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基于网络药理学和实验验证探讨感咳颗粒干预急性肺损伤的作用机制

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中国中药杂志 2024年第8期49卷 2197-2209页

作者：梁桓李香妤张雄伟包懿文丁美灵袁强华何成诗曾南西南特色中药资源国家重点实验室四川成都611137 成都中医药大学药学院四川成都611137 成都中医药大学附属医院四川成都610075

依据感咳颗粒在大鼠体内的入血成分研究基础,结合网络药理学、分子对接和动物实验验证探究感咳颗粒干预急性肺损伤(acute lung injury,ALI)的潜在作用机制。将感咳颗粒的大鼠入血成分导入SwissTargetPrediction平台预测药物靶点,从疾病... 详细信息

依据感咳颗粒在大鼠体内的入血成分研究基础,结合网络药理学、分子对接和动物实验验证探究感咳颗粒干预急性肺损伤(acute lung injury,ALI)的潜在作用机制。将感咳颗粒的大鼠入血成分导入SwissTargetPrediction平台预测药物靶点,从疾病数据库收集ALI相关靶点,取交集并构建蛋白-蛋白互作(protein-protein interaction,PPI)网络筛选核心靶点,随后进行基因本体(Gene Ontology,GO)功能和京都基因和基因组百科全书(Kyoto Encyclopedia of Genes and Gnomes,KEGG)通路富集分析。构建“入血成分-靶点-通路-疾病”网络,根据其拓扑参数筛选感咳颗粒干预疾病的核心成分。借助分子对接预测核心成分与关键靶点的结合能力。通过脂多糖(lipopolysaccharide,LPS)诱导的ALI小鼠模型验证感咳颗粒干预急性肺损伤的关键靶点。PPI拓扑参数分析得到与ALI有关的STAT3、SRC、HSP90AA1、MAPK3、HRAS、MAPK1前6个关键靶点。GO功能分析可知主要与ERK1和ERK2级联、炎症反应、对脂多糖反应等有关;KEGG分析结果显示,主要富集通路显示为MAPK、中性粒细胞胞外诱捕网(neutrophil extracellular trap,NET)形成等。根据“入血成分-靶点-通路-疾病”网络拓扑参数分析筛选出前6个核心成分(五味子酯乙、五味子醇甲、五味子醇乙、哈巴俄苷、异鸢尾黄素、颈花胺)。分子对接结果显示6个核心成分和该颗粒含量最高的射干苷与MAPK3、SRC、MAPK1、STAT3关键靶点具有较高的亲和力。体内实验结果表明,与模型组相比,感咳颗粒能有效缓解LPS诱导的小鼠肺组织病理损伤,抑制炎性浸润,降低支气管肺泡灌洗液(bronchoalveolar lavage fluid,BALF)中总蛋白含量、一氧化氮(nitric oxide,NO)与髓过氧化物酶(myeloperoxidase,MPO)水平,以及肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、干扰素γ(interferon-γ,IFN-γ)、白细胞介素(interleukin,IL)-1β、IL-6、血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)以及趋化因子(C-X-C基序)配体1[chemokine(C-X-C motif)ligand 1,CXCL1]含量,显著下调肺组织中淋巴细胞抗原6G(lymphocyte antigen 6G,Ly6G)、瓜氨酸化组蛋白3(citrullinated histones 3,Cit-H3)表达水平及SRC、ERK1/2、STAT3磷酸化蛋白表达水平。综上,感咳颗粒可有效抑制LPS诱导的急性肺损伤炎症反应,保护肺组织,调节炎性因子释放,抑制中性粒细胞浸润及NET形成,作用机制可能与抑制SRC/ERK1/2/STAT3信号通路激活有关。

关键词：感咳颗粒急性肺损伤入血成分网络药理学炎症反应中性粒细胞胞外诱捕网 SRC/ERK1/2/STAT3

Three-dimensional porous V2O5 hierarchical octahedrons with adjustable pore architectures for long-life lithium batteries

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Nano Research 2015年第2期8卷 481-490页

作者： Qinyou An Pengfei zhang Fangyu xiong Qiulong wei Jinzhi Sheng Qinqin Wang Liqiang Mai State Key Laboratory of Advanced Technology for Materials Synthesis and Processing WUT-Harvard Joint Nano Key LaboratoryWuhan University of Technology Wuhan Hubei 430070 China

Three-dimensional （3D） porous V2O5 octahedrons have been successfully fabricated via a solid-state conversion process of freshly prepared ammonium vanadium oxide （AVO） octahedrons. The formation of AVO octahedrons is a result of the selective adsorption of capping reagents and the favourable supersaturation of growth species. Subsequently, 3D porous V2O5 octahedrons were obtained by simple thermolysis of the AVO octahedrons via a calcination treatment. As cathode material for lithium batteries, the porous V2O5 octahedron cathode exhibits a capacity of 96 mAh·g^-1 at high rate up to 2 A·g^-1 in the rang of 2.4 4 V and excellent cyclability with little capacity loss after 500 cycles, which can be ascribed to its high specific surface area and tunable pore architecture. Importantly, this facile solid-state thermal conversion strategy can be easily extended to controllably fabricate other porous metal oxide micro/nano materials with specific surface textures and morphologies.

关键词： V2O5 octahedron adjustable pore long-life lithium battery

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基于响应面法的泵站导流墩开孔参数优化

中国农村水利水电 2024年第2期 115-120,128页

作者：陈叶欣奚斌陈志刚沈世煊陈伟邹燕张雄伟王欣昱徐健扬州大学水利科学与工程学院江苏扬州225009 江苏省江都水利工程管理处江苏扬州225200 金湖县河湖管理所江苏淮安211600

针对扩建泵站工程进水建筑物内存在的偏流、漩涡等不良流态,工程往往采取布置导流墩的方法来优化流态,但其结构参数通常根据经验进行调整,难以达到最优效果。为了确定导流墩开孔的最佳结构参数,研究将导流墩的开孔长度、宽度、高度和间... 详细信息

针对扩建泵站工程进水建筑物内存在的偏流、漩涡等不良流态,工程往往采取布置导流墩的方法来优化流态,但其结构参数通常根据经验进行调整,难以达到最优效果。为了确定导流墩开孔的最佳结构参数,研究将导流墩的开孔长度、宽度、高度和间距作为设计变量,基于中心组合设计法进行试验方案设计,以轴向流速均匀度作为评价指标,构建响应面模型进行优化分析,确定了导流墩开孔的最佳参数组合。在最佳参数组合下进行数值模拟,发现实际值与响应面模型预测值误差仅为0.33%,轴向流速均匀度相较于原方案提升了11.17%,显著改善了前池流态。研究结果表明建立的响应面模型能够反应评价指标和设计变量的关系,并且可以将该方法应用到整流措施的结构参数优化中。

关键词：扩建泵站优化导流墩响应面法数值模拟

Structural phase transition in a new organic-inorganic hybrid post-perovskite:(N,N-dimethylpyrrolidinium)[Mn(N(CN)_(2))_(3)]

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Chinese Journal of Structural Chemistry 2024年第6期43卷 40-44页

作者： Le Ye wei-xiong zhang MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of ChemistryIGCMESun Yat-Sen UniversityGuangzhou510275China

In the realm of molecular phase transition research,particularly for applications in sensors,data storage and switching technologies,the role of organic-inorganic hybrid perovskite materials has been increasingly recognized for their significant ***,hybrid post-perovskites,as a critical subclass of perovskites,have not been thoroughly studied and mainly limit in the instances based on polyatomic bridging agents like dicyanamide(dca^(-))and non-cyclic organic ***,a polar cyclic quaternary ammonium cation,N,N-dimethylpyrrolidinium(DMP^(+)),was used to assemble a new hybrid post-perovskite,(DMP)[Mn(dca)_(3)](1),which undergoes a phase transition from orthorhombic Bmmb to monoclinic P2_(1)/n space group at 249 *** employing multiple techniques such as differential scanning calorimetry,variable-temperature single-crystal X-ray analysis,dielectric measurements,and Hirshfeld surface analysis,we disclosed the role of polar cyclic quaternary ammonium DMP^(+)in elevating the phase-transition temperature by 48 K,generating significant dielectric switching effect and facilitating interlayer sliding of inorganic framework.

关键词： Structural phase transitions Dielectric switching Organic-inorganic hybrid crystals Post-perovskites

Recent progress on the functionalization of white phosphorus in China

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National Science Review 2024年第6期11卷 308-320页

作者： Xinlei Huangfu Zhongzhen Wang Yu Chen Junnian wei wei Liu Wen-xiong zhang Beijing National Laboratory for Molecular Sciences(BNLMS) State Key Laboratory of Rare-Earth Materials Chemistry and Applications & Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of Chemistry and Molecular Engineering Peking University

Direct synthesis of organophosphorus compounds from white phosphorus represents a significant but challenging subject, especially in the context of ongoing efforts to comprehensively improve the phosphorus-derived chemical industry driven by sustainability and safety concerns. China is the world's largest producer of white phosphorus, creating a significant demand for the green transformation of this crucial feedstock. This review provides an overview of advancements in white phosphorus activation by Chinese research teams, focusing on the direct construction of P–C/N/O/S/M bonds from white phosphorus. Additionally, we offer some insights into prospective directions for the activation and transformation of white phosphorus in the future. This review paper aims to attract more researchers to engage in this area, stimulating follow-up exploration and fostering enduring advances.

关键词： white phosphorus organophosphorus compound activation selectivity efficiency

Theoretical understanding of correlation between magnetic phase transition and the superconducting dome in high-Tc cuprates

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 167-173页

作者： Chen zhang Cai-Xin zhang Su-Huai wei Haiqing Lin Hui-xiong Deng State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Beijing Computational Science Research Center Beijing 100193China

Many issues concerning the origin of high-temperature superconductivity(HTS)are still under *** example,how the magnetic order varies with doping and its relationship with the superconducting temperature(Tc);and why Tcalways peaks near the quantum critical *** this paper,taking hole-doped La_(2)CuO_(4)as a classical example,we employ the first-principles band structure and total energy calculations with Monte Carlo simulations to explore how the symmetry-breaking magnetic ground state evolves with hole doping and the origin of a dome-shaped superconductivity region in the phase *** demonstrate that the local antiferromagnetic order and doping play key roles in determining the electron-phonon coupling,thus ***,the La_(2)CuO_(4)possesses a checkerboard local antiferromagnetic ground *** the hole doping increases,Tcincreases with the enhanced electron-phonon coupling *** as the doping increases further,the strength of the antiferromagnetic interaction weakens and spin fluctuation *** the critical doping level,a magnetic phase transition occurs that reduces the local antiferromagnetism-assisted electron-phonon coupling,thus diminishing the *** superconductivity disappears in the heavily overdoped region when the ferromagnetic order *** observations could account for why cuprates have a dome-shaped superconductivity region in the phase *** study,thus,contributes to a fundamental understanding of the correlation between doping,local magnetic order,and superconductivity of HTS.

关键词： high-temperature superconductivity antiferromagnetic order electron-phonon coupling doping effect cuprates

Study of a new fast adaptive filtering algorithm

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Frontiers of Electrical and Electronic Engineering in China 2006年第3期1卷 334-339页

作者： WANG Zhen-li zhang xiong-wei YANG Ji-bin CHEN Gong Institute of Communications Engineering People’s Liberation Army University of Science and TechnologyNanjing 210007China

A new fast adaptive filtering algorithm was presented by using the correlations between the signal’s former and latter sampling *** proof of the new al-gorithm was also presented,which showed that its optimal weight vector was the solution of generalized Wiener *** new algorithm was of simple structure,fast con-vergence,and less stable *** can handle many signals including both uncorrelated signal and strong corre-lation ***,its computational complexity was comparable to that of the normalized least-mean-square(NLMS)*** results show that for uncor-related signals,the stable maladjustment of the proposed algorithm is less than that of the VS-NLMS algorithm,and its convergence is comparable to that of the algorithm pro-posed in references but faster than that of L.E-LMS *** strong correlation signal,its performance is su-perior to those of the NLMS algorithm and DCR-LMS al-gorithm.

关键词： adaptive filter NLMS algorithm Wiener equation correlation

QoS Routing Optimization Based on Deep Reinforcement Learning in SDN

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Computers, Materials & Continua 2024年第5期79卷 3007-3021页

作者： Yu Song Xusheng Qian Nan zhang wei Wang Ao xiong State Key Laboratory of Networking and Switching Technology Beijing University of Posts and TelecommunicationsBeijing100876China Marketing Service Center State Grid Jiangsu Electric Power Co.Ltd.Nanjing220000China Customer Service Center State Grid Co.Ltd.Nanjing211161China

To enhance the efficiency and expediency of issuing e-licenses within the power sector, we must confront thechallenge of managing the surging demand for data traffic. Within this realm, the network imposes stringentQuality of Service (QoS) requirements, revealing the inadequacies of traditional routing allocation mechanismsin accommodating such extensive data flows. In response to the imperative of handling a substantial influx of datarequests promptly and alleviating the constraints of existing technologies and network congestion, we present anarchitecture forQoS routing optimizationwith in SoftwareDefinedNetwork (SDN), leveraging deep reinforcementlearning. This innovative approach entails the separation of SDN control and transmission functionalities, centralizingcontrol over data forwardingwhile integrating deep reinforcement learning for informed routing decisions. Byfactoring in considerations such as delay, bandwidth, jitter rate, and packet loss rate, we design a reward function toguide theDeepDeterministic PolicyGradient (DDPG) algorithmin learning the optimal routing strategy to furnishsuperior QoS provision. In our empirical investigations, we juxtapose the performance of Deep ReinforcementLearning (DRL) against that of Shortest Path (SP) algorithms in terms of data packet transmission delay. Theexperimental simulation results show that our proposed algorithm has significant efficacy in reducing networkdelay and improving the overall transmission efficiency, which is superior to the traditional methods.

关键词： Deep reinforcement learning SDN route optimization QoS

Genetic Engineered Ultrasound-Triggered Injectable Hydrogels for Promoting Bone Reconstruction

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Research 2024年第2期2023卷 431-447页

作者： Zhenyu Zhao Huitong Ruan Aopan Chen wei xiong Mingzhu zhang Ming Cai Wenguo Cui Department of Orthopaedics Shanghai Tenth People's HospitalSchool of MedicineTongji University No.301 Middle Yanchang RoadShanghai 200072China Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University Schoolof Medicine197 Rujin 2nd RoadShanghai 200025China Department of Foot and Ankle Surgery Beijing Tongren HospitalCapital Medical University1 Dongjiao MinxiangBeijing 100730China

Genetic engineering technology can achieve specific gene therapy for a variety of diseases, but the current strategy still has some flaws, such as a complex system, single treatment, and large implantation trauma. Herein, the genetic engineering injectable hydrogels were constructed by ultrasonic technology for the first time to realize in vivo ultrasound-triggered in situ cross-linking and cell gene transfection, and finally complete in situ gene therapy to promote bone reconstruction. First, ultrasound-triggered calcium release was used to activate transglutaminase and catalyze the transamidation between fibrinogen. Simultaneously, liposome loaded with Zinc-finger E-box-binding homeobox 1 (ZEB1) gene plasmid (Lip-ZEB1) was combined to construct an ultrasound-triggered in situ cross-linked hydrogels that can deliver Lip-ZEB1. Second, ultrasound-triggered injectable hydrogel introduced ZEB1 gene plasmid into endothelial cell genome through Lip-ZEB1 sustained release, and then acted on the ZEB1/Notch signal pathway of cells, promoting angiogenesis and local bone reconstruction of osteoporosis through genetic engineering. Overall, this strategy provides an advanced gene delivery system through genetic engineered ultrasound-triggered injectable hydrogels.

关键词： sustained release linking