the tumor growth and survival time of bladder cancer mouse models given the combination treatment of chemotherapeutic agents and integrinα2β1 ligand peptide TFA(TFA).Results:Collagen gels played a repressive role in bladder cancer cell apoptosis induced by DOX and *** mechanism,collagen activated the integrinβ1/AKT cascade to drive bladder cancer cells into a premature senescence state via the p21/p53 pathway,thus attenuating chemotherapy-induced *** addition,TFA had the ability to mediate the switch from senescence to apoptosis of bladder cancer cells in xenograft ***,TFA combined with chemotherapeutic drugs produced a substantial suppression of tumor growth as well as an extension of survival time in ***:Based on our finding that integrinβ1/AKT acted primarily to impart premature senescence to bladder cancer cells cultured in collagen gel,we suggest that integrinβ1 might be a feasible target for bladder cancer eradication.

关键词： premature senescence integrins bladder cancer chemotherapy collagen

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高超声速目标相干双频激光雷达探测技术

红外与激光工程 2019年第11期48卷 58-64页

作者：刘潇明赵长明张子龙北京理工大学光电学院北京100081 信息光子技术工业和信息化部重点实验室北京100081

为研究双频激光雷达技术在高超声速目标探测方面的应用,理论分析了激光在等离子中的吸收衰减特性,以RAM-C实验数据为参考,通过仿真计算得到不同高超声速飞行场景下钝头体模型的等离子体电子密度,验证了计算的准确性。计算得到钝头体驻... 详细信息

为研究双频激光雷达技术在高超声速目标探测方面的应用,理论分析了激光在等离子中的吸收衰减特性,以RAM-C实验数据为参考,通过仿真计算得到不同高超声速飞行场景下钝头体模型的等离子体电子密度,验证了计算的准确性。计算得到钝头体驻点线上温度分布范围为8000~16000 K,并结合理论分析得到了激光在等离子体鞘套中的衰减与电子密度、温度和激光频率的关系,表明等离子体鞘套对激光的吸收十分微小;通过对双频激光和单频激光在湍流传输中回波信噪比的对比分析,得到了双频激光的抗湍流干扰特性。由此表明双频激光雷达是探测高超声速目标的有效方式。

关键词：双频激光雷达等离子体湍流高超声速目标

Prognostic value of inflammation-immunity-nutrition score in patients with hepatocellular carcinoma treated with anti-PD-1 therapy

在线全文

学校读者我要写书评

暂无评论

Prognostic value of inflammation-immunity-nutrition score in...

从外资企业参与英国“知识转移合作伙伴计划”看我国产学研合作

2022CCTB中国肿瘤标志物学术大会暨中国整合肿瘤学大会暨第十六届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者： zilong zhang yuxin liang jin shang ying shi xiaolun huang Department of Hepatobiliary-Pancreatic Surgery Cell Transplantation CenterSichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of China

Background:There are no validated biomarkers that can predict the clinical benefit of immune checkpoint blockers against the programmed cell death protein 1(PD-1) treatments in hepatocellular carcinoma(HCC).This study aimed to investigate the prognostic value of inflammation-immunity-nutrition score(IINS) in patients with HCC treated with ***:A consecutive series of 101 HCC patients treated with PD-1 inhibitors in Sichuan Provincial Peoples Hospital between January 2018 and August 2020 were enrolled in the retrospective ***(0–6) was constructed based on pretreatment high-sensitivity C-reactive protein(hsCRP),lymphocyte(LYM),and albumin(ALB).The patients were divided into high and low IINS groups according to IINS *** values of each variable were evaluated with univariate and multivariate time-dependent Cox regression *** curves were calculated and compared using the Kaplan–Meier method and log-rank *** prognostic performance of IINS was further compared with that of other traditional prognostic indicators by receiver operating characteristic(ROC) curve and the areas under the ROC ***:Patients with low IINS had longer overall survival(OS)(HR:4.711,95% CI:1.80–12.37,p=.001) and progression-free survival(HR:3.411,95% CI:1.79–6.51,p<.0001) than those with high *** multivariate analysis identified IINS(HR:3.746,95% CI:1.05–13.38,p=.042) and tumor number(HR:5.111,95% CI:1.075–24.299,p=.04) as independent prognostic *** to ROC analysis,IINS(AUC=0.729,95% CI:0.597–0.861,p=.002) presented better prognostic performance than other traditional prognostic *** area of the IINS-CA19-9 under the ROC curve(AUC) was higher than that of the IINS or CA19-9 levels for the prediction of ***:The results suggest that IINS may be an independent prognostic indicator for HCC patients treated with anti-PD-1 ***-CA19-9 classification may be more effective in predicting clinica

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

科技管理研究 2013年第23期33卷 33-35页

作者：张子龙上海大学上海市200444

英国政府历来对于科研成果的商业化格外重视,一方面为此制定了一系列相应的科技计划,另一方面随着全球化的发展积极吸引世界上先进的科技力量。"知识转移合作伙伴计划"(KTP)是英国重要的产学研计划,通过对外资企业参与英国KTP的考察,可... 详细信息

英国政府历来对于科研成果的商业化格外重视,一方面为此制定了一系列相应的科技计划,另一方面随着全球化的发展积极吸引世界上先进的科技力量。"知识转移合作伙伴计划"(KTP)是英国重要的产学研计划,通过对外资企业参与英国KTP的考察,可以清晰地看到这两种趋势的高效结合,这对于我国有效吸引外资、完善产学研计划具有借鉴意义。

关键词：产学研合作 KTP伙伴计划外资企业

在线全文

学校读者我要写书评

暂无评论

焦距测量中线纹清晰度评价函数的研究

光学学报 2023年第9期43卷 117-126页

作者：刘济豪卢荣胜张紫龙张艾琳合肥工业大学仪器科学与光电工程学院安徽合肥230009

当自动对焦用于玻罗板线纹等方向性强的目标时,线纹方向的不确定性导致一些清晰度函数的鲁棒性降低甚至无法找到对焦位置。针对上述问题,通过Hough直线检测得到离焦线纹的角度,构建一种基于Hough变换的线纹清晰度评价函数,该函数的灰度... 详细信息

当自动对焦用于玻罗板线纹等方向性强的目标时,线纹方向的不确定性导致一些清晰度函数的鲁棒性降低甚至无法找到对焦位置。针对上述问题,通过Hough直线检测得到离焦线纹的角度,构建一种基于Hough变换的线纹清晰度评价函数,该函数的灰度算子垂直于线纹,对线纹方向变化具有较强的鲁棒性。为了比较线纹方向对清晰度函数性能的影响,对5组不同角度的线纹图像进行评价,得到清晰度曲线,并引入平缓区标准差等参数对曲线进行定量评定。实验结果表明,与传统的评价函数相比,基于Hough变换的评价函数的平缓区均值减小59.85%,标准差减小46.05%,对焦偏差减小92.63%,平均运行时间减少36.37%,镜头焦距的相对误差减小62.12%。

关键词：测量自动对焦清晰度评价焦距测量放大率法 Hough变换

在线全文

学校读者我要写书评

暂无评论

深部直墙拱形巷道围岩板裂破坏的试验研究

采矿与岩层控制工程学报 2024年第4期6卷 111-125页

作者：司雪峰张子龙宫凤强南华大学资源环境与安全工程学院湖南衡阳421001 衡阳华研工程科技有限公司湖南衡阳421001 东南大学土木工程学院江苏南京211189

为了研究深部直墙拱形巷道围岩板裂破坏特征,利用TRW-3000岩石真三轴电液伺服诱变试验机,对含直墙拱形贯穿巷道的立方体花岗岩试样进行了三向不等压加载试验,并借助微型摄像机实时监控围岩破坏情况。试验结果表明,花岗岩直墙拱形巷道围... 详细信息

为了研究深部直墙拱形巷道围岩板裂破坏特征,利用TRW-3000岩石真三轴电液伺服诱变试验机,对含直墙拱形贯穿巷道的立方体花岗岩试样进行了三向不等压加载试验,并借助微型摄像机实时监控围岩破坏情况。试验结果表明,花岗岩直墙拱形巷道围岩产生平行于直墙的板裂化结构,呈明显的拉伸破坏特征。随着板裂破坏沿巷道两侧围岩逐渐向深部发展,最终在围岩两侧距拱底(0.20~0.25)h(h为直墙拱形巷道的高度)处形成对称的V型槽。在相同应力条件下,与花岗岩圆形巷道破坏特征相比,直墙拱形巷道围岩初始破坏应力较高,主要表现为静态破坏,产生的岩片较大,呈细长条状,具有明显的层裂现象;而圆形巷道围岩破坏较为剧烈,属于动态破坏,产生的岩片相对较小,但是两种断面产生的岩片均表现出中间厚两边薄的特征。通过对比不同岩性直墙拱形巷道围岩破坏特征发现,花岗岩的破坏较为剧烈,红砂岩的较弱。对于千枚岩直墙拱形巷道,随着层理角度的增加,围岩的破坏模式从平行于层理面的拉伸破坏转变为平行于层理面的剪切滑移破坏,再到穿越层理面的剪切破坏,最后转化为穿越层理面的拉伸破坏。

关键词：直墙拱形巷道板裂破坏真三轴试验三维高应力岩性

Forming conditions of interlayer oxidation zone in northeastern Ordos Basin

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Forming conditions of interlayer oxidation zone in northeast...

Uranium Mineralization in Northeastern Ordos Basin

第三届全国青年地质大会

作者： Mingjian Dai Lu Liu Yunbiao Peng Yangquan Jiao Aisheng Miao zilong zhang Chengyong zhang China University of Geosciences CNNC Geological Party No.208 Beijing Research Institute of Uranium Geology East China Institute of Technology

1 Introduction The interlayer oxidation zone in northeastern Ordos Basin was huge with width up to60 km and extending laterally about 300 *** spatial distribution of ore bodies was obvious affected by the oxidation *** of the downward migration of uranium-bearing oxygen-containing confined groundwater along the permeable sandstones,uranium was enriched near the roll-front line of interlayer oxidation zone to form uranium deposits(Quan and Li,2002).

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Uranium Mineralization in Northeastern Ordos Basin

第三届全国青年地质大会

作者： Lu Liu Mingjian Dai Yunbiao Peng Yangquan Jiao Aisheng Miao zilong zhang Chengyong zhang China University of Geosciences CNNC Geological Party No.208 Beijing Research Institute of Uranium Geology East China Institute of Technology

1 Introduction The study area is located at the northeastern part of Ordos Basin and belongs to the Yimeng Uplift of Yishan Monocline area,near the Hangjinqi sag at the southern margin and Hetao graben at the northern *** Northeastern Ordos basin,main super large sized uranium deposits discovered include Zaohuohao,Nalinggou and Daying uranium *** sandstone-type uranium metallogenic belt is consisted by these

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

苏区马克思主义图书出版中国化的话语建构

出版发行研究 2020年第3期 88-93,87页

作者：张品良张子龙江西财经大学新闻传播系江西财经大学马克思主义学院

苏区时期,党和苏维埃政府在条件十分艰苦的环境下,以组织传播的方式编译出版发行了大量马克思主义图书,用于指导中国苏维埃运动的实践,取得了巨大传播成果。但由于当时受党内“左”倾教条主义错误思想的影响,一些人不顾中国国情复制移... 详细信息

苏区时期,党和苏维埃政府在条件十分艰苦的环境下,以组织传播的方式编译出版发行了大量马克思主义图书,用于指导中国苏维埃运动的实践,取得了巨大传播成果。但由于当时受党内“左”倾教条主义错误思想的影响,一些人不顾中国国情复制移植苏俄模式,照抄照套苏俄理论,使中国苏维埃运动遭受挫折。正是以毛泽东为代表的中国共产党人在总结经验教训的反思中,同党内错误路线进行了坚决斗争,把马克思列宁主义与中国革命具体实践相结合,开启了马克思主义中国化的起始语境。

关键词：苏区马克思主义图书出版中国化话语