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中国民族民间医药 2024年第11期33卷 80-83页

作者：张恒芬谭艳肖瑶琪章薇(指导) 湖南中医药大学第一中医临床学院湖南长沙410007 湖南中医药大学第一附属医院湖南长沙410007

章薇教授认为中风后痉挛偏瘫病机责之阴阳失调,气血不通,在治疗上章教授运用首创的张力平衡针法平衡患侧肢体屈肌与伸肌的肌力,恢复患者肢体正常的肌张力,促进患肢神经功能修复,结合头针整体治疗,同时予以中药、康复训练等综合治疗,为... 详细信息

章薇教授认为中风后痉挛偏瘫病机责之阴阳失调,气血不通,在治疗上章教授运用首创的张力平衡针法平衡患侧肢体屈肌与伸肌的肌力,恢复患者肢体正常的肌张力,促进患肢神经功能修复,结合头针整体治疗,同时予以中药、康复训练等综合治疗,为患者谋求最优疗效,并附以医案佐证。

关键词：中风后痉挛偏瘫针灸章薇张力平衡针法

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Seizures dynamics in a neural field model of cortical-thalamic circuitry

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Science china(Technological Sciences) 2017年第7期60卷 974-984页

作者： zhang HongHui ZHENG YanHong SU JianZhong xiao PengCheng School of Natural and Applied Science Northwestern Polytechnical University college of mathematics and {2. Science Fujian Normal University Department of mathematics the University of Texas at Arlington Department of mathematics University of Evansville

The focus of this study is to explore the mechanisms during seizure behavior using a physiologically motivated by corticothalamic circuity. The model is based on the assumption that, the inhibitory projects from thalamus reticular nucleus(TRN) to specific relay nuclei(SRN) are mediated by GABAA and GABAB receptors which react different time scales in synaptic ***, we include the effects of slow modulation on the threshold current of TRN population that were found to generate bursting behavior. Our model can reproduce healthy and pathological dynamics including wake, spindle, deep sleep, and also seizure states. In addition, contour maps are used to explore the transition of different activity states. It is worthy to point out seizure duration is significantly affected by a time-varying delay as illustrated in our numerical simulation. Finally, a reduced model ignoring the cerebral cortex mass can also capture the feature of spike wave discharge as generated in the full network.

关键词： seizure spike wave neural field modeling corticothalamic

A PUF-Based and Cloud-Assisted Lightweight Authentication for Multi-Hop Body Area Network

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Tsinghua Science and Technology 2021年第1期26卷 36-47页

作者： Wang xiao Tan Jiliang zhang Yuanjing zhang Zheng Qin Yong Ding Xingwei Wang the college of computer Science and Electronic Engineering Hunan UniversityChangsha 410082China Cyberspace Security Research Center Peng Cheng LaboratoryShenzhen 518000China Guangxi Key Laboratory of Cryptography and Information Security Guilin University of Electronic TechnologyGuilin 541004China the college of computer Science and Engineering Northeastern UniversityShenyang 110004China

Wireless sensor technology plays an important role in the military,medical,and commercial fields *** Body Area Network(WBAN)is a special application of the wireless sensor network in human health monitoring,through which patients can know their physical condition in real time and respond to emergencies on *** reliability,guaranteed by the trust of nodes in WBAN,is a prerequisite for the effective treatment of ***,authenticating the sensor nodes and the sink nodes in WBAN is *** paper proposes a lightweight Physical Unclonable Function(PUF)-based and cloud-assisted authentication mechanism for multi-hop body area networks,which compared with the star single-hop network,can enhance the adaptability to human motion and the integrity of data *** authentication mechanism can significantly reduce the storage overhead and resource loss in the data transmission process.

关键词： Physical Unclonable Function(PUF) hardware security Wireless Body Area Network(WBAN)

Peptide nanotube loaded with a STING agonist,c-di-GMP,enhance cancer immunotherapy against melanoma

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Nano Research 2023年第4期16卷 5206-5215页

作者： Ziyuan zhang Juan Liu Min xiao Quanfeng zhang Zhonghua Liu Meiyan Liu Peng zhang Youlin Zeng Key Laboratory of the Assembly and Application of Organic Functional Molecules of hunan Province Hunan Normal UniversityChangsha 410081China Laboratory of Chemical Biology and Traditional Chinese Medicine Research(Ministry of Education of china) Hunan Normal UniversityChangsha 410081China The National&Local Joint Engineering Laboratory of Animal Peptide Drug Development College of Life SciencesHunan Normal UniversityChangsha 410081China

The activation of the stimulating factor of the interferon gene(STING)pathway can enhance the immune response within the *** diguanylate monophosphate(c-di-GMP)is a negatively charged,hydrophilic STING agonist,however,its effectiveness is limited due to the poor membrane permeability and low ***,we introduced KL-7 peptide derived from Aβamyloid fibrils that can self-assemble to form nanotubes to load and deliver c-di-GMP,which significantly enhanced c-di-GMP’s effectiveness and then exhibited a robust“in situ immunity”to kill melanoma ***-7 peptide nanotube,also called PNT,was loaded with negatively charged c-di-GMP via electrostatic interaction,which prepared a nanocomposite named *** of RAW 2.4.7 cells(leukemia cells in mouse macrophage)with c-di-GMP-PNT markedly stimulated the secretion of IL-6 and INF-βalong with phospho-STING(Ser365)protein expression,indicating the activation of the STING *** the unilateral flank B16-F10(murine melanoma cells)tumor-bearing mouse model,compared to PNT and cdi-GMP,c-di-GMP-PNT can promote the expression of INF-β,TNF-α,IL-6,and IL-1β.At the same time,up-regulated CD4 and CD8 active T cells kill tumors and enhance the immune response in tumor tissues,resulting in significant inhibition of tumor growth in tumor-bearing *** importantly,in a bilateral flank B16-F10 tumor model,both primary and distant tumor growth can also be significantly inhibited by ***,c-di-GMP-PNT demonstrated no obvious biological toxicity on the main organs(heart,liver,spleen,lung,and kidney)and biochemical indexes of *** summary,our study provides a strategy to overcome the barriers of free c-di-GMP in the tumor microenvironment and c-di-GMP-PNT may be an attractive nanomaterial for anti-tumor immunity.

关键词： cyclic diguanylate monophosphate stimulating factor of the interferon gene(STING) peptide nanotubes in situ immunity tumor immunotherapy

面向56 Gb/s高速SerDes接收机DSP设计

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计算机工程与科学 2024年第7期46卷 1202-1209页

作者：胡小月王强吕方旭许超龙张锦国防科技大学计算机学院湖南长沙410073 长沙理工大学计算机与通信工程学院湖南长沙410004

高速接口芯片是高性能互连网络通信中的一款重要IP,针对56 Gb/s四脉冲幅度调制信号在高性能互连网络背板通信中,由于传输距离长信道衰减严重导致误码率高的问题,提出一种面向56 Gb/s高速Serdes接收机DSP设计。该DSP采用64路并行结构,通... 详细信息

高速接口芯片是高性能互连网络通信中的一款重要IP,针对56 Gb/s四脉冲幅度调制信号在高性能互连网络背板通信中,由于传输距离长信道衰减严重导致误码率高的问题,提出一种面向56 Gb/s高速Serdes接收机DSP设计。该DSP采用64路并行结构,通过16抽头前向反馈均衡器,以及1抽头预判决反馈均衡器对接收端数字化后的信号进行处理;采用基于K-均值聚类算法生成动态变化的判决电平并结合最小均方误差算法,能够处理15~35 dB不同信道衰减下的均衡问题。为了验证算法的性能,还搭建了一个基于模拟前端芯片和现场可编程门阵列的实验验证平台。实验结果表明,在信道衰减为15~35 dB@14 GHz,速率为56 Gb/s的条件下,误码率均小于5e-10。

关键词： K-均值算法前向反馈均衡预判决反馈均衡自适应均衡

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance {2. Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH university of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing normal university Beijing Brown university ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china normal {2. WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced Science and Technology Beijing china Institute of Atomic Energy Beijing china Jiliang university HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china university of Geosciences Beijing china university of Geosciences WuhanHubei china university of Mining and Technology XuzhouJiangsu china West normal {2. NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu university DalianLiaoning Dalian university of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East china university Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2.s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2.1.)and the Conceptual Design Report(CDR,2.1.),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2.2.-2.2.,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2.30s.

关键词： initiated exceeding precise

Energy-Aware Scheduling with Uncertain Execution Time for Real-Time Systems

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Chinese Journal of Electronics 2017年第1期26卷 42-49页

作者： zhang Longxin TONG Zhao ZHU Ningbo xiao Zheng LI Kenli college of computer and Communication Hunan University of Technology college of computer Science and Electronic Engineering Hunan University college of Mathematic and computer Science Hunan Normal University

Energy-saving is extraordinary important for real-time systems. Dynamic voltage scaling(DVS) is an important technique to reduce the energy consumption of processors that support voltage scaling. It has been exploited extensively in task scheduling. However, many approaches take simple treatments and some of them even neglect the large voltage transition overheads. Although some strategies consider the penalty, frequency switching produces extra large time overhead and deadline misses occur frequently. In our paper, we propose an energy efficient soft real-time dynamic program scheme by using quantitative switching overhead and communication penalty for multitask scheduling with uncertain execution time. The experiments show that our approaches significantly outperform existing solutions both on simple-core and multi-core systems in terms of energy-saving.

关键词： Dynamic voltage scaling(DVS) Energy minimization Real-time Task scheduling

低鱼粉高脂饲料添加大豆卵磷脂对黄鳝生长、血清生化指标及肠道菌群的影响

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水生生物学报 2024年第3期48卷 361-371页

作者：汤哲林东晓蔡明浪张俊智朱波石勇钟蕾胡毅湖南农业大学水产学院长沙410128

试验旨在研究低鱼粉高脂饲料中添加大豆卵磷脂对黄鳝(Monopterusalbus)生长、血清生化指标及肠道菌群的影响,为降低黄鳝鱼粉使用量提供依据。以初始体重(2..03±0.01)g黄鳝为研究对象,以含有42.鱼粉、2.%豆粕、6%粗脂肪的饲料为正常鱼粉... 详细信息

试验旨在研究低鱼粉高脂饲料中添加大豆卵磷脂对黄鳝(Monopterusalbus)生长、血清生化指标及肠道菌群的影响,为降低黄鳝鱼粉使用量提供依据。以初始体重(2..03±0.01)g黄鳝为研究对象,以含有42.鱼粉、2.%豆粕、6%粗脂肪的饲料为正常鱼粉组,另以含有2.%鱼粉、52.豆粕和9%粗脂肪的饲料为低鱼粉高脂组,分别在低鱼粉高脂组中添加1%和2.的大豆卵磷脂,进行为期56d的养殖试验,于室外池塘进行网箱养殖,日投喂1次,喂量为黄鳝体重3%—5%。结果表明:(1)与对照组相比,低鱼粉高脂组黄鳝增重率显著降低(P2.大豆卵磷脂后黄鳝增重率显著提高(P2.对比正常鱼粉组,低鱼粉高脂饲料组黄鳝血清甘油三酯、总胆固醇、高密度脂蛋白、低密度脂蛋白、血氨、尿素氮、谷草转氨酶、谷丙转氨酶、酸性磷酸酶与免疫球蛋白M含量显著增加(P2.大豆卵磷脂使黄鳝血清的高密度脂蛋白含量与碱性磷酸酶活性显著增加(P2.大豆卵磷脂后黄鳝后肠绒毛高度与杯状细胞数目上升;(4)与对照组相比,低鱼粉高脂组不动杆菌属与考克氏菌属相对丰度上升,而与低鱼粉高脂组相比,添加2.大豆磷脂后黄鳝肠道群落的丰富度与多样性显著增加(P2.大豆卵磷脂可促进脂肪代谢和提高机体免疫性能,并修复肠道组织结构与维持菌群稳态,进而缓解低鱼粉高脂饲料对黄鳝生长的负面影响。

关键词：低鱼粉高脂饲料大豆卵磷脂血清生化指标肠道菌群黄鳝

Achievements and challenges of primate conservation in china

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Zoological Research(Diversity and Conservation) 2024年第1期1卷 66-74页

作者： Bao-Guo Li He zhang Ming Li Xue-Long Jiang Peng-Fei Fan Jiang Zhou Song-Tao Guo xiao-Guang Qi Jin-Hua Li Ji-Qi Lu Dong-Po Xia Liang-Wei Cui Zuo-Fu Xiang Qi-Hai Zhou Zhi-Pang Huang Cheng-Ming Huang Wen xiao Hui-Jian Hu Zhi-Xin Zhou Ming-Yong Chen Da-Yong Li Peng-Lai Fan Yin Yang Ru-Liang Pan Shaanxi Key Laboratory for Animal Conservation College of Life SciencesNorthwest UniversityXi’anShaanxi 710069China Jiangxi Provincial Key Laboratory of Conservation Biology College of ForestryJiangxi Agricultural UniversityNanchangJiangxi 330045China Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650201China School of Life Sciences Sun Yat-sen UniversityGuangzhouGuangdong 510275China School of Karst Science Guizhou Normal UniversityGuiyangGuizhou 550025China International Collaborative Research Center for Huangshan Biodiversity and Tibetan Macaque Behavioral Ecology Anhui UniversityHefeiAnhui 230601China Institute of Biodiversity and Ecology Zhengzhou UniversityZhengzhouHenan 450001China Key Laboratory for Conserving Wildlife with Small Populations in Yunnan Southwest Forestry UniversityKunmingYunnan 650224China college of Life Sciences and Technology Central South University of Forestry and TechnologyChangshaHunan 410004China Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection(Ministry of Education) Guangxi Normal UniversityGuilinGuangxi 541004China International Centre of Biodiversity and Primate Conservation Centre Dali UniversityDaliYunnan 671003China Guangdong Key Laboratory of Animal Conservation and Resource Utilization Institute of ZoologyGuangdong Academy of SciencesGuangzhouGuangdong 510663China School of Life Sciences Yunnan UniversityKunmingYunnan 650500China Key Laboratory of Southwest china Wildlife Resources Conservation(Ministry of Education) China West Normal UniversityNanchongSichuan 637001China Institute of International Rivers and Eco-security Yunnan UniversityKunmingYunnan 650500China School of Human Sciences The University of Western AustraliaPerthWA 6009Australia

The dual impact of climate change and human activities has precipitated a sharp decline in primate biodiversity *** is home to the most diverse primate species in the Northern hemisphere,which face severe ecological threats due to the expansion of modern agriculture,extensive exploitation and consumption of natural resources,and excessive land development during its transition from an agricultural to a modern *** response,china has implemented various ecological conservation measures,including habitat restoration and *** efforts have made substantial strides in biodiversity conservation,with certain regions witnessing an increase in primate *** the current study,we conducted a systematic review of historical documents and field research data related to Chinese primates,evaluating the endangered status of primate species in *** improvements in the habitats of most primate species and some population growth,many species still face severe threats,including declining and small *** such as the Myanmar snub-nosed monkey(Rhinopithecus strykeri),eastern black crested gibbon(Nomascus nasutus),and Hainan gibbon(***)remain particularly vulnerable due to their limited distribution ranges and extremely small *** scientific data,fragmented information,and not enough studies in conservation biology further compound the ***,there is a notable lack of detailed population monitoring data for species such as the Bengal slow loris(Nycticebus bengalensis),pygmy slow loris(***),Indochinese gray langur(Trachypithecus crepusculus),Shortridge’s langur(***),and capped langur(***),which hinders the development of practical and targeted conservation management ***,for national biodiversity conservation,there is an urgent need for specialized primate surveys,enhancing habitat protection and restoration,and increasing focus on cross-border conse

关键词： Primates Biodiversity Habitat fragmentation Habitat restoration Conservation strategies