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A novel high-Cr CoNi-based superalloy with superior high-temperature microstructural stability, oxidation resistance and mechanical properties

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1373-1381页

作者： xiaorui zhang Min Zou Song Lu Longfei Li Xiaoli Zhuang Qiang Feng Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced MetalsUniversity of Science and Technology BeijingBeijing 100083China

A novel multicomponent high-Cr CoNi-based superalloy with superior comprehensive performance was prepared,and the evaluation of its high-temperature microstructural stability,oxidation resistance,and mechanical properties was conducted mainly using its cast polycrystalline alloy.The results disclosed that the morphology of theγ′phase remained stable,and the coarsening rate was slow during the long-term aging at 900–1000℃.The activation energy forγ′precipitate coarsening of alloy 9CoNi-Cr was(402±51)kJ/mol,which is higher compared with those of CMSX-4 and some other Ni-based and Co-based superalloys.Importantly,there was no indica-tion of the formation of topologically close-packed phases during this process.All these factors demonstrated the superior microstructural stability of the alloy.The mass gain of alloy 9CoNi-Cr was 0.6 mg/cm^(2) after oxidation at 1000℃ for 100 h,and the oxidation resistance was comparable to advanced Ni-based superalloys CMSX-4,which can be attributed to the formation of a continuous Al_(2)O_(3) protective layer.Moreover,the compressive yield strength of this cast polycrystalline alloy at high temperatures is clearly higher than that of the conventional Ni-based cast superalloy and the compressive minimum creep rate at 950℃ is comparable to that of the conventional Ni-based cast superalloy,demonstrating the alloy’s good mechanical properties at high temperature.This is partially because high Cr is bene-ficial in improving theγandγ′phase strengths of alloy 9CoNi-Cr.

关键词： CoNi-based superalloys microstructure coarsening oxidation mechanical properties

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KH550-SiO_(2)/polyimide insulating paper preparation and characterisation

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High Voltage 2024年第2期9卷 466-473页

作者： Minghe Chi Xue Sun xiaorui zhang Jiahao Shi Ling Weng Yang Yu School of Electrical and Electronic Engineering Harbin University of Science and TechnologyHarbinChina Key Laboratory of Engineering Dielectrics and Its Application Ministry of EducationHarbin University of Science and TechnologyHarbinChina School of Materials Science and Engineering Harbin University of Science and TechnologyHarbinChina

Oil-paper insulation material is an essential component for oil-filled transformers,and polyimide(PI)insulation paper is a novel material in the field of electricity.The improvement of insulation class for insulation paper has gained significant attention in recent years.In this study,SiO_(2)nanoparticles were modified with a silane coupling agent(KH550),and the KH550-SiO_(2)was added to the fibre membrane through in situ poly-merisation.The chemical composition and microcosmic characteristics of the PI porous fibre membrane were characterised using FT-IR and SEM FT-IR and SEM.Conse-quently,the dielectric constant of the composite paper was reduced to 2.3 upon adding 3 wt%of KH550-SiO_(2),and the dielectric strength reached its maximum value of 85 kV/mm.The results demonstrate that the insulation performance of the KH550-SiO_(2)/PI composite was significantly improved due to the incorporation of nano-SiO_(2).This establishes an efficient approach for achieving excellent electrical and thermal properties in practical applications using the KH550-SiO_(2)/PI fibre membrane.

关键词： composite insulation fibre

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Research on the longitudinal protection of a through-type cophase traction direct power supply system based on the empirical wavelet transform

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Global Energy Interconnection 2024年第2期7卷 206-216页

作者： Lu Li Zeduan zhang Wang Cai Qikang Zhuang Guihong Bi Jian Deng Shilong Chen xiaorui Kan Faculty of Electric Power Engineering Kunming University of Science and TechnologyKunming 650500P.R.China Brunel University London London UB83PHUnited Kingdom Yunnan Power Grid Co. Ltd.Kunming 650041P.R.China

This paper proposes a longitudinal protection scheme utilizing empirical wavelet transform(EWT)for a through-type cophase traction direct power supply system,where both sides of a traction network line exhibit a distinctive boundary structure.This approach capitalizes on the boundary’s capacity to attenuate the high-frequency component of fault signals,resulting in a variation in the high-frequency transient energy ratio when faults occur inside or outside the line.During internal line faults,the high-frequency transient energy at the checkpoints located at both ends surpasses that of its neighboring lines.Conversely,for faults external to the line,the energy is lower compared to adjacent lines.EWT is employed to decompose the collected fault current signals,allowing access to the high-frequency transient energy.The longitudinal protection for the traction network line is established based on disparities between both ends of the traction network line and the high-frequency transient energy on either side of the boundary.Moreover,simulation verification through experimental results demonstrates the effectiveness of the proposed protection scheme across various initial fault angles,distances to faults,and fault transition resistances.

关键词： Through-type Cophase traction direct power supply system Traction network Empirical wavelet transform(EWT) Longitudinal protection

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Plant-based dietary patterns and risk of esophageal cancer:A prospective cohort study spanning 17 years

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Chinese Journal of Cancer Research 2024年第1期36卷 36-45页

作者： xiaorui zhang Feifan He Jiayue Li Ru Chen Xinqing Li Li Li Fen Liu Shaoming Wang Wenqiang Wei Department of Epidemiology and Health Statistics School of Public HealthBeijing Municipal Key Laboratory of Clinical EpidemiologyCapital Medical UniversityBeijing 100069China National Central Cancer Registry office National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Cancer Epidemiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective: Plant-based diets have multiple health benefits for cancers;however, little is known about the association between plant-based dietary patterns and esophageal cancer(EC).This study presents an investigation of the prospective associations among three predefined indices of plant-based dietary patterns and the risk of EC.Methods: We performed endoscopic screening for 15,709 participants aged 40-69 years from two high-risk areas of China from January 2005 to December 2009 and followed the cohort until December 31, 2022. The overall plant-based diet index(PDI), healthful plant-based diet index(h PDI), and unhealthful plant-based diet index(u PDI), were calculated using survey responses to assess dietary patterns. We applied Cox proportional hazard regression to estimate the multivariable hazard ratios(HRs) and 95% confidence intervals(95% CIs) of EC across 3plant-based diet indices and further stratified the analysis by subgroups.Results: The final study sample included 15,184 participants in the cohort. During a follow-up of 219,365person-years, 176 patients with EC were identified. When the highest quartile was compared with the lowest quartile, the pooled multivariable-adjusted HR of EC was 0.50(95% CI, 0.32-0.77) for h PDI. In addition, the HR per 10-point increase in the h PDI score was 0.42(95% CI, 0.27-0.66) for ECs. Conversely, u PDI was positively associated with the risk of EC, and the HR was 1.80(95% CI, 1.16-2.82). The HR per 10-point increase in the u PDI score was 1.90(95% CI, 1.26-2.88) for ECs. The associations between these scores and the risk of EC were consistent in most subgroups. These results remained robust in sensitivity analyses.Conclusions: A healthy plant-based dietary pattern was associated with a reduced risk of EC. Emphasizing the healthiness and quality of plant-based diets may be important for preventing the development of EC.

关键词： Esophageal cancer diet dietary pattern epidemiology nutrition prospective cohort study

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circRNA3669 promotes goat endometrial epithelial cells proliferation via miR-26a/RCN2 to activate PI3K/AKT-mTOR and MAPK pathways

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Journal of Integrative Agriculture 2024年第3期23卷 960-974页

作者： xiaorui Liu Jiuzeng Cui Mengyao Wei Xiaofei Wang Yuexia Liu Zhongshi Zhu Min Zhou Gui Ba Langda Suo Yuxuan Song Lei zhang Division of Laboratory Safety and Services Northwest A&F UniversityYangling 712100China College of Animal Science and Technology Northwest A&F UniversityYangling 712100China Institute of Animal Sciences Tibet Academy of Agricultural and Animal Husbandry SciencesLhasa 850009China

The development of receptive endometrium(RE) from pre-receptive endometrium(PE) for successful embryo implantation is a complex dynamic process in which the morphology and physiological states of the endometrial epithelium undergo a series of significant changes, including cell proliferation and apoptosis. However, the molecular mechanisms are not yet fully understood. In this study, a higher circRNA3669 level was observed in PE than in RE of goats. Functional assays revealed that this overexpression promoted the proliferation of goat endometrial epithelial cells(GEECs) by activating the expression of genes related to the PI3K/AKT-mTOR and MAPK pathways,thereby inhibiting apoptosis in vitro. Furthermore, circRNA3669 functioned as a competing endogenous RNA(ceRNA) to upregulate Reticulocalbin-2(RCN2) expression at the post-transcriptional level by interacting with and downregulating miR-26a in GEECs. In addition, RCN2, which is highly expressed in the PE of goats, was found to be regulated by β-estradiol(E2) and progesterone(P4). Our results demonstrated that RCN2 also affected the key proteins PI3K, AKT, mTOR, JNK, and P38 in the PI3K/AKT-mTOR and MAPK pathways, thereby facilitating GEECs proliferation and suppressing their apoptosis in vitro. Collectively, we constructed a new circRNA3669-miR-26aRCN2 regulatory network in GEECs, which further provides strong evidence that circRNA could potentially play a crucial regulatory role in the development of RE in goats.

关键词： circRNA3669 RCN2 miR-26a goat endometrial epithelial cells(GEECs) proliferation

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阳离子自交联苯丙聚合物及其改性ASA乳液的制备与性能研究

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中国造纸 2024年第5期43卷 124-129,170页

作者：张勇李小瑞张家口市生态环境局沽源县分局河北沽源076550 陕西科技大学化学与化工学院陕西西安710021

本研究选用甲基丙烯酰氧乙基三甲基氯化铵(DMC)、丙烯酰胺(AM)、苯乙烯(St)、丙烯酸丁酯(BA)、N-羟甲基丙烯酰胺(NMA)为共聚单体,经水溶液共聚方式制得阳离子自交联苯丙聚合物,并对其乳化ASA的实验条件进行了探究。结果表明,功能型单体... 详细信息

本研究选用甲基丙烯酰氧乙基三甲基氯化铵(DMC)、丙烯酰胺(AM)、苯乙烯(St)、丙烯酸丁酯(BA)、N-羟甲基丙烯酰胺(NMA)为共聚单体,经水溶液共聚方式制得阳离子自交联苯丙聚合物,并对其乳化ASA的实验条件进行了探究。结果表明,功能型单体的最佳用量为(相对于共聚单体)DMC 9.5%、NMA 2%,ASA与阳离子自交联苯丙聚合物最佳质量比为4.5∶1,改性后的ASA乳液具有优良的分散性和稳定性;用阳离子淀粉、矾土为双元助留剂,在浆料pH值为6.5,改性ASA乳液用量(相对于阔叶木浆)为0.15%,抄造的纸张施胶度达92 s;与原纸相比,施胶纸张耐折度、撕裂指数、抗张指数、环压指数分别提高41.2%、38.3%、45.6%、58.7%;碳酸钙填料为15%~20%,具有良好的施胶效果,适用于中性施胶。

关键词：阳离子自交联苯丙聚合物改性ASA施胶剂分散性稳定性中性施胶

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PBX/Knotted 1 homeobox-2(PKNOX2)is a novel regulator of myocardial fibrosis

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2231-2249页

作者： Liang Chen Haotong Li xiaorui Liu Ningning zhang Kui Wang Anteng Shi Hang Gao Deniz Akdis Ardan MSaguner Xinjie Xu Elena Osto Willem Van de Veen Guangyu Li Antoni Bayés-Genís Firat Duru Jiangping Song Xiangjie Li Shengshou Hu State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China School of Statistics and Data Science Nankai UniversityTianjinChina Department of Cardiology University Heart CenterUniversity Hospital Zurich and University of ZurichZurichSwitzerland Institute for Clinical Chemistry University Hospital Zurich and University of ZürichZurichSwitzerland Swiss Institute of Allergy and Asthma Research(SIAF) University of ZurichDavosSwitzerland Heart Institute Hospital Universitari Germans Trias i PujolBadalonaCIBERCVSpain

Much effort has been made to uncover the cellular heterogeneities of human hearts by single-nucleus RNA sequencing.However,the cardiac transcriptional regulation networks have not been systematically described because of the limitations in detecting transcription factors.In this study,we optimized a pipeline for isolating nuclei and conducting single-nucleus RNA sequencing targeted to detect a higher number of cell signal genes and an optimal number of transcription factors.With this unbiased protocol,we characterized the cellular composition of healthy human hearts and investigated the transcriptional regulation networks involved in determining the cellular identities and functions of the main cardiac cell subtypes.Particularly in fibroblasts,a novel regulator,PKNOX2,was identified as being associated with physiological fibroblast activation in healthy hearts.To validate the roles of these transcription factors in maintaining homeostasis,we used single-nucleus RNA-sequencing analysis of transplanted failing hearts focusing on fibroblast remodelling.The trajectory analysis suggested that PKNOX2 was abnormally decreased from fibroblast activation to pathological myofibroblast formation.Both gain-and loss-of-function in vitro experiments demonstrated the inhibitory role of PKNOX2 in pathological fibrosis remodelling.Moreover,fibroblast-specific overexpression and knockout of PKNOX2 in a heart failure mouse model induced by transverse aortic constriction surgery significantly improved and aggravated myocardial fibrosis,respectively.In summary,this study established a high-quality pipeline for single-nucleus RNA-sequencing analysis of heart muscle.With this optimized protocol,we described the transcriptional regulation networks of the main cardiac cell subtypes and identified PKNOX2 as a novel regulator in suppressing fibrosis and a potential therapeutic target for future translational studies.

关键词： NOX2 homeostasis fibrosis

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酶法制备花生α-葡萄糖苷酶抑制肽的工艺优化

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中国油脂 2024年第1期49卷 43-49页

作者：张晓瑞章绍兵河南工业大学粮油食品学院郑州450001

为促进花生蛋白资源的开发利用及发挥花生肽的降血糖作用,采用碱溶酸沉法制备花生蛋白,并利用不同商品蛋白酶水解花生蛋白制备花生肽。以α-葡萄糖苷酶抑制率为评价指标,对蛋白酶进行了筛选。在此基础上,采用单因素试验和响应面试验对... 详细信息

为促进花生蛋白资源的开发利用及发挥花生肽的降血糖作用,采用碱溶酸沉法制备花生蛋白,并利用不同商品蛋白酶水解花生蛋白制备花生肽。以α-葡萄糖苷酶抑制率为评价指标,对蛋白酶进行了筛选。在此基础上,采用单因素试验和响应面试验对花生α-葡萄糖苷酶抑制肽的制备工艺进行了优化。另外,考察了花生蛋白水解度和花生肽α-葡萄糖苷酶抑制活性的相关性。结果表明:与其他商品蛋白酶相比,胰蛋白酶制备的花生肽的α-葡萄糖苷酶抑制活性最高;酶法制备花生α-葡萄糖苷酶抑制肽的最优工艺条件为将花生蛋白于95℃加热5 min进行预处理,采用胰蛋白酶水解,水解时间62 min,加酶量8.9%,底物质量浓度4.1 g/100 mL,在最优条件下花生肽α-葡萄糖苷酶抑制率达到(68.82±0.24)%,此时花生蛋白的水解度为10.09%;水解度在8.0%~11.5%范围内与花生肽的α-葡萄糖苷酶抑制活性呈显著正相关。综上,花生蛋白经胰蛋白酶水解后得到的花生肽对α-葡萄糖苷酶具有显著的体外抑制活性。

关键词：花生肽酶法 α-葡萄糖苷酶水解度

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Research progress of alkaline earth metal iron-based oxides as anodes for lithium-ion batteries

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Journal of Semiconductors 2024年第2期45卷 21-33页

作者： Mingyuan Ye xiaorui Hao Jinfeng Zeng Lin Li Pengfei Wang Chenglin zhang Li Liu Fanian Shi Yuhan Wu School of Environmental and Chemical Engineering Shenyang University of TechnologyShenyang 110870China College of Materials Science and Engineering Nanjing Tech UniversityNanjing 211816China College of Pharmacy Xinjiang Medical UniversityEngineering Research Center of Xinjiang and Central Asian Medicine Resources(Ministry of Education)Urumqi 830000China Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China School of Physics and Electronic Engineering Jiangsu UniversityZhenjiang 212013China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Nankai UniversityTianjin 300071China

Anode materials are an essential part of lithium-ion batteries(LIBs),which determine the performance and safety of LIBs.Currently,graphite,as the anode material of commercial LIBs,is limited by its low theoretical capacity of 372 mA·h·g^(−1),thus hindering further development toward high-capacity and large-scale applications.Alkaline earth metal iron-based oxides are considered a promising candidate to replace graphite because of their low preparation cost,good thermal stability,superior stability,and high electrochemical performance.Nonetheless,many issues and challenges remain to be addressed.Herein,we systematically summarize the research progress of alkaline earth metal iron-based oxides as LIB anodes.Meanwhile,the material and structural properties,synthesis methods,electrochemical reaction mechanisms,and improvement strategies are introduced.Finally,existing challenges and future research directions are discussed to accelerate their practical application in commercial LIBs.

关键词： alkali-earth metal iron-based oxides anodes lithium-ion batteries electrochemical energy storage

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赤藓糖醇的生物学功能及临床应用研究进展

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食品与发酵工业 2024年第3期50卷 357-365页

作者：张译尹邢晓蕊王茹上海体育学院运动健康学院上海200438

赤藓糖醇作为一种甜味剂,目前广泛应用于食品添加行业。它不仅天然存在于水果和蔬菜中,近期研究揭示其也是一种内源性代谢物。赤藓糖醇在调节糖脂代谢、氧化应激和胃肠道功能等方面发挥着重要的作用。同时,赤藓糖醇还可以作为一种新型... 详细信息

赤藓糖醇作为一种甜味剂,目前广泛应用于食品添加行业。它不仅天然存在于水果和蔬菜中,近期研究揭示其也是一种内源性代谢物。赤藓糖醇在调节糖脂代谢、氧化应激和胃肠道功能等方面发挥着重要的作用。同时,赤藓糖醇还可以作为一种新型疾病生物标志物,预测肥胖、糖尿病、癌症等多种疾病的发生风险。该文系统梳理了赤藓糖醇的相关研究,在介绍其基本特征和代谢途径的基础上,综述其生物学功能和临床应用前景,以期为赤藓糖醇在不同健康或疾病状态人群中的应用提供新思路。

关键词：赤藓糖醇甜味剂糖脂代谢氧化应激胃肠道生物标志物

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