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Simulation of Precipitation in Monsoon Regions of China by CMIP3 Models

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Atmospheric and Oceanic Science Letters 2009年第4期2卷 194-200页

作者： TU Kai YAN Zhong-Wei zhang xue-bin DONG Wen-Jie RCE-TEA Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China Graduate Univers ty of the Chinese Academy of Sciences Beijing 100049 China Climate Data and Analysis Section Environment Canada Toronto Ontario Canada State Key Laboratory for Earth Surface Process and Resource Ecology Beijing Normal University Beijing 100875 China

The output of 25 models used in the Coupled Model Intercomparison Project phase 3 (CMIP3) were evaluated,with a focus on summer precipitation in eastern China for the last 40 years of the 20th *** mod-els failed to reproduce rainfall associated with the East Asian summer monsoon (EASM),and hence the seasonal cycle in eastern China,but provided reasonable results in Southwest (SW) and Northeast China (NE).The simula-tions produced reasonable results for the Yangtze-Huai (YH) Basin area,although the Meiyu phenomenon was underestimated in *** typical regional phe-nomenon,a seasonal northward shift in the rain belt from early to late summer,was completely missed by most *** long-term climate trends in rainfall over eastern China were largely underestimated,and the ob-served geographical pattern of rainfall changes was not reproduced by most *** extremes were evaluated via parameters of fitted GEV (Generalized Ex-treme Values) *** annual extremes were grossly underestimated in the monsoon-dominated YH and SW regions,but reasonable values were calculated for the North China (NC) and NE *** results suggest a general failure to capture the dynamics of the EASM in current coupled climate ***,models with higher resolution tend to reproduce larger decadal trends and annual extremes of precipitation in the regions studied.

关键词： precipitation East Asian Monsoon IPCC AR4 coupled models generalized extreme values

Pretreatment with interleukin-33 reduces warm hepatic ischemia/ reperfusion injury in mice

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Chinese Medical Journal 2013年第10期126卷 1855-1859页

作者： LI Shu ZHU Feng-xue zhang Hong-bin LI Hui AN You-zhong Department of Critical Care Medicine Peking University People'sHospital Beijing 100044 China

Background Interleukin （IL）-33 is a recently identified member of the IL-1 family that binds to the receptor, ST2L. This study examined IL-33 production in mouse liver and investigated its role in hepatic ischemia/reperfusion （I/R） injury. Methods Male BALB/c mice （（22＋3） g） were subjected to 90 minutes partial hepatic ischemia, followed by 6 hours reperfusion. First, mice were randomized into two groups： control group （laparotomy only, without blocking blood supply） and ischemia model group. IL-33 mRNA and serum protein levels were measured at 30, 60, 90 minutes after ischemia and 2 and 6 hours after reperfusion. Second, mice were randomized into four groups： control, model （injection of rabbit IgG polyclonal antibody）, recombinant IL-33 intervention and anti-ST2L antibody intervention group. Mice were sacrificed 6 hours after reperfusion. Liver pathology was observed via transmission electron microscopy. Serum aspartate aminotransferase （AST）, alanine aminotransferase （ALT）, IL-4, IL-5, IL-13, interferon-y （IFN-y） and tumor necrosis factor-a （TNF-a） levels were measured. Results Levels of IL-33 mRNA and protein did not change during ischemia （P 〉0.05） but increased significantly during reperfusion （P 〈0.05）. After reperfusion for 6 hours, serum levels of ALT, AST, IL-4, IL-5, IL-13, IFN-~ and TNF-a were significantly increased （P 〈0.05）, and hepatocellular ultrastructure was damaged. Pretreatment with IL-33 attenuated severity of liver damage compared with controls, but pretreatment with anti-ST2L antibody increased severity. Serum levels of IL-4, IL-5 and IL-13 protein increased whereas IFN-y decreased following IL-33 pretreatment. Pretreatment with anti-ST2L antibody significantly decreased serum IL-4, IL-5, IL-13 levels and increased serum IFN-r levels compared with controls （P 〈0.05）. There was no change in the level of TNF-a. Conclusion IL-33 is produced systematically and locally in liver during I/R injury. Pretreatment with IL-33 is therapeutic for hepatic

关键词： liver ischemia/reperfusion T helper lymphocyte,interleukin-33

A novel deletion-frameshift mutation in the S1 region of HERG gene in a Chinese family with long QT syndrome

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Chinese Medical Journal 2013年第16期126卷 3093-3096页

作者： GAO Ying zhang Ping LI xue-bin WU Cun-cao GUO Ji-hong Department of Cardiac Electrophysiology People's Hospital PekingUniversity Beijing 100044 China

Background The congenital Long QT syndrome （LQTS） is a hereditary cardiac channelopathy that is characterized by a prolonged QT interval,syncope,ventricular arrhythmias,and sudden *** chromosome 7-linked type 2 congenital LQTS （LQT2） is caused by gene mutations in the human ether-a-go-go-related gene （HERG）.Methods A Chinese family diagnosed with LQTS were screened for KCNQ1,HERG and SCN5A,using polymerase chain reaction （PCR）,direct sequencing,and clong *** also investigated the mRNA expression of the HERG *** We identified a novel i414fs＋98X mutation in the HERG *** deletion mutation of 14-bp in the first transmembrane segment （S1） introduced premature termination codons （PTCs） at the end of exon *** mutation would result in a serious phenotype if the truncated proteins co-assembled with normal subunit to form the defective *** only the proband was *** We found that the mRNA level of the HERG gene was significantly lower in 1414fs＋98X carriers than in *** found a novel 1414fs＋98X *** mRNA level supports that NMD mechanism might regulate the novel mutation.

关键词： deletion mutation HERG inherited arrhythmia Long QT syndrome nonsense mediated decay

Hourglass Control in Dynamic Explicit Simulation of Cold Ring Rolling Process

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Computer Aided Drafting,Design and Manufacturing 2007年第2期17卷 37-42页

作者： zhang xue-bin LI Zhi-gang LIU Yu-qi State Key Laboratory of Material Processes and Die ＆ Mould Technology Huazhong University of Science and Technology Wuhan 430074 China

Hourglass is remarkably aroused in ring rolling simulation with reduced integration element because of violent ring vibration and small contact area of ring with forming rollers. Hourglass energy can be reduced by improving mesh density. Combined approach of artificial damping and artificial stiffness can control the hourglass. A ring with rectangular section is simulated with the weight factor of artificial stiffness resistance set to 0.2. The artificial damping hourglass control coefficient is set to 0.1, and the artificial stiffness hourglass control coefficient is set to 0.001. The ratio of hourglass energy to internal energy is reduced to 2.5 percent. Compared with axial spread width test, the effectiveness of hourglass control in ring rolling simulation is verified.

关键词： hourglass control finite element cold ring rolling combined method

Analysis of Chinese Medical Syndrome Features of Ischemic Stroke Based on Similarity of Symptoms Subgroup

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Chinese Journal of Integrative Medicine 2023年第5期29卷 441-447页

作者： LIU Xiao-qing zhang Run-shun ZHOU xue-zhong ZHOU Hong HE Yu-yao HAN Shu zhang Jing SHU Zi-xin zhang xue-bin JI Jing-hui ZHONG Quan zhang Li-li MOU Zi-jun HE Li-yun zhang Lun-zhong YANG Jie HU Yan-jie CHEN Zheng-guang LI Xiao-zhen TAN Yan YAN Zhan-feng CAO Ke-gang MENG Wei ZHAO He zhang Wei ZHONG Li-qun Department of Neurology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing(100700)China Department of Gastroenterology Guanganmen HospitalChina Academy of Chinese Medical SciencesBeijing(100053)China School of Computer and Information Technology and Beijing Key Lab of Traffic Data Analysis and Mining Beijing Jiaotong UniversityBeijing(100044)China Department of Neurology Weifang Hospital of Traditional Chinese MedicineWeifangShandong Province(261041)China Beijing Zhong Teng Bai Mai Medical Technology Co.Ltd. Beijing(100027)China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing(100700)China Department of Radiology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing(100700)China School of Life Sciences Beijing University of Chinese MedicineBeijing(100029)China Department of Otolaryngology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing(100029)China Department of Psychiatry Massachusetts General HospitalHarvard Medical SchoolBoston(MA 02115)United States

Objective: To derive the Chinese medicine(CM) syndrome classification and subgroup syndrome characteristics of ischemic stroke patients. Methods: By extracting the CM clinical electronic medical records(EMRs) of 7,170 hospitalized patients with ischemic stroke from 2016 to 2018 at Weifang Hospital of Traditional Chinese Medicine, Shandong Province, China, a patient similarity network(PSN) was constructed based on the symptomatic phenotype of the patients. Thereafter the efficient community detection method BGLL was used to identify subgroups of patients. Finally, subgroups with a large number of cases were selected to analyze the specific manifestations of clinical symptoms and CM syndromes in each subgroup. Results: Seven main subgroups of patients with specific symptom characteristics were identified, including M3, M2, M1, M5, M0, M29and M4. M3 and M0 subgroups had prominent posterior circulatory symptoms, while M3 was associated with autonomic disorders, and M4 manifested as anxiety;M2 and M4 had motor and motor coordination disorders;M1 had sensory disorders;M5 had more obvious lung infections;M29 had a disorder of consciousness. The specificity of CM syndromes of each subgroup was as follows. M3, M2, M1, M0, M29 and M4 all had the same syndrome as wind phlegm pattern;M3 and M0 both showed hyperactivity of Gan(Liver) yang pattern;M2 and M29 had similar syndromes, which corresponded to intertwined phlegm and blood stasis pattern and phlegm-stasis obstructing meridians pattern, respectively. The manifestations of CM syndromes often appeared in a combination of 2 or more syndrome elements. The most common combination of these 7 subgroups was wind-phlegm. The 7 subgroups of CM syndrome elements were specifically manifested as pathogenic wind, pathogenic phlegm,and deficiency pathogens. Conclusions: There were 7 main symptom similarity-based subgroups in ischemic stroke patients, and their specific characteristics were obvious. The main syndromes were wind phlegm pat

关键词： ischemic stroke patient similarity network subgroup syndrome Chinese medicine

Wall Imaging for Unilateral Intracranial Vertebral Artery Hypoplasia with Three-dimensional High-isotropic Resolution Magnetic Resonance Images

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Chinese Medical Journal 2015年第12期128卷 1601-1606页

作者： Xian-Jin Zhu Wu Wang bin DU Lei Liu Xin-Xin He Li-bin Hu xue-bin zhang Zun-Jing Liu Wei-Jian Jiang Department of Radiology China-Japan Friendship Hospital Beijing 100029 China New Era Stroke Care and Research Institute The Second Artillery General Hospital of PLA Beijing 100088 China Department of Neurology China-Japan Friendship Hospital Beijing 100029 China International Medicine Center China-Japan Friendship Hospital Beijing 100029 China

Background：There are few studies for evaluating wall characteristics of intracranial vertebral artery hypoplasia （VAH）.The aim of this study was to determine wall characteristics of VAH with three-dimensional volumetric isotropic turbo spin echo acquisition （3D VISTA） images and differentiate between acquired atherosclerotic stenosis and ***：Thirty patients with suspicious VAH by luminograms were retrospectively enrolled between January 2014 and February *** patients were classified as ＂acquired atherosclerotic stenosis＂ or ＂VAH＂ based on 3D VISTA *** wall characteristics of VAH were assessed to determine the presence of atherosclerotic lesions,and the patients were classified into two subgroups （VAH with atherosclerosis and VAH with normal wall）.Wall characteristics of basilar arteries and vertebral arteries were also *** clinical and wall characteristics were compared between the two ***：Five of 30 patients with suspicious VAH were finally diagnosed as acquired atherosclerotic stenosis by 3D VISTA images.25 patients were finally diagnosed as VAH including 16 （64.00%） patients with atherosclerosis and 9 （36.00%） patients with normal *** the 16 patients with atherosclerosis,plaque was found in 9 patients,slight wall thickening in 6 patients,and thrombus and wall thickening in 1 *** with VAH patients with normal wall,VAH patients with atherosclerosis showed atherosclerotic basilar arteries and dominant vertebral arteries more frequently （P =0.000）.Conclusions：Three-dimensional VISTA images enable differentiation between the acquired atherosclerotic stenosis and *** was also prone to atherosclerotic processes.

关键词： Atherosclerosis High Resolution Magnetic Resonance Images Vertebral Artery Hypoplasia

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一种基于共享执行策略的间隔查询优化技术

软件学报 2016年第12期27卷 3067-3084页

作者：周新张孝薛忠斌王珊数据工程与知识工程教育部重点实验室(中国人民大学) 北京100872 中国人民大学信息学院北京100872 神华国华(北京)电力研究院有限公司北京100069

间隔查询作为重要的查询类型,广泛应用在社交网络、信息检索和数据库领域.为了支持高效的间隔查询,涌现出多种优化技术.尽管已有方法能够快速响应单个间隔查询,然而当查询负载超过服务器的处理能力时,70%的查询均不能在期望时间内得到响... 详细信息

间隔查询作为重要的查询类型,广泛应用在社交网络、信息检索和数据库领域.为了支持高效的间隔查询,涌现出多种优化技术.尽管已有方法能够快速响应单个间隔查询,然而当查询负载超过服务器的处理能力时,70%的查询均不能在期望时间内得到响应.针对这一问题,提出采用共享执行策略优化间隔查询的方法 SESIQ(shared execution strategy for interval queries).SESIQ对间隔查询进行批处理,分析一组间隔查询间可共享的操作,减少重复数据的访问,从而降低磁盘I/O和网络传输代价,提高检索性能.理论分析并实验验证了SESIQ的可行性,基于两种真实数据集的大量实验结果表明,SESIQ是有效的,间隔查询的检索性能可提升数十倍.

关键词：间隔查询优化共享执行

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CT导引在胰腺和法特壶腹区活检中的应用

中华医学杂志 2006年第4期86卷 218-222页

作者：张雪哲黄振国张学滨卫生部中日友好医院影像中心放射科北京100029

目的评估CT导引细针穿刺在胰腺和法特（Vater）壶腹区活检中的临床应用价值。方法回顾性研究中日友好医院自1985年8月至2004年12月CT导引细针穿刺胰腺和法特壶腹区106例，男71例，女35例，年龄21～74岁，平均48．7岁。患者就诊症状多为... 详细信息

目的评估CT导引细针穿刺在胰腺和法特（Vater）壶腹区活检中的临床应用价值。方法回顾性研究中日友好医院自1985年8月至2004年12月CT导引细针穿刺胰腺和法特壶腹区106例，男71例，女35例，年龄21～74岁，平均48．7岁。患者就诊症状多为腹部不适、腹痛、消瘦乏力，部分有不同程度的皮肤黄染和上腹部包块。术前均作CT平扫和增强扫描，均采用前入路进针。穿刺活检部位分布为胰头壶腹区70例，胰体24例，胰尾12例。病灶大小1．5～5em；〈3em32例，≥3cm74例。使用22G（84例）和20G（22例）细针穿刺。穿刺活检要点为选择最佳层面和进针点，作多点扇状快速穿刺抽吸。活检标本送病理科作细胞病理学检查。结果106例均安全地穿刺到病变内，活检刺中率为100％。穿刺活检诊断为恶性病变78例，良性18例，真阴性3例，假阴性7例。穿刺活检总正确率、敏感性和特异性分别为93％、93％和100％。CT导引活检对恶性、良性病变的正确率为94％和90％（P〉0．05）。较大肿块病灶[〈3cm28／32（88％），≥3．0cm 71／74（96％）]和病变位于胰尾（胰尾100％，胰头壶腹区93％，胰体92％）的正确率稍高，经统计学检验正确率差异没有统计学意义（P〉0．05），未发现严重的并发症。结论CT导引经皮细针穿刺胰腺和壶腹区活检是一种安全的有效的并发症发生率低的诊断和鉴别诊断方法。

关键词：胰腺肿瘤放射学,介入性活组织检查,针吸法特氏壶腹

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钻式采煤机工作原理与截齿设计

煤矿机械 2012年第12期33卷 19-20页

作者：张学斌王家岭煤业有限公司山西保德036604

钻式采煤机是一种用于薄与极薄煤层的开采设备,钻式采煤机不仅能够提高煤炭的开采、回收效率,而且能够有效预防瓦斯突出,实现工作面无人化,有广阔的发展前景。介绍了钻式采煤机的工作原理,并阐述了截齿的设计过程和方法,为钻式采煤机的... 详细信息

钻式采煤机是一种用于薄与极薄煤层的开采设备,钻式采煤机不仅能够提高煤炭的开采、回收效率,而且能够有效预防瓦斯突出,实现工作面无人化,有广阔的发展前景。介绍了钻式采煤机的工作原理,并阐述了截齿的设计过程和方法,为钻式采煤机的设计提供了一定的帮助。

关键词：钻式采煤机钻头截齿