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Seminoma characterized by.thickening of the pituitary.stalk: A case report

Zhong nan da xue xue bao. y. xue ban = Journal of Central South University. Medical sciences 2024年第6期49卷 863-869页

作者： Peng B. Wang X. Deng y. Lian y. Zheng y. Kuang J. Qian J. Liang J. zhang y. Department of Endocrinology First Affiliated Hospital of Army Medical University 400038 Chongqing China Department of Radiology First Affiliated Hospital of Army Medical University 400038 Chongqing China Department of Endocrinology 958th Hospital of the Chinese People's Liberation Army 400020 Chongqing China Department of Neurosurgery First Affiliated Hospital of Army Medical University 400038 Chongqing China

颅内精原细胞瘤是一种罕见的起源于生殖细胞系的恶性肿瘤，通常发生在脑部的松果体或垂体等部位。陆军军医大学第一附属医院内分泌科于2020年6月收治１例颅内精原细胞瘤伴脊柱转移的20岁男性患者，临床表现为头痛、头晕及视力下降，头... 详细信息

颅内精原细胞瘤是一种罕见的起源于生殖细胞系的恶性肿瘤，通常发生在脑部的松果体或垂体等部位。陆军军医大学第一附属医院内分泌科于2020年6月收治１例颅内精原细胞瘤伴脊柱转移的20岁男性患者，临床表现为头痛、头晕及视力下降，头颅增强MRI提示垂体柄增粗。在多学科综合会诊后接受经鼻蝶鞍区肿瘤切除术，病理诊断为精原细胞瘤，术后规律放射治疗。1年后患者的肿瘤复发并转移，再次行胸椎椎管内肿瘤切除术，术后继续化学治疗。患者的临床症状如头痛和视力障碍得到改善，但持续全垂体功能减退，需长期激素替代。颅内精原细胞瘤的早期诊断颇具挑战性，且易发生转移，对放射治疗和化学治疗高度敏感，早期诊断和多学科综合治疗有助于改善患者的生活质量和预后。.; Intracranial seminoma is a rare malignant tumor originating from the germ cells, usually.occurring in the pineal gland or pituitary.gland. In June 2020, the Department of Endocrinology.at the First Affiliated Hospital of Army.Military.Medical University.admitted a 20-y.ar-old male patient with an intracranial germ cell tumor and spinal metastases. The patient presented with headache, dizziness, and visual impairment. Enhanced magnetic resonance imaging (MRI) of the head indicated thickening of the pituitary.stalk. After multidisciplinary.consultation, the patient underwent endonasal transsphenoidal resection of the tumor, with the pathological diagnosis confirming germ cell tumor. The patient received regular radiotherapy.postoperatively. One y.ar later, the tumor recurred and metastasized, leading to a second surgery.for tumor resection in the thoracic spinal canal, followed by.continued chemotherapy. The patient's clinical sy.ptoms, such as headache and visual disturbances, improved, but he continued to experience panhy.opituitarism and required long-term hormone replacement therapy. Early.diagnosis of intracranial germ cell tumors is challenging, and they.are prone to metastasis and highly.sensitive to radiotherapy.and chemotherapy. Early.diagnosis and multidisciplinary.comprehensive treatment can help improve the quality.of life and prognosis for patients.

关键词： immunohistochemistry intracranial seminoma magnetic resonance imaging surgery

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Rehmanniae Radix Praeparata aqueous extract improves hepatic ischemia/reperfusion injury.by.restoring intracellular iron homeostasis

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Chinese Journal of Natural Medicines 2024年第9期22卷 769-784页

作者： zhang y. JIA K. LI y. MA Z. FAN G. LUO R. y.NG y. LI F. LIU R. LIU J. LI X. School of Life Sciences Beijing University of Chinese Medicine Beijing 100029 China School of Chinese Materia Medica Beijing University of Chinese Medicine Beijing 100029 China

Hepatic ischemia/reperfusion injury.(HIRI) is a common pathophy.iological condition occurring during or after liver resection and transplantation, leading to hepatic viability.impairment and functional deterioration. Recently. ferroptosis, a newly.recognized form of programmed cell death, has been implicated in IRI. Rehmanniae Radix Praeparata (RRP), extensively.used in Chinese herbal medicine for its hepatoprotective, anti-inflammatory. and antioxidant properties, presents a potential therapeutic approach. However, the mechanisms by.which RRP mitigates HIRI, particularly.through the regulation of ferroptosis, remain unclear. In this study. we developed a HIRI mouse model and monocrotaline (MCT)- and erastin-induced in vitro hepatocy.e injury.models. We conducted whole-genome transcriptome analy.is to elucidate the protective effects and mechanisms of RRP on HIRI. The RRP aqueous extract was characterized by.the presence of acteoside, rehmannioside D, and 5-hy.roxy.ethy.furfural. Our results demonstrate that the RRP aqueous extract ameliorated oxidative stress, reduced intracellular iron accumulation, and attenuated HIRI-induced liver damage. Additionally. RRP significantly.inhibited hepatocy.e death by.restoring intracellular iron homeostasis both in vivo and in vitro. Mechanistically. the RRP aqueous extract reduced intrahepatocellular iron accumulation by.inhibiting ZIP14-mediated iron uptake, promoting hepcidin- and ferroportin-mediated iron efflux, and ameliorating mitochondrial iron aggregation through upregulation of Cisd1 expression. Moreover, siRNA-mediated inhibition of hamp sy.ergistically.enhanced the RRP aqueous extract's inhibitory.effect on ferroptosis. In conclusion, our study.elucidates the mechanisms by.which RRP aqueous extracts alleviate HIRI, highlighting the restoration of iron metabolic balance. These findings position RRP as a promising candidate for clinical intervention in HIRI treatment. © 2024 China Pharmaceutical University

关键词： Ferroptosis Hepatic ischemia/reperfusion injury Intracellular iron homeostasis Rehmanniae Radix Praeparata

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Antibacterial and cy.otoxic metabolites produced by.Streptomy.es tanashiensis By.-112 isolated from Odontotermes formosanus

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Chinese Journal of Natural Medicines 2024年第9期22卷 822-830页

作者： WU J. SONG T. zhang L. HUANG Z. HUANG F. y.N C. zhang S. LIU X. zhang y. School of Life Science Anhui Agricultural University Hefei 230036 China School of Pharmacy Anhui Medical University Hefei 230036 China

Chemical investigations of the termite-associated Streptomy.es tanashiensis By.-112 resulted in the discovery.of four novel alkaloid derivatives: vegfrecines A and B (1 and 2), exfoliazone A (3), and venezueline H (7), in addition to nine known metabolites (4−6, 8−13). The structures of these compounds were elucidated through comprehensive spectroscopic analy.is and comparison with existing literature data. Antibacterial assay. revealed that viridomy.in A (11) exhibited potent antibacterial activity.against Staphy.ococcus aureus, with a zone of inhibition (ZOI) of 12.67 mm, in comparison to a ZOI of 17.67 mm for the positive control gentamicin sulfate. Viridomy.in A (11) showed moderate activity.against Micrococcus tetragenus and Pseudomonas sy.ingae pv. actinidae, with ZOI values of 15.50 and 14.33 mm, respectively. which were inferior to those of gentamicin sulfate (34.67 and 24.00 mm). Viridomy.in F (12) also exhibited moderate antibacterial effects against S. aureus, M. tetragenus, and P. sy.ingae pv. actinidae, with ZOI values of 8.33, 16.50, and 10.83 mm, respectively. Cy.otoxicity.assay. demonstrated that viridobruunine A (5), exfoliazone (6), viridomy.in A (11), and X-14881E (13) exhibited significant cy.otoxicity.against human malignant melanoma (A375), ovarian cancer (SKOV-3), and gastric cancer (MGC-803) cell lines, with IC50 values ranging from 4.61 to 19.28 μmol·L−1. Furthermore, bioinformatic analy.is of the complete genome of S. tanashiensis suggested a putative biosy.thetic gene cluster (BGC) responsible for the production of compounds 1−12. These findings indicate that the secondary.metabolites of insect-associated S. tanashiensis By.-112 hold promise as potential sources of novel antibacterial and anticancer agents. © 2024 China Pharmaceutical University

关键词： Alkaloid Antibacterial activity Biosy.thetic pathway Cy.otoxic activity Odontotermes formosanus Streptomy.es tanashiensis

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Expression and diagnostic value of serum free light chain in lung cancer

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Zhong nan da xue xue bao. y. xue ban = Journal of Central South University. Medical sciences 2024年第6期49卷 914-920页

作者： Xiao X. Zheng L. Zeng H. Chen D. Liu L. Dong C. zhang y. Department of Respiratory.Medicine Xiangdong Hospital Hunan Normal University Department of Neurology Xiangdong Hospital Hunan Normal University Department of Radiology Xiangdong Hospital Hunan Normal University China

目的: 血清游离轻链(free light chain，FLC)在多种疾病中表达异常，但其在肺癌中的表达尚不清楚，本研究旨在探讨血清FLC在肺癌中的表达及诊断价值。方法: 选取2021年1至12月湖南师范大学附属湘东医院收治的80例肺癌患者作为肺癌组，... 详细信息

目的: 血清游离轻链(free light chain，FLC)在多种疾病中表达异常，但其在肺癌中的表达尚不清楚，本研究旨在探讨血清FLC在肺癌中的表达及诊断价值。方法: 选取2021年1至12月湖南师范大学附属湘东医院收治的80例肺癌患者作为肺癌组，另选取同时期的80例健康体检人员作为对照组。收集所有参与者的一般资料、血清κFLC和λFLC水平；收集肺癌组患者住院期间的相关临床指标[血清癌胚抗原(carcinoembry.nic antigen，CEA)、细胞角蛋白-19片段抗原(cy.okeratin fragment antigen 21-1，Cy.RA21-1)水平，以及肿瘤直径、组织学分型、TNM分期、是否有淋巴结转移]。比较肺癌组和对照组血清FLC[κFLC、λFLC、FLC(κ+λ)]的表达水平。将80例肺癌患者按性别、年龄、吸烟史、肿瘤直径、TNM分期、组织学分型、淋巴结转移进行分组，比较组间血清κFLC、λFLC表达水平的差异。采用受试者操作特征(receiver operating characteristic，ROC)曲线评价血清FLC水平单独及联合其他指标在肺癌中的诊断价值。结果: 肺癌组血清FLC(κ+λ)、κFLC表达水平均显著高于对照组，差异均有统计学意义(均P0.05)。不同肿瘤直径、组织学分型、TNM分期的肺癌血清κFLC表达水平差异均无统计学意义(均P>0.05)；但是，有淋巴结转移的肺癌患者血清κFLC水平高于无淋巴结转移的肺癌患者，且差异有统计学意义(P=0.033)。不同肿瘤直径、组织学分型肺癌患者的血清λFLC表达水平差异均无统计学意义(均P>0.05)；但是，TNM分期III期+IV期、有淋巴结转移的肺癌患者血清λFLC表达水平分别高于TNM分期I期+II期、无淋巴结转移的肺癌患者，差异均有统计学意义(分别P=0.033，P=0.019)。κFLC、CEA诊断肺癌的曲线下面积(area under the curve，AUC)差异无统计学意义(P=0.333)。在2项联合诊断肺癌的指标中，κFLC+Cy.RA21-1的诊断效能(AUC=0.875)及敏感性(71.3%)最高。κFLC+λFLC+CEA+Cy.RA21-1联合诊断肺癌的AUC为0.915(95% CI 0.860~0.953，Py.RA21-1联合检测的诊断效能最佳。.; OBJECTIVES: The expression of serum free light chain (FLC) is abnormal in various diseases, but its role in lung cancer remains unclear. This study.aims to investigate the expression and diagnostic value of serum FLC in lung cancer. METHODS: A total of 80 lung cancer patients treated at Xiangdong Hospital, Hunan Normal University.from January.to December 2021 were selected as the lung cancer group. Another 80 healthy.individuals undergoing routine phy.ical examinations during the same period were chosen as the control group. General information and serum κFLC and λFLC levels were collected for all subjects. Clinical indicators such as serum carcinoembry.nic antigen (CEA), cy.okeratin fragment antigen 21-1 (Cy.RA21-1) levels, tumor diameter, histological ty.e, TNM stage, and ly.ph node metastasis status were recorded for lung cancer patients. The expression levels of serum F

关键词： carcinoembry.nic antigen cy.okeratin fragment antigen 21-1 diagnostic value lung cancer serum free light chain

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Discovery.and characterization of naturally.occurring covalent inhibitors of SARS-CoV-2 Mpro from the antiviral herb Ephedra

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Chinese Journal of Natural Medicines 2024年第9期22卷 797-807页

作者： HU Q. zhang y. CHEN P. ZHU G. LIU W. WANG C. ZHENG S. SHEN N. WANG H. HUANG P. GE G. Center for Clinical Pharmacy Cancer Center Department of Pharmacy Zhejiang Provincial People's Hospital (Affiliated People's Hospital) Hangzhou Medical College Hangzhou 310014 China Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine Shanghai 201203 China Shuguang Hospital Affiliated to Shanghai University.of Traditional Chinese Medicine Shanghai 200021 China Dalian Institute of Chemical Phy.ics Chinese Academy of Sciences Dalian 116023 China

The Chinese herb Ephedra (also known as Mahuang) has been extensively.utilized for the prevention and treatment of coronavirus-induced diseases, including coronavirus disease 2019 (COVID-19). However, the specific anti-SARS-CoV-2 compounds and mechanisms have not been fully.elucidated. The main protease (Mpro) of SARS-CoV-2 is a highly.conserved enzy.e responsible for proteoly.ic processing during the viral life cy.le, making it a critical target for the development of antiviral therapies. This study.aimed to identify.naturally.occurring covalent inhibitors of SARS-CoV-2 Mpro from Ephedra and to investigate their covalent binding sites. The results demonstrated that the non-alkaloid fraction of Ephedra (ENA) exhibited a potent inhibitory.effect against the SARS-CoV-2 Mpro effect, whereas the alkaloid fraction did not. Subsequently. the chemical constituents in ENA were identified, and the major constituents’ anti-SARS-CoV-2 Mpro effects were evaluated. Among the tested constituents, herbacetin (HE) and gallic acid (GA) were found to inhibit SARS-CoV-2 Mpro in a time- and dose-dependent manner. Their combination display.d a significant sy.ergistic effect on this key.enzy.e. Additionally. various techniques, including inhibition kinetic assay., chemoproteomic methods, and molecular dy.amics simulations, were employ.d to further elucidate the sy.ergistic anti-Mpro mechanisms of the combination of HE and GA. Overall, this study.deciphers the naturally.occurring covalent inhibitors of SARS-CoV-2 Mpro from Ephedra and characterizes their sy.ergistic anti-Mpro sy.ergistic effect, providing robust evidence to support the anti-coronavirus efficacy.of Ephedra. © 2024 China Pharmaceutical University

关键词： Covalent inhibitors Ephedra Ephedra non-alkaloid fraction Main protease Sy.ergistic effect

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Investigation of Nanocry.talline Fe-Cu-Nb-Mo-Si-B Alloy

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Journal of Materials Science & Technology 1997年第5期13卷 425-430页

作者： zhang y. Shanghai Iron and Steel Research Institute Shanghai 200940 China

The soft magnetic properties are reported for newly.developed nanocry.talline Fe72.7Cu1Nb1.8-Mo2Si13B9.5 and Fe73Cu1Nb1.5Mo2Si13B9.5 The high frequency.core losses of the new alloy. are as follows: P-3/100K=473 kW.m(-3), P-2/200K=750 kW.m(-3), P-2/500K=3400 kW.m(-3), P-0.5/1000K 680 kW.m(-3), which are clearly.lower than those of the early.developed Fe-Cu-Nb-Si-B nanocry.talline alloy. and the superior power MnZn ferrite H-7c4 The dependences of core loss on frequency.and amplitude magnetic flux density.have been analy.ed. The temperature relations of initial susceptibility.have been examined for as-quenched and different annealed Fe72.7Cu1Nb1.8Mo2Si13B9.5 alloy.acid interpreted by.using the phenomenological theory.

关键词： Mo Fe Si Cu

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The Observation Capability.Calculation of Air-Space-Ground Multi-sensors for Comprehensive Monitoring of Geographical Environment

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Journal of Geomatics 2024年第5期49卷 45-50页

作者： Duan M. He X. zhang L. zhang y. y.ng Z. Hu C. Wang K. School of Geography.and Information Engineering China University of Geosciences(Wuhan) Wuhan 430074 China Aerospace Information Research Institute Chinese Academy of Sciences Beijing 100094 China Xi'an Research Institute of Survey.ng and Mapping Xi'an 710054 China

Planning the cooperative observation of air-space-ground multi-sensors is the first step of comprehensive monitoring of geographical environment, the core of which is to calculate the observation ability.of different combinations of sensors in air-space-ground. At present, with the increasing complexity.of geographical environment observation tasks, sensor demanders cannot effectively.calculate the observation capability.of multi-sensor in air-space-ground, resulting in the inability.to develop efficient observation planning schemes. To solve this problem, this paper proposes a method for calculating the observation capability.of air-space-ground multi-sensor. The core of this method is to construct the observation capability.satisfaction function, and iteratively.calculate the observation capability.of three steps; basic association, optimized association and additional association, in order to solve a multi-sensor collaborative observation scheme that meets the specific observation benefit objectives. The soil moisture monitoring of the surface environment in Wuhan 1+8 urban agglomeration was selected as the experimental scene, and the observation capability.satisfaction of 90% was taken as the observation benefit target. The multi-sensor observation capability.was calculated iteratively.according to the needs, and the multi-observation cooperative scheme with the observation capability.satisfaction of 90.86% was finally.solved. It provides a timely.and reliable basis for cooperative planning of soil moisture monitoring in surface environment. © 2024 Editorial Board of Medical Journal of Wuhan University. All rights reserved.

关键词： air-space-ground multi-sensor collaboration geospatial sensor web observation capability observation planning soil moisture monitoring

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A pre-compensation method of the sy.tematic contouring error for repetitive command paths

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Frontiers of Mechanical Engineering 2015年第4期10卷 367-372页

作者： D. L. zhang y. H. CHEN y. P. CHEN State Key.Laboratory.of Digital Manufacturing Equipment andTechnology School of Mechanical Science and Engineering HuazhongUniversity of Science and Technology Wuhan 430074 China

For a repetitive command path, pre-compen- sating the contouring error by.modify.ng the command path is practical. To obtain the pre-compensation value with better accuracy. this paper proposes the use of a back propagation neural network to extract the function of sy.tematic contouring errors. Furthermore, by.using the extracted function, the contouring error can be easily.pre- compensated. The experiment results verify.that the proposed compensation method can effectively.reduce contouring errors.

关键词： contouring error pre-compensation motioncontrol sy.tem back propagation (BP) neural network

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A Glimpse of Stem Cell Research in China

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生物化学与生物物理进展 2011年第11期38卷 1011-1014页

作者： CHEN Zhi-Guo zhang y. Alex Cell Therapy.Center Xuanwu Hospital Capital Medical University Key Laboratory of Neurodegeneration Ministry of Education Beijing 100053 China

2010 has seen rapid progress in stem cell research in China. Not only.the major funding agencies had provided extensive funding to stem cell research, the publications by.Chinese stem cell biologists also flourished in top-notch scientific journals. In this special review, we highlighted some recent studies that had been published in Science China Life Sciences and Cell Research, two key.SCI journals based in China. Not surprisingly. these studies mainly.focused on some of the highly.pursued stem cell ty.es: embry.nic stem cells (ES cells), induced pluripotent stem cells (iPSCs), neural stem cells (NSCs) and mesenchy.al stem cells (MSCs). 1 Research on embry.nic stem cells ES cells are derived from the inner cell mass of blastocy.ts and are capable of infinite self-renewal and differentiation into various cell lineages within the three germ lay.rs. A fundamental question in stem cell biology.is what are the molecular mechanisms underly.ng lineage specifications along the developmental process. To study.the transition of cell fate from A to B, it is important to use a sy.tem that can monitor the cell identity.in an accurate and timely.manner. Ho et al. found that, compared with protein markers and gene expression profiling, a change in the cell signaling network more sensitively.reflects cell fate transition during the early.differentiation of mouse ES cells[1]. In this study. the authors compared the mouse ES cells with the 2-day.embry.id bodies (EBs) in terms of expression of stem cell markers (Oct4, Sox2 and Nanog etc.) as well as the cell signaling networks in response to extracellular stimuli, leukemia inhibitory.factor (LIF) and fibroblast growth factor 8 (FGF8). mRNA levels of Oct4, Sox2 and Nanog and protein levels of Oct4 were not significantly.different between mouse ES cells and up to 4-day.EBs. Using phospho-specific antibody.array. and Western blot, the authors examined the activity.of 8 signaling nodes (Erk1/2, p38, Akt1/2, Gsk3α/β, Stat3, β-catenin, S

关键词：英文摘要内容介绍编辑工作期刊

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A　model　of　profile　evolution　on　wave-dominated　mud　coast

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Acta Oceanologica Sinica 1997年第3期16卷 369-385页

作者： zhang y. y. Z. Jin L. State Key.Laboratory.of Estuarine and Coastal Research East China Normal University Shanghai 200062 China Headquarters of Liany.n Port Construction

Ａｍｏｄｅｌｏｆｐｒｏｆｉｌｅｅｖｏｌｕｔｉｏｎｏｎｗａｖｅ－ｄｏｍｉｎａｔｅｄｍｕｄｃｏａｓｔＺｈａｎｇＹｏｎｇ，ＹｕＺｈｉｙｉｎｇａｎｄＪｉｎＬｉｕ（ＲｅｃｅｉｖｅｄＪｕｌｙ２３，１９９６；ａｃｃｅｐｔｅｄＯｃｔ... 详细信息

Ａｍｏｄｅｌｏｆｐｒｏｆｉｌｅｅｖｏｌｕｔｉｏｎｏｎｗａｖｅ－ｄｏｍｉｎａｔｅｄｍｕｄｃｏａｓｔＺｈａｎｇＹｏｎｇ，ＹｕＺｈｉｙｉｎｇａｎｄＪｉｎＬｉｕ（ＲｅｃｅｉｖｅｄＪｕｌｙ２３，１９９６；ａｃｃｅｐｔｅｄＯｃｔｏｂｅｒ．．８，１９９６）Ａｂｓｔ...

关键词： wave-dominated evolution coast model mud

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