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Total glucosides of paeony alleviates cGAS-STING-mediated diseases by blocking the STING-IRF3 interaction

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chinese Journal of Natural Medicines 2024年第5期22卷 402-415页

作者： XIU Ye WANG Sihao zhang Ping LI {1.gwei WU Zhixin wen Jincai XU Yingjie LV Guiji ZHAO Xiaomei DONG Xu {1. Yichong LI Junjie WANG Yan ZOU Liang XIAO Xiaohe BAI Zhaofang School of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350122China Department of Hepatology The Fifth Medical Center of PLA General HospitalBeijing 100039China china Military {1. of chinese Materia Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Pharmacy Medical Supplies Center of PLA General HospitalBeijing 100039China School of Food and Biological Engineering Chengdu UniversityChengdu 610106China National Key Laboratory of Kidney Diseases Chinese PLA General HospitalBeijing 100039China

In the realm of autoimmune and inflammatory diseases,the cyclic GMP-AMP synthase(cGAS)stimulator of interferon genes(STING)signaling pathway has been thoroughly investigated and *** this,the clinical approval of drugs targeting the cGAS-STING pathway has been *** Total glucosides of paeony(TGP)is highly anti-inflammatory and is commonly used in the treatment of rheumatoid arthritis(RA),emerged as a subject of our *** found that the TGP markedly reduced the activation of the cGAS-STING signaling pathway,triggered by various cGAS-STING agonists,in mouse bone marrow-derived macrophages(BMDMs)and Tohoku Hospital Pediatrics-1.THP-1.*** inhibition was noted alongside the suppression of interferon regulatory factor 3(IRF3)phosphorylation and the expression of interferon-beta(IFN-β),C-X-C motif chemokine ligand 1.(CXCL1.),and inflammatory mediators such as tumor necrosis factor-alpha(TNF-α)and interleukin-6(IL-6).The mechanism of action appeared to involve the TGP’s attenuation of the STING-IRF3 interaction,without affecting STING oligomerization,thereby inhibiting the activation of downstream signaling *** vivo,the TGP hindered the initiation of the cGAS-STING pathway by the STING agonist dimethylxanthenone-4-acetic acid(DMXAA)and exhibited promising therapeutic effects in a model of acute liver injury induced by lipopolysaccharide(LPS)and D-galactosamine(D-GalN).Our findings underscore the potential of the TGP as an effective inhibitor of the cGAS-STING pathway,offering a new treatment avenue for inflammatory and autoimmune diseases mediated by this pathway.

关键词： Total glucosides of gaeony cGAS-STING pathway Inflammation LPS/D-GalN STING inhibitor

Loop-mediated isothermal amplification:rapid detection of Angiostrongylus cantonensis infection in Pomacea canaliculata

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Loop-mediated isothermal amplification:rapid detection of An...

中国动物学会·中国海洋湖沼学会贝类学分会第九次会员代表大会暨第十五次学术讨论会

作者： Rui chen~1.Qun-Bo Tong~1.Yi {1.~2 Di Lou~1.Qing-Ming Kong~1.Shan Lv~2 Ming-Ming Zhuo~1.Li-Yong wen~1.Shao-Hong Lu~1.1.institute of Parasitology,Zhejiang academy of Medical sciences, Hangzhou,People’s Republic of china 2 National institute of Parasitic Diseases,chinese Center for Disease Control and Prevention,Shanghai,People’s Republic of china

Background:Angiostrongylus cantonensis is a zoonotic parasite that causes eosinophilic meningitis in *** most common source of infection with *** is the consumption of raw or undercooked mollusks(e.g.,snails and slugs)harbouring infectious third-stage larvae(L).However,the parasite is difficult to identify in *** purpose of this study was to develop a quick,simple molecular method to survey for *** in intermediate host snails.

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东辛油田东南部油藏描述及滚动勘探目标选择

石油学报 2004年第2期25卷 36-40页

作者：张煜陈恭洋史文东张永贵中石化胜利油田公司山东东营257094 长江大学地球科学学院湖北荆州434023 中石化勘探开发研究院北京100083

通过高分辨率层序地层划分与对比、全三维地震资料构造解释与微构造分析、测井地震约束波阻抗反演、地震资料油气预测等配套新技术的综合应用 ,重新建立了东辛油田东南部地区的油藏地质模型。在对成藏规律认识的基础上 ,提出了工区构... 详细信息

通过高分辨率层序地层划分与对比、全三维地震资料构造解释与微构造分析、测井地震约束波阻抗反演、地震资料油气预测等配套新技术的综合应用 ,重新建立了东辛油田东南部地区的油藏地质模型。在对成藏规律认识的基础上 ,提出了工区构造油藏和岩性油藏两类共 7个滚动勘探目标。前者主要为沙三中以下目的层 ;后者为微构造或斜坡背景下的岩性尖灭型圈闭。

关键词：油藏描述滚动勘探目标选择东辛油田

Characteristics and genesis of groundwater salinization in coastal areas of the Lower Reaches of Oujiang Basin

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Journal of Groundwater Science and Engineering 2024年第2期12卷 190-204页

作者： Mei-hui zhang Shi-{1. Zhou Dan-dan Liu Ying zhang Yu-xi zhang Xi chen Hui-wei Wang Bei Li Wei Kang Bing Yi Wan-peng Shi institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China Fujian Provincial Key Laboratory of Water Cycling and Eco–geological Processes Xiamen 361021FujianChina china University of Geo{1.(Beijing) Beijing 100083China Changsha Center of Natural Resources Comprehensive Survey China Geological SurveyChangsha 410600China Hydrogeological Environmental geological Survey Center of china geological Survey Tianjin 071501China china University of Geo{1. Wuhan 430074China

The coastal areas of the lower reaches of Oujiang River Basin are rich in groundwater ***,the unsustainable exploitation and utilization of groundwater have led to significant changes in the groundwater *** the characteristics and genesis of groundwater salinization is crucial for preventing its deterioration and ensuring sustainable *** this study,a comprehensive approach combining the ion ratio method,mineral saturation index method and multivariate statistical analysis was employed to investigate the hydrochemical characteristics and main controlling factors in the study *** findings reveal that:(1.Groundwater samples in study area exhibit a neutral to slightly alkaline *** predominant chemical types of unconfined water are HCO_(3)-Ca·Na,HCO_(3)·Cl-Na·Ca and HCO_(3)·SO_(4)-Ca·Na,while confined water mainly exhibits Cl·HCO_(3)-Na and Cl-Na types.(2)Salinity coefficients indicate an increase in salinity from unconfined to confined ***,Na^(+)and Cl^(–)concentrations show an increasing trend from mountainous to coastal areas in unconfined water,while confined water displays variability in TDS,Na^(+)and Cl^(–)concentrations.(3)Groundwater salinity is mainly influenced by water-rock interactions,including the dissolution of halite and gypsum,cation exchange,and seawater intrusion ***,human activities and carbonate dissolution contribute to salinity in unconfined *** intrusion is identified as the primary factor leading to higher salinity in confined water compared to unconfined water,with increasing cation exchange and seawater interaction observed from unconfined to confined water.

关键词： Hydrochemical Multivariate statistical analysis Seawater intrusion

XELOX(capecitabine plus oxaliplatin)plus bevacizumab(anti-VEGF-A antibody)with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer:a multicenter,open-label,randomized,controlled,phase 3 trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2104-2113页

作者： Qiu-Zhong Pan Jing-Jing Zhao Liang Liu Dong-Sheng zhang Li-Ping Wang {1.-Wei Hu De-Sheng {1.g Xiang Xu Yi-Zhuo Li Yan Tang Wei-Hong zhang Jie-Yao Li Xiao Zheng Qi-Jing Wang Yong-Qiang Li Tong Xiang Li Zhou Shuang-Ning yang chen Wu Rong-Xing Huang Jia He Wei-Jiao Du Lu-Jun chen Yue-Na Wu Bin Xu Qiong Shen Yi zhang Jing-Ting Jiang Xiu-Bao Ren Jian-Chuan Xia State Key Laboratory of Oncology in South china Guangdong Provincial Clinical Research Center for CancerCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060PR China Department of Biotherapy Sun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060PR China Tianjin Medical University Cancer institute and Hospital National Clinical Research Center for CancerTianjin 300060PR China Key Laboratory of Cancer Immunology and Biotherapy Tianjin 300060PR China Department of Biotherapy/Immunology Tianjin Medical University Cancer Institute and HospitalTianjin 300060PR China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060PR China Department of Oncology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052PR China Department of Tumor Biological Treatment the Third Affiliated Hospital of Soochow UniversityChangzhouJiangsu 213003PR China Jiangsu Engineering Research Center for Tumor Immunotherapy ChangzhouJiangsu 213003PR China institute for Cell Therapy of Soochow University ChangzhouJiangsu 213003PR China Department of Stem Cell&Regenerative Medicine State Key Laboratory of TraumaBurn and Combined InjuryDaping HospitalArmy Medical UniversityChongqing 400042PR China Imaging Diagnosis and Interventional Center Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060PR China

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer(mCRC),but the prognosis remains *** phase 3 trial(***:NCT039501.4)assessed the efficacy and adverse events(AEs)of the combination of PD-1.blockade-activated DC-CIK(PD1.T)cells with XELOX plus bevacizumab as a first-line therapy in patients with mCRC.A total of 202 participants were enrolled and randomly assigned in a 1.1.ratio to receive either first-line XELOX plus bevacizumab(the control group,n=1.2)or the same regimen plus autologous PD1.T cell immunotherapy(the immunotherapy group,n=1.0)every 21.days for up to 6 cycles,followed by maintenance treatment with capecitabine and *** main endpoint of the trial was progression-free survival(PFS).The median follow-up was 1..5 *** PFS was 1..8 months(95%CI,1..6-1..0)for the immunotherapy group compared with 9.9 months(8.0-1..8)for the control group(hazard ratio[HR],0.60[95%CI,0.40-0.88];p=0.009).Median overall survival(OS)was not reached for the immunotherapy group and 25.6 months(95%CI,1..3-32.8)for the control group(HR,0.57[95%CI,0.33-0.98];p=0.043).Grade 3 or higher AEs occurred in 20.0%of patients in the immunotherapy group and 23.5%in the control groups,with no toxicity-associated deaths *** addition of PD1.T cells to first-line XELOX plus bevacizumab demonstrates significant clinical improvement of PFS and OS with well tolerability in patients with previously untreated mCRC.

关键词： PD1 immunotherapy bevacizumab

Study on Chromosome Doubling for Haploid Produced by Wheat×Maize Crossing

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Agricultural sciences in{1. 2002年第5期1卷 486-490页

作者： chen Xin-min, {1. wen-xiang, GUI Shu-Ian and chen Xiao(institute of Crop Breeding and Cultivation , chinese academy of Agricultural sciences , Beijing 100081 , P. R . china) institute of Crop Breeding and Cultivation Chinese Academy of Agricultural Sciences Beijing 100081 P. R. China

There is no spontaneous chromosome doubling in haploid plants produced by wheat X maize crossing. In order to obtain doubled haploid, two chromosome doubling methods were used. Results showed that: After adding colchicine solution directly into a medium for young embryos that had been cultured 7 days, frequencies of embryo germination in colchicine concentrations of 50mg/L, 1.0mg/L and 200mg/L were 32.1. , 26.4% and 1..3% , respectively, and frequencies of chromosome doubling were 85.3% , 1.0% and 50.0% , respectively. But in the control without colchicine, the frequency of embryo germination was 67.4% and no seed was setting. As the time of colchicine treatment increased from 24 to 72 hours, the frequency of embryo germination was reduced, and 24 hours had better results. After soaking seeding crowns and roots with colchicine solution of 500mg/L, 750mg/L and 1.000mg/L for 5 hours, the frequencies of doubling were 89.6%, 76.0% and 73.3%, respectively. By soaking crowns and roots of strong seedings with 500mg/L colchicine solution, the frequency and efficiency of doubling were 98.2% and 93.2% , respectively.

关键词： Wheat X maize crosses Haploid Doubled haploid

Synthesis, Crystal Structure and Spectral Properties of [Ce（NO3）5（H2O）2]·2（Hphen）·（H2O）

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chinese Journal of Structural Chemistry 2004年第8期 870-874+840页

作者： chen Da-Guia, b chenG wen-Dana zhang Haoa zhang Yong-Chuna (State Key Laboratory of Structural Chemistry, Fujian institute of Research on the Structure of Matter, The chinese academy of sciences, Fuzhou, Fujian 350002, china) (Graduate School of the chinese academy of sciences 1.0039, china)

A novel complex [Ce(NO3)5(H2O)2]2(Hphen)(H2O) (phen =1.1.-phenanthro-line) with formula C24H24CeN9O1. and Mr = 866.64 has been synthesized and structurally characterized by X-ray diffraction. It crystallizes in triclinic, space group P with a = 7.5534(2), b = 8.083(2), c = 25.8377(6) , = 86.847(1., = 89.937(1., = 86.981.1., V = 1.72.94(6) 3, Dc = 1.830 g/cm3, F(000) = 866, m = 1.545 cm-1.and Z = 2. The final refinement gave R = 0.0486 and wR = 0.1.78 for 4852 observed reflections with I > 2s(I). It consists of discrete [Ce-(NO3)5(H2O)2]2- anion, two Hphen+ cations and a lattice water molecule. In the compound, all of the five nitrates are bidentate, and the coordination of Ce(III) is 1.. The photo-luminescence of this compound was also investigated.

关键词： cerium nitrate 1 1.-phenanthroline crystal structure photoluminescence

用串接电光偏转器提高时空变换装置进行激光脉冲整形的能力

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中国激光 2003年第11期30卷 985-988页

作者：曾文章张生佳韦辉马忠林许世忠刘百玉陈绍和泉州师范学院物理系功能材料研究所福建泉州362000 中国科学院上海光学精密机械研究所上海201800 中国科学院西安光学精密机械研究所陕西西安710068

介绍了在时空变换装置中用两个电光偏转器串接和并接的工作原理 ,从理论上分析了用其提高激光脉冲整形的能力 ,进行了激光脉冲削波实验 ,实验结果与理论分析一致。用两个偏转器串接后。

关键词：光电子学电光偏转器串接并接激光脉冲整形

Map-based cloning of spl5,a lesion-mimic gene in rice

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Map-based cloning of spl5,a lesion-mimic gene in rice