检索结果-南通市图书馆

TCP-1.a novel peptide to diagnose early colon cancer

chinese Chemical Letters 2024年第3期35卷 226-233页

作者： Hang Yu Baoying wen Min Huang Ru Feng Libin Pan Manyi Xu Hao Lin Lin Cong Sen {1. Yan Li Chi-Hin Cho Chongjing {1. Xiaoguang {3. Yan Wang State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical SciencesBeijing 100050China School of Biomedical sciences Faculty of MedicineThe Chinese University of Hong KongHong KongChina

A nine cyclic peptide(TCP-1.showed excellent specificity for colon ***-1.binds with human tumor tissues at early stages and mice tumor with diameters of 1.4 mm,suggesting that TCP-1.may be used for early diagnosis of colon *** mechanism of the targeted binding of TCP-1.to colon cancer was also studied using immunoprecipitation,LC-MS and *** screening and identifying of the possible binding target proteins of TCP-1.keratin,typeⅡcytoskeletal 5 was speculated to be the specific binding target protein of TCP-1.in human tumor *** studies were conducted to investigate the target-mediated drug disposition of the new tumor-specific peptide by LC-MS/*** tissue distribution study showed that TCP-1.was found only in colon tumors(the target site)in tumor mice did not bind to any other *** TCP-1.to tumor markedly increased its removal rate from blood circulation but mildly extended its staying time in *** tumor mice,a lower AUC of TCP-1.reduced by almost 3.%)and 2-fold higher clearance were found compared to that of normal *** proposed metabolic pathway of TCP-1.in the kidney was also determined using LC-MS^(n)-*** high specificity and low toxicity of the peptide may be caused by its extremely tight binding to the *** applications for future clinical use,including MRI and PET/CT were also explored,and this research may promote the development of colon cancer diagnostic technology research and provide new ideas and technical routes for tumor diagnostic technology.

关键词： Colon cancer TCP-1 Peptide Cytokeratin 5 Pharmacokinetics/pharmacodynamics(PK/PD)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Characteristics and origin of low-organicmatter carbonate source rocks in the Middle-Upper Ordovician, Tarim Basin, northwestern China

引用

Journal of Palaeogeography 2024年第3期13卷 594-619页

作者： Jun-Qing chen Fu-Jie Jiang Xiong-Qi Pang Hai-Jun {1. Kan-Yuan Shi Bo Pang Hong Pang Jian-Fa chen Zhuo-Heng chen Xin-Gang zhang Song Wu State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing 102249China Basic Research Center for Energy Interdisciplinary College of ScienceChina University of Petroleum(Beijing)Beijing 102249China beijing Key Laboratory of Optical Detection Technology for Oil and Gas China University of Petroleum(Beijing)Beijing 102249China College of Geosciences China University of Petroleum(Beijing)Beijing 102249China Research institute of Petroleum Exploration and Development PetroChina Tarim Oilfield CompanyKorla 841000Xinjiang Uygur Autonomous RegionChina geological Survey of Canada Natural Resources CanadaCalgary T2L 2A7Canada

The continually-discovered large volumes of marine hydrocarbons indicate a huge exploration potential within the carbonate rocks of Ordovician in the Tarim Basin,northwestern *** Middle-Upper Ordovician(O2+3.carbonate source rocks are at a highly mature *** rocks presently contain a low amount of total organic carbon(TOC_(pd)≤0.5%)(TOC_(pd) means the present-day TOC).A mass balance approach is used to identify the source rocks that have expelled *** characteristics and origin of hydrocarbon expulsion from low-TOC_(pd) source rocks are studied,which are significant for oil exploration in the *** results showed that a low-TOC_(pd) O2+3.source rock having expelled hydrocarbons was type I and had a very narrow oil *** a high rock maturity and a high original TOC(TOCo)value exceeding 1.,nearly 80%of the generated hydrocarbons were *** content of gammacerane and C28 steranes in the oil and source rock extracts were relatively lean,with a V-shaped distribution of regular steranes,suggesting a possible genetic relation between the low-TOC_(pd) source rocks and the marine oil in the Tabei *** planktonic algae or acritarchs were the main hydrocarbon parent materials,distributed in the subsiding platform-slope *** matter was preserved under reducing conditions,and source rocks were formed with a favorable kerogen type and a moderate hydrocarbon generation *** study illustrates the hydrocarbon expulsion of low TOC_(pd) source rocks in northern Tarim Basin,which is greatly significant for analyzing the genesis of marine crude oil in Tarim Basin,and evaluating the distribution of marine source *** research method is theoretically significant for oil and gas exploration in the same type of highlymature carbonate paleobasins.

关键词： Carbonate source rock Mass balance approach Present-day TOC Genesis mechanism Tarim Basin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hydrocarbon accumulation in network and its application in the continental rift basin

引用

Science China Earth sciences 2008年第S2期51卷 88-100页

作者： PANG XiongQi1.2,chen DongXia1.{1. Shanwen3.HAO Fang1.LIU Zheng1.LIU KeYu3.SONG GuoQi4,WANG YongShi4,LUO XiaoRong5 & WU XiaoChun61.State Key Laboratory of Petroleum Resource and Prospecting,chinese University of Petroleum,beijing 1.2249,China 2 Basin and Reservoir Center,chinese University of Petroleum,beijing 1.2249,China 3.SINOPEC Shengli Oilfield,Dongying 257051.China 4 CSIRO Petroleum,P. O. Box 1.3.,Bentley,WA 61.2,Australia 5 institute of Geology and Geophysics,chinese academy of Science,beijing 1.0029,China 6 China National Petroleum Corporation,beijing 1.0724,China chinese Univ Petr State Key Lab Petr Resource & Prospecting Beijing 102249 Peoples R China chinese Univ Petr Basin & Reservoir Ctr Beijing 102249 Peoples R China SINOPEC Shengli Oilfield Dongying 257051 Peoples R China CSIRO Petr Bentley WA 6102 Australia chinese Acad Sci Inst Geol & Geophys Beijing 100029 Peoples R China China Natl Petr Corp Beijing 100724 Peoples R China

The concept of hydrocarbon accumulation in network was presented on basis of the overall analysis of the formation and evolution characteristics of the continental faulted basin and of the systemic re-search on the major controlling factors on the hydrocarbon accumulation. The hydrocarbon accumu-lation in network can be defined as hydrocarbon accumulation in a three-dimensional network system which is constituted by the hydrocarbon migration passages under multiple dynamics,following the hydrocarbon generation from source rocks. The research shows that the hydrocarbon accumulation in network is composed of four elements,i.e.,hydrocarbon source (source rock kitchen),hydrocarbon accumulation terminal (trap),network pathway connecting source and terminal (transporting system),and network potential driving hydrocarbon migration in the network pathway (migration dynamics). Compared with other networks,hydrocarbon accumulation in network has three basic characteristics: the irreversible {1. process of material and information flow in the network; the loss of material and information in the flow process in the network; the multiple dynamics in the flow process. Interac-tion of all the elements in the {1. process can be called hydrocarbon accumulation in network. There are three basic models for hydrocarbon accumulation in network,that is,hydrocarbon accumu-lation in the network source area,hydrocarbon accumulation in the network pathway,and hydrocarbon accumulation in the network terminal. The key in the application of the hydrocarbon accumulation models in network in practice is to confirm the major accumulation stage and the function range of the four elements controlling the hydrocarbon firstly,to predict the profitable accumulation region by su-perposition of the favorable areas confirmed by four elements consequently,and to evaluate the oil-bearing property of the trap as well as confirm drilling targets. This paper takes the Dongying De-pression in the

关键词： continental rift basin hydrocarbon accumulation theory hydrocarbon network hydrocarbon accumulation in network Bohai Bay Basin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Study on the Total Synthesis of Hainanolide (Ⅱ)──An Unexpected Hydroperoxide Containing Tricyclic Skeleton

引用

chinese Chemical Letters 1997年第1期8卷 15-16页

作者： Lu Yan zhang {1. Qian yang Shi Zhi {3. Liang HUANG(institute of Materia Medica, chinese {3. of Medical sciences,Peking Union Medical College,beijing,1.0050) institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China

An unexpected compound, hydroperoxide (4) formed from (3., the exo-cycloaddition product, which was synthesized through the Lewis acid catlyzed intramolecular Diels-Alder (IMDA) reaction. Its structure was confirmed b... 详细信息

关键词： ppm An Unexpected Hydroperoxide Containing Tricyclic Skeleton Study on the Total Synthesis of Hainanolide

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Identification of AtENT3.as the main transporter for uridine uptake in Arabidopsis roots

引用

Cell Research 2006年第4期16卷 377-388页

作者： Kun Ling chen~(1.2,*) Min Xin Xu~(2,3.*) Guang Yong Li~(2,3.*) Hui Liang~2 Zong Liang Xia~(2,3. Xin Liu~2 Ji Shu {1.~1.Ai Min {1.~2 Dao wen Wang~2 ~1.chool of Life sciences,Northwest Agricultural and Forestry University,yangling 71.1.0,China ~2Center for Plant Gene Research(beijing)and the State Kev Laboratory of Plant Cell and Chromosome Engineering,institute of Genetics and Developmental Biology,{13. academy of sciences,Datun Road,Chaovang District,beijing 1.01.1.China ~3.raduate School of the {13. academy of sciences,Yuquan Road,Shijingshan District,beijing 1.003.,China SchoolofLifesciences NorthwestAgriculturalandForestryUniversityYangling712100China andtheStateKeyLaboratoryofPlantCellandChromosomeEngineering InstituteofGeneticsandDevelopmen

Previous studies have shown that Arabidopsis equilibrative nucleoside transporters （AtENTs） possess transport activitieswhen produced in yeast cells and are differentially expressed in Arabidopsis ***,we report further analysis onthe nucleoside transport activities and transcriptional patterns of AtENT *** recombinant proteins of AtENTs3.6,and 7,but not those of AtENTs 1.2,4,and 8,were found to transport thymidine with high *** to previ-ous suggestion that AtENT1.may not transport uridine,this work showed that recombinant AtENT1.was a pH-dependentand high-affinity transporter of *** grown on MS plates,the AtENT3.knockout plants were more tolerant tothe cytotoxic uridine analog 5-fluorouridine than wild-type plants and the knockout plants ofAtENT 1.or ***-sistent with this observation,the AtENT3.knockout line exhibited a significantly decreased ability to take up [3.]uridinevia the roots when compared with wild-type plants and the plants with mutated AtENT 1.or *** indicates thatAtENT3.but not AtENTs 1.and 6,is the main transporter for uridine uptake in Arabidopsis *** transcription ofAtENTs 1.3.4,6,7,and 8 was regulated in a complex manner during leaf development and *** contrast,thesix AtENT members were coordinately induced during seed *** work provides new information on thetransport properties of recombinant AtENT proteins and new clues for future studies of the in vivo transport activitiesand physiological functions of the different ENT proteins in Arabidopsis plants.

关键词： Arabidopsis equilibrative nucleoside transporter expression pattern nucleoside transport functional analysis

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

超短脉冲强激光与固体靶相互作用产生超热电子的能谱研究

引用

物理学报 2000年第3期49卷 592-596页

作者：陈黎明张杰梁天骄李玉同王龙江文勉中国科学院物理研究所光物理开放研究实验室中国工程物理研究院核物理与化学研究所绵阳621000 中国工程物理研究院核物理与化学研究所

较详尽地描述了能对激光与靶物质相互作用所产生的超热电子进行直接测量的电子磁谱仪的建造及其相应的参量,并利用这台磁谱仪测量了超短脉冲强激光与靶物质相互作用后出射的超热电子的能谱,在5×1.1.W/cm2的激光强度下,超热电子的最大... 详细信息

较详尽地描述了能对激光与靶物质相互作用所产生的超热电子进行直接测量的电子磁谱仪的建造及其相应的参量,并利用这台磁谱仪测量了超短脉冲强激光与靶物质相互作用后出射的超热电子的能谱,在5×1.1.W/cm2的激光强度下,超热电子的最大能量大于500keV,能谱结构呈双温Maxwell分布,能谱的峰值出现在50keV附近。

关键词：超短脉冲强激光固体靶相互作用超热电子能谱

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

国产MOCVD-YBCO带材高温超导线圈研制与磁场温度特性研究

引用

物理学报 2018年第6期67卷 250-257页

作者：丁发柱张京业谭运飞陈治友董泽斌张慧亮商红静许文娟张贺屈飞高召顺周微微古宏伟中国科学院电工研究所北京100190 中国科学院应用超导重点实验室北京100190 中国科学院大学北京100049 中国科学院强磁场科学中心合肥230031

超导磁体的场强与超导材料的载流能力、磁体口径和低温环境有密切关系.为了在中高温区域实现高磁场强度的超导磁体,采用国产第二代高温超导带材,成功绕制出内直径为1.0 mm的高温超导线圈.该超导线圈在77,65,55和46 K不同温区下进行了性... 详细信息

超导磁体的场强与超导材料的载流能力、磁体口径和低温环境有密切关系.为了在中高温区域实现高磁场强度的超导磁体,采用国产第二代高温超导带材,成功绕制出内直径为1.0 mm的高温超导线圈.该超导线圈在77,65,55和46 K不同温区下进行了性能测试,其最大运行电流分别为65,1.7,257和3.8 A,对应的中心磁场强度分别为0.78,1.77,3.1.4.08 T.所研制的超导线圈的中平面上磁场基本一致.

关键词：高温超导磁体钇钡铜氧带材

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Magnetic survey and ChinaGRF 2000

Magnetic survey and ChinaGRF 2000

引用

中国科学院地质与地球物理研究所2003.术年会

作者： wen-Yao Xu~1.Guo-Hui Xia~1.Zhen-Chang An~1.Geng-Xiong {1.~1.Feng-Yu zhang~1.Yue-Hua Wang~1. Yu-Gang Tian~1.Zi-Gang Wei~1.Shi-Zhuang Ma~2,and Hong-Fei {1.~3.1.{13. of Geology and Geophysics,chinese {3. of sciences,beijing.China 2 Graduate School,chinese {3. of sciences,beijing,China 3.Peking University,beijing,China

The magnetic survey in China carried out in resent years is briefly *** the basis of the magnetic data at 1.9 repeat stations,3. permanent observatories and 20 grid values of the IGRF 2000,the magnetic charts and mode... 详细信息

关键词： Magnetic survey Magnetic chart ChinaGRF

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

华南陆缘晚中生代造山及其地质意义

引用

中国地质 2013年第1期40卷 86-105页

作者：崔建军张岳桥董树文江博明徐先兵马立成李建华苏金宝李勇中国地质科学院地质力学研究所北京100081 台湾大学地球科学系台北10699 中国地质大学地球科学学院武汉430074

长乐—南澳带位于华南大陆的东南缘,是揭示晚中生代古太平洋板块与欧亚大陆相互作用和华南陆缘地质演化的一条关键性构造带。该构造带的T3.J含煤地层不整合下伏于下白垩统南园组之下,或以角闪岩相包体形式赋存于晚侏罗—早白垩世片麻状... 详细信息

长乐—南澳带位于华南大陆的东南缘,是揭示晚中生代古太平洋板块与欧亚大陆相互作用和华南陆缘地质演化的一条关键性构造带。该构造带的T3.J含煤地层不整合下伏于下白垩统南园组之下,或以角闪岩相包体形式赋存于晚侏罗—早白垩世片麻状花岗岩体内。这些具有透入性混合岩化特征的副变质岩包体(T3.J)与围岩(片麻状花岗岩)发生过同变形,并且被未变形的白垩纪岩体/脉侵入。这些晚三叠—早侏罗世地层的变质和变形具有朝陆内(NW)方向减弱的特征。下白垩统南园组普遍发生褶皱和绿片岩相变质,并且被未变质的上白垩统石帽山群不整合覆盖。长乐—南澳带的主要岩石单元与构造特征表明华南陆缘在晚中生代经历过两期挤压(造山)。在第一期挤压(造山)过程中,T3.J陆相地层发生褶皱和变质。随后,这些经历了变形和变质的T3.J沉积地层与中-上地壳的其他岩石在早白垩世早期发生构造折返,其间伴随着大规模同构造岩浆作用(1.7～1.5 Ma)和区域性混合岩化。在第二期挤压过程中,早白垩世南园组发生褶皱和变质。华南陆缘1.0～1.0 Ma的岩浆杂岩、1.0～90 Ma的A型花岗岩和90～80 Ma的双峰式火成岩可能分别与这次挤压事件及其后的地壳伸展、减薄过程有关。因此,华南晚中生代两大岩浆旋回(1.5～1.0 Ma和1.0～80 Ma)可能受控于同期的两大构造旋回(1.5～1.0 Ma和1.5～80 Ma)。每个构造旋回包括一个地壳受挤压增厚过程和一个随后发生的地壳伸展减薄过程。值得注意的是,华南沿海地区的晚中生代构造-岩浆作用与陆内同期构造-岩浆作用似乎具有可比性。

关键词：长乐-南澳构造带平潭-东山杂岩带福清-云霄变质带晚中生代陆缘造山

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Real-Time Warning System of Regional Landslides Supported by WEGISB and Its Application in Typhoon Rananim,Zhejiang Province,China

引用

地学前缘 2009年第S1期16卷 68-69页

作者： Guirong zhang~1.Kunlong Yin~2,Lixia {1.~2 1.Geotechnical Engineering institute of Nanjing Hydraulic Research institute,Nanjing 21.03.,China. 2.China University of Geosciences(beijing),beijing 1.0083.China

As one of the provinces of highest economic growth in coastal China,Zhejiang Province is experiencing serious geological disasters during the past development of *** main kinds of geo-hazards include landslides,rock falls and debris-flows in Zhejiang Province,which are mainly induced by intensive rainfall during typhoon season or by long-term rainfall from May to June every ***,

关键词： landslide prediction real-time warning effective rainfall rainfall intensity WEBGIS typhoon

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：