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Liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

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Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei Wu Yuqing Liu Hongli Li Lemei Zhu Lingfeng Zeng zhen zhang Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

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单宁酸改性互穿网络水凝胶促进断裂跟腱术后的组织重塑

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中国组织工程研究 2025年第4期29卷 721-729页

作者：张博张振江东北京大学第三医院运动医学科北京市100191

背景:跟腱断裂术后的再生与重塑是临床治疗的难点,组织工程水凝胶材料为促进跟腱修复提供了可能。目的:探究单宁酸改性互穿网络水凝胶对大鼠断裂跟腱组织再生与重塑的作用。方法:①通过蓝光照射及CaSO4溶液浸泡交联制备单宁酸改性互穿... 详细信息

背景:跟腱断裂术后的再生与重塑是临床治疗的难点,组织工程水凝胶材料为促进跟腱修复提供了可能。目的:探究单宁酸改性互穿网络水凝胶对大鼠断裂跟腱组织再生与重塑的作用。方法:①通过蓝光照射及CaSO4溶液浸泡交联制备单宁酸改性互穿网络水凝胶,表征水凝胶的微观形貌、力学性能、黏附性能、体外释药性能与生物相容性。②取30只SD大鼠,采用随机数字表法分为假手术组、手术组与水凝胶组,每组10只,后2组建立右后肢跟腱断裂模型,手术组采用改良Kessler法将断裂跟腱重新缝合,水凝胶组采用相同术式缝合断裂跟腱后将单宁酸改性互穿网络水凝胶贴片完全缠绕包裹于断端接合处。术后4周,对断裂跟腱进行影像学检查、组织学评价、生物力学测试及炎症因子水平检测。结果与结论:①扫描电镜下可见单宁酸改性互穿网络水凝胶呈多孔微观结构,孔径为3-10μm,并且水凝胶具备良好的体外释药性能、黏附强度与拉伸强度;CCK-8检测与活/死染色显示,该水凝胶对大鼠骨髓间充质干细胞增殖活性无明显影响,具备良好的生物相容性。②MRI成像显示,与手术组比较,水凝胶组大鼠跟腱呈均一低信号,跟腱前后径厚度减小,与周围组织分界更为明确,表现更接近假手术组。苏木精-伊红与Masson染色显示,手术组大鼠跟腱纤维排列松散混乱,细胞密度增加且排布杂乱,伴有明显炎性细胞浸润,部分区域出现腱内骨化;水凝胶组大鼠跟腱纤维排列有序,细胞密度降低且排布规整,炎性细胞浸润明显减少。手术组大鼠跟腱的拉伸强度低于假手术组(P<0.05),水凝胶组大鼠跟腱的拉伸强度高于手术组(P<0.05)。与假手术组比较,手术组大鼠跟腱中白细胞介素1β、白细胞介素6及肿瘤坏死因子α质量浓度及mRNA表达升高(P<0.05);与手术组比较,水凝胶组3种炎症因子水平及mRNA表达降低。③结果表明,单宁酸改性互穿网络水凝胶可显著抑制局部炎症反应、促进断裂跟腱组织重塑。

关键词：单宁酸水凝胶互穿网络跟腱断裂组织重塑组织再生

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基于Vision Transformer的车辆重识别模型优化

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郑州大学学报（理学版） 2025年第1期57卷 46-52页

作者：张震张亚斌田鸿朋郑州大学电气与信息工程学院河南郑州450001

针对车辆重识别任务中样本类内差异性大和类间相似度高的问题,提出了一种Vision Transformer框架下的车辆重识别方法。设计一种关键区域选择模块,整合Transformer中注意力分数矩阵,加强车辆的具有辨别性区域的关注程度,减小局部区域过... 详细信息

针对车辆重识别任务中样本类内差异性大和类间相似度高的问题,提出了一种Vision Transformer框架下的车辆重识别方法。设计一种关键区域选择模块,整合Transformer中注意力分数矩阵,加强车辆的具有辨别性区域的关注程度,减小局部区域过度集中的注意力权重;构建一种包含对比损失和中心损失的混合损失函数,对比损失函数的引入增强了模型捕捉和比较样本之间的差异的能力,中心损失使得同一类别的样本更加紧密地聚集在一起,增强类间样本的区分度。实验结果验证了其有效性。

关键词：车辆重识别自注意力机制注意力权重区域选择

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Seismic fragility analysis of clay-pile-pier systems considering the optimization of ground motion intensity measures

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Earthquake Engineering and Engineering Vibration 2023年第4期22卷 965-977页

作者： zhang Panpan zhang Lei zhang zhen School of Civil Engineering and Architecture Wuhan University of TechnologyWuhan 430070China

The performance of clay-pile-pier system under earthquake shaking was comprehensively examined via three-dimensional finite element analyses,in which the complex stress-strain relationships of a clay and piled pier system were depicted by a hyperbolic-hysteretic and an equivalent elastoplastic model,*** hundred twenty ground motions with varying peak accelerations were considered,along with the variations in bridge superstructure mass and pile flexural *** comparison studies suggested that peak pile-cap acceleration and peak pile-cap velocity are the optimal ground motion intensity measures for seismic responses of the pier and the pile,***,based on two optimal ground motion intensity measures and using curvature ductility to quantify different damage states,seismic fragility analyses were *** pier generally had no evident damage except when the bridge girder mass was equal to 960 t,which seemed to be comparatively insensitive to the varying pile flexural *** comparison,the pile was found to be more vulnerable to seismic damage and its failure probabilities tended to clearly reduce with the increment of pile flexural rigidity,while the influence of the bridge girder mass was relatively minor.

关键词： clay-pile-pier system seismic fragility analysis ground motion intensity measures damage probability

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Process, mechanism and impacts of scale formation in alkaline flooding by a variable porosity and permeability model

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Acta Mechanica Sinica 2016年第3期32卷 406-421页

作者： zhen zhang Jiachun Li Key Laboratory of Mechanics in Fluid Solid Coupling Systems Institute of Mechanics Chinese Academy of Sciences

In spite of the role of alkali in enhancing oil recovery（EOR）, the formation of precipitation during alkaline-surfactant-polymer（ASP） flooding can severely do harm to the stratum of oil reservoirs, which has been observed in situ tests of oil fields such as scale deposits found in oil stratum and at the bottom of oil wells. On the other hand,remarkable variation of stratum parameters, e.g., pore radius,porosity, and permeability due to scale formation considerably affects seepage flow and alkaline flooding process in return. The objective of this study is to firstly examine these mutual influential phenomena and corresponding mechanisms along with EOR during alkaline flooding when the effects of precipitation are no longer negligible. The chemical kinetic theory is applied for the specific fundamental reactions to describe the process of rock dissolution in silicabased reservoirs. The solubility product principle is used to analyze the mechanism of alkali scale formation in *** a 3D alkaline flooding coupling model accounting for the variation of porosity and permeability is established to quantitatively estimate the impact of alkali scales on reservoir stratum. The reliability of the present model is verified in comparison with indoor experiments and field tests of the Daqing oil field. Then, the numerical simulations on a 1/4well group in a 5-spot pattern show that the precipitation grows with alkali concentration, temperature, and injection pressure and, thus, reduces reservoir permeability and oil recovery correspondingly. As a result, the selection of alkaliwith a weak base is preferable in ASP flooding by tradeoff strategy.

关键词： Alkali Precipitation Chemical flood Permeability Oil recovery

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Bio-inspired motion planning for reaching movement of a manipulator based on intrinsic tau jerk guidance

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Advances in Manufacturing 2019年第3期7卷 315-325页

作者： zhen zhang Xu Yang School of Mechatronic Engineering and Automation Shanghai UniversityShanghai 200444People's Republic of China

This study proposed a bio-inspired motion planning approach for the reaching movement of a robot manipulator based on a novel intrinsic tau jerk guidance strategy,which was established by some cognitive science researchers when they studied motion patterns through *** accordance with the rules of human reaching movement,the intrinsic tau jerk guidance strategy ensures continuity of the acceleration;further,it also ensures that its value is zero at the start and end of the *** approach has been implemented on a three-degrees-offreedom 3R planar *** results show that,within a defined time,both the position gap and attitude gap can be reposefully closed,and the curves of joint velocity,acceleration,and driving torque are continuous and *** to the dynamic analysis,the proposed approach tends to consume less *** bioinspired method has the potential to be applied in particular scenarios in the future,such as a mobile robot with a manipulator exploring an unknown environment.

关键词： Bio-inspired Motion planning Manipulator Reaching movement Intrinsic tau jerk guidance

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A Study on the Technique of Observing Interplanetary Scintillation with Simultaneous Dual-Frequency Measurements

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Chinese Journal of Astronomy and Astrophysics 2007年第5期7卷 712-720页

作者： Xi-zhen zhang National Astronomical Observatories Chinese Academy of Sciences Beijing 100012

Ground-based observation of Interplanetary Scintillation （IPS） is an important approach of monitoring solar wind speed. We describe both the principle and method of observing the solar wind speed by using the normalized cross-spectrum of simultaneous dualfrequency IPS measurement. The effects of the solar wind properties and the angular size of the scintillation source on the measurement of solar wind speed are investigated by numerical analysis. We carry out a comparison of this method with the traditional single station-single frequency method. We outline a new IPS observation system using this method now under construction at the National Astronomical Observatories, CAS （NAOC）.

关键词： interplanetary scintillation -- method -- instrument -- telescope

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EBSD parameter assessment and constitutive models of crept HR3C austenitic steel

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Journal of Iron and Steel Research International 2023年第4期30卷 772-781页

作者： Jie zhang zheng-fei Hu zhen zhang Shanghai Key Laboratory for R&D and Application of Metallic Functional Materials School of Materials Science and EngineeringTongji UniversityShanghai 201804China School of Materials Science and Engineering Nanjing Institute of TechnologyNanjing 211167JiangsuChina

Creep damage and evolution of HR3C steel at 650℃ were investigated using electron backscatter diffraction(EBSD),and EBSD-based parameter assessments were *** analyses show that the grain size is almost unchanged and no obvious texture formed after creep at different creep *** lowest proportion of low Σ coincidence site lattice grain boundaries under 150 MPa implies that the primary twin structures are preserved under the low stress level,while some twin structures evolved into general grain boundaries at the high creep *** main damage features of microcracks and cavities can be seen along the grain boundaries:the former emerged at higher stress levels,while the latter appeared at the lower stress level,and both were shown under medium *** contrast shows that the most severe creep damage is present at 170 *** implies that the creep mechanism differs distinctly under different stress levels,and the transition point is around 170 *** average misorientation is better to describe the local plastic deformation related to the strain distribution while grain reference orientation deviation describes the inhomogeneous strain *** lifetime prediction models including the isothermal method,Larson-Miller parameter method and Monkman–Grant relation were evaluated by the experimental data and literature data,and they are valid for predicting creep behavior.

关键词： Austenitic heat-resistant steel Creep damage Electron backscatter diffraction Creep constitutive model Creep lifetime prediction

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Enzyme annotation for orphan reactions and its applications in biomanufacturing

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Green Chemical Engineering 2023年第2期4卷 137-145页

作者： zhen zhang Chun Li Key Lab for Industrial Biocatalysis Ministry of EducationDepartment of Chemical EngineeringTsinghua UniversityBeijing100084China Center for Synthetic&Systems Biology Department of Chemical EngineeringTsinghua UniversityBeijing100084China

There are lots of biochemical reactions in the biosynthetic pathway without associated *** predicted by retro-biosynthetic tools are not assigned gene ***,non-natural reactions designed with novel functions also lack suitable *** these reactions can be categorized as orphan *** absence of protein-encoding genes in these orphan reactions limits their direct experimental *** tools have been developed to find candidate enzymes for these orphan ***,we discuss recent advances in these computational tools,including reaction similarity-based methods for calculating the substructural similarity between orphan reactions and known enzymatic reactions;sequence-based tools combine metabolic knowledge base and phenotypic information with genomic,transcriptomic,and metabolomic data to mine appropriate enzymes for orphan reactions;and approaches based on the creation of enzyme variants for orphan reactions as enzyme engineering modifications and de novo design of *** believe that our review will greatly facilitate the design of microbial cell factories and contribute to the development of the biomanufacturing field.

关键词： Enzyme annotation Orphan reactions Reaction similarity Gene mining Computational enzyme design

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Ab initio study of the reaction path of the reaction HNCO+CN

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Science China Chemistry 2005年第4期48卷 279-285页

作者： zhang Xinzhuang zhen zhen LIU Xinhou Technical Institute of Physics and Chemistry of Chinese Academy of Sciences Beijing 100101China Technical Institute of Physics and Chemistry of Chinese Academy of SciencesBeijing 100101China Technical Institute of Physics and Chemistry of Chinese Academy of SciencesBeijing 100101China

We report ab initio UMP2 calculations of the reaction of CN with HNCO using 6-311G(d,p) basis *** obtained results show that the reaction has two product channels:HNCO+CN→HCN+NCO (1) and HNCO+CN→HNCN+CO (2).Channel (1) is a hydrogen abstraction reaction,which is a concerted *** calculated potential energy barrier is 20.80 kJ/mol at UMP2(full)/6-311G(d,p) *** the range of reaction temperature (1000―2100 K),the conventional transition theory rate constant for channel (1) ranges from 0.32×10?11 to 6.9×10?11cm3?mol?1·s?1,which is close to the experimental *** (2) is a stepwise re-action involving an intermediate during the process of *** UMP2(full)/6-311G(d,p) po-tential energy barrier is 83.42 kJ/mol for the rate-controlling step,which is much higher than that of channel (1).

关键词： isocyanic acid, radical reaction, ab initio method, intermediate.

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