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Noncanonical PI3Kγ signaling addiction is a therapeutic target in a subset of leukemias

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The Innovation 2024年第6期5卷 21-22页

作者： Yu zhang Qian Kong yonglong zhang Department of Clinical Laboratory Shanghai Sixth People’s Hospital Affiliated with Shanghai Jiao Tong University School of MedicineShanghai 200233China Department of General Surgery Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China

Acute myeloid leukemia(AML)is a devastating disease with a median age of diagnosis of over 60 ***,most AML patients are not eligible for intensive *** remains common in patientswith AML despite intensive therapy,which significantly compromises therapeutic *** several targeted therapies have been licensed for treating AML subsets bearing specific mutations and variant proteins essential for AML propagation,no actionablemolecular targets are available for most AML patients.

关键词： therapeutic diagnosis Acute

Generating Periodic Orbits for Explorations of Elongated Asteroids

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Journal of Beijing Institute of Technology 2020年第1期29卷 129-138页

作者： Huihui Wang Yuntao Jiang Long Xiao yonglong zhang Beijing Aerospace Automatic Control Institute Beijing 100854China National Key Laboratory of Science and Technology on Aerospace Intelligence Control Beijing 100854China School of Aerospace Engineering Tsinghua UniversityBeijing 100084China

A practical method is proposed to search for periodic orbits of elongated *** method obtains required initial variables of periodic orbits by using the rotating mass dipole with appropriate parameters,and then implement local iterations to obtain the real orbits over an asteroid in the polyhedral *** this paper the dipole and polyhedral models,and list detailed procedures of the searching method are introduced.A planar single lobe orbit is presented to evaluate the effectiveness of the method,with the asteroid 216 Kleopatra of the triple asteroid system as a representative elongated *** applying the above method,ten families of periodic orbits around Kleopatra are identified and discussed with respect to their orbital stabilities and *** sample of the sombrero orbit is checked by calculating 1000 hours to examine its orbital *** the above orbits,the intriguing head-surrounding orbit is also analyzed.

关键词： periodic orbits elongated asteroids dipole model numerical iteration

Truthful Mechanism for Crowdsourcing Task Assignment

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Tsinghua Science and Technology 2018年第6期23卷 645-659页

作者： yonglong zhang Haiyan Qin Bin Li Jin Wang Sungyoung Lee Zhiqiu Huang School of Computer Science and Technology Nanjing University of Aeronautics and Astronautics Nanjing 211106 China College of Information Engineering Yangzhou University Yangzhou 225127 China Department of Computer Engineering Kyung Hee University Suwon 449-701 Korea

As an emerging ＂human problem solving strategy＂, crowdsourcing has attracted much attention where requesters want to employ reliable workers to complete specific tasks. Task assignment is an important branch of crowdsourcing. Most existing studies in crowdsourcing have not considered self-interested individuals＇ strategy. To guarantee truthfulness, auction has been regarded as a promising method to charge the requesters for the tasks completed and reward the workers for performing the tasks. In this study, an online task assignment scenario is considered where each worker has a set of experienced skills, whereas a specific task is budget-constrained and requires one or more skills. In this scenario, the crowdsourcing task assignment was modeled as a reverse auction where the requesters are buyers and the workers are sellers. Three incentive mechanisms, namely, Truthful Mechanism for Crawdsourcing-Vickrey-Clarke-Grove （TMC-VCG）, TMC-Simple Task （ST） for a simple task case, and TMC-Complex Task （CT） for a complex task case are proposed. Here, a simple task case means that the requester asks for a single skill, and a complex task case means that the requester asks for multiple skills. The related properties of each of the three mechanisms are determined theoretically. Moreover, the truthfulness is verified, and other performances are evaluated by extensive simulations.

关键词： crowdsourcing task assignment auction truthfulness

Adenosine triphosphate mediates the pain tolerance effect of manual acupuncture at Zusanli(ST36) in mice

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Journal of Traditional Chinese Medicine 2024年第4期44卷 660-669页

作者： LI Zhongzheng ZHAO Yadan Ma Weigang zhang yonglong XU Zhifang XI Qiang LI Yanqi QIN Siru zhang Zichen WANG Songtao ZHAO Xue LIU Yangyang GUO Yi GUO Yongming Research Center of Experimental Acupuncture Science Tianjin University of Traditional Chinese MedicineTianjin 301617China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 301617China Department of Acupuncture and Moxibustion Qingdao Hiser Hospital Affiliated of Qingdao University(Qingdao Traditional Chinese Medicine Hospital)Qingdao 266033China School of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China School of Acupuncture and Moxibustion and Tuina Tianjin University of Traditional Chinese MedicineTianjin 301617China

OBJECTIVE:To investigate the mechanisms behind the effects of acupuncture in Traditional Chinese Medicine,we delved into the adenosine triphosphate/peripheral purinergic P2X receptor 3(ATP/P2X3)receptor signaling system as an indicator of the body's energy state,commonly referred to as"Qi".METHODS:The tail-flick test was utilized to explore the impact of acupuncture on pain tolerance threshold(PTT)in mice,while also assessing adenosine(ADO)levels and adenylate energy charge(EC)at Zusanli(ST36).The study further investigated the dose-dependent effects of acupuncture on PTT and ADO levels at Zusanli(ST36).To shed light on the underlying mechanisms of acupuncture's effects,the study examined the impact of ATP,a P2X3 receptor antagonist,and adenosine disodium on PTT following acupuncture ***:Acupuncture at Zusanli(ST36)led to significant improvements in PTT in mice,with the most effective interventions being twirling for 2 min and needle retention for 28 *** interventions also resulted in significant increases in ATP *** effects of acupuncture were further augmented by administration of different doses of ATP at Zusanli(ST36),and pretreatment with a P2X3 receptor antagonist decreased *** EC peaked at 30 min after intraperitoneal injection of ATP,and pretreatment with various doses of *** 30 min prior to acupuncture increased PTT in a dose-dependent ***,pretreatment with an *** intramuscular injection of adenosine disodium enhanced the effects of ***:This research provides compelling evidence that ATP is involved in the regulation of PTT through acupuncture,revealing new avenues for achieving enhanced clinical outcomes.

关键词： acupuncture point ST36(Zusanli) adenosine triphosphate receptors,purinergic P2X3 energy state

Simulation of greenhouse cucumber growth,water and nitrogen dynamics in areas with high groundwater(HG)levels using the HG EU-Rotate_N model

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Vegetable Research 2022年第1期2卷 148-158页

作者： Bing Hua Zhuangzhuang Cao Kefeng zhang Xiangying Xu yonglong zhang Haibo Dai Zhiping zhang Jiezeng Jiang Minmin Miao College of Horticulture and Plant Protection Yangzhou UniversityYangzhou 225009China Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China Yangzhou UniversityYangzhou 225009China Key Laboratory of Plant Functional Genomics of the Ministry of Education/Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding Yangzhou UniversityYangzhou 225009China Ningbo Institute of Technology Zhejiang UniversityNingbo 315100China College of Information Engineering Yangzhou UniversityYangzhou 225009China

The fruit yield of cucumber are associated with high input of nitrogen,which poses a risk of pollution to the *** EU-Rotate_N model has been used widely for its high performance in the simulation of vegetable growth,water and nitrogen ***,whether the underground water level affects the performance of the EU-Rotate_N model is *** this study,we modified the groundwater level algorithms to the original model and named the modified model'the HG EU-Rotate_N model'.Experiments over two years on greenhouse cucumber with four different nitrogen(N)treatments(N1-N4)were conducted in Jiangsu Province,China,which has a high groundwater level(area_(HG)).Both original and modified models were used to simulate cucumber growth,water movement and N *** the soil water content,the measured values were significantly larger than the simulated values of the original model(value_(O))and closer to those of the HG model(value_(HG));for the soil available nitrogen concentration(SNC),the measured values were significantly higher and lower than value_(O) in 0−10 cm and 10−30 cm soil layers,respectively,and were also closer to those of the values_(HG).The higher SNC in the 0-10 cm soil layer indicated that a high groundwater level might increase the upwards movement of water and nitrogen in the 0-30 cm soil *** root mean square error,Nash Sutcliffe Efficiency and difference values show that the HG model was more applicable for areaHG than the original *** this study,the nitrogen dosage of the N3 treatment was sufficient to meet the requirements of cucumber growth,indicating that the fertilization recommendation according to nitrogen nutrient balance was applicable in this area.

关键词： greenhouse closer soil

GPS monitoring and analysis of ground movement and deformation induced by transition from open-pit to underground mining

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Journal of Rock Mechanics and Geotechnical Engineering 2012年第1期4卷 82-87页

作者： Fengshan Ma Haijun Zhao Yamin zhang Jie Guo Aihua Wei Zhiquan Wu yonglong zhang Key Laboratory of Engineering Geomechanics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China 2Longshou Mine Jinchuan Group Co.Ltd.Jinchang737100China

To trace the potential hazards of open-pit slope in Longshou mine,global positioning system（GPS） is applied to monitoring ground movement and deformation induced by transition from open-pit to underground *** long-term monitoring from 2003 to 2008,huge amounts of data were *** results show that large-scale ground movement and deformation have occurred in mining area,and the movement area is *** displacement boundary of settlement trough is 2.0 km long along the exploratory line,and 1.5 km long along the strike of ore *** monitoring results basically agree with the practical deformation state of open-pit *** is indicated that the long-term GPS monitoring is an effective way to understand the mechanism of ground movement and deformation in mine area. 更多

关键词： open-pit ground movement long-term GPS monitoring deformation analysis

Hydrodynamic Performance Analysis of a Submersible Surface Ship and Resistance Forecasting Based on BP Neural Networks

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Journal of Marine Science and Application 2022年第2期21卷 34-46页

作者： Yuejin Wan Yuanhang Hou Chao Gong Yuqi zhang yonglong zhang Yeping Xiong Naval Architecture and Ocean Engineering College Dalian Maritime UniversityDalian 116026China Faculty of Engineering and Physical Sciences University of SouthamptonBoldrewood Innovation CampusSO167QF SouthamptonUK

This paper investigated the resistance performance of a submersible surface ship(SSS)in different working cases and scales to analyze the hydrodynamic performance characteristics of an SSS at different speeds and diving depths for engineering ***,a hydrostatic resistance performance test of the SSS was carried out in a towing ***,the scale effect of the hydrodynamic pressure coefficient and wave-making resistance was *** differences between the three-dimensional real-scale ship resistance prediction and numerical methods were ***,the advantages of genetic algorithm(GA)and neural network were combined to predict the resistance of *** propagation neural network(BPNN)and GA-BPNN were utilized to predict the SSS *** also studied neural network parameter optimization,including connection weights and thresholds,using K-fold *** results showed that when a SSS sails at low and medium speeds,the influence of various underwater cases on resistance is not obvious,while at high speeds,the resistance of water surface cases increases sharply with an increase in *** improving the weights and thresholds through K-fold cross-validation and GA,the prediction results of BPNN have high consistency with the actual *** research results can provide a theoretical reference for the optimal design of the resistance of SSS in practical applications.

关键词： Submersible surface ship K-fold cross-validation Scale effect Genetic algorithm BP neural network

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细胞周期蛋白E与白血病

中华血液学杂志 2001年第4期22卷 219-221页

作者：王颖徐世荣河北医科大学第二医院石家庄050000

血病细胞的细胞周期存在异常调节。细胞周期蛋白(cyclin)与细胞周期蛋白依赖激酶(cyclin dependent kinase,CDK)结合，形成细胞周期调节复合物(cyclin-CDK),激活CDK，使cyclin-CDK具酶活性，催化相应底物磷酸化是细胞周期进展所必需。cy... 详细信息

血病细胞的细胞周期存在异常调节。细胞周期蛋白(cyclin)与细胞周期蛋白依赖激酶(cyclin dependent kinase,CDK)结合，形成细胞周期调节复合物(cyclin-CDK),激活CDK，使cyclin-CDK具酶活性，催化相应底物磷酸化是细胞周期进展所必需。cyclin E属于G1期细胞周期的正调节因子，参与G１/S转换点功能的调控，与其他参与G1/S转换点功能调控的因子cyclin DS、抑癌基因视网膜神经胶质细胞瘤蛋白(retinoblastoma protein, pRb)、转录因子E2F、抑癌基因P53、KIP家族、CDK2,4,5等相互作用决定细胞的生存和凋亡[1]。

关键词：白血病细胞周期蛋白E 生物学特性基因结构

基于改进Mask R-CNN的黄瓜叶面积测量模型

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农业工程学报 2023年第17期39卷 182-189页

作者：章永龙解亚玲徐向英缪旻珉扬州大学信息工程学院扬州225000 扬州大学园艺与植物保护学院扬州225000 教育部农业与农产品安全国际联合实验室扬州225000 教育部植物功能基因组学重点实验室/江苏省作物基因组学与分子育种重点实验室扬州225000

植物叶面积可以反映出植物的生长速率、养分吸收以及光合作用能力,针对锯齿状边缘的黄瓜叶片分割精度较低,叶面积测量误差较大等问题。该研究提出一种深度卷积网络模型Marm,在Mask R-CNN的基础上利用Sobel算子进行边缘检测,使模型生成... 详细信息

植物叶面积可以反映出植物的生长速率、养分吸收以及光合作用能力,针对锯齿状边缘的黄瓜叶片分割精度较低,叶面积测量误差较大等问题。该研究提出一种深度卷积网络模型Marm,在Mask R-CNN的基础上利用Sobel算子进行边缘检测,使模型生成的掩膜更接近叶片的边缘。另外,引入边缘损失以提升叶片边缘的分割精度。借助参照物标签,利用模型输出的掩膜图像进行面积计算,获得黄瓜叶片在不同生长周期的叶面积。试验结果表明,Marm模型精确率、召回率和交并比达到99.1%、94.87%和92.18%,比原始的Mask R-CNN分别提高1.28个百分点、1.13个百分点和1.05个百分点,面积误差率下降1.43个百分点。当图像中存在叶片遮挡和阴影等多种影响,黄瓜叶片的面积误差率仍然能保持在5.45%左右。该研究有效解决了锯齿状边缘的叶片分割问题,将为植物表型研究提供技术支撑。

关键词：图像分割深度学习 Mask R-CNN 植物表型实例分割黄瓜