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Enhancing efficiency and stability of organic solar cells through a simplified four-step synthesis of fully non-fused ring electron acceptor

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Journal of Energy Chemistry 2024年第6期93卷 601-608,I0015页

作者： Chenyang Han Huanhuan Gao Yanna Sun Yuanyuan Kan Zhaozhao Bi Wei Ma yani zhang Juan Antonio Zapien Yingguo Yang Ke Gao College of New Energy Xi’an Shiyou UniversityXi’an 710065ShaanxiChina Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion Institute of Frontier ChemistrySchool of Chemistry and Chemical EngineeringShandong UniversityQingdao 266237ShandongChina State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049ShaanxiChina Department of Materials Science and Engineering City University of Hong KongKowloonHong Kong 99907China School of Microelectronics Fudan UniversityShanghai 200433China

Design and synthesis of superior cost-effective non-fullerene acceptors(NFAs)are still big challenges for facilitating the commercialization of organic solar cells(OSCs),yet to be ***,two medium bandgap fully non-fused ring electron acceptors(NFREAs,medium bandgap,i,e.,1,3-1,8 eV),namely PTR-2Cl and PTR-4Cl are synthesized with only four steps by using intramolecular noncovalent interaction central core,structured alkyl side chain orientation linking units and flanking with different electron-withdrawing end *** them,PTR-4C1 exhibits increased average electrostatic potential(ESP)difference with polymer donor,enhanced crystallinity and compactπ-πstacking compared with the control molecule *** a result,the PTR-4Cl-based OSC achieved an impressive power conversion efficiency(PCE)of 14.72%,with a much higher open-circuit voltage(V_(OC))of 0.953 V and significantly improved fill factor(FF)of 0.758,demonstrating one of the best acceptor material in the top-performing fully NFREA-based OSCs with both high PCE and V_(OC).Notably,PTR-4Cl-based cells maintain a good T_80lifetime of its initial PCE after over 936 h under a continuous thermal annealing treatment and over1300 h T_(80)lifetime without *** work provides a cost-effective design strategy for NFREAs on obtaining high V_(OC),efficient exciton dissociation,and ordered molecular packing and thus high-efficiency and stable OSCs.

关键词： Organic solar cells Fully non-fused ring acceptors End group engineering Morphology regulation High efficiency

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Discovery and characterization of naturally occurring covalent inhibitors of SARS-CoV-2 M~(pro)from the antiviral herb Ephedra

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Chinese Journal of Natural Medicines 2024年第9期22卷 797-807页

作者： HU Qing zhang Yiwen CHEN Pengcheng zhang yani ZHU Guanghao LIU Wei WANG Chaoran ZHENG Shuilian SHEN Nonger WANG Haonan HUANG Ping GE Guangbo Center for Clinical Pharmacy Cancer CenterDepartment of PharmacyZhejiang Provincial People’s Hospital(Affiliated People’s Hospital)Hangzhou Medical CollegeHangzhou 310014China Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine ResearchShanghai University of Traditional Chinese MedicineShanghai 201203China Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 200021China Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023China

The Chinese herb Ephedra(also known as Mahuang)has been extensively utilized for the prevention and treatment of coronavirus-induced diseases,including coronavirus disease 2019(COVID-19).However,the specific anti-SARS-CoV-2 compounds and mechanisms have not been fully *** main protease(M~(pro))of SARS-CoV-2 is a highly conserved enzyme responsible for proteolytic processing during the viral life cycle,making it a critical target for the development of antiviral *** study aimed to identify naturally occurring covalent inhibitors of SARS-CoV-2 M~(pro)from Ephedra and to investigate their covalent binding *** results demonstrated that the non-alkaloid fraction of Ephedra(ENA)exhibited a potent inhibitory effect against the SARS-CoV-2 M~(pro)effect,whereas the alkaloid fraction did ***,the chemical constituents in ENA were identified,and the major constituents'anti-SARS-CoV-2 M~(pro)effects were *** the tested constituents,herbacetin(HE)and gallic acid(GA)were found to inhibit SARS-CoV-2 M~(pro)in a time-and dose-dependent *** combination displayed a significant synergistic effect on this key ***,various techniques,including inhibition kinetic assays,chemoproteomic methods,and molecular dynamics simulations,were employed to further elucidate the synergistic anti-M~(pro)mechanisms of the combination of HE and ***,this study deciphers the naturally occurring covalent inhibitors of SARS-CoV-2 M~(pro)from Ephedra and characterizes their synergistic anti-M~(pro)synergistic effect,providing robust evidence to support the anti-coronavirus efficacy of Ephedra.

关键词： Main protease Ephedra Ephedra non-alkaloid fraction Covalent inhibitors Synergistic effect

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Autophagy plays a pro-apoptotic role in arsenic trioxide-induced cell death of liver cancer

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Journal of Integrative Medicine 2024年第3期22卷 295-302页

作者： Zhengting Deng Shufang Liang Guokai Huang Yuqian Wang Xiaoyu Tu yani zhang Shu Li Tao Liu Binbin Cheng Taizhou Hospital of Traditional Chinese Medicine Nanjing University of Chinese MedicineTaizhou 225300Jiangsu ProvinceChina Oncology Department of Traditional Chinese Medicine The First Affiliated Hospital of Naval Medical UniversityShanghai 200433China School of Traditional Chinese Medicine Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Gastroenterology Baoshan Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 201900China

Objective: The effects of arsenic trioxide(As2O3) on hepatocellular carcinoma have been documented widely. Autophagy plays dual roles in the survival and death of cancer cells. Therefore, we investigated the exact role of autophagy in As2O3-induced apoptosis in liver cancer ***: The viability of hepatoma cells was determined using the MTT assay with or without fetal bovine serum. The rate of apoptosis in liver cancer cells treated with As2O3was evaluated using flow cytometry, Hoechst 33258 staining, and TUNEL assays. The rate of autophagy among liver cancer cells treated with As2O3was detected using immunofluorescence, Western blot assay and transmission electron ***: Upon treatment with As2O3, the viability of HepG2 and SMMC-7721 cells was decreased in a time-and dose-dependent manner. The apoptosis rates of both liver cancer cell lines increased with the concentration of As2O3, as shown by flow cytometry. Apoptosis in liver cancer cells treated with As2O3was also shown by the activation of the caspase cascade and the regulation of Bcl-2/Bax ***, As2O3treatment induced autophagy in liver cancer cells;this finding was supported by Western blot, immunofluorescence of LC3-II and beclin 1, and transmission electron microscopy. In liver cancer cells, As2O3inhibited the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin(PI3K/AKT/mTOR) signal pathway that plays a vital role in both apoptosis and autophagy. The PI3K activator SC-79 partially reversed As2O3-induced autophagy and apoptosis. Furthermore, inhibiting autophagy with 3-methyladenine partially reversed the negative effects of As2O3on cell *** starvation increased autophagy and amplified the effect of As2O3on cell ***: As2O3induces apoptosis and autophagy in liver cancer cells. Autophagy induced by As2O3may have a proapoptotic effect that helps to reduce the viability of liver cancer cells. This study provides novel insights

关键词： Apoptosis Arsenic trioxide Autophagy Primary liver cancer

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Discovery and characterization of naturally occurring covalent inhibitors of SARS-CoV-2 Mpro from the antiviral herb Ephedra

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Chinese Journal of Natural Medicines 2024年第9期 797-807页

作者： HU Qing zhang Yiwen CHEN Pengcheng zhang yani ZHU Guanghao LIU Wei WANG Chaoran ZHENG Shuilian SHEN Nonger WANG Haonan HUANG Ping GE Guangbo Center for Clinical Pharmacy Cancer Center Department of Pharmacy Zhejiang Provincial People's Hospital (Affiliated People's Hospital) Hangzhou Medical College Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine ResearchShanghai University of Traditional Chinese Medicine Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Dalian Institute of Chemical Physics Chinese Academy of Sciences

The Chinese herb Ephedra（also known as Mahuang） has been extensively utilized for the prevention and treatment of coronavirus-induced diseases, including coronavirus disease 2019（COVID-19）. However, the specific anti-SARS-CoV-2 compounds and mechanisms have not been fully elucidated. The main protease(Mpro) of SARS-CoV-2 is a highly conserved enzyme responsible for proteolytic processing during the viral life cycle, making it a critical target for the development of antiviral therapies. This study aimed to identify naturally occurring covalent inhibitors of SARS-CoV-2 Mprofrom Ephedra and to investigate their covalent binding sites. The results demonstrated that the non-alkaloid fraction of Ephedra（ENA） exhibited a potent inhibitory effect against the SARS-CoV-2 Mproeffect, whereas the alkaloid fraction did not. Subsequently, the chemical constituents in ENA were identified, and the major constituents' anti-SARS-CoV-2 Mproeffects were evaluated. Among the tested constituents, herbacetin（HE） and gallic acid（GA）were found to inhibit SARS-CoV-2 Mproin a time-and dose-dependent manner. Their combination displayed a significant synergistic effect on this key enzyme. Additionally, various techniques, including inhibition kinetic assays, chemoproteomic methods, and molecular dynamics simulations, were employed to further elucidate the synergistic anti-Mpromechanisms of the combination of HE and GA. Overall, this study deciphers the naturally occurring covalent inhibitors of SARS-CoV-2 Mprofrom Ephedra and characterizes their synergistic anti-Mprosynergistic effect, providing robust evidence to support the anti-coronavirus efficacy of Ephedra.

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基于RIR-MOO与可拓符号学的茶山瑶族服饰元素家具产品设计研究

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包装工程 2024年第14期45卷 374-383页

作者：徐云章雅妮桂林理工大学艺术学院广西桂林541004

目的拓展茶山瑶族服饰元素在现代家具中的应用途径,保护和传承茶山瑶族传统服饰文化。将RIR-MOO(相对重要性等级“多目标优化”)的产品优化设计逻辑跨界融合至家具产品设计中,使家具产品设计与传统民族文化深度融合。方法首先基于RIR-MO... 详细信息

目的拓展茶山瑶族服饰元素在现代家具中的应用途径,保护和传承茶山瑶族传统服饰文化。将RIR-MOO(相对重要性等级“多目标优化”)的产品优化设计逻辑跨界融合至家具产品设计中,使家具产品设计与传统民族文化深度融合。方法首先基于RIR-MOO逻辑流程筛选用户关键性需求,计算用户需求与设计目标的关联度,从而确定家具产品设计目标,其次运用可拓符号学理论,构建茶山瑶族服饰元素特征图库,进而利用可拓基元变换将原始元素符号转换为设计元素符号,最终生成家具产品设计方案。结果结合具体的设计案例实践,详细阐述了该设计流程的可实践性。结论基于RIR-MOO与可拓符号学的茶山瑶族服饰元素家具产品设计方法研究,丰富了关于茶山瑶族传统服饰文化的理论研究。将茶山瑶服饰元素融入家具产品设计,彰显了民族文化与现代家居环境的契合性,注重特定设计与人居环境的恰当融合,为基于民族传统服饰文化的家具产品创意设计提供了有效的设计思路与方法参考。

关键词：茶山瑶服饰元素 RIR-MOO逻辑流程可拓符号学家具产品设计

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中国本科院校向职业教育转型研究

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高教学刊 2024年第S2期10卷 23-26页

作者：张雅妮北京工业大学北京102206

中国的高等教育一直以来都是以本科教育为主导,但是近年来,随着职业教育的崛起和发展,越来越多的人开始重视职业教育的重要性。该文以中国本科院校向职业教育转型为研究主题,探讨该转型的必要性、可行性和挑战。通过对相关文献和案例的... 详细信息

中国的高等教育一直以来都是以本科教育为主导,但是近年来,随着职业教育的崛起和发展,越来越多的人开始重视职业教育的重要性。该文以中国本科院校向职业教育转型为研究主题,探讨该转型的必要性、可行性和挑战。通过对相关文献和案例的研究分析,该文认为,本科院校向职业教育转型可以为学生提供更加实用和针对性的教育,增强学生的就业竞争力和创新能力。同时,这种转型也有利于学校与社会经济发展的对接,推动高等教育的多元化和协调发展。然而,该文也指出,本科院校向职业教育转型面临的挑战,包括师资力量、课程体系、评价体系等方面的问题。因此,提出一些对策建议,包括加强师资队伍建设、调整课程设置和评价标准、加强与企业合作等,以促进本科院校向职业教育转型的顺利进行。

关键词：本科院校职业教育转型政策法规

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基于FPGA的开环光纤陀螺数字信号处理算法的设计与研究

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移动信息 2024年第6期46卷 300-303页

作者：张艳丽大连理工大学盘锦产业技术研究院辽宁盘锦124221

文中提出了一种开环光纤陀螺的数字信号处理算法,数字信号处理采用FPGA实现。利用合成器信号发生器驱动PZT并调节频率和幅度,以实现调制深度稳定的算法。通过实验验证,证明该算法具有良好的性能。低角度随机游走小于0.03deg hour,偏置... 详细信息

文中提出了一种开环光纤陀螺的数字信号处理算法,数字信号处理采用FPGA实现。利用合成器信号发生器驱动PZT并调节频率和幅度,以实现调制深度稳定的算法。通过实验验证,证明该算法具有良好的性能。低角度随机游走小于0.03deg hour,偏置稳定性为0.12 deg/h。

关键词：开环光纤陀螺 FPGA 锁相放大器LIA Sagnac效应

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5E教学模式的发展脉络与趋势研究

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福建电脑 2024年第9期40卷 46-50页

作者：张小丽张娅妮黔南民族师范学院计算机与信息学院贵州都匀558000

为深入了解我国5E教学模式的研究现状、热点与发展趋势,本文对CNKI数据库平台中文献的来源、分布、热点、趋势进行分析。研究发现,5E教学模式的研究逐渐从理论研究转变为实践研究,基于5E教学模式的研究正逐渐从概念教学向实践教学和核... 详细信息

为深入了解我国5E教学模式的研究现状、热点与发展趋势,本文对CNKI数据库平台中文献的来源、分布、热点、趋势进行分析。研究发现,5E教学模式的研究逐渐从理论研究转变为实践研究,基于5E教学模式的研究正逐渐从概念教学向实践教学和核心素养扩展,且有关5E教学模式的研究热度正呈现大幅上升的态势。

关键词： 5E教学模式研究现状热点发展趋势

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白细胞介素-6在肿瘤免疫检查点抑制剂治疗中的作用研究进展

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中国肿瘤临床 2024年第11期51卷 585-589页

作者：朱玲玲张亚妮史婷婷于晓辉张久聪中国人民解放军联勤保障部队第九四〇医院消化内科兰州市730050 甘肃中医药大学第一临床医学院

免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)作为一种免疫疗法,在多种癌症的治疗中发挥着重要作用,同时,其可诱导多种免疫相关不良事件(immune-related adverse events,irAEs)的发生。白细胞介素-6(interleukin-6,IL-6)是一种重要的炎症因子,已被证明可通过多种机制促进癌症进展及影响ICIs的临床应用。本文就细胞因子IL-6如何调节免疫检查点的表达以及对免疫阻断疗法和irAEs的影响进行探讨,总结靶向IL-6信号转导对ICIs功效及irAEs治疗的作用。

关键词：白细胞介素-6 肿瘤免疫检查点抑制剂免疫相关不良事件

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基于可拓符号学的茶山瑶族服饰图案创新设计

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时尚设计与工程 2024年第4期 52-54页

作者：章雅妮徐云桂林理工大学艺术学院

作为金秀瑶族五大支系之一的茶山瑶,茶山瑶族的服饰纹样以及服饰色彩搭配给人以强烈的视觉冲击感和民族认同感。现代茶山瑶族服饰文化衍生产品设计要最大限度发挥茶山瑶族服饰文化的独特优势。基于可拓符号学理论,提取茶山瑶服饰图案元... 详细信息

作为金秀瑶族五大支系之一的茶山瑶,茶山瑶族的服饰纹样以及服饰色彩搭配给人以强烈的视觉冲击感和民族认同感。现代茶山瑶族服饰文化衍生产品设计要最大限度发挥茶山瑶族服饰文化的独特优势。基于可拓符号学理论,提取茶山瑶服饰图案元素,并构建相应的可拓基元模型,结合具体设计实践,验证该方法的可行性,以此传承和弘扬茶山瑶族服饰文化,探索对茶山瑶族传统服饰文化加以保护和寻求创新发展的新途径。

关键词：可拓符号学服饰图案可拓基元变换逼近理想解法产品设计

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