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Reconstruction of the most recent common ancestor sequences of SARS-Cov S gene and detection of adaptive evolution in the spike protein

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chinese Science Bulletin 2004年第12期49卷 1311-1313页

作者： zhang yuan1, zheng nan2.3, hao pei4,5 & zhong yang6 1. laboratory of systematic and evolutionary botany, institute of bot- any, chinese academy of sciences, beijing 100093, china 2. College of Life sciences, beijing Normal University, beijing 100875, china 3. institute of Viral Disease Control and Prevention, chinese CDC, beijing 100052, china 4. Bioinformation Center, Shanghai institutes for Biological sciences, chinese academy of sciences, Shanghai 200031, china 5. Shanghai Center for Bioinformation Technology, Shanghai 200235, china 6. School of Life sciences, Fudan University, Shanghai 200433, china 1.0} of {1. and evolutionary botany Institute of Botany Chinese Academy of Sciences 100093 Beijing China. 2College of Life sciences Beijing Normal University 100875 Beijing China. 3institute of Viral Disease Control and Prevention Chinese CDC 100052 Beijing China. 4Bioinformation Center Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 200031 Shanghai China. 5Shanghai Center for Bioinformation Technology 200235 Shanghai China. 6School of Life sciences Fudan University 200433 Shanghai China.

The genome organization and expression strategy of severe acute respiratory syndrome coronavirus (SARSCoV) have been described extensivelyl1. 1.]. As a structural glycoprotein on the virion surface, the spike protein is responsible for binding to host cellular receptors and for the fusion between the viral envelope and the cellular membrane. It also induces neutralizing antibodies in the host and mediates cellular immunity[1.]. Previous studies suggested that amino acid replacements in the spike protein could dramatically alter the pathogenesis and virulence of some coronaviruses[1.]. It is therefore reasonable to test the hypothesis that radical amino acid replacements in the spike protein, favored by environmental selective pressure during the process of SARS-CoV interspecific transmission[1.], might make this pathogen adapt to a new host. In this study, we investigated a total of 1.8complete sequences of the SARS-CoV S gene from GenBank (until March 23, 2004). After omission of those records containing frame-shift mutations or low quality sequences, e.g. ZJ01. and selection of one sequence for identical records, an alignment of 42 sequences was obtained using the program Clustal-X[1.]. Then, we reconstructed the most recent common ancestor (MRCA) sequences of the SARS-CoV S gene and detected the adaptive evolution in the spike protein.

关键词： SARS冠状病毒自适应进化基因表达糖蛋白分子免疫学波峰病毒

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