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Patient-Reported Outcomes of Postoperative NSCLC Patients with or without Staged Chinese Herb Medicine Therapy during Adjuvant Chemotherapy(NALLC 2): A Randomized, Double-Blind, Placebo-Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第11期30卷 963-973页

作者： zhang yi-lu JIAO Li-jing GONG Ya-bin XU Jian-fang NI Jian SHEN Xiao-yong zhang Jie ZHOU Di QIAN Cheng-xin WANG Qin YAO Jia-lin YANG Wen-xiao SU Ling-zi WANG Li-yu LI Jia-qi YAO yi-qin zhang Yuan-hui WANG yi-chao CHEN Zhi-wei XU Ling Oncology Department Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine Institute of Traditional Chinese Medicine Oncology Shanghai University of Traditional Chinese Medicine Oncology Department Shanghai Pulmonary Hospital Shanghai Tongji University Thoracic Surgery Department Huadong Hospital Shanghai Fudan University Thoracic Surgery Department Shanghai Cancer Hospital Shanghai Fudan University Oncology Department Shanghai Chest Hospital Shanghai Jiao Tong University

Objective:To investigate whether the combination of chemotherapy with staged Chinese herbal medicine(CHM) therapy could enhance health-related quality of life(QoL) in non-small-cell lung cancer(NSCLC)patients and prolong the time before deterioration of lung cancer symptoms,in comparison to chemotherapy ***:A prospective,double-blind,randomized,controlled trial was conducted from December 14,2017 to August 28,2020.A total of 180 patients with stage ⅠB-ⅢA NSCLC from 5 hospitals in Shanghai were randomly divided into chemotherapy combined with CHM(chemo+CHM) group(120 cases) or chemotherapy combined with placebo(chemo+placebo) group(60 cases) using stratified blocking *** European Organization for Research and Treatment of Cancer(EORTC) Quality-of-Life-Core 30 Scale(QLQ-C30) was used to evaluate the patient-reported outcomes(PROs) during postoperative adjuvant chemotherapy in patients with early-stage *** events(AEs) were assessed in the safety ***:Out of the total 180 patients,173 patients(116in the chemo+CHM group and 57 in the chemo+placebo group) were included in the PRO *** initial mean QLQ-C30 Global Health Status(GHS)/QoL scores at baseline were 57.16±1.64 and 57.67±2.25 for the two respective groups(P>0.05).Compared with baseline,the chemo+CHM group had an improvement in QLQ-C30GHS/QoL score at week 18 [least squares mean(LSM) change 17.83,95% confidence interval(CI) 14.29 to 21.38].Conversely,the chemo+placebo group had a decrease in the score(LSM change-13.67,95% CI-22.70 to-4.63).A significant between-group difference in the LSM GHS/QoL score was observed,amounting to 31.63 points(95% CI25.61 to 37.64,P<0.001).The similar trends were observed in physical functioning,fatigue and appetite *** week 18,patients in the chemo+CHM group had a higher proportion of improvement or stabilization in GHS/QoL functional and symptom scores compared to chemo+placebo group(P<0.001).The median time to deterioration

关键词： Chinese herbal medicine adjuvant chemotherapy health-related quality of life non-small-cell lung cancer patient-reported outcome

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基于社会情感学习的初中学困生转化策略研究

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哈尔滨学院学报 2024年第8期45卷 1-6页

作者：周佳张璐怡杭州师范大学经亨颐教育学院浙江杭州311121 杭州师范大学中国教育现代化研究院浙江杭州311121

虽然学困生智力水平正常,但往往由于多重因素影响,难以实现既定学习目标。特别是在初中阶段,知识量、学业负担和学习难度的急剧增加,使得学困生的问题愈发突出,成为制约初中教育质量提升的重要障碍。社会情感学习关注学生的非认知技能,... 详细信息

虽然学困生智力水平正常,但往往由于多重因素影响,难以实现既定学习目标。特别是在初中阶段,知识量、学业负担和学习难度的急剧增加,使得学困生的问题愈发突出,成为制约初中教育质量提升的重要障碍。社会情感学习关注学生的非认知技能,对于促进学生的全面发展具有重要的教育价值。文章通过分析初中学习困难学生在认知、情感、行为三个方面的困境,明确其需求和面临的挑战,提出从认知重塑、教学革新、情感培育、社会支持四维度实施转化策略,旨在推动教育公平和卓越发展,培育适应21世纪需求的复合型人才。

关键词：社会情感学习初中生学困生策略

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HDAC2抑制剂CAY10683通过自噬对急性肝衰竭小鼠的保护作用

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中西医结合肝病杂志 2024年第2期34卷 126-130页

作者：张璐懿石春霞张丹眉龚作炯武汉大学人民医院感染科湖北武汉430061

目的:探究HDAC2抑制剂CAY10683在急性肝衰竭小鼠模型中的保护机制。方法:将C57BL/6雄性小鼠随机分为正常组、模型组、CAY10683组、自噬抑制剂MRT68921组和CAY10683/MRT68921联合组。D-氨基半乳糖和脂多糖诱导建立急性肝衰竭小鼠模型,获... 详细信息

目的:探究HDAC2抑制剂CAY10683在急性肝衰竭小鼠模型中的保护机制。方法:将C57BL/6雄性小鼠随机分为正常组、模型组、CAY10683组、自噬抑制剂MRT68921组和CAY10683/MRT68921联合组。D-氨基半乳糖和脂多糖诱导建立急性肝衰竭小鼠模型,获取小鼠血清及肝脏标本。检测血清中丙氨酸氨基转移酶和天门冬氨酸氨基转移酶含量;一部分肝组织用于HE染色和电镜下观察,另一部分肝组织用于生化检测,蛋白质印迹法检测自噬蛋白UNC-51样激酶1和苹果酸脱氢酶1(MDH1)的相对含量,生化试剂盒检测组织中葡萄糖、丙酮酸、乳酸和乳酸脱氢酶含量。结果:CAY10683可增加急性肝衰竭小鼠模型中肝脏内的自噬水平,对小鼠肝脏具有一定的保护作用,CAY10683可降低急性肝衰竭小鼠模型中肝组织内的葡萄糖、丙酮酸、乳酸和LDH含量,增加肝组织内MDH1含量;MRT68921则相反;CAY10683一定程度上可拮抗MRT68921的作用。结论:HDAC2抑制剂CAY10683在小鼠肝衰竭进程中可能通过提高自噬水平改善肝脏内代谢,对肝脏起到一定的保护作用。

关键词：急性肝衰竭自噬代谢 HDAC2抑制剂

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Economic and Social Impact Assessment of the Alternatives to DDT Usage for Antifouling Paint Production in China

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Chinese Journal of Population,Resources and Environment 2008年第3期6卷 48-55页

作者： zhang yi Xiao Yali lu Yongsen College of Environmental Science and Engineering Tongji University Shanghai 200092 China

China is the only nation that uses DDT in antifouling pain at present, approximately 5% of DDT is applied as the additive of the antifouling paint production. Therefore, actions shall be taken urgently for banning the use of DDT and substituting with non-POPs alternatives in antifouling paints. The paper researches the social and economic backgrounds of DDT booster antifouling paint production and usage, analyzes the social and economic impact assessment of the alternatives to DDT usage for antifouling paint. The implementation of the project of alternatives will completely eliminate the adverse impact of DDT booster antifouling paint on terrestrial, marine ecosystem and human health. The broad use of alkali silicate and pepper alkali as substitutes will be feasible if appropriate measures will be taken to encourage their development, and the social and economic risk will be reduced to accepted levels.

关键词： DDT antifouling paint social and economic impact assessment alternatives

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Molecular characterization and gene functional analysis of Dicer-2 gene from Nilaparvata lugens （Hemiptera： Geometroidea）

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Insect Science 2013年第1期20卷 61-68页

作者： Xiao-yi zhang Kai lu Jia-Liang Zhou Qiang Zhou State Key Laboratory of Biological Control and Institute of Entomology Sun Yat-sen University Guangzhou China

Nilaparvata lugens （St^il）（Hemiptera： Geometroidea）, a serious rice pest in many countries of Asia, causes a great loss in rice production every year. RNA interference （RNAi） is a powerful technology for gene fimction study in insects and a potential tool for pest control. As a core component of RNAi pathway, Dicer-2 （Dcr-2） protein determines the production of small interfering RNA （siRNA） and is crucial for the efficiency of RNAi. In this study, the full-length complementary DNA （cDNA） ofN. lugens Dcr-2 （NlDcr-2） was first cloned and analyzed, and then the RNAi experiment was conducted to explore the function ofNlDcr-2 gene. The complete Dcv-2 cDNA ofN. lugens was 4 971 bp in length with an open reading frame （ORF） of 1,656 amino acids. Phylogenetic and protein domain analysis showed that the predicted N1Dcr-2 protein was similar to Tribolium castaneum. In the RNAi experiment, the messenger RNA level of NlDcr-2 was significantly reduced by NlDcr-2 double-stranded RNA （dsRNA）（dsDcr-2）. Fifty-five per cent decrease of N1Dcr-2 was found after 4 days of unremitting feeding. No significant effect was observed on the development ofN. lugens after dsRNA ingestion.

关键词： clone Dicer-2 Nilaparvata lugens RNAi qRT-PCR

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西格列汀联合唑来膦酸与二甲双胍治疗2型糖尿病合并骨质疏松症对患者骨代谢及胰岛素抵抗的影响

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中国药物经济学 2024年第2期19卷 57-60,65页

作者：张艺露白雪剑高九青辽宁健康产业集团阜新矿总医院全科医学科辽宁阜新123000 辽宁健康产业集团阜新矿总医院骨科辽宁阜新123000 辽宁健康产业集团阜新矿总医院内分泌科辽宁阜新123000

目的探讨西格列汀联合唑来膦酸、二甲双胍治疗2型糖尿病合并骨质疏松症对患者骨代谢及胰岛素抵抗的影响。方法选取2020年3月至2021年3月辽宁健康产业集团阜新矿总医院收治的120例2型糖尿病合并骨质疏松症患者作为研究对象,根据信封法随... 详细信息

目的探讨西格列汀联合唑来膦酸、二甲双胍治疗2型糖尿病合并骨质疏松症对患者骨代谢及胰岛素抵抗的影响。方法选取2020年3月至2021年3月辽宁健康产业集团阜新矿总医院收治的120例2型糖尿病合并骨质疏松症患者作为研究对象,根据信封法随机分为观察组(61例)和对照组(59例)。对照组口服二甲双胍联合唑来膦酸治疗,观察组口服西格列汀联合唑来膦酸、二甲双胍治疗。比较两组患者治疗效果,治疗前后体重指数、血糖指标、骨代谢水平、胰岛素抵抗情况。结果观察组治疗有效率96.72%显著高于对照组的84.75%,差异有统计学意义(P0.05);治疗后两组体重指数、空腹血糖、糖化血红蛋白、碱性磷酸酶较治疗前降低,且观察组低于对照组,两组骨钙素较治疗前升高,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,观察组HOMA-IR低于对照组,HOMA-β高于对照组,差异有统计学意义(P<0.05)。结论西格列汀联合唑来膦酸、二甲双胍治疗2型糖尿病合并骨质疏松症,可有效改善患者骨代谢水平,同时抑制机体胰岛素抵抗。

关键词：西格列汀唑来膦酸二甲双胍 2型糖尿病骨质疏松症治疗效果糖化血红蛋白空腹血糖碱性磷酸酶骨钙素

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Heterogeneous engineering of MnSe@NC@ReS_(2) core-shell nanowires for advanced sodium-/potassium-ion batteries

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Rare Metals 2024年第8期43卷 3713-3723页

作者： Sheng-Jun lu Jin-yi Lin Cai-Hong Wang Yu-Fei zhang yi zhang Hao-Sen Fan College of Materials Science and Metallurgy Engineering Guizhou University Guiyang 550025China School of Energy Science and Engineering Nanjing Tech UniversityNanjing 211816China School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou 510006China

Sodium-ion batteries(SIBs) and potassium-ion batteries(PIBs) have been attracting great attentions and widely been exploited due to the abundant sodium/potassium ***,the preparation of high-powered anode materials for SIBs/PIBs plays a decisive role for the commercial applications of SIBs/PIBs in the *** selenides are a class of potential anode materials for SIBs/PIBs because of their small band gap and high electrical *** this work,MnSe and ReS_(2) core-shell nanowires connecting by polydopamine derived carbon nanotube(MnSe@NC@ReS_(2)) have been successfully synthesized from growing ReS_(2) nanosheets array on the surface of MnSe@NC nano wires,which present excellent Na^(+)/K^(+) storage *** applied as SIBs anode,the specific capacity of 300 mAh·g^(-1) was maintwined after 400 cycles at the current density of 1.0 A·g^(-1).Besides,it could also keep 120 mAh·g^(-1) specific capacity after 900 cycles at 1.0 A·g^(-1) for the anode of *** heterogeneous engineering and one-dimensional-two-dimensional(1D-2D) hybrid strategies could provide an ideal strategy for the synthesis of new hetero-structured anode materials with outstanding battery performance for SIBs and PIBs.

关键词： Heterogeneous engineering Core-shell nanowires MnSe@NC@ReS_(2)nanowires Na^(+)batteries K^(+)batteries

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2株青贮玉米根际固氮菌的筛选鉴定及促生作用研究

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草业学报 2024年第3期33卷 174-185页

作者：孟超楠赵玉洁陈佳欣张旖璐王彦佳冯丽荣孙玉刚郭长虹黑龙江省分子细胞遗传与遗传育种重点实验室哈尔滨师范大学生命科学与技术学院黑龙江哈尔滨150000 黑龙江国宏节能环保有限公司黑龙江哈尔滨150028

为了获得优良的固氮菌,并评价其对青贮玉米的促生效果,本研究采用稀释涂布平板法,利用阿须贝氏固体培养基从青贮玉米根际土壤中分离筛选到10株固氮菌,对其固氮能力进行分析,结果表明,菌株ZL-2和ZL^(-1)3的固氮能力较强,菌株ZL-2的固氮量... 详细信息

为了获得优良的固氮菌,并评价其对青贮玉米的促生效果,本研究采用稀释涂布平板法,利用阿须贝氏固体培养基从青贮玉米根际土壤中分离筛选到10株固氮菌,对其固氮能力进行分析,结果表明,菌株ZL-2和ZL^(-1)3的固氮能力较强,菌株ZL-2的固氮量为1.07μg·mL^(-1),ZL^(-1)3的固氮量为0.95μg·mL^(-1)。通过细菌形态学、16S rDNA序列分析和生理生化特征,确定菌株ZL-2为生癌肠杆菌和ZL^(-1)3为成团泛菌。对2株固氮菌的促生特性进行分析,结果表明,2个菌株具有泌铵能力、溶磷能力、产嗜铁素能力和合成吲哚-3-乙酸(IAA)的能力。盆栽试验结果表明,接种固氮菌ZL-2和ZL^(-1)3能够显著提高青贮玉米的株高、根长、地上和地下干、鲜重(P<0.05)。田间试验结果表明,2株固氮菌单接种和双接种均能提高青贮玉米的株高、茎粗、产量、粗蛋白含量和全磷含量(P<0.05)。接种2株固氮菌的青贮玉米,其氮代谢和氨同化相关基因(ZmAMT-4、ZmAMTB、ZmGOGAT2和ZmGS1-3)的表达量显著提高(P<0.05)。因此,2株固氮菌具有较好的促生特性,在提高青贮玉米的产量和品质方面发挥了重要作用,是开发微生物菌剂的优质菌种资源。

关键词：青贮玉米固氮菌泌铵促生作用基因表达

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Combination of Nitrogen-Rich Skeleton and Coordination Group:Synthesis of a High-Energy Primary Explosive Based on 1H-Tetrazole-5-Carbohydrazide

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Defence Technology（防务技术） 2024年第1期31卷 271-277页

作者： Tingwei Wang Zujia lu Shu Bu Baolong Kuang lu zhang Zhenxin yi Kun Wang Shunguan Zhu Jianguo zhang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China School of Chemical Engineering Nanjing University of Science and Technology200 Xiaolingwei StreetXuanwuNanjing 210094China Department of Chemistry Laboratory of Structure and Functional Regulation of Hybrid MaterialsAnhui UniversityMinistry of EducationHefei 230601China

The high energy coordination compounds Cu(TZCA)_(2)(ClO_(4))_(2)(ECCs-1) was prepared by 1H-tetrazole-5-carbohydrazide(TZCA) with a high energy skeleton and a strong coordination ability *** the same time,the reaction activity of the ligand was explored,and the single crystal structure of it and intermediate were *** structures of all substances were characterized by IR and *** the structure and composition of ECCs-1 are confirmed by ESP,AC,SEM and *** and chemical properties tests show that ECCs-1 has an acceptable thermal stability(T_(d)=177℃) and extremely sensitive mechanical stimulation(IS=1 J,FS=5 N).The comprehensive performance test results show that ECCs-1 has excellent initiation *** addition,the decomposition mechanism of ECCs-1 is explored from two aspects of experiment and theoretical calculation.

关键词： 1H-tetrazole-5-carbohydrazide Primary explosive Decomposition mechanism Coordination polymers Laser

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A thermo-responsive rewritable plasmonic bio-memory by regulating single core-satellite gold nanocluster dissociation

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Nano Research 2024年第8期17卷 7275-7282页

作者： Wen zhang yi Wang Yamin Wang Xiaomei lu Weibing Wu Quli Fan Lei zhang State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM) Nanjing University of Posts&TelecommunicationsNanjing 210023China Jiangsu Co-Innovation Center for Efficient Processing and Utilization of Forest Resources College of Light Industry and Food EngineeringNanjing Forestry UniversityNanjing 210037China Zhengzhou Institute of Biomedical Engineering and Technology Zhengzhou 450001China Key Laboratory of Flexible Electronics(KLOFE) Institute of Advanced Materials(IAM)&School of Flexible Electronics(Future Technologies)Nanjing Tech University(Nanjing Tech)Nanjing 211816China

A thermo-responsive rewritable plasmonic bio-memory chip has been successfully fabricated on an indium tin oxide(ITO)glass slide by assembling core-satellite gold nanoclusters with different size of gold nanoparticles(AuNPs)using double-strand DNA(dsDNA)*** the prepared 70@DNA20@13 gold nanoclusters(AuNCs)exhibited more stable and greater photothermal conversion *** short time irradiation by 633 nm microbeam laser,every individual AuNCs could be excited and remove the satellite AuNPs on its ***,in the dissociation process of AuNCs with 3−5 satellite,its color would change from yellow to green,which showed more significant reduction in the red channel of the dark-field microscopy(DFM)images and could be defined to state“0”and“1”***,this plasmonic nano bio-memory could transform cyclically its state between 0 and 1 which exhibited excellent rewritable ability.

关键词： plasmonic assembly thermal-responsive single nanoparticle rewritable bio-memory

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