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Murine calcium-activated chloride channel family member 3 induces asthmatic airway inflammation independently of allergen exposure

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Chinese Medical Journal 2013年第17期126卷 3283-3288页

作者： MEI Li HE Li WU Si-si zhang Bo XUYong-jian zhang zhen-xiang ZHAO Jian-ping zhang Hui-lan Department of Respiratory Medicine Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430030 China Department of Respiratory Medicine Jingzhou Central Hospital Jingzhou Hubei 434020 China

Background Expression of murine calcium-activated chloride channel family member 3 （mCLCA3） has been reported to be increased in the airway epithelium of asthmatic mice challenged with ovalbumin （OVA）. However, its role in asthmatic airway inflammation under no OVA exposure has not yet been clarified. Methods mCLCA3 plasmids were transfected into the airways of normal BALB/c mice. mCLCA3 expression and airway inflammation in mouse lung tissue were evaluated. Cell differentials and cytokines in bronchoalveolar lavage fluid （BALF） were analyzed. The expression of mCLCA3 protein and mucus protein mucin-5 subtype AC （MUC5AC） were analyzed by Western blotting. The mRNA levels of mCLCA3, MUC5AC and interleukin-13 （IL-13） were determined quantitatively. Results mCLCA3 expression was not detected in the control group while strong immunoreactivity was detected in the OVA and mCLCA3 plasmid groups, and was strictly localized to the airway epithelium. The numbers of inflammatory cells in lung tissue and BALF were increased in both mCLCA3 plasmid and OVA groups. The protein and mRNA levels of mCLCA3 and MUC5AC in the lung tissue were significantly increased in the mCLCA3 plasmid and OVA groups compared to the control group. The level of IL-13, but not IL-4, IL-5, IFN-y, CCL2, CCL5 or CCL11, was significantly increased compared with control group in BALF in the mCLCA3 plasmid and OVA groups. The level of IL-13 in the BALF in the mCLCA3 plasmid group was much higher than that in the OVA group （P 〈0.05）. The level of mCLCA3 mRNA in lung tissue was positively correlated with the levels of MUC5AC mRNA in lung tissue, IL-13 mRNA in lung tissue, the number of eosinophils in BALF, and the content of IL-13 protein in BALE The level of IL-13 mRNA in lung tissue was positively correlated with the number of eosinophils in BALF and the level of MUC5AC mRNA in lung tissue. Conclusion These findings suggest that increased expression of a single-gene, mCLCA3, could simulate an asthma attack, a

关键词： murine calcium-activated chloride channel family member 3 asthma inflammation

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Reduction of unactivated alkyl chlorides enabled by light-induced single electron transfer

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Science China Chemistry 2024年第2期67卷 471-481页

作者： Lei Dai Zhao-Fei zhang xiang-Yu Chen School of Chemical Sciences University of the Chinese Academy of SciencesBeijing100049China Institute of Chemistry Chinese Academy of SciencesBeijing100190China Binzhou Institute of Technology Weiqiao-UCAS Science and Technology ParkBinzhou256606China

Alkyl chlorides are abundant and easily accessible starting ***,due to the high reduction potentials associated with unactivated alkyl chlorides,achieving their single electron reduction remains a persistent *** challenge has spurred the exploration of efficient activation methods to overcome this *** recent years,photocatalysis has emerged as a mild and potent tool for the single electron reduction of unactivated alkyl chlorides,opening up new possibilities in this *** the rapid advancements in this area,a comprehensive review that provides a conceptual understanding of this emerging field,with a specific focus on reaction design and catalytic mechanisms,would be timely and highly ***,we present an overview of various synthetic techniques for photoinduced single electron reduction of unactivated alkyl ***,we also discuss the limitations of the present methods and future directions that lie ahead in this field.

关键词： photocatalysis unactivated alkyl chlorides single electron transfer radical reactions

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E-MobileNeXt: face expression recognition model based on improved MobileNeXt

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Optoelectronics Letters 2024年第2期20卷 122-128页

作者： zhang xiang YAN Chunman School of Physics and Electronic Engineering Northwest Normal UniversityLanzhou 730070China1

In response to the high complexity and low accuracy of current facial expression recognition networks, this paper proposes an E-Mobile Ne Xt network for facial expression recognition. E-Mobile Ne Xt is built based on our proposed E-Sand Glass block. In addition, we also improve the overall performance of the network through Rep Conv and SGE attention mechanisms. The experimental results show that the network model improves the expression recognition accuracy by 6.5% and 7.15% in RAF-DB and CK+ datasets, respectively, while the parameter and floating-point operations decreased by 0.79 M and 4.2 M compared with Mobile Ne Xt.

关键词： facial mechanisms. network

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Conservation genomics provides insights into genetic resilience and adaptation of the endangered Chinese hazelnut, Corylus chinensis

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Plant Diversity 2024年第3期46卷 294-308页

作者： zhen Yang Lisong Liang Weibo xiang Lujun Wang Qinghua Ma Zhaoshan Wang Key Laboratory of Tree Breeding and Cultivation National Forestry and Grassland AdministrationResearch Institute of ForestryChinese Academy of ForestryBeijing 100091China National Engineering Research Center of Eco-Environment Protection for Yangtze River Economic Belt China Three Gorges CorporationBeijing 100083China Rare Plants Research Institute of Yangtze River China Three Gorges CorporationYichang 443133China Research Institute of Economic Forest Cultivation and Processing Anhui Academy of ForestryHefei 230031China

Global climate change has increased concerns regarding biodiversity ***,many key conservation issues still required further research,including demographic history,deleterious mutation load,adaptive evolution,and putative *** we generated the first chromosome-level genome of the endangered Chinese hazelnut,Corylus chinensis,and compared the genomic signatures with its sympatric widespread ***-C yunnanensis *** found large genome rearrangements across all Corylus species and identified species-specific expanded gene families that may be involved in *** genomics revealed that both *** and the *** complex had diverged into two genetic lineages,forming a consistent pattern of southwestern-northern *** size of the narrow southwestern lineages of both species have decreased continuously since the late Miocene,whereas the widespread northern lineages have remained stable(***) or have even recovered from population bottlenecks(*** complex) during the *** with ***-C. yunnanensis complex,*** showed significantly lower genomic diversity and higher inbreeding ***,*** carried significantly fewer deleterious mutations than ***-C. yunnanensis complex,as more effective purging selection reduced the accumulation of homozygous *** also detected signals of positive selection and adaptive introgression in different lineages,which facilitated the accumulation of favorable variants and formation of local ***,both types of selection and exogenous introgression could have mitigated inbreeding and facilitated survival and persistence of ***,our study provides critical insights into lineage differentiation,local adaptation,and the potential for future recovery of endangered trees.

关键词： Conservation genomics Demographic history Inbreeding Genetic load Runs of homozygosity Local adaptation

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Ordovician integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas

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Science China Earth Sciences 2024年第4期67卷 971-1004页

作者： xiang FANG Yong Yi zhen Guangxu WANG Xin WEI Zhongyang CHEN Yan LIANG Xuejin WU Wenjie LI Chao LI Renbin ZHAN Yuandong zhang State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China Geological Survey of New South Wales W.B.Clarke Geoscience CentreNSW 2753Australia University of Chinese Academy of Sciences Beijing 100049China

The Ordovician rocks on the Qinghai-Tibetan Plateau represent the oldest non-metamorphic strata,and are critical to understanding the history of regional geology and biotic evolution of the entire *** of Floian,Darriwilian,Sandbian,Katian and Hirnantian are represented in the plateau with a hiatus of variable duration occurring underneath the basal Ordovician across the *** stratigraphical regions,including the Himalaya,Gangdise-Zayu,Qiangtang-Qamdo,Songpan-Garze,and Karakoram-Kunlun-Altun,are differentiated for the Ordovician strata,which are correlated with their equivalents in the Sibumasu,Indochina,Qaidam-Qilian,Tarim-Tianshan,and the Yangtze(western margin)stratigraphical *** the QinghaiTibetan Plateau,graptolites,conodonts,and cephalopods are the most common and useful fossils for the Ordovician *** Ordovician biotas of the Qinghai-Tibetan Plateau bear some distinguishable palaeobiogeographical signatures,among which the cephalopods are characterized by the flourishing actinocerids of North China affinity in the Early-Middle Ordovician,and by the thriving lituitids and orthocerids of South China affinity in the Middle-Late *** occurrences and their palaeobiogeographical evolution provide critical evidence bearing on the reconstruction of the geological history of the Qinghai-Tibetan Plateau and surrounding terranes in northeastern *** stratigraphical successions of the Cambrian-Ordovician transition in the Himalaya and Lhasa and nearby Sibumasu terranes were significantly affected by the Kurgiakh Orogeny,which resulted in the extensive unconformity between the Ordovician and the underlying rocks in most areas of the Qinghai-Tibetan *** southern Xizang,a warm-water biota of Middle Ordovician age was recovered from oolitic limestones,suggesting a likely palaeogeographical location in low-latitudes near the *** the Himalaya and Sibumasu regions,the Upper Ordovician was typified by t

关键词： Ordovician Chronostratigraphy Lithostratigraphy Biostratigraphy Palaeobiogeography Qinghai-Tibetan Plateau

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Accurate atomic scanning transmission electron microscopy analysis enabled by deep learning

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Nano Research 2024年第4期17卷 2971-2980页

作者： Tianshu Chu Lei Zhou Bowei zhang Fu-zhen Xuan Shanghai Key Laboratory of Intelligent Sensing and Detection Technology East China University of Science and TechnologyShanghai 200237China School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China Key Laboratory of Pressure Systems and Safety of Ministry of Education East China University of Science and TechnologyShanghai 200237China

Currently,the machine learning(ML)-based scanning transmission electron microscopy(STEM)analysis is limited in the simulative stage,its application in experimental STEM is needed but ***,we built up a universal model to analyze the vacancy defects and single atoms accurately and rapidly in experimental STEM images using a full convolution *** our model,the unavoidable interference factors of noise,aberration,and carbon contamination were fully considered during the training,which were difficult to be considered in the *** toward the simultaneous identification of various vacancy types and low-contrast single atoms in the low-quality STEM images,our model showed rapid process speed(45 images per second)and high accuracy(>95%).This work represents an improvement in experimental STEM image analysis by ML.

关键词： deep learning low-dimensional materials atomic defects single atoms

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A state-of-the-art review of the development of self-healing concrete for resilient infrastructure

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Frontiers of Structural and Civil Engineering 2024年第2期18卷 151-169页

作者： Dong LU Xi JIANG Yao zhang Shaowei zhang Guoyang LU zhen LENG Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong Kong 999077China Laboratory of Fire Safety School of Safety Engineering and Emergency ManagementShijiazhuang Tiedao UniversityShijiazhuang 050043China Department of Architecture and Civil Engineering City University of Hong KongHong Kong 999077China

The brittleness of cement composites makes cracks almost inevitable,producing a serious limitation on the lifespan,resilience,and safety of concrete *** address this brittleness,self-healing concrete has been developed for regaining its mechanical and durability properties after becoming cracked,thereby promising sustainable development of concrete *** paper provides a comprehensive review of the latest developments in self-healing *** begins by summarizing the methods used to evaluate the self-healing efficiency of ***,it compares strategies for achieving healing *** then discusses the typical approaches for developing self-healing ***,critical insights are proposed to guide future studies on the development of novel self-healing *** review will be useful for researchers and practitioners interested in the field of self-healing concrete and its potential to improve the durability,resilience,and safety of concrete infrastructure.

关键词： resilient infrastructure sustainable concrete self-healing cracks

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Multicolor upconversion reversible modulations in YNbO_(4):Er^(3+)/Tm^(3+)/Yb^(3+) photochromic materials

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Journal of Rare Earths 2024年第2期42卷 270-277,I0002页

作者： zhen zhang Peng Li Ziyi Xu Zhihao zhang Qiwei zhang Haiqin Sun Xihong Hao Inner Mongolia Key Laboratory of Ferroelectric-related New Energy Materials and Devices Schoolof Materials and MetallurgyInner Mongolia University of Science and TechnologyBaotou014010China College of Physics and Technology Guangxi Normal UniversityGuilin541004China

Photochromic materials with multicolor upconversion reversible modulations are attractive in optical switching ***,the fabricated YNbO_(4):Er^(3+)/Tm^(3+)/Yb^(3+) materials exhibit excellent photochromism and multicolor upconversion properties from green,red to near infrared(NIR) emissions with increasing Yb *** multiband upconversion modulations are achieved by alternating light(365 and 405 nm) or thermal *** 365 nm irradiation,the luminescence color changes from yellow to red,the luminescent photoswitching contrast reaches up to 86.21%(green),82.12%(red) and 77.38%(NIR) in the Y_(0.83)Er_(0.01)Tm_(0.01)NbO_(4):0.15 Yb ***,the upconversion emission intensity before and after photochromic reaction shows remarkable change in a wide temperature range of 298-718 *** results indicate that the Er^(3+)/Tm^(3+)/Yb^(3+) tri-doped YNbO_(4) materials can be a good candidate in optical switching and data storage applications.

关键词： Photochromic materials Luminescence modulation Multicolor emission Photoswitching contrast Rare earths

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Anti-saturation fault-tolerant adaptive torsional vibration control with fixed-time prescribed performance for rolling mill main drive system

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Journal of Iron and Steel Research International 2024年第3期31卷 660-669页

作者： Shuang Liu Chen Du Cong zhang zhen-hua Bai Key Lab of Industrial Computer Control Engineering of Hebei Province Yanshan UniversityQinhuangdao 066004HebeiChina National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan UniversityQinhuangdao 066004HebeiChina

An anti-saturation fault-tolerant adaptive torsional vibration control method with fixed-time prescribed performance for the rolling mill main drive system(RMMDS)was investigated,which is affected by control input saturation,actuator faults,sensor measurement errors,and parameter ***,we gave a continuously differentiable saturation function to approximate the control input saturation characteristic of the RMMDS,translating the saturation characteristic into the matched uncertainty and unknown time-varying gain in the ***,an RMMDS mathematical model with unmatched uncertainty and unknown time-varying gain was developed,taking into account the presence of control input saturation,actuator faults,sensor measurement errors,and parameter *** on the established mathematical model,an error transformation model of the roll speed tracking was constructed by the equivalent error transformation *** to the error transformation model,a barrier Lyapunov function and a novel adaptive controller were studied to ensure that the roll speed tracking error always evolves inside a fixed-time asymmetric ***,numerical simulations were performed in Matlab/Simulink to verify the effectiveness and superiority of the proposed control method in suppressing the RMMDS torsional vibration.

关键词： Fixed-time prescribed performance Control input saturation Actuator fault Unknown time-varying gain Adaptive control Asymmetric constraint

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Data-driven rational design of single-atom materials for hydrogen evolution and sensing

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Nano Research 2024年第4期17卷 3352-3358页

作者： Lei Zhou Pengfei Tian Bowei zhang Fu-zhen Xuan Shanghai Key Laboratory of Intelligent Sensing and Detection Technology East China University of Science and TechnologyShanghai 200237China School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China Key Laboratory of Pressure Systems and Safety of Ministry of Education East China University of Science and TechnologyShanghai 200237China

Herein we proposed a data-driven high-throughput principle to screen high-performance single-atom materials for hydrogen evolution reaction(HER)and hydrogen sensing by combing the theoretical computations and a topology-based multi-scale convolution kernel machine learning *** the rational training by 25 groups of data and prediction of all 168 groups of single-atom materials for HER and sensing,respectively,a high prediction accuracy(>0.931 R^(2) score)was achieved by our *** show that the promising HER catalysts include Pt atoms in C_(4) and Sc atoms in C_(1)N_(3) coordination ***,Y atoms in C_(4) coordination environment and Cd atoms in C_(2)N_(2)-ortho coordination environment were predicted with great potential as hydrogen sensing *** method provides a way to accelerate the discovery of innovative materials by avoiding the time-consuming empirical principles in experiments.

关键词： machine learning single-atom materials sensing hydrogen evolution

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