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Public policies and conservation plans of historic urban landscapes under the sustainable heritage tourism milieu: discussions on the equilibrium model on Kulangsu Island, UNESCO World Heritage site

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Built Heritage 2023年第1期7卷 24-43页

作者： Long Zhao Yuan Li Na zhang zhenxin zhang School of Architecture and Civil Engineering Xiamen UniversityNo.422Siming South RoadXiamen 361005FujianChina Xiamen Key Laboratory of Integrated Application of Intelligent Technology for Architectural Heritage Protection Xiamen 361005China Department of Architecture Xiamen UniversityNo.422Siming South RoadXiamen 361005FujianChina School of Architecture Urban Planning Construction Engineering Polytechnic University of MilanPiazza Carlo D'Arco346100 MantuaLombardiaItaly

Purpose The tensions and threats in historic urban landscapes brought about by heritage tourism are still regional,global,general,and dynamic *** Kulangsu,there is an obvious problem in the connection between the current conservation plan and public *** a large extent,public policy cannot effectively,specifically,and flexibly respond to the dynamic problems in the implementation of the conservation plan,which seems insufficient concerning the effect of these conservation plans and public policies on promoting the adaptive reuse and sustainable tourism of the historic urban in Kulangsu heritage ***,giving more consideration to the combination of public policies and conservation plans of historic urban landscapes under the heritage tourism milieu,ensuring a balanced,sustainable,and integrated development pattern still calls for new discussions in achieving good performance of sustainable heritage *** study conceptually discusses the equilibrium model of historic urban landscapes with a range of strategies under a sustainable heritage tourism background and responds to the synthetic contradiction of the imbalances among public policy,conservation plans,and development ***/methodology/approach The study is based on a range of prepared desktop studies(public policy studies,conservation plans),field surveys,participant observations,and randomised interviews to respond to the insufficiency of the current *** This study discusses the equilibrium model of sustainable heritage tourism at heritage *** takes Kulangsu Island,a UNESCO World Heritage site in Southeast China,as an example to discuss the equilibrium model,which encompasses a convergent parallel framework and three dimensions concerning heritage management and *** equilibrium model of historic urban landscapes is a dynamic framework that integrates social,economic,environmental,and cultural concerns into a holistic collaborative framew

关键词： sustainable heritage tourism historic urban landscapes equilibrium model public policies conservation plans Kulangsu Island

DDX6通过调控CKMT1A mRNA稳定性促进鼻咽癌细胞增殖和迁移的机制研究

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中国癌症杂志 2024年第5期34卷 451-459页

作者：熊茄妍雷伟游波张振新谢海静单颖夏天周勇南通大学附属医院耳鼻咽喉头颈外科研究所江苏南通226001 南通大学医学院江苏南通226001 苏州大学附属第二医院耳鼻咽喉头颈外科江苏苏州215000 南通大学附属医院耳鼻咽喉头颈外科江苏南通226001

背景与目的:DDX是一类腺苷三磷酸(adenosine triphosphate,ATP)依赖的RNA解旋酶,与mRNA调控、肿瘤增殖及侵袭等密切相关。本研究旨在探讨DDX家族成员DDX6对CKMT1A mRNA稳定性的影响以及DDX6-CKMT1A轴对人鼻咽癌细胞CNE2增殖和迁移能力... 详细信息

背景与目的:DDX是一类腺苷三磷酸(adenosine triphosphate,ATP)依赖的RNA解旋酶,与mRNA调控、肿瘤增殖及侵袭等密切相关。本研究旨在探讨DDX家族成员DDX6对CKMT1A mRNA稳定性的影响以及DDX6-CKMT1A轴对人鼻咽癌细胞CNE2增殖和迁移能力的影响及其分子机制。方法:检索癌症基因组图谱(The Cancer Genome Atlas,TCGA)数据库中DDX6和CKMT1A在人头颈部鳞状细胞癌中的表达情况并进行相关性分析,利用蛋白质印迹法(Western blot)检测南通大学附属医院保存的人体鼻咽癌组织和正常鼻咽部组织中CKMT1A和DDX6的表达,本研究通过了南通大学附属医院伦理委员会的审查(编号:2022-L114)。利用transwell实验检测细胞迁移能力,采用EdU试剂盒检测细胞增殖能力,采用细胞集落形成实验检测克隆形成能力。转染慢病毒、质粒,构建南通大学附属医院保存的人源鼻咽癌细胞CNE2的shDDX6、sh-CKMT1A、sh-CKMT1A+sh-DDX6和oe-CKMT1A细胞模型,明确DDX6和CKMT1A表达水平对鼻咽癌细胞恶性生物学表型的影响。构建BALC/c裸小鼠皮下移植瘤模型,检测DDX6和CKMT1A在小鼠体内对鼻咽癌细胞成瘤性的影响。采用RNA稳定性实验检测敲除DDX6对CKMT1A mRNA的影响,进一步明确DDX6的分子机制。结果:人鼻咽癌组织中DDX6高表达,CKMT1A低表达,DDX6与CKMT1A表达呈负相关。DDX6通过破环CKMT1A mRNA稳定性,抑制CKMT1A蛋白质翻译。在CNE2细胞中,CKMT1A低表达可增强细胞迁移和增殖能力,高表达则抑制细胞迁移和增殖能力,而DDX6的敲除可逆转CKMT1A下调导致的恶性行为进展。在裸鼠皮下移植瘤模型中,低表达CKMT1A促进肿瘤细胞生长,低表达DDX6抑制肿瘤细胞生长,而同时敲除DDX6与CKMT1A能恢复单独敲低DDX6导致的抑制效果。结论:鼻咽癌细胞中DDX6通过破坏CKMT1A mRNA稳定性,负调控CKMT1A蛋白质翻译,增强鼻咽癌细胞增殖和迁移能力,从而促进鼻咽癌恶性进展。

关键词：鼻咽癌 CKMT1A DDX6 细胞增殖细胞迁移

多场所实验室环境监测质量管理体系的构建与实践

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中国环境监测 2024年第3期40卷 27-33页

作者：彭刚华尹群康长安李晓燕张振欣蔡芹欧阳涛钟鸿雁陈宜夏新江西省生态环境监测中心江西南昌330000 中国环境监测总站国家环境保护环境监测质量控制重点实验室北京100012

在事业单位机构改革过程中,部分事业单位的法人资格被重组到上一级机构,而不再具有独立法人资格,其原有的CMA检验检测资质不复存在。撤并以后的环境监测机构各项业务如何融合开展,资质认定如何管理,多个实验室场所质量管理体系如何构建... 详细信息

在事业单位机构改革过程中,部分事业单位的法人资格被重组到上一级机构,而不再具有独立法人资格,其原有的CMA检验检测资质不复存在。撤并以后的环境监测机构各项业务如何融合开展,资质认定如何管理,多个实验室场所质量管理体系如何构建,是当前一些检验检测机构亟待解决的普遍性问题。为此,该研究在优化多场所实验室质量管理体系,制定科学、合理、全面、具备开放性和可拓展的多场所实验室质量管理体系文件方面进行了积极探索。以江西省生态环境监测中心“1+11”多场所实验室质量管理为例,结合江西省环境监测机构改革现状,兼顾资质认定有关法律法规要求,就环境监测多场所实验室提出了一套系统性的质量管理体系构建模式,希望为多场所检验检测机构的质量管理提供借鉴。

关键词：机构改革环境监测多场所实验室质量管理体系

Combination of Nitrogen-Rich Skeleton and Coordination Group:Synthesis of a High-Energy Primary Explosive Based on 1H-Tetrazole-5-Carbohydrazide

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Defence Technology（防务技术） 2024年第1期31卷 271-277页

作者： Tingwei Wang Zujia Lu Shu Bu Baolong Kuang Lu zhang zhenxin Yi Kun Wang Shunguan Zhu Jianguo zhang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China School of Chemical Engineering Nanjing University of Science and Technology200 Xiaolingwei StreetXuanwuNanjing 210094China Department of Chemistry Laboratory of Structure and Functional Regulation of Hybrid MaterialsAnhui UniversityMinistry of EducationHefei 230601China

The high energy coordination compounds Cu(TZCA)_(2)(ClO_(4))_(2)(ECCs-1) was prepared by 1H-tetrazole-5-carbohydrazide(TZCA) with a high energy skeleton and a strong coordination ability *** the same time,the reaction activity of the ligand was explored,and the single crystal structure of it and intermediate were *** structures of all substances were characterized by IR and *** the structure and composition of ECCs-1 are confirmed by ESP,AC,SEM and *** and chemical properties tests show that ECCs-1 has an acceptable thermal stability(T_(d)=177℃) and extremely sensitive mechanical stimulation(IS=1 J,FS=5 N).The comprehensive performance test results show that ECCs-1 has excellent initiation *** addition,the decomposition mechanism of ECCs-1 is explored from two aspects of experiment and theoretical calculation.

关键词： 1H-tetrazole-5-carbohydrazide Primary explosive Decomposition mechanism Coordination polymers Laser

Research on One-Piece Structure Target Flow Sensing Technology Based on Fiber Bragg Grating

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Photonic Sensors 2016年第4期6卷 303-311页

作者： Chuntong LIU Zhengyi zhang Hongcai LI zhenxin HE Xiaofeng ZHAO Rongjing WU Department Two Rocket Force University of Engineering Xi 'an 710025 China

In view of problems existing in the detection of the traditional hydraulic system, such as the large volume of sensor and the low measurement accuracy, a new one-piece target type flow sensor is designed and researched based on fiber Bragg grating （FBG）. A compact structure is designed, which is convenient to be dismantled, processed, and installed, based on the analysis of the principle of FBG and the structure of target type flow sensor. The force of target put in fluid flow is turned into the FBG wavelength drift, with a corresponding relationship. The problem on the cross sensitivities of the temperature and strain is solved effectively by using double FBG symmetrically pasted on the both surfaces of the cantilever. The impact on the fluid state is analyzed through simulation in the software FLUENT, and the results show that the impact was smaller than that of the traditional structure. The results of experiments in the hydraulic system show that there is a good linear relationship between the change in the dual FBG central wavelength and mass loading on the target sheet has a good linear relationship, and the sensitivity is twice that of a single FBG sensitivity.

关键词： Fiber Bragg grating flow sensor target type structure equal intensity cantilever beam

Mortality of Dementia and Its Major Subtypes in Urban and Rural Communities of Beijing

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Biomedical and Environmental Sciences 2011年第5期24卷 483-490页

作者： WEN HongBo zhang zhenxin HUANG JueBin DUAN LeiLei WANG QingHua Department of Neurology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing100730 China

Objective To identify the mortality and epidemiological pattern of dementia and its various major subtypes among urban and rural senior residents in *** Based on Beijing＇s dementia prevalence survey among residents aged 55 years and above in 1997,respondents were selected by stratified multiple‐stage cluster sampling and 12 urban communities and 17 rural village communities were randomly sampled then follow‐up in *** regression was used to analyze relative risks controllingconfounding factors on deaths of dementia *** The mortality of dement patients in the 55‐64 age‐group was 0.82/100 person‐*** age‐standardized mortality of dement cases was 0.90/100 person‐*** mortality in the 65 and above age‐group was 1.44/100 person‐year,and the age‐standardized mortality was 1.56/100 person‐*** AD cases,the above two mortalities were 0.35/100 and 0.42/100 person‐year respectively,and among VaD cases,0.34/100 and 0.36/100 person‐year *** both AD and VaD cases,their mortality increased with ***,gender and age were more significant to survival of AD *** One major subtype of dementia,AD,among elderly urban and rural residents in Beijing,has a different mortality and epidemiological pattern from VaD.

关键词： Dementia Mortality Alzheimer's disease Vascular dementia

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气候变化对青藏高原河流源区径流的影响

Engineering 2024年第3期34卷 133-142页

作者： zhenxin Bao Jianyun zhang Yanqing Lian Guoqing Wang Junliang Jin Zhongrui Ning Jiapeng zhang Yanli Liu Xiaojun Wang State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai UniversityNanjing 210098China Nanjing Hydraulic Research Institute Nanjing 210024China Yangtze Institute for Conservation and Development Hohai UniversityNanjing 210098China College of Hydrology and Water Resources Hohai UniversityNanjing 210098China

The Tibetan Plateau(TP)is the headwater of the Yangtze,Yellow,and the transboundary Yarlung Zangbo,Lancang,and Nujiang Rivers,providing essential and pristine freshwater to around 1.6 billion people in Southeast and South ***,the temperature rise TP has experienced is almost three times that of the global warming *** rising temperature has resulted in glacier retreat,snow cover reduction,permafrost layer thawing,and so *** we show,based on the longest observed streamflow data available for the region so far,that changing climatic conditions in the TP already had significant impacts on the streamflow in the headwater basins in the *** analysis indicated that the annual average temperature in the headwater basins of these five major rivers has been rising on a trend averaging 0.38℃-decade^(-1) since 1998,almost triple the rate before 1998,and the change of streamflow has been predominantly impacted by precipitation in these headwater *** a result,streamflow in the Yangtze,Yarlung Zangbo,Lancang,and Nujiang River headwater areas is on a decreasing trend with a reduction of flow ranging from 3.0-10^(9)-5.9-10^(9) m^(3)·decade^(-1)(-9.12%to-16.89%per decade)since *** increased precipitation in the Tangnahai(TNH)and Lanzhou(LZ)Basins contributed to the increase of their streamflows at 8.04%and 14.29%per decade,*** the increased streamflow in the headwater basins of the Yellow River may ease some of the water resources concerns,the decreasing trend of streamflow in the headwater areas of the southeastern TP region since 1998 could lead to a water crisis in transboundary river basins for billions of people in Southeast and South Asia.

关键词： Tibetan Plateau Streamflow Change trend Climate change

基于印度主流媒体的中印边界争端批判地缘政治解读

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地理学报 2024年第4期79卷 991-1006页

作者：余珍鑫胡志丁张喆华东师范大学地理科学学院上海200241 华东师范大学世界地理与地缘战略研究中心上海200062 华东师范大学全球创新与发展研究院上海200062

边界问题是困扰中印关系发展的重要议题之一。学界往往从殖民、历史、安全、第三方介入等因素解释中印边界争端的原因,忽视边界可作为资源被国内外多方行为体复杂权力斗争所利用,进而制造边界争端的事实。本文援引批判地缘政治的理念与... 详细信息

边界问题是困扰中印关系发展的重要议题之一。学界往往从殖民、历史、安全、第三方介入等因素解释中印边界争端的原因,忽视边界可作为资源被国内外多方行为体复杂权力斗争所利用,进而制造边界争端的事实。本文援引批判地缘政治的理念与分析方法,从多方行为体协同作用的角度对其进行话语分析并划分地缘政治想象类型,进而提出理解边界争端的新分析框架,以解读2020年5月—2021年2月的中印边界争端。研究表明:①边界争端可以看作不同行为体利用的工具或资源,即多方行为体协同对边界争端进行话语与地缘政治想象的建构,以达成其目的或利益。②基于2020年4月—2021年3月印度主流媒体报道,印度国内的印人党、国大党、军队、外交部、企业社会精英等将中印边界争端作为谋取政治、军事、外交和经济利益的工具,通过话语建构偏执风格式、亲密隐喻式或道德抵制式的地缘政治想象,制造或加剧边界争端形势。③边界争端可被认为是印方行为体制造利用而持续发生的过程,即当其目的还未达成时,班公湖对峙等争端事件再次发生或持续,而当其目的基本达成后才趋于缓和或平息。对此,中国须理性认识近年来中印边界争端呈现的阶段性和持续性特征,并适时发挥积极性探究的方式建设两国间经贸互补的合作性结构,以有效缓和或化解边界问题。

关键词：批判地缘政治中印边界争端话语地缘政治想象印度

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Analysis of Candidate Genes for Iron/Zinc Regulation in Potato

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Analysis of Candidate Genes for Iron/Zinc Regulation in Pota...