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Early embryonic failure caused by a novel mutation in the TUBB8 gene:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2092-2098页

作者： Xiao-Yu zhang xing-xing zhang Lei Wang Department of Reproductive Center Zaozhuang Maternal and Child Healthcare HospitalZaozhuang 277000Shandong ProvinceChina

BACKGROUND This study aimed to explore the relationship between gene mutations and early embryonic development arrest and to provide more possibilities for the diagnosis and treatment of repeated implantation failure.CASE SUMMARY Here,we collected and described the clinical data of a patient with early embryonic development stagnation after repeated in vitro fertilization attempts for primary infertility at the Department Reproductive Center of Zaozhuang Maternal and Child Healthcare Hospital.We also detected the whole-exon gene of the patient's spouse and parents,and conducted bioinformatics analysis to determine the pathogenesis of the gene.CONCLUSION A novel mutant of the TUBB8 gene[c.602G>T(p.C201F)]was identified,and this mutant provided new data on the genotype-phenotype relationships of related diseases.

关键词： Genes Mutation Embryonic development Fertilization in vitro Intracytoplasmic sperm injection Case report

Numerical simulation study on the hygrothermal performance of building exterior walls under dynamic wind-driven rain condition

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Building Simulation 2024年第2期17卷 207-221页

作者： xing Hu Huibo zhang Hui Yu School of Design Shanghai Jiao Tong UniversityShanghai200240China

Wind-driven rain(WDR)has a significant influence on the hygrothermal performance,durability,and energy consumption of building components.The calculation of WDR loads using semi-empirical models has been incorporated into the boundary conditions of coupled heat and moisture transfer models.However,prior research often relied on fixed WDR absorption ratio,which fail to accurately capture the water absorption characteristics of porous building materials under rainfall scenarios.Therefore,this study aims to investigate the coupled heat and moisture transfer of exterior walls under dynamic WDR boundary conditions,utilizing an empirically obtained WDR absorption ratio model based on field measurements.The developed coupled heat and moisture transfer model is validated against the HAMSTAD project.The findings reveal that the total WDR flux calculated with the dynamic WDR boundary is lower than that obtained with the fixed WDR boundary,with greater disparities observed in orientations experiencing higher WDR loads.The variations in moisture flow significantly impact the surface temperature and relative humidity of the walls,influencing the calculation of cooling and heating loads by different models.Compared to the transient heat transfer model,the coupled heat and moisture transfer model incorporating dynamic WDR boundary exhibits maximum increases of 17.6%and 16.2%in cooling and heating loads,respectively.The dynamic WDR boundary conditions provide more precise numerical values for surface moisture flux,offering valuable insights for the thermal design of building enclosures and load calculations for HVAC systems.

关键词： wind-driven rain building component hygrothermal model transient simulation cooling and heating loads

Morphological determination of localization and function of Golgi proteins

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Biophysics Reports 2024年第2期10卷 121-132页

作者： Yusheng xing Yannan Jian Xiaodan Zhao Yue zhang Zhenqian zhang xing zhang Xiaoyan zhang College of Biomedicine and Health College of Life Science and Technology Huazhong Agricultural University

In animal cells, the Golgi apparatus serves as the central hub of the endomembrane secretory pathway.It is responsible for the processing, modification, and sorting of proteins and lipids. The unique stacking and ribbon-like architecture of the Golgi apparatus forms the foundation for its precise functionality. Under cellular stress or pathological conditions, the structure of the Golgi and its important glycosylation modification function may change. It is crucial to employ suitable methodologies to study the structure and function of the Golgi apparatus, particularly when assessing the involvement of a target protein in Golgi regulation. This article provides a comprehensive overview of the diverse microscopy techniques used to determine the specific location of the target protein within the Golgi apparatus. Additionally, it outlines methods for assessing changes in the Golgi structure and its glycosylation modification function following the knockout of the target gene.

关键词： Golgi apparatus Golgi fragmentation Immunofluorescence Super-resolution microscopy Electron microscopy Lectin staining Glycosylation

Annexin A1 in the nervous and ocular systems

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Neural Regeneration Research 2024年第3期19卷 591-597页

作者： Aijia Wang Hong zhang xing Li Yin Zhao Department of Ophthalmology 2Department of AnesthesiologyTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

The therapeutic potential of Annexin A1,an important member of the Annexin superfamily,has become evident in results of experiments with multiple human systems and animal models.The anti-inflammatory and pro-resolving effects of Annexin A1 are characteristic of pathologies involving the nervous system.In this review,we initially describe the expression sites of Annexin A1,then outline the mechanisms by which Annexin A1 maintains the neurological homeostasis through either formyl peptide receptor 2 or other molecular approaches;and,finally,we discuss the neuroregenerative potential qualities of Annexin A1.The eye and the nervous system are anatomically and functionally connected,but the association between visual system pathogenesis,especially in the retina,and Annexin A1 alterations has not been well summarized.Therefore,we explain the beneficial effects of Annexin A1 for ocular diseases,especially for retinal diseases and glaucoma on the basis of published findings,and we explore present and future delivery strategies for Annexin A1 to the retina.

关键词： Annexin A1(ANXA1) glaucoma nervous system neuroprotection neuroregeneration ocular disease retina

An optimization-oriented modeling approach using input convex neural networks and its application on optimal chiller loading

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Building Simulation 2024年第4期17卷 639-655页

作者： Shanshuo xing Jili zhang Song Mu Dalian University of Technology Dalian116024China Guangdong Airport Baiyun Information Technology Co. Ltd.Guangzhou510000China

Optimization for the multi-chiller system is an indispensable approach for the operation of highly efficient chiller plants.The optima obtained by model-based optimization algorithms are dependent on precise and solvable objective functions.The classical neural networks cannot provide convex input-output mappings despite capturing impressive nonlinear fitting capabilities,resulting in a reduction in the robustness of model-based optimization.In this paper,we leverage the input convex neural networks(ICNN)to identify the chiller model to construct a convex mapping between control variables and the objective function,which enables the NN-based OCL as a convex optimization problem and apply it to multi-chiller optimization for optimal chiller loading(OCL).Approximation performances are evaluated through a four-model comparison based on an experimental data set,and the statistical results show that,on the premise of retaining prior convexities,the proposed model depicts excellent approximation power for the data set,especially the unseen data.Finally,the ICNN model is applied to a typical OCL problem for a multi-chiller system and combined with three types of optimization strategies.Compared with conventional and meta-heuristic methods,the numerical results suggest that the gradient-based BFGS algorithm provides better energy-saving ratios facing consecutive cooling load inputs and an impressive convergence speed.

关键词： chiller plant input convex neural network optimal load distribution convex optimization

Fabrication of Biomimetic Surface for Hydrophobic and Anti-icing Purposes via the Capillary Force Lithography

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Journal of Bionic Engineering 2024年第1期21卷 74-83页

作者： Wenqiang xing Yiping Tang Fengzhou Zhao Lichun zhang Dengying zhang School of Physics and Optoelectronic Engineering Ludong UniversityYantai 264025China

In this paper,inspired by lotus leaf surfaces,we fabricated biomimetic multi-scale micro-nano-structures by Two-Step Capillary Force Lithography(TS-CFL)and UV-assisted Capillary Force Lithography(UV-CFL).The experimental results indicated that TS-CFL was unfitted to fabricate large-area multi-scale micro-nano-structures.Conversely,UV-CFL can fabricate large-area multi-scale micro-nano-structures.We discussed the hydrophobic and anti-icing properties of the biomimetic surfaces fabricated by these two technologies.We found that small structures are significant for improving the hydrophobic anti-icing properties of single-structured or structureless surfaces.We believe that these results can complement the experimental details of both technologies and enable the development of more interesting micro-nano-structures biomimetic surfaces by both technologies in the future.

关键词： Capllary force lithography Biomimetic lotus leaf Multi-scale structures Hydrophobic Anti-icing

A brief review on the recent development of phonon engineering and manipulation at nanoscales

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International Journal of Extreme Manufacturing 2024年第1期6卷 177-206页

作者： Siqi Xie Hongxin Zhu xing zhang Haidong Wang Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Engineering MechanicsTsinghua UniversityBeijing 100084People’s Republic of China

Phonons are the quantum mechanical descriptions of vibrational modes that manifest themselves in many physical properties of condensed matter systems. As the size of electronic devices continues to decrease below mean free paths of acoustic phonons, the engineering of phonon spectra at the nanoscale becomes an important topic. Phonon manipulation allows for active control and management of heat fow, enabling functions such as regulated heat transport. At the same time, phonon transmission, as a novel signal transmission method, holds great potential to revolutionize modern industry like microelectronics technology, and boasts wide-ranging applications. Unlike fermions such as electrons, polarity regulation is difficult to act on phonons as bosons, making the development of effective phonon modulation methods a daunting task.This work reviews the development of phonon engineering and strategies of phonon manipulation at different scales, reports the latest research progress of nanophononic devices such as thermal rectifiers, thermal transistors, thermal memories, and thermoelectric devices,and analyzes the phonon transport mechanisms involved. Lastly, we survey feasible perspectives and research directions of phonon engineering. Thermoelectric analogies, external field regulation, and acousto-optic co-optimization are expected to become future research hotspots.

关键词： phonon engineering phononic device nanoscale

miR‑423 sponged by lncRNA NORHA inhibits granulosa cell apoptosis

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Journal of Animal Science and Biotechnology 2024年第2期15卷 632-644页

作者： Yuqi Li Zhuofan zhang Siqi Wang xing Du Qifa Li College of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210095China

Background Atresia and degeneration,a follicular developmental fate that reduces female fertility and is triggered by granulosa cell(GC)apoptosis,have been induced by dozens of miRNAs.Here,we report a miRNA,miR-423,that inhibits the initiation of follicular atresia(FA),and early apoptosis of GCs.Results We showed that miR-423 was down-regulated during sow FA,and its levels in follicles were negatively correlated with the GC density and the P4/E2 ratio in the follicular fluid in vivo.The in vitro gain-of-function experiments revealed that miR-423 suppresses cell apoptosis,especially early apoptosis in GCs.Mechanically speaking,the miR-423 targets and interacts with the 3’-UTR of the porcine SMAD7 gene,which encodes an apoptosis-inducing factor in GCs,and represses its expression and pro-apoptotic function.Interestingly,FA and the GC apoptosis-related lncRNA NORHA was demonstrated as a ceRNA of miR-423.Additionally,we showed that a single base deletion/insertion in the miR-423 promoter is significantly associated with the number of stillbirths(NSB)trait of sows.Conclusion These results demonstrate that miR-423 is a small molecule for inhibiting FA initiation and GC early apoptosis,suggesting that treating with miR-423 may be a novel approach for inhibiting FA initiation and improving female fertility.

关键词： Granulosa cell apoptosis miR-423 NORHA SMAD7 Sow fertility traits

The dynamics of traveling wavefronts for a model describing host tissue degradation by bacteria

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International Journal of Biomathematics 2024年第3期17卷 265-287页

作者： xing-xing Yang Guo-Bao zhang Ge Tian College of Mathematics and Statistics Northwest Normal University Lanzhou Gansu 730070P.R.China

In this paper,we mainly investigate the dynamics of traveling wavefronts for a model describing host tissue degradation by bacteria.We first establish the existence of spreading speed,and show that the spreading speed coincides with the minimal wave speed of traveling wavefronts.Moreover,a lower bound estimate of the spreading speed is given.Then,we prove that the traveling wavefronts with large speeds are globally exponentially stable,when the initial perturbation around the traveling wavefronts decays exponentially asχ→-∞,but the initial perturbation can be arbitrarily large in other locations.The adopted methods are the weighted energy and the squeezing technique.

关键词： Host tissue degradation bacterial infection traveling wavefronts minimal wave speed stability