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Efficacy of Sailuotong(塞络通)on neurovascular unit in amyloid precursor protein/presenilin-1 transgenic mice with Alzheimer's disease

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Journal of Traditional Chinese Medicine 2024年第2期44卷 289-302页

作者： SUN Linjuan LI Chengfu LIU Jiangang LI Nannan HAN Fuhua QIAO Dandan TAO Zhuang ZHAN Min CHEN Wenjie zhang Xiaohui TONG Chenguang CHEN Dong Qi Jiangxia LIU Yang LIANG Xiao ZHENG Xiaoying zhang yunling Department of Neurology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China China Population and Development Research Center Beijing 100081China Department of Institute of Population Research Peking UniversityBeijing 100087China Graduate School of China Academy of Chinese Medical Sciences Beijing 100700China Graduate School of Beijing University of Chinese Medicine Beijing 100029China

OBJECTIVE:To discuss the influence of Sailuotong(塞络通,SLT)on the Neurovascular Unit(NVUs)of amyloid precursor protein(APP)/presenilin-1(PS1)mice and evaluate the role of gas supplementation in activating blood circulation during the progression of Alzheimer's disease(AD).METHODS:The mice were allocated into the following nine groups:(a)the C57 Black(C57BL)sham-operated group(control group),(b)ischaemic treatment in C57BL mice(the C57 ischaemic group),(c)the APP/PS1 sham surgery group(APP/PS1 model group),(d)ischaemic treatment in APP/PS1 mice(APP/PS1 ischaemic group),(e)C57BL mice treated with aspirin following ischaemic treatment(C57BL ischaemic+aspirin group),(f)C57BL mice treated with SLT following ischaemic treatment(C57BL ischaemic+SLT group),(g)APP/PS1 mice treated with SLT(APP/PS1+SLT group),(h)APP/PS1 mice treated with donepezil hydrochloride following ischaemic treatment(APP/PS1 ischaemic+donepezil hydrochloride group)and(i)APP/PS1 mice treated with SLT following ischaemic treatment(APP/PS1 ischaemic+SLT group).The ischaemic model was established by operating on the bilateral common carotid arteries and creating a microembolism.The Morris water maze and step-down tests were used to detect the spatial behaviour and memory ability of mice.The hippocampus of each mouse was observed by haematoxylin and eosin(HE)and Congo red staining.The ultrastructure of NVUs in each group was observed by electron microscopy,and various biochemical indicators were detected by enzymelinked immunosorbent assay(ELISA).The protein expression level was detected by Western blot.The mRNA expression was detected by quantitative real-time polymerase chain reaction(qRT-PCR).RESULTS:The results of the Morris water maze and step-down tests showed that ischemia reduced learning and memory in the mice,which were restored by SLT.The results of HE staining showed that SLT restored the pathological changes of the NVUs.The Congo red staining results revealed that SLT also improved the scattered orange-red sediments in the upper cortex and hip

关键词： Alzheimer disease amyloid beta-protein precursor presenilin-1 mice transgenic replenishing Qi and activating blood neurovascular unit Sailuotong

Mixed methods research in complementary and alternative medicine:a scoping review

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Journal of Traditional Chinese Medicine 2022年第4期42卷 652-666页

作者： DU Wanqing WANG Liuding JIA Min LIANG Xiao LI Bo zhang yunling LIAO Xing Department of Neurology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091China Center for Evidence-based Chinese Medicine Institute of Basic Research in Clinical MedicineChina Academy of Chinese Medical SciencesBeijing 100700China Xiyuan School of Clinical Medicine Beijing University of Chinese MedicineBeijing100029China Department of Clinical Epidemiology Beijing Traditional Chinese Medicine HospitalCapital Medical UniversityBeijing Institute of Traditional Chinese MedicineBeijing 100010China

OBJECTIVE:To update the current characteristics about the scope and quality of mixed methods research(MMR)in complementary and alternative medicine(CAM)after nearly 10 years.METHODS:A 5-stage approach for conducting a scoping review was adopted.Articles published on the top 10 journals in CAM with the highest impact factor in 2020 were screened for MMR.Information of included articles were extracted,and then synthesized to illustrate the current state.Methodological quality was evaluated according to the Mixed Method Appraisal Tool(MMAT)2018 version.RESULTS:A total of 55(55/2991,2%)articles using mixed methods were retrieved,including 17 medical studies and 38 ethnobotanical studies.We performed an in-depth analysis on the 17 medical studies,which studied cancer,stress,pain,fatigue,exercises,mindfulness intervention,herbal medicine use,art and acupuncture.Thirteen pilot studies applied MMR to evaluate the feasibility of interventions or programs(13/17,76%);phenomenology was inferred as the most common philosophical assumptions(13/17,76%);the most applied type of MMR was convergent design(16/17,94%);integration often took place at integration(12/17,71%).Among the 16 eligible studies for quality appraisal,majority were rated as good(14/16,88%),whereas two studies were rated as poorly described.Primarily,a poor rating was due to incomplete reporting of data analysis and citations in qualitative components;lack of confounder controlling and the sampling strategy in quantitative components;poor description of integration and justification for mixed methods.Comparing with the previous review,fewer MMR were published in 2020 in CAM,but the proportion of studies that clearly reported MMR has increased by 4 times(4%→15%).CONCLUSION:CAM researchers need to realize the benefits that MMR can have on conducting further health care research.Our findings highlight that applying MMR will be helpful to understand the complex dynamics and interdisciplinary nature of complex intervention.In addition,addressing a standardized report

关键词： complementary therapies review biomedical research pilot projects mixed methods

China's Relations with Neighbors

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Contemporary World 2022年第3期 39-43页

作者： zhang yunling Chinese Academy of Social Sciences Institute of International Studies of Shandong University

China has a large number of neighboring countries, and its relations with them together with the situation of the neighborhood mean special and important interests for China. Given that, China has put its relations with neighboring countries in the first place in its foreign relations, and has put forward the basic concepts of developing relations with the neighboring countries, such as good neighborliness.

关键词： neighboring China neighborhood

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基于深度学习模型的复杂困难路网提取方法

测绘通报 2024年第5期 155-159页

作者：张楠张蕴灵中国公路工程咨询集团有限公司北京100097 中咨数据有限公司北京100097

针对复杂困难地区公路信息提取中存在的数据获取困难、道路特征不统一、自然环境干扰、道路变化频繁等难点问题,本文应用高分遥感技术,开展了复杂困难地区路网信息的提取、处理研究。基于深度学习模型不断优化的路网提取方法,以高分卫... 详细信息

针对复杂困难地区公路信息提取中存在的数据获取困难、道路特征不统一、自然环境干扰、道路变化频繁等难点问题,本文应用高分遥感技术,开展了复杂困难地区路网信息的提取、处理研究。基于深度学习模型不断优化的路网提取方法,以高分卫星为主要数据源,通过对复杂困难地区不同类型农村公路的光谱、纹理及可分离性特征集等进行学习,识别出等级低和道路条件差的农村公路,为农村路网识别与判别提供准确的数据保障;及时获取客观、准确和全面的农村公路基础数据解决了复杂困难地区路网信息不足的问题;为复杂困难地区公路网的规划、建设提供科学的决策依据,为出行交通诱导提供了便利。

关键词：卫星遥感数据路网提取深度学习

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周边关系、周边区域与中国的周边环境

当代世界 2024年第3期 10-15页

作者：张蕴岭山东大学国际问题研究院中国社会科学院

中国周边邻国众多,基于历史、政治、经济、文化等多方面原因,周边关系复杂。中国与周邻国家共同构成一个相互连接的共生区域,有着共享的利益。中国通过参与和共建周边区域合作机制,构建了以合作为导向的区域共处、共生与共享空间。对于... 详细信息

中国周边邻国众多,基于历史、政治、经济、文化等多方面原因,周边关系复杂。中国与周邻国家共同构成一个相互连接的共生区域,有着共享的利益。中国通过参与和共建周边区域合作机制,构建了以合作为导向的区域共处、共生与共享空间。对于中国来说,周边具有整体性特征,营造好整体的周边环境至关重要。百年变局下中国周边环境面临新的挑战,周边矛盾、冲突、热点相互交织且呈现突变性特点。中国需要与相关周邻国家加强协调与合作,有效管控矛盾,防止冲突升级,维护周边和平稳定大局。

关键词：周边外交周边关系区域合作周边环境

Registration of intervention trials of Traditional Chinese Medicine for four neurological diseases on Chinese Clinical Trial Registry and Clinical Trials.gov:a narrative review

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Journal of Traditional Chinese Medicine 2022年第1期42卷 148-153页

作者： WEI Jingjing GUO Rongjuan FU Guojing LIANG Xiao XU Zhenmin JIA Min ZENG Zixiu DU Wanqing JIAO Weiwei SUN Linjuan LIU Hongmei GUO Chunli TONG Chenguang zhang yunling LIAO Xing Graduate school Beijing University of Chinese MedicineBeijing 10029China Center for Evidence Based Chinese Medicine Institute of Basic Research in Clinical MedicineChina Academy of Chinese Medical SciencesBeijing 100700China Department of Neurology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China Department of Neurology Dongfang HospitalBeijing University of Chinese MedicineBeijing 100078China

OBJECTIVE:To analyze the current status of clinical trial registration of Traditional Chinese Medicine(TCM)for the treatment of neurological diseases.METHODS:Interventional clinical trials of TCM treatment for ischemic stroke,hemorrhagic stroke,vascular cognitive impairment,tension-type headache before September 22,2020 on the platform of Chinese Clinical Trial Registry(Chi CTR),and Clinical Trials.gov were searched.Two researchers independently selected the literature and extracted data.RESULTS:A total of 180 interventional clinical trials were included for analysis.Out of 180 trials,127 were from Chi CTR and 53 from Clinical Trials.gov.The countries primary sponsoring the included trials were China(176,97.8%),and the common categories of primary sponsors were hospital(131,72.8%).Among the study design,the largest proportion of allocation was randomized(172,95.6%),interventional model assignment was parallel(163,90.6%),masking was double blind 49(27.2%),and the sample size was≤400(144,80.0%).The trials were most carried out at a single center(102,56.7%).Among the included studies,112(62.2%)registered on Chi CTR attached the ethical approval documents.In terms of trial stages,50(27.7%)studies were in phaseⅣ.The mostly used intervention was Chinese herbal medicines(99,55%),acupuncture(68,37.8%)was the second.By searching the registration number on China National Knowledge Infrastructure Database and Pub Med,38(21.1%)registered trials were published,including 25 protocol studies and 14 research results with one(NCT02275949)published both the protocol and the results.CONCLUSIONS:Irregular and inadequate reporting,untimely update and publication,insufficient information on traditional medicine unique characteristics,and lack of international collaborations are the problems existing in the interventional clinical registration trials of traditional medicine treatment on neurological diseases.More efforts need to be made from the above aspects to standardize and improve the registration of traditional medicine trials.

关键词： medicine Chinese traditional ischemic stroke cognitive dysfunction tension-type headache hemorrhagic stroke Chinese Clinical Trial Registry Clinical Trials.gov critical appraisal

数字经济时代“专利黑代理”监管两阶段演化博弈研究

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管理评论 2024年第3期36卷 185-196页

作者：张俊艳张芸苓王迪张晴天津大学管理与经济学部天津300072 山西财经大学管理科学与工程学院太原030006

基于动态新协同监管理论构建了电商平台中“专利黑代理”监管的两阶段博弈模型,系统分析商户、电商平台、政府三方的博弈演化过程及其稳定策略,通过仿真模拟研究了规制“专利黑代理”行为的有效路径。结果表明:(1)没有政府参与的第一阶... 详细信息

基于动态新协同监管理论构建了电商平台中“专利黑代理”监管的两阶段博弈模型,系统分析商户、电商平台、政府三方的博弈演化过程及其稳定策略,通过仿真模拟研究了规制“专利黑代理”行为的有效路径。结果表明:(1)没有政府参与的第一阶段博弈稳定策略不符合预期,第二阶段政府与平台协同监管后,三方博弈可以达到理想演化稳定状态;(2)政府参与下,提高电商平台专业性、政府“互联网+”监管的正确率、无资质代理罚款、电商约谈损失,可以促使三方博弈快速演化至理想稳定状态;(3)政府参与下,促使系统演化至理想稳定状态的最佳监管措施因监管对象而异,对于商户而言,直接监管比间接监管更为有效,对电商平台而言,事中监管比事后监管更有效。

关键词：数字经济专利黑代理电商平台两阶段演化博弈

China＇s Neighborhood： New Situation and Consideration

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China International Studies 2015年第1期35卷 41-55页

作者： zhang yunling Chinese Academy of Social Sciences

Cohabiting with so many neighbors that form a unique surrounding area,China has always had complex and changeable neighborhood relationships.To understand Chinas' relations with its neighboring countries (or neighborhood relations),one may take the following four different perspectives,namely,geography,relationship,interests and competition.Different perspectives will give rise to different characteristics and meanings of the relationship.The most direct and profound meaning of geography is that China and its neighbors are closely connected and co-habit in the same area,which is a fact that could never be changed.Relationship contains bilateral and multilateral relations as well as immediate and long-term relations,which constitute complex,multi-layer and mixed levels of relations and network.Interests are various and varied;but no matter how different they may be,they are direct and difficult to give up.As to competition,not only it exists between China and its neighbors but there are also involvement and scheming by outside forces.No other country in the world has so complex and complicated neighborhood relations as China does.How China should co-exist with its neighbors and vice versa has always been a difficult problem.

关键词：中国周边环境邻里关系周边地区周边国家混合水平地理学多层次

Key Points for Promoting the Recovery of the Global Economy

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Qiu Shi 2017年第3期9卷 86-91页

作者： zhang yunling