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The differential effects of integrase strand transfer inhibitors and efavirenz on neuropsychiatric conditions and brain imaging in HIV-positive men who have sex with men

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Biosafety and Health 2024年第4期6卷 216-224页

作者： Yihui He yang {1. Jiaxin Zhen Guangqiang Sun Zhen Li Bo yang Bin yang Keyi Chang Xue chen Yulin {1. Caiping Guo wen Wang Ping Wu Tong {1. Lei Wang Postgraduate Union Training Base of Jinzhou Medical University PLA Rocket Force Characteristic Medical CenterBeijing 100088China Department of Neurology PLA Rocket Force Characteristic Medical CenterBeijing 100088China Center for Infectious Disease Beijing Youan HospitalCapital Medical UniversityBeijing 100069China beijing Key Laboratory for HIV/AIDS Research Beijing 100069China beijing {1. for Sexually Transmitted Disease Control Beijing 100069China beijing Key Laboratory of Mental Disorders National Clinical Research Center for Mental Disorders and National Center for Mental DisordersBeijing Anding HospitalCapital Medical UniversityBeijing 100088China Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijing 100069China The Second Hospital of beijing Beijing 100031China Department of Respiratory and Critical Care Medicine Beijing Youan HospitalCapital Medical UniversityBeijing 100069China National institute on Drug Dependence and {1. Key Laboratory of Drug Dependence Peking UniversityBeijing 100191China Key Discipline for Neuroscience of the Ministry of Education Department of NeurobiologySchool of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China

Integrase strand transfer inhibitors(INSTIs)have emerged as the first‐line choice for treating human immunodeficiency virus(HIV)infection due to their superior efficacy and ***,the impact of INSTIs on the development of neuropsychiatric conditions in people living with HIV(PLWH)is not fully understood due to limited *** this study,we conducted a cross‐sectional examination of PLWH receiving antiretroviral therapy,with a specific focus on HIV‐positive men who have sex with men(MSM)on INSTI‐based regimens(n=61.and efavirenz(EFV)‐based regimens(n=2.).Participants underwent comprehensive neuropsychiatric evaluations and multimodal magnetic resonance imaging(MRI)scans,including T1.weighted images and resting‐state functional *** to the EFV group,the INSTI group exhibited primarily reduced gray matter volume(GMV)in the right superior parietal gyrus,higher regional homogeneity(ReHo)in the left postcentral gyrus,lower ReHo in the right orbital part of the inferior frontal gyrus,and increased voxel‐wise functional connectivity for the seed region in the left inferior temporal gyrus with clusters in the right ***,the analysis revealed a main effect of antiretroviral drugs on GMV changes,but no main effect of neuropsychiatric disorders or their *** repeated analysis of participants who did not switch regimens confirmed the GMV changes in the INSTI group,validating the initial *** study demonstrated gray matter atrophy and functional brain changes in PLWH on INSTI‐based regimens compared to those on EFV‐based *** neuroimaging results provide valuable insights into the characteristics of brain network modifications in PLWH receiving INSTI‐based regimens。

关键词： Human immunodeficiency virus(HIV) Multimodal magnetic resonance imaging(MRI) Integrase strand transfer inhibitors(INSTIs) Efavirenz(EFV)

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中国含硫化氢天然气的研究及勘探前景

天然气工业 2004年第9期24卷 1-4页

作者：朱光有戴金星张水昌李剑金强陈践发中国石油勘探开发研究院石油大学地球资源与信息学院石油大学资源与信息学院

我国目前已在四川盆地、渤海湾盆地、鄂尔多斯盆地、塔里木盆地和准噶尔盆地等发现了含硫化氢气藏 ,含硫化氢天然气和高含硫化氢天然气已成为我国天然气资源的重要组成部分。由于硫化氢极强的毒性和腐蚀性 ,威胁着钻采生产过程中的每一... 详细信息

我国目前已在四川盆地、渤海湾盆地、鄂尔多斯盆地、塔里木盆地和准噶尔盆地等发现了含硫化氢气藏 ,含硫化氢天然气和高含硫化氢天然气已成为我国天然气资源的重要组成部分。由于硫化氢极强的毒性和腐蚀性 ,威胁着钻采生产过程中的每一个环节 ,极易发生事故。而目前国内外对硫化氢的成因机理、分布规律和控制因素等方面的认识尚不能做到有效预测 ,安全钻采等工艺技术尚不配套成熟 ,在硫化氢出现时的防御措施也不到位 ,因此尽快开展硫化氢研究已是当务之急。研究了硫化氢天然气勘探开发中存在的问题 :地质认识不足 ,形成机理掌握不够 ,地化特性考虑不充分等。指出了中国含硫化氢天然气资源潜力在陆上已开发气区和海陆碳酸盐岩储层中都十分巨大。

关键词：硫化氢含硫勘探前景天然气资源气藏渤海湾盆地碳酸盐岩储层中国分等到位

Taming heat with tiny pressure

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The Innovation 2024年第2期5卷 70-78页

作者： Kun zhang Zhe zhang Hailong Pan Haoyu Wang Xueting Zhao Ji Qi Zhao zhang Ruiqi Song chenyang Yu Biaohong Huang Xujing Li Huaican chen wen Yin Changlong Tan Weijin Hu Michael Wüubbenhorst Jiangshui Luo Dehong Yu Zhidong zhang Bing Li Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Laboratory for Soft Matter and Biophysics Department of Physics and AstronomyKU Leuven3001 LeuvenBelgium institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China College of Materials Science and Engineering Sichuan UniversityChengdu 610064China School of Materials Science and Chemical Engineering Harbin University of Science and TechnologyHarbin 150080China Australian Nuclear Science and Technology Organisation Lucas HeightsNSW 2234Australia

Heat is almost *** electricity,which can be easily manipulated,the current ability to control heat is still highly limited owing to spontaneous thermal dissipation imposed by the second law of *** illumination and pressure have been used to switch endothermic/exothermic responses of materials via phase transitions;however,these strategies are less cost-effective and ***,we spectroscopically demonstrate the glassy crystal state of 2.amino-2.methyl-1.3-propanediol(AMP)to realize an affordable,easily manageable approach for thermal energy *** supercooled state of AMP is so sensitive to pressure that even several megapascals can induce crystallization to the ordered crystal,resulting in a substantial temperature increase of 48 K within 2. ***,we demonstrate a proof-of-concept device capable of programable heating with an extremely high work-to-heat conversion effi-ciency of*** delicate and efficient tuning of heat may remarkably facilitate rational utilization of waste heat.

关键词： illumination thermal rational

Study of the response of 1.B-doped MCP to wide-energy range neutrons from eV to MeV

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Nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： Qiang Li Li‑Jiao Wang Xiang‑Biao Qiu Jing‑wen Li Wei Xu Tao Li Ze‑Bin Lin Chang‑Jun Ning Yong‑Hao {1. Rui‑Rui Fan Kang Sun Jing‑Yu Tang Rong {2. Han‑Tao Jing Bo Mei Qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping {1. Zhen {1. Zeng‑Qi Cui An‑Chuan Fan Chang‑Qing Feng Fan‑Zhen Feng Ke‑Qing Gao Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑{1.g He yang Hong Yi‑Wei Hu Han‑Xiong Huang Wei‑Hua Jia Hao‑Yu Jiang Wei Jiang Zhi‑Jie Jiang Zheng‑Yao Jin Ling Kang Bo Li Chao Li Gong Li Jia‑wen Li Xiao Li yang Li Jie Liu Rong Liu Shu‑Bin Liu Guang‑Yuan Luan Bin‑Bin Qi Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Zhi‑Xin Tan Sheng‑Da Tang Peng‑{1.g Wang Zhao‑Hui Wang Zhong‑Wei wen Xiao‑Guang Wu Xuan Wu Li‑Kun Xie Yi‑Wei yang Han Yi Yong‑Ji Yu Guo‑Hui {2. Lin‑Hao {2. Mo‑Han {2. Qi‑Wei {2. Xian‑Peng {2. Yu‑Liang {2. Yue {2. Zhi‑Yong {2. Mao‑Yuan Zhao Lu‑Ping Zhou Zhi‑Hao Zhou Ke‑Jun Zhu institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China North Night Vision Science&Technology(Nanjing)Research institute Co.Ltd. Nanjing 211106China Sino‑French institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest institute of Nuclear Technology Xi’an 710024China University of chinese {1. of Sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.1.B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 1. mol%1.B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the china Spallation Neutron *** neutron detection efficiency was calibrated at 1.eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 1. B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 1.B-doped MCP Neutron response Wide-energy range neutrons

Study on the Total Synthesis of Hainanolide (Ⅱ)──An Unexpected Hydroperoxide Containing Tricyclic Skeleton

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chinese Chemical Letters 1997年第1期8卷 15-16页

作者： Lu Yan zhang {1. Qian {2. Shi Zhi chen Liang HUANG(institute of Materia Medica, chinese academy of Medical Sciences,Peking Union Medical College,beijing,1.0050) institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China

An unexpected compound, hydroperoxide (4) formed from (3), the exo-cycloaddition product, which was synthesized through the Lewis acid catlyzed intramolecular Diels-Alder (IMDA) reaction. Its structure was confirmed b... 详细信息

关键词： ppm An Unexpected Hydroperoxide Containing Tricyclic Skeleton Study on the Total Synthesis of Hainanolide

Study on Mineralization Age of Xiaoban Gold Deposit, Fujian Province

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Journal of china University of Geosciences 2002年第3期13卷 225-233页

作者： chen Bailin institute of {2., CAGS, beijing 100081 Wu Ganguo Faculty of Earth Sciences and Mineral Resources, china University of Geosciences, beijing 100083 zhang Da institute of {2., CAGS, beijing 100081 Huang Rensheng West Fujian geological Party of FBGMRE, Sanming 365000 Wu Jianshe Fujian Bureau of geological and Mineral Resources Exploration, Fuzhou 350003 institute of {1. CAGS Beijing 100081 Faculty of Earth Sciences and Mineral Resources China University of Geosciences Beijing 100083 West Fujian geological Party of FBGMRE Sanming 365000 Fujian Bureau of geological and Mineral Resources Exploration Fuzhou 350003

The Xiaoban gold deposit is a large-size deposit recently found in middlearea of Fujian Province. It belongs to magmatic hydrothermal type occurred in Mayuan Groupmetamorphic rocks of Middle Proterozoic and is controlled by low angle fault (detachment)structures. The contents of Au in Mayuan Group metamorphic rocks, Caledonian-Indosinian deformedgranite and early Yanshanian granite are higher with Au enrichment coefficient of 2. 06-5.68, 5.1.and 6.67 than those in other geological bodies. And the higher enrichment coefficients (>2. of Ag,S, Sn and Te are similar to those of gold ore. Meanwhile, the distribution of Au in Mayuan Groupmetamorphic rocks and early Yanshanian granite with a low D-value (0.58 and 0.67) is favorable togold mineralization. REE characteristics of gold ore, ratios of (LREE/HREE), (La/Sm)_n, (Yb/Lu)_n,(La/Tb)_n and (Sm/Nd)_n are similar to Mayuan Group metamorphic rocks, only non or little normal Euabnormal of ore is dissimilar to metamorphic rocks. The δ(^(34)S) of the gold ore, with a highhomogenization, is (-4.7X1.^(-3) - (-2.7X 1.^(-3)). The study of inclusion indicates 1.0-2.9℃ ofmineralization temperature, 3. 69 %-1.. 81.% of salinities and 0. 869-0.991.g/cm^3 of densities ofmineralization fluid. Based on hydrogen and oxygen isotope (δ(^(1.)O) = 1.. 0 X 1.^(-3) -1..7 X1.^(-3), δ(D) = (-48 X 1.^(-3)) - (-62.X 1.^(-3))) and initial w(^(87)Sr)/w(^(86)Sr) =0. 71.,combining to the analysis of geological history, regional metamorphism and magamtic activity, theauthors confirm that the source for the ore fluid was mainly from magmatic, partly from metamorphicwater, and with a little influence of meteoric water. Isotopic dating made on Rb-Sr isochron age of1.2.Ma, by using alteration minerals of gold-ores from the deposit, indicates that themineralization occurs in early Yanshanian epoch. This is close to the age of 1.7 Ma of the Anchunmagmatite with a similar alteration and gold mineralization to the Xiaoban gold deposit. The age ofearly Yanshan

关键词： mineralization age early yanshanian epoch xiaoban gold deposit fujian

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东辛油田东南部油藏描述及滚动勘探目标选择

石油学报 2004年第2期25卷 36-40页

作者：张煜陈恭洋史文东张永贵中石化胜利油田公司山东东营257094 长江大学地球科学学院湖北荆州434023 中石化勘探开发研究院北京100083

通过高分辨率层序地层划分与对比、全三维地震资料构造解释与微构造分析、测井地震约束波阻抗反演、地震资料油气预测等配套新技术的综合应用 ,重新建立了东辛油田东南部地区的油藏地质模型。在对成藏规律认识的基础上 ,提出了工区构... 详细信息

通过高分辨率层序地层划分与对比、全三维地震资料构造解释与微构造分析、测井地震约束波阻抗反演、地震资料油气预测等配套新技术的综合应用 ,重新建立了东辛油田东南部地区的油藏地质模型。在对成藏规律认识的基础上 ,提出了工区构造油藏和岩性油藏两类共 7个滚动勘探目标。前者主要为沙三中以下目的层 ;后者为微构造或斜坡背景下的岩性尖灭型圈闭。

关键词：油藏描述滚动勘探目标选择东辛油田

Three-Dimensional Density Distribution and Seismic Activity along the Guxiang–Tongmai Segment of the Jiali Fault,Tibet

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Acta Geologica Sinica(English Edition) 2024年第2期98卷 454-467页

作者： FAN Pengxiao YU Changqing WANG Ruixue ZENG Xiangzhi QU chen {1. Yue institute of Land and Resources Engineering Kunming University of Science and Technology Kunming 650000China institute of Geology Chinese Academy of Geological SciencesBeijing 100037China Jiangsu Donghai Continental Deep Hole Crustal Activity National Observation and Research StationLianyungangJiangsu 222000China

The Guxiang-Tongmai segment of the Jiali fault is situated northeast of the Namche Barwa Syntaxis in northeastern *** is one of the most active strike-slip faults near the syntaxis and plays a pivotal role in the examination of seismic activity within the eastern Himalayan *** study in the research region has yielded a 1.2.0000 gravity dataset covering an area 1.00 km^(2..Using wavelet transform multiscale decomposition,scratch analysis techniques,and 3D gravity inversion methods,gravity anomalies,fault distributions,and density structures were determined across various *** the integration of our new gravity data with other geophysical and {2. information,our findings demonstrate substantial variations in the overall crustal density within the region,with the fault distribution closely linked to these density *** in stratigraphic density are important causes of variations in the capacity of {2. formations to endure regional tectonic *** are predominantly concentrated within the density transition zone and are primarily situated in regions of elevated *** hanging wall stress within the Guxiang-Tongmai segment of the Jiali fault exhibits a notable concentration,marked by pronounced anisotropy,and is positioned within the density differential zone,which is prone to earthquakes.

关键词： seismicity deep-density structure wavelet transform multi-scale decomposition scratch analysis 3D gravity inversion Jiali fault Tibet

Study of B Microalloying Steel for Base Material of Cold Rolling in CSP Line

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Study of B Microalloying Steel for Base Material of Cold Rol...