检索结果-南通市图书馆

Direct anti-HCV agents

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2016年第1期6卷 26-31页

作者： xingquan zhang Division of Infectious Diseases University of CaliforniaSan Diego School of Medicine

Unlike human immunodeficiency virus(HIV)and hepatitis B virus(HBV),hepatitis C virus(HCV)infection is a curable *** direct antiviral agent(DAA)targets are focused on HCV NS3/4A protein(protease),NS5 B protein(polymerase)and NS5 A *** first generation of DAAs includes boceprevir and telaprevir,which are protease inhibitors and were approved for clinical use *** cure rate for genotype 1 patients increased from 45% to 70% when boceprevir or telaprevir was added to standard PEG-IFN/*** effective and less toxic second generation DAAs supplanted these drugs by *** second generation of DAAs includes sofosbuvir(Sovaldi),simeprevir(Olysio),and fixed combination medicines Harvoni and Viekira *** drugs increase cure rates to over 90%without the need for interferon and effectively treat all HCV *** these drugs the "cure HCV"goal has become a *** remain about drug resistance mutations and the high cost of these *** investigation of new HCV drugs is progressing rapidly;fixed dose combination medicines in phase III clinical trials include Viekirax,asunaprevirtdaclatasvirtbeclabuvir,grazoprevirtelbasvir and others.

关键词： Hepatitis C virus Cure HCV Sustained virologic response Direct antiviral agents NS3/4A protease inhibitor

SIMULATION OF CYLINDRICAL UPSETTING OF POROUS MATERIALS BY FINITE ELEMENT METHOD

在线全文

学校读者我要写书评

暂无评论

中国有色金属学会会刊：英文版 1998年第1期8卷 25-28,142页

作者： zhang, xingquan Peng, Yinghong Ruan, Xueyu Li, Miaoquan Wu, Shichun Shanghai Jiao Tong Univ Shanghai China

ＳＩＭＵＬＡＴＩＯＮＯＦＣＹＬＩＮＤＲＩＣＡＬＵＰＳＥＴＴＩＮＧＯＦＰＯＲＯＵＳＭＡＴＥＲＩＡＬＳＢＹＦＩＮＩＴＥＥＬＥＭＥＮＴＭＥＴＨＯＤ①ＺｈａｎｇＸｉｎｇｑｕａｎ，ＰｅｎｇＹｉｎｇｈｏｎｇａｎｄＲｕａｎＸｕｅｙ... 详细信息

ＳＩＭＵＬＡＴＩＯＮＯＦＣＹＬＩＮＤＲＩＣＡＬＵＰＳＥＴＴＩＮＧＯＦＰＯＲＯＵＳＭＡＴＥＲＩＡＬＳＢＹＦＩＮＩＴＥＥＬＥＭＥＮＴＭＥＴＨＯＤ①ＺｈａｎｇＸｉｎｇｑｕａｎ，ＰｅｎｇＹｉｎｇｈｏｎｇａｎｄＲｕａｎＸｕｅｙｕＮａｔｉｏｎａｌＤｉｅ＆Ｍｏｌｄ...

关键词： porous metal materials the critical technological parameters defects

Analysis of the Lost Circulation Problem

在线全文

学校读者我要写书评

暂无评论

Fluid Dynamics & Materials Processing 2023年第6期19卷 1721-1733页

作者： xingquan zhang Renjun Xie Kuan Liu Yating Li Yuqiang Xu CNOOC Research Institute Beijing100101China College of Petroleum Engineering China University of PetroleumQingdao266580China

The well-known“lost circulation”problem refers to the uncontrolled flow of whole mud into a *** order to address the problem related to the paucity of available data,in the present study,a model is introduced for the lost-circulation risk sample profile of a drilled *** model is built taking into account effective data(the Block L).Then,using a three-dimensional geological modeling software,relying on the variation function and sequential Gaussian simulation method,a three-dimensional block lost-circulation risk model is introduced able to provide relevant information for regional analyses.

关键词： Geostatistics risk assessment variation function sequential gaussian simulation drilling risk lost circulation evaluation method

Analysis of the Applicability of a Risk Quantitative Evaluation Method to High Temperature-Pressure Drilling Engineering

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fluid Dynamics & Materials Processing 2023年第6期19卷 1385-1395页

作者： Renjun Xie xingquan zhang Baolun He Ningyu Zheng Yuqiang Xu CNOOC Research Institute Beijing100101China College of Petroleum Engineering China University of PetroleumQingdao266580China

The optimization of methods for the quantitative evaluation of risks in drilling engineering is an effective means to ensure safety in situations where high temperature and high pressure blocks are *** such a context,this study analyzes the complexity of the drilled wells in such *** is shown that phenomena such as well kick,loss,circulation,and sticking,are related to the imbalance of wellbore pressure.A method for risk quantitative evaluation is proposed *** method is used to evaluate the risk for 9 drilled *** comparing the predictions of the method with actual historical data related to these wells,it is found that the coincidence rate is about 95%.

关键词： Risk assessment applicability formation pressure

Twinning aspects and their efficient roles in wrought Mg alloys:A comprehensive review

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2024年第6期12卷 2201-2230页

作者： S.S.A.Shah Manping Liu Azim Khan Farooq Ahmad M.R.Abdullah xingquan zhang Shiwei Xu Zhen Peng School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China School of Mechanical Engineering Anhui University of TechnologyMáanshan 243002China College of Mechanical and Vehicle Engineering Hunan UniversityChangsha 410082China

Twinning is widely recognized as an effective and cost-efficient method for controlling the microstructure and properties of wrought magnesium(Mg)***,twins play a crucial role in initiating dynamic recrystallization(DRX),while twin regions experience rapid recrystallization during static recrystallization(SRX).The activation of twinning can lead to changes in lattice orientation,significantly impacting the final texture in Mg *** active roles of twinning are influenced by various factors during the activation process,and the mobility of twin boundaries(TB)can be amplified by stress effects,dislocation interactions,and thermal ***,annealing treatments that involve proper segregation or precipitation on TBs serve to stabilize them,restraining their *** such as segregation may also alter the twinning propensity in Magnesium-rare earth(Mg-RE)***{10–11}contraction twins(CT)and{10–11}-{10–12}double twins(DT)can promote dynamic recrystallization(DRX),they also pose a risk as potential sources of voids and ***,understanding the nucleation and growth mechanisms of twinning is crucial,and these aspects are briefly reviewed in this *** the factors mentioned above,this article summarizes the recent research progress in this field,shedding light on advancements in recent eras.

关键词： Mg alloys Twinning Recrystallization Texture Mechanical properties

Experimental Research on Laser Shot Peening to Form Aluminum Alloy

在线全文

学校读者我要写书评

暂无评论

武汉理工大学学报 2006年第S3期28卷 837-840页

作者： zhang xingquan zhang Yongkang GU Yongyu ZHOU Jianzhong YANG Chaojun School of Mechanical Engineering,Jiangsu University,Zhenjiang 212013,China, School of Mechanical Engineering Jiangsu UniversityZhenjiang 212013China

Laser shot peening forming is a novel technology,which employs residual stress induced by intense laser to shape precisely the *** this paper,the aeronautic aluminum alloy LY12CZ was selected as an object to research experimentally the magnitude of deformation versus numbers of laser shot peening,and surface quality in laser shot zone was also *** specimen was impacted along its centerline by the high-power,short-duration pulses *** experimental results show that the arc height and hardness becomes greater with numbers of shot peening increasing and eventually arrives to saturated state,and sur- face roughness after laser shot peening decreases slightly and dislocation density increases greatly,which indicates that the laser shot peening is a technique combining laser shock processing and metal forming.

关键词： laser shot peening deformation hardness roughness microstructure

Research on Residual Stress Induced by Laser Shot Peening

在线全文

学校读者我要写书评

暂无评论

工程科学（英文版） 2006年第3期4卷 77-80页

作者： zhang xingquan zhang Yongkang Gu Yongyu Kong Dejun Ni Mingxiong School of Mechanical Engneering Jiangsu UniversityZhenjiang Jiangsu 212013

Laser shot peening (LSP) is a novel technology to impress a compressive residual stress into the surfaces of metals or alloys. This treatment can reduce the rate of fatigue cracking and stress corrosion cracking in structural metals or alloys. In this paper, some preliminary experiments were carried out with Nd:Glass laser of a pulse of 20 ns duration and 1.064 μm wavelength, an energy per pulse of 10 to 60 joules, and specimen was selected LY12CZ. The residual stress along the thickness effected by number of laser shots was taken into account in experiment. The magnitude of compressive residual stress near the surface increases with number of laser shots increasing, while decreases with the depth increasing. The mathematical modeling of laser shock processing was established, and a finite-element analysis method was based on ABAQUSExplicit software. The results of simulation are in agreement with those of the experiments, which indicate that the numerical simulation can play a direction role in laser shot peening.

关键词：激光表面处理残余应力处理机制疲劳裂纹应力腐蚀裂纹

双层孔隙铁基粉末冶金材料可控制备及自润滑机理分析

在线全文

学校读者我要写书评

暂无评论

金属学报 2019年第11期55卷 1448-1456页

作者：张国涛尹延国童宝宏张兴权安徽工业大学机械工程学院马鞍山243002 合肥工业大学摩擦学研究所合肥230009

通过在表层添加造孔剂TiH2、在基层添加致密剂酰胺蜡,采用粉末冶金工艺制备基体致密、表层多孔含油的双层铁基轴承材料,利用SEM、XRD等分析材料微观组织与物相分布,用端面摩擦试验机测试其边界润滑工况下的摩擦学性能,结合逐级加载工况... 详细信息

通过在表层添加造孔剂TiH2、在基层添加致密剂酰胺蜡,采用粉末冶金工艺制备基体致密、表层多孔含油的双层铁基轴承材料,利用SEM、XRD等分析材料微观组织与物相分布,用端面摩擦试验机测试其边界润滑工况下的摩擦学性能,结合逐级加载工况下的单、双层铁基材料的摩擦实验结果,分析单、双层烧结材料在不同载荷工况下的供油自润滑机理。结果表明,改变表层中TiH2的含量可以实现双层材料表层孔隙率和含油率的变化,同时由原位合成反应生成的硬度较高的TiC颗粒可提高材料的表面硬度,满足高承载时的耐磨性能要求,维持摩擦副接触界面和润滑状态稳定。含3.5%TiH2的双层材料综合力学和摩擦学性能较好;双层材料的疏松表层具有较好的含油自润滑性能,致密基体能增大材料强度,也使润滑油保持在两对偶面之间,综合摩擦学性能和力学性能较单层材料好,适用于重载或复杂润滑工况。

关键词：双层孔隙铁基材料摩擦自润滑

职业化进程中中国足球“失范现象”的社会学分析

在线全文

学校读者我要写书评

暂无评论

沈阳体育学院学报 2016年第6期35卷 29-33页

作者：张兴泉沈阳体育学院运动训练学院辽宁沈阳110102

结合社会学中的失范理论,利用理论与实证分析相结合的方法探讨了职业化进程中中国足球"失范现象"的形成机制。研究认为:早在中国足球职业化改革前,操纵比赛的行为就已经存在,这为职业化后期越轨行为的涌现做了价值观准备和行为模式准备... 详细信息

结合社会学中的失范理论,利用理论与实证分析相结合的方法探讨了职业化进程中中国足球"失范现象"的形成机制。研究认为:早在中国足球职业化改革前,操纵比赛的行为就已经存在,这为职业化后期越轨行为的涌现做了价值观准备和行为模式准备。职业联赛开始之后,足球被赋予更高的政治意义和经济价值,在高强度的利益驱动下,社会中的某些个人、团体尝试冲击和违反规范。面对这些失范行为,社会规范出现了供给不足和执行不力的局面,于是出现了失范者获利,遵守规范者利益受损的规范贴现效应,从而导致失范行为被广泛复制。

关键词：失范职业化足球越轨行为