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Differentiation potential of bone marrow mesenchymal stem cells into retina in normal and laser-injured rat eye

Science china(Life {1.) 2004年第3期47卷 241-250页

作者： zhang Jie1.2. SHAN Qing1. MA Ping1. JIANG Yanming1. {1. Peng1. wen Jingxia1. ZHOU You1. QIAN Huanwen1.& PEI Xuetao2.1. beijing institute of Radiation Medicine, beijing 1.0850, china 2. beijing institute of Transfusion Medicine, beijing 1.0850, china beijing {1. of Radiation Medicine Beijing 100850 China beijing {1. of Transfusion Medicine Beijing 100850 China beijing {1. of Radiation Medicine Beijing 100850 China beijing {1. of Transfusion Medicine Beijing 100850 China

Bone marrow mesenchymal stem cells (MSCs) can develop into hematopoietic and mesenchymal lineages but have not been known to participate in the production of retina. Here we report that bone marrow mesenchymal stem cells, after being subretinally transplanted into normal or Nd: YAG laser-injured rat eye, can integrate into RPE layer, photoreceptor layer, bi-polar cell layer and ganglion layer. DAPI-labeling detection was used to trace the origin of the repopulating cells. DAPI fluorescence was used to identify retina cells of bone marrow origin 1., 2., 35 and 50 days after transplantation. No formation of rosettes was found but some random cells were found at the end of the observation. MSCs-originated cells spread more widely in the injured retinas than in the normal ones. Immunohistochemical detection showed that though the cells could express neuronal nuclei (NeuN), neuron specific enolase (NSE), glial fibrillary acidic protein (GFAP) and cytokeratin (CK), the proteins expression in the injured transplantation group was abnormal in some region compared with that in the normal transplantation group. Elec-troretinogram (ERG) showed that ERG-b wave of the injured transplantation group is significantly higher than that of the two laser-injured control groups. These results suggest that a proportion of MSCs can differentiate into retina-like structure in vivo and the differentiation differs in normal and laser-injured retinas.

关键词： MSCs, retina, laser, differentiation.

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Acatulides A-G,neuroprotective macrolides from Acaulium album H-JQSF

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chinese Chemical Letters 2024年第3期35卷 379-383页

作者： Zhi-Wu Tong Ting-Ting Wang Pei yang Jia-Lin Sun {1.-Peng {2. Salman Khan Xin-Cun Wang Rui-Hua Jiao Hui-Ming Ge wen-Ying Zhuang Gang Hu Ren Xiang Tan State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional BiomoleculesNanjing UniversityNanjing 210023China State Key Laboratory Cultivation Base for TCM Quality and Efficacy Nanjing University of Chinese MedicineNanjing 210023China Insitute of Microbiology Chinese Academy of SciencesBeijing 100101China

Fungal symbionts co-evolve with hosts and microbial co-inhabitants to acquire an unpredictable potential for producing novel bioactive metabolites,but the knowledge about the topic remains patchy and *** we present the chemical characterization of acatulides A-G(1.7)as architecturally unprecedented macrolides from the solid-state culture of Acaulium album H-JQSF,an arthropod-associated *** acatulide structures were elucidated by spectroscopic analysis,modified Mosher's method and single-crystal X-ray *** plausible biosynthetic pathways for compounds 1.4 are ***,acatulides B-D(2.4)and G(7)were demonstrated to be neuroprotective against the 1.methyl-4-phenylpyridinium(MPP+)-induced damage to SH-SY5Y cells and nematode Caenorhabditis elegans(***).

关键词： Acaulium album Macrolides Acatulides A–G Mosher’s method Neuroprotective

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^(40)Ar/^(39)Ar Dating of Deformation Events and Reconstruction of Exhumation of Ultrahigh-Pressure Metamorphic Rocks in Donghai, East china

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Acta Geologica Sinica(English Edition) 2003年第2期77卷 155-168页

作者： LI Jinyi, yang Tiannan, {1. {2. and zhang Sihong institute of Geology, chinese Academy of geological sciences, beijing 1.0037E-mail: jyli@*** chinese Acad Geol Sci Inst Geol Beijing 100037 Peoples R China

Recent investigations reveal that the ultrahigh-pressure metamorphic (UHPM) rocks in the Donghai region of East china under{1.t ductile and transitional ductile-brittle structural events during their exhumation. The earlier ductile deformation took place under the condition of amphibolite facies and the later transitional ductile-brittle deformation under the condition of greenschist facies. The hanging walls moved southeastward during both of these two events. The 40Ar/39Ar dating of muscovites from muscovite-plagioclase schists in the Haizhou phosphorous mine, which are structurally overlain by UHPM rocks, yields a plateau age of 2.1}.0±2.9 Ma and isochron age of 2.1}.8Ma, indicating that the earlier event of the ampibolite-facies deformation probably took place about 2.0 Ma ago. The 40Ar/39Ar dating of oriented amphiboles parallel to the movement direction of the hanging wall on a decollement plane yields a plateau age of 2.1}.1.0.3 Ma and isochron age of 2.1}.4±4.1.Ma, probably representing the age of the later event. The dating of pegmatitic biotites and K-feldspars near the decollement plane from the eastern Fangshan area yield plateau ages of 2.3.4±0.3 Ma, 2.3.6±0.4 Ma and 2.4.8±2.2.Ma, and isochron ages of 2.4.0±2.0 Ma, 2.0.6±3.1.Ma and 2.4.0±5.0 Ma, respectively, implying that the rocks in the studied area had not been cooled down to closing temperature of the dated biotites and K-feldspars until the beginning of the Jurassic (about 2.4 Ma). The integration of these data with previous chronological ages on the ultrahigh-pressure metamorphism lead to a new inference on the exhumation of the UHPM rocks. The UHPM rocks in the area were exhumed at the rate of 3-4 km/Ma from the mantle (about 80-1.0 km below the earth's surface at about 2.0 Ma) to the lower crust (at the depth of about 2.-30km at 2.0 Ma), and at the rate of 1.2.km/Ma to the middle crust (at the depth of about 1. km at 2.1} Ma), and then at the rate of less than 1.km/Ma to the upper crust about 1. km

关键词： ultrahigh-pressure metamorphic rocks structural deformation 40Ar/39Ar dating exhumation Donghai East china

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TCP-1.a novel peptide to diagnose early colon cancer

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chinese Chemical Letters 2024年第3期35卷 226-233页

作者： Hang Yu Baoying wen Min Huang Ru Feng Libin Pan Manyi Xu Hao Lin Lin Cong Sen {1. Yan Li Chi-Hin Cho Chongjing {1. Xiaoguang chen Yan Wang State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical SciencesBeijing 100050China School of Biomedical sciences Faculty of MedicineThe Chinese University of Hong KongHong KongChina

A nine cyclic peptide(TCP-1.showed excellent specificity for colon ***-1.binds with human tumor tissues at early stages and mice tumor with diameters of 1.4 mm,suggesting that TCP-1.may be used for early diagnosis of colon *** mechanism of the targeted binding of TCP-1.to colon cancer was also studied using immunoprecipitation,LC-MS and *** screening and identifying of the possible binding target proteins of TCP-1.keratin,typeⅡcytoskeletal 5 was speculated to be the specific binding target protein of TCP-1.in human tumor *** studies were conducted to investigate the target-mediated drug disposition of the new tumor-specific peptide by LC-MS/*** tissue distribution study showed that TCP-1.was found only in colon tumors(the target site)in tumor mice did not bind to any other *** TCP-1.to tumor markedly increased its removal rate from blood circulation but mildly extended its staying time in *** tumor mice,a lower AUC of TCP-1.reduced by almost 35%)and 2.fold higher clearance were found compared to that of normal *** proposed metabolic pathway of TCP-1.in the kidney was also determined using LC-MS^(n)-*** high specificity and low toxicity of the peptide may be caused by its extremely tight binding to the *** applications for future clinical use,including MRI and PET/CT were also explored,and this research may promote the development of colon cancer diagnostic technology research and provide new ideas and technical routes for tumor diagnostic technology.

关键词： Colon cancer TCP-1 Peptide Cytokeratin 5 Pharmacokinetics/pharmacodynamics(PK/PD)

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Characteristics and origin of low-organicmatter carbonate source rocks in the Middle-Upper Ordovician, Tarim Basin, northwestern china

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Journal of Palaeogeography 2024年第3期13卷 594-619页

作者： Jun-Qing chen Fu-Jie Jiang Xiong-Qi Pang Hai-Jun {1. Kan-Yuan Shi Bo Pang Hong Pang Jian-Fa chen Zhuo-Heng chen Xin-Gang zhang Song Wu State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing 102249China Basic Research Center for Energy Interdisciplinary College of ScienceChina University of Petroleum(Beijing)Beijing 102249China beijing Key Laboratory of Optical Detection Technology for Oil and Gas China University of Petroleum(Beijing)Beijing 102249China College of Geosciences China University of Petroleum(Beijing)Beijing 102249China Research institute of Petroleum Exploration and Development PetroChina Tarim Oilfield CompanyKorla 841000Xinjiang Uygur Autonomous RegionChina geological Survey of Canada Natural Resources CanadaCalgary T2L 2A7Canada

The continually-discovered large volumes of marine hydrocarbons indicate a huge exploration potential within the carbonate rocks of Ordovician in the Tarim Basin,northwestern *** Middle-Upper Ordovician(O2.3)carbonate source rocks are at a highly mature *** rocks presently contain a low amount of total organic carbon(TOC_(pd)≤0.5%)(TOC_(pd) means the present-day TOC).A mass balance approach is used to identify the source rocks that have expelled *** characteristics and origin of hydrocarbon expulsion from low-TOC_(pd) source rocks are studied,which are significant for oil exploration in the *** results showed that a low-TOC_(pd) O2.3 source rock having expelled hydrocarbons was type I and had a very narrow oil *** a high rock maturity and a high original TOC(TOCo)value exceeding 1.,nearly 80%of the generated hydrocarbons were *** content of gammacerane and C2. steranes in the oil and source rock extracts were relatively lean,with a V-shaped distribution of regular steranes,suggesting a possible genetic relation between the low-TOC_(pd) source rocks and the marine oil in the Tabei *** planktonic algae or acritarchs were the main hydrocarbon parent materials,distributed in the subsiding platform-slope *** matter was preserved under reducing conditions,and source rocks were formed with a favorable kerogen type and a moderate hydrocarbon generation *** study illustrates the hydrocarbon expulsion of low TOC_(pd) source rocks in northern Tarim Basin,which is greatly significant for analyzing the genesis of marine crude oil in Tarim Basin,and evaluating the distribution of marine source *** research method is theoretically significant for oil and gas exploration in the same type of highlymature carbonate paleobasins.

关键词： Carbonate source rock Mass balance approach Present-day TOC Genesis mechanism Tarim Basin

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Radioimmunotherapy of carcinoma of colon with [1.1.]-labeled recombinant chimeric monoclonal antibodies to carcinoembryonic antigen

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Acta Pharmacologica Sinica 2005年第10期26卷 1259-1264页

作者： Qiu-jun LU~1. Guang-xing BIAN, Yuan-yuan chen, Min {1., Shao-ming GUO, Li-qing wen institute of Radiation Medicine, beijing 1.0850, china institute of Radiation Medicine Beijing China

Aim: To study the distribution of [1.1.]-labeled anti-CEA MoAbs and its therapeutic effect on the human colonic cancer model in nude mice. Methods: A nude mice model of human colonic cancer was established. [~1.1.]-labeled anti-CEA MoAbs were injected intravenously into mice. The distribution of the MoAbs was then determined and the effect of RIT on human colonic cancer was observed. Results: The [1.1.]-labeled anti-CEA MoAbs had a specific distribution after injection. Tumor/non-tumor ratios for [1.1.]-labeled anti-CEA MoAbs were 1.-2. times higher than [1.1.]-labeled IgG 96 h after injection. Thirty days after injection, significant inhibition of the volume and weight of tumor was observed in the treated mice compared with the control. The tumor growth inhibition rate of 3,1.mCi/kg CEA MoAbs group (LS1.0, LS1.4T, SW1.1.) was 47.8%～64.0%. This was 69.6%-78.6% in the 6.2. mCi/kg CEA MoAbs group, and 81.8%-86.2. in the 1..5 mCi/kg [1.1.]-labeled anti-CEA MoAbs group. The plasma CEA level was alo lower in treated mice. Conclusion: The results indicate that [1.1.]-labeled anti-CEA MoAbs can be effective in RIT on colonic cancers.

关键词： humanized chimeric recombinant monoclonal antibody radioimmunotherapy colonic cancer nude mice

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Geochemistry of the Middle Dovenian Picritic Rocks of the South Margin of Altay Orogenic Belt: Implications for the Tectonic Setting and Petrogenesis

Geochemistry of the Middle Dovenian Picritic Rocks of the So...

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火山作用与地球层圈演化——全国第四次火山学术研讨会

作者： Zhao Li~1 zhang Zhaochong~(1,2) Yan Shenghao~3 chen Bailin~4 Zhou Gang~5 HeYongkang~5 Chai Fengmei~2 He Lixin~5 1. State Key laboratory of geological Processes and Mineral Resources, china University of Geosciences, beijing 100083 2. institute of Geology, chinese Academy of geological sciences, beijing 100037 3. institute of Mineral Resources, chinese Academy of geological sciences, beijing 100037 4. institute of geomechanics, chinese Academy of geological sciences, beijing 100081 5. No. 4 geological Party, Xinjiang Bureau of Geology and Resources, Aertai, Xinjiang

＜正＞ The Altay orogenic belt, Xinjiang Uygur Autonomous Region in NW china, represents one of the important sites of juvenile crustal growth during the Phanerozoic time. However, some important issues, e.g., tectonic evolution and petrogenesis, still remain controversial. Two layers of the picritic rocks in the south margin of the Altay orogenic belt, were discovered in the lower part of marine volcanic-sedimentary

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超短脉冲强激光与固体靶相互作用产生超热电子的能谱研究

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物理学报 2000年第3期49卷 592-596页

作者：陈黎明张杰梁天骄李玉同王龙江文勉中国科学院物理研究所光物理开放研究实验室中国工程物理研究院核物理与化学研究所绵阳621000 中国工程物理研究院核物理与化学研究所

较详尽地描述了能对激光与靶物质相互作用所产生的超热电子进行直接测量的电子磁谱仪的建造及其相应的参量,并利用这台磁谱仪测量了超短脉冲强激光与靶物质相互作用后出射的超热电子的能谱,在5×1.1.W/cm2.激光强度下,超热电子的最大... 详细信息

较详尽地描述了能对激光与靶物质相互作用所产生的超热电子进行直接测量的电子磁谱仪的建造及其相应的参量,并利用这台磁谱仪测量了超短脉冲强激光与靶物质相互作用后出射的超热电子的能谱,在5×1.1.W/cm2.激光强度下,超热电子的最大能量大于500keV,能谱结构呈双温Maxwell分布,能谱的峰值出现在50keV附近。

关键词：超短脉冲强激光固体靶相互作用超热电子能谱

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Distribution and Development of the TCM Syndromes in Psoriasis Vulgaris

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Journal of Traditional chinese Medicine 2009年第3期29卷 195-200页

作者：张广中王莒生王萍姜春燕邓丙戌李萍赵一鸣刘瓦利瞿幸陈维文曾琳周冬梅孙丽蕴李若瑜王新中 Department of Dermatology and Venereology Beijing TCM Hospital Affiliated to the Capital Medical University beijing {1. of Traditional {2. Medicine Research Centre of Clinical Epidemiology the Third Hospital of Beijing University Department of Dermatology and Venereology Guanganmen Hospital Affiliated to China Academy of Chinese Medical Sciences Department of Dermatology and Venereology Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine Department of Dermatology and Venereology First Hospital of Beijing University

Objective: To study the distribution and development rules of the TCM syndromes in psoriasis vulgaris. Methods: Based on the clinical epidemiologic mass survey, the study was carried out by means of a status survey, multi-center and large-sample research. The data base was set up by EPIINFO6.0. The SPSS was used to do the statistical analyses in 2.51.cases of psoriasis vulgaris to study the correlations among the distribution and development of the TCM syndromes, the stages of the disease, nationality, psoriasis history, family history, smoking history, alcohol drinking history, and severity of the disease. Results: The TCM syndromes in psoriasis vulgaris mainly include the blood-heat syndrome (53.8%), blood-dryness syndrome (2..4%), and blood-stasis syndrome (1..1.). Other syndromes were rarely seen, covering 0.6%. The concurrent syndromes mainly involve dampness, heat, blood stasis and toxin. The distribution differences of the main syndromes at different stages of the disease had statistical significance (P1.. The syndrome distribution is not related with nationality and family history (P>0.05), but it was closely related with the psoriasis history, smoking history, alcohol drinking history, and severity of the disease (P1.. Conclusion: At the initial stage, psoriasis vulgaris usually manifests itself as the blood-heat syndrome, and later it may be improved or turn into the blood-dryness or blood-stasis syndrome. Smoking, alcohol consumption, and severity of the disease may play a role in the syndrome's transformation.

关键词：中医证候银屑病 TCM EPIINFO6.0

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国产MOCVD-YBCO带材高温超导线圈研制与磁场温度特性研究

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物理学报 2018年第6期67卷 250-257页

作者：丁发柱张京业谭运飞陈治友董泽斌张慧亮商红静许文娟张贺屈飞高召顺周微微古宏伟中国科学院电工研究所北京100190 中国科学院应用超导重点实验室北京100190 中国科学院大学北京100049 中国科学院强磁场科学中心合肥230031

超导磁体的场强与超导材料的载流能力、磁体口径和低温环境有密切关系.为了在中高温区域实现高磁场强度的超导磁体,采用国产第二代高温超导带材,成功绕制出内直径为1.0 mm的高温超导线圈.该超导线圈在77,65,55和46 K不同温区下进行了性... 详细信息

超导磁体的场强与超导材料的载流能力、磁体口径和低温环境有密切关系.为了在中高温区域实现高磁场强度的超导磁体,采用国产第二代高温超导带材,成功绕制出内直径为1.0 mm的高温超导线圈.该超导线圈在77,65,55和46 K不同温区下进行了性能测试,其最大运行电流分别为65,1.7,2.7和338 A,对应的中心磁场强度分别为0.78,1.77,3.1.4.08 T.所研制的超导线圈的中平面上磁场基本一致.

关键词：高温超导磁体钇钡铜氧带材

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