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以新发展格局推动高水平区域合作——基于中国和拉美的区域国别视角

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中共中央党校（国家行政学院）学报 2024年第3期28卷 107-117页

作者：张勇中国社会科学院拉丁美洲研究所

构建新发展格局,意味着要强化国内大循环的主导作用,以国际循环提升国内大循环效率和水平。鉴于国内国际双循环与区域合作存在着间接和直接的联系,区域合作将成为承接国际循环的重要支点,并为畅通国内国际双循环提供重要动能。基于需求... 详细信息

构建新发展格局,意味着要强化国内大循环的主导作用,以国际循环提升国内大循环效率和水平。鉴于国内国际双循环与区域合作存在着间接和直接的联系,区域合作将成为承接国际循环的重要支点,并为畅通国内国际双循环提供重要动能。基于需求、供给和全球价值链的结构视角,中国和拉美地区具有发展利益的汇合点。因此,以新发展格局推动中国与拉美地区高水平区域合作具有重要意义。鉴于区域合作与新发展格局的互动逻辑,中拉双方推动高水平区域合作具有必然性。其路径选择包括构建高水平的区域经济一体化,促进贸易投资便利;抓住共建“一带一路”的契机,促进国际产能合作;加强金融合作和创新,增添经贸合作发展活力;提升全要素生产率,提高经贸合作的质量和效率。

关键词：新发展格局区域合作拉美地区结构视角

供应链客户稳定度对上市公司违规行为治理效应研究

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现代财经（天津财经大学学报） 2024年第1期44卷 87-106页

作者：张勇南京林业大学经济管理学院江苏南京210037

本文围绕党的二十大报告提出的“着力提升产业链供应链韧性和安全水平”“健全资本市场功能,提高直接融资比重”相关精神,考察了供应链客户稳定度能否对处于资本市场核心位置的上市公司违规行为产生治理效应。研究结果表明,客户稳定度越... 详细信息

本文围绕党的二十大报告提出的“着力提升产业链供应链韧性和安全水平”“健全资本市场功能,提高直接融资比重”相关精神,考察了供应链客户稳定度能否对处于资本市场核心位置的上市公司违规行为产生治理效应。研究结果表明,客户稳定度越高,公司违规的概率和程度越低。机制检验表明,较高的客户稳定度能够从业绩效应、信息效应以及监督效应三个方面发挥积极作用,进而抑制公司违规行为。进一步的异质性分析表明,在内部、外部监督治理机制不同的情况下,客户稳定度对公司违规行为的治理效果存在显著差异:内部监督治理机制方面,客户稳定度对公司违规行为的抑制作用在内部控制质量低、监事会经济独立性弱的公司中更强;外部监督治理机制方面,客户稳定度对公司违规行为的抑制作用在分析师关注度低、所处地区法制环境差的公司中更强。

关键词：客户稳定度公司违规业绩效应信息效应监督效应

Integrated network pharmacology and metabolomics to explore the mechanisms of Shenzao dripping pill against chronic myocardial ischemia

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Traditional Medicine Research 2024年第11期9卷 12-26页

作者： Jie-Hui Kuang Tao Hu Lu-yong zhang Yu-Feng Yao Ming-Hua Xian Shu-Mei Wang School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of Traditional Chinese Medicine Guangdong Pharmaceutical UniversityGuangzhou 510006China Engineering&Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province Guangdong Pharmaceutical UniversityGuangzhou 510006China Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems Guangdong Pharmaceutical UniversityGuangzhou 510006China Traditional Chinese Medicine Resource Germplasm Bank Management Center Yunfu 527500China.

Background:Shenzao dripping pill(SZDP)is empirically prescribed for treating cardiac ***,there is a lack of comprehensive knowledge regarding the underlying mechanisms contributing to its therapeutic *** objective of this study is to investigate the underlying mechanism of SZDP against chronic myocardial ischemia(CMI)in a rat ***:In this study,we utilized electrocardiographic and echocardiographic detection along with pathological tissue analysis to evaluate the efficacy of *** integration of network pharmacology and metabolomics was conducted to investigate the *** docking and molecular dynamics simulations were used to validate the binding energy between the compounds of SZDP and the associated ***:The results showed that SZDP was able to improve T wave voltage,reverse CMI abnormalities in ejection fraction and fractional shortening,and restore histopathological heart *** results indicated that disturbances of metabolic profile in CMI rats were partly corrected after SZDP administration,mainly affecting purine metabolism.13-Docosenamide may be the potential metabolic biomarker of the therapeutic application of SZDP for *** network pharmacology and metabolomics,thiopurine S-methyltransferase(TPMT),xanthine dehydrogenase/oxidase(XDH),bifunctional purine biosynthesis protein ATIC(ATIC),and cytochrome p4501A1(CYP1A1)were identified as possible targets of SZDP to exert therapeutic effects by enhancing the metabolic levels of L-Tryptophan,Deoxyribose 1-phosphate and Phosphoribosyl ***:SZDP has a therapeutic effect on CMI by regulating metabolite levels,acting on the targets of TMPT,XDH,ATIC,and CYP1A1,and reducing cardiomyocyte injury and myocardial fibrosis.

关键词： chronic myocardial ischemia metabolomics network pharmacology serum metabolites Shenzao dripping pill

Spatially resolved transcriptomic profiling of placental development in dairy cow

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Zoological Research 2024年第3期45卷 586-600页

作者： Guang-Hui Tan Shi-Jie Liu Ming-Le Dou De-Feng Zhao Ao zhang Heng-Kuan Li Fu-Nong Luo Tao Shi Hao-Ping Wang Jing-Yuan Lei yong zhang Yu Jiang Yi Zheng Fei Wang Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYanglingShaanxi 712100China Key Laboratory of Livestock Biology Northwest A&F UniversityYanglingShaanxi 712100China Key Laboratory of Animal Biotechnology of the Ministry of Agriculture Northwest A&F UniversityYanglingShaanxi 712100China College of Information Engineering Northwest A&F UniversityYanglingShaanxi 712100China

The placenta plays a crucial role in successful mammalian *** animals possess a semi-invasive placenta characterized by a highly vascularized structure formed by maternal endometrial caruncles and fetal placental cotyledons,essential for full-term fetal *** cow placenta harbors at least two trophoblast cell populations:uninucleate(UNC)and binucleate(BNC)***,the limited capacity to elucidate the transcriptomic dynamics of the placental natural environment has resulted in a poor understanding of both the molecular and cellular interactions between trophoblast cells and niches,and the molecular mechanisms governing trophoblast differentiation and *** fill this knowledge gap,we employed Stereo-seq to map spatial gene expression patterns at near single-cell resolution in the cow placenta at 90 and 130 days of gestation,attaining high-resolution,spatially resolved gene expression *** on clustering and cell marker gene expression analyses,key transcription factors,including YBX1 and NPAS2,were shown to regulate the heterogeneity of trophoblast cell *** communication and trajectory analysis provided a framework for understanding cell-cell interactions and the differentiation of trophoblasts into BNCs in the placental *** analysis of cell trajectories identified a set of genes involved in regulation of trophoblast ***,spatial modules and co-variant genes that help shape specific tissue structures were ***,these findings provide foundational insights into important biological pathways critical to the placental development and function in cows.

关键词： Spatial transcriptomics Dairy cow Placenta Gestation

Effects of 8-OHdG,H-FABP and CRP on the Development of Ischemic Cardiomyopathy

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Medicinal Plant 2024年第4期15卷 69-72页

作者： Qingquan WU yong zhang Xiuxian HUANG Hainan Provincial Geriatric Hospital Haikou 571100China Hainan Provincial People's Hospital Haikou 571100China

[Objectives]To analyze the relationship between serum 8-hydroxydeoxyguanosine(8-OHdG),heart fatty acid-binding protein(H-FABP),C-reactive protein(CRP)levels and clinical efficacy and short-term prognosis in patients with ischemic cardiomyopathy.[Methods]The clinical data of 100 patients with ischemic cardiomyopathy from October 2021 to November 2022 were retrospectively analyzed,and the serum levels of 8-OHdG,H-FABP and CRP were compared before and one week after *** patients were followed up for 12 months after discharge,and the incidence of major adverse cardiovascular events(MACE)was counted during the follow-up *** and multivariate Logistic regression analysis were used to analyze the prognostic factors of patients with ischemic cardiomyopathy in the near future,and the predictive value of serum 8-OHdG,H-FABP and CRP levels for the prognosis of patients was evaluated by ROC curve.[Results]After 1 week of treatment,the serum levels of 8-OHdG,H-FABP and CRP in patients with ischemic cardiomyopathy were significantly lower than those before treatment(P<0.05).During the follow-up period,34 patients developed MACE;the serum levels of 8-OHdG,H-FABP and CRP in the MACE group were higher than those in the non-MACE group,and the differences were statistically significant(P<0.05).Multivariate Logistic regression analysis showed that 8-OHdG,H-FABP and CRP were the risk factors of MACE in patients with ischemic cardiomyopathy(P<0.05).ROC curve analysis showed that the combined prediction of 8-OHdG,H-FABP and CRP for MACE in patients with ischemic cardiomyopathy was higher than that of CRP,H-FABP and 8-OHdG alone(P<0.05).[Conclusions]8-OHdG,H-FABP and CRP are closely related to the clinical efficacy and short-term prognosis of patients with ischemic cardiomyopathy,and the detection of serum 8-OHdG,H-FABP and CRP levels can help to evaluate the clinical efficacy and short-term prognosis of patients with ischemic cardiomyopathy.

关键词： chemic cardiomyopathy 8-hydroxydeoxyguanosine heart type fatty acid binding protein C-reactive protein Clinical efficacy Short-term prognosis

Production Practice of Solid Waste Desulfurizer Disposal in European Metallurgical Furnace

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Frontiers of Metallurgical Industry

Frontiers of Metallurgical Industry 2024年第1期2卷 1-4页

作者： yong zhang Song Jin Zhizhong He Iron Works of Xinjiang Bayi Iron and Steel Co. Ltd.

In order to realize the OY Smelting Furnace disposal of solid waste,municipal waste,form a model of steel enterprises and urban integration,through the production practice of smelting furnace,analyzes the mechanism of solid waste disposal,and proposed the disposal of solid waste desulfurization agent and disposal method:According to the theory to guide the actual production process,the test ton of iron with 10-15kg of desulfurizer in the production process does not affect the quality of molten iron and slag quality.

关键词： OY smelting furnace solid waste disposal desulfurizing agent

Bile acids inhibit ferroptosis sensitivity through activating farnesoid X receptor in gastric cancer cells

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World Journal of Gastroenterology 2024年第5期30卷 485-498页

作者： Chu-Xuan Liu Ying Gao Xiu-Fang Xu Xin Jin Yun zhang Qian Xu Huan-Xin Ding Bing-Jun Li Fang-Ke Du Lin-Chuan Li Ming-Wei Zhong Jian-Kang Zhu Guang-yong zhang Department of General Surgery Shandong Provincial Qianfoshan HospitalShandong UniversityJinan 250014Shandong ProvinceChina Department of General Surgery Linyi People's HospitalLinyi 276034Shandong ProvinceChina Department of Nursing Huantai TCM HospitalZibo 256400Shandong ProvinceChina Center for Translational medical Research The First Affiliated Hospital of Shandong First Medical UniversityJinan 250014Shandong ProvinceChina Department of General Surgery The First Affiliated Hospital of Shandong First Medical UniversityJinan 250014Shandong ProvinceChina

BACKGROUND Gastric cancer(GC)is associated with high mortality *** acids(BAs)reflux is a well-known risk factor for GC,but the specific mechanism remains *** GC development in both humans and animals,BAs serve as signaling molecules that induce metabolic *** confers additional cancer phenotypes,including ferroptosis *** is a novel mode of cell death characterized by lipid peroxidation that contributes universally to malignant ***,it is not fully defined if BAs can influence GC progression by modulating *** To reveal the mechanism of BAs regulation in ferroptosis of GC *** In this study,we treated GC cells with various stimuli and evaluated the effect of BAs on the sensitivity to *** used gain and loss of function assays to examine the impacts of farnesoid X receptor(FXR)and BTB and CNC homology 1(BACH1)overexpression and knockdown to obtain further insights into the molecular mechanism *** Our data suggested that BAs could reverse erastin-induced ferroptosis in GC *** effect correlated with increased glutathione(GSH)concentrations,a reduced GSH to oxidized GSH ratio,and higher GSH peroxidase 4(GPX4)expression ***,we confirmed that BAs exerted these effects by activating FXR,which markedly increased the expression of GSH synthetase and ***,BACH1 was detected as an essential intermediate molecule in the promotion of GSH synthesis by BAs and ***,our results suggested that FXR could significantly promote GC cell proliferation,which may be closely related to its anti-ferroptosis *** This study revealed for the first time that BAs could inhibit ferroptosis sensitivity through the FXR-BACH1-GSHGPX4 axis in GC *** work provided new insights into the mechanism associated with BA-mediated promotion of GC and may help identify potential therapeutic targets for GC patients with BAs reflux.

关键词： Gastric cancer Ferroptosis Bile acids Chenodeoxycholic acid Farnesoid X receptor Glutathione

TypeⅠcritical dynamical scalarization and descalarization in Einstein-Maxwell-scalar theory

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 40-58页

作者： Jia-Yan Jiang Qian Chen Yunqi Liu Yu Tian Wei Xiong Cheng-yong zhang Bin Wang Department of Physics and Siyuan Laboratory Jinan UniversityGuangzhou 510632China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Center for Gravitation and Cosmology College of Physical Science and TechnologyYangzhou UniversityYangzhou 225009China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510641China School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai 200240China

We investigated the critical dynamical scalarization and descalarization of black holes within the framework of the EinsteinMaxwell-scalar theory featuring higher-order coupling *** the critical scalarization and descalarization displayed first-order phase *** examining the nonlinear dynamics near the threshold,we always observed critical solutions that are linearly unstable static scalarized black *** critical dynamical scalarization and descalarization share certain similarities with the typeⅠcritical gravitational ***,their initial configurations,critical solutions,and final outcomes differ *** provide further insights into the dynamical results,we conducted a comparative analysis involving static solutions and perturbative analysis.

关键词： black hole(de)scalarization dynamical critical behavior attractor

Effect of interrupted aging on mechanical properties and corrosion resistance of 7A75 aluminum alloy

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Transactions of Nonferrous Metals Society of China 2024年第8期34卷 2415-2430页

作者： Xian-wen YANG Ling-ying YE yong zhang Quan-shi CHENG School of Materials Science and Engineering Central South UniversityChangsha 410083China Aerospace Precision Production Co. Ltd.Tianjin 300300China

The effects of interrupted aging on mechanical properties and corrosion resistance of 7A75 aluminum alloy extruded bar were investigated through various analyses,including electrical conductivity,mechanical properties,local corrosion properties,and slow strain rate tensile stress corrosion *** characterization techniques such as metallographic microscopy,scanning electron microscopy(SEM),and transmission electron microscopy(TEM)were also *** results indicate that the tensile strength of the alloy produced by T6I6 aging is similar to that produced by T6I4 aging,and it even exceeds 700 ***,the yield strength increases by 52.7 MPa,reaching 654.8 MPa after T6I6 aging *** maximum depths of intergranular corrosion(IGC)and exfoliation corrosion(EXCO)decrease from 116.3 and 468.5μm to 89.5 and 324.3μm,*** stress corrosion factor also decreases from 2.1%to 1.6%.These findings suggest that the alloy treated with T6I6 aging exhibits both high strength and excellent stress corrosion cracking ***,when the alloy is treated with T6I4,T6I6 and T6I7 aging,the sizes of grain boundary precipitates(GBPs)are found to be 5.2,18.4,and 32.8 nm,*** sizes of matrix precipitates are 4.8,5.7 and 15.7 nm,*** atomic fractions of Zn in GBPs are 9.92 at.%,8.23 at.%and 6.87 at.%,respectively,while the atomic fractions of Mg are 12.66 at.%,8.43 at.%and 7.00 at.%,***,the atomic fractions of Cu are 1.83 at.%,2.47 at.%and 3.41 at.%,respectively.

关键词： 7A75 aluminum alloy interrupted aging aging precipitation behavior mechanical properties intergranular corrosion exfoliation corrosion stress corrosion cracking