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INCloud:integrated neuroimaging cloud for data collection,management,analysis and clinical translations

General Psychiatry 2021年第6期34卷 58-65页

作者： Qingfeng Li Lijuan Jiang Kaini Qiao Yang Hu Bing Chen xiaochen zhang Yue Ding Zhi Yang Chunbo Li Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghaiChina Jing Hengyi School of Education Hangzhou Normal UniversityHangzhouZhejiangChina Institute of Psychological and Behavioral Sciences Shanghai Jiao Tong UniversityShanghaiChina Brain Science and Technology Research Center Shanghai Jiao Tong UniversityShanghaiChina Center for Excellence in Brain Science and Intelligence Technology(CEBSIT) Chinese Academy of SciencesShanghaiChina

Background Neuroimaging techniques provide rich and accurate measures of brain structure and function,and have become one of the most popular methods in mental health and neuroscience *** growing neuroimaging research generates massive amounts of data,bringing new challenges in data collection,large-scale data management,efficient computing requirements and data mining and *** To tackle the challenges and promote the application of neuroimaging technology in clinical practice,we developed an integrated neuroimaging cloud(INCloud).INCloud provides a full-stack solution for the entire process of large-scale neuroimaging data collection,management,analysis and clinical *** INCloud consists of data acquisition systems,a data warehouse,automatic multimodal image quality check and processing systems,a brain feature library,a high-performance computing cluster and computer-aided diagnosis systems(CADS)for mental disorders.A unique design of INCloud is the brain feature library that converts the unit of data management from image to image features such as hippocampal *** the CADS to the scientific database,INCloud allows the accumulation of scientific data to continuously improve the accuracy of objective diagnosis of mental *** Users can manage and analyze neuroimaging data on INCloud,without the need to download them to the local *** users can query,manage,analyze and share image features based on customized *** examples of'mega-analyses'based on the brain feature library are *** Compared with traditional neuroimaging acquisition and analysis workflow,INCloud features safe and convenient data management and sharing,reduced technical requirements for researchers,high-efficiency computing and data mining,and straightforward translations to clinical *** design and implementation of the system are also applicable to imaging research platforms in other fields.

关键词： image diagnosis translation

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Remediation of di(2-ethylhexyl)phthalate(DEHP)contaminated black soil by freeze-thaw aging biochar

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Journal of Environmental Sciences 2024年第1期135卷 681-692页

作者： Lei Wang Zeyu Dou Chaoran Ma xiaochen Jia Hongye Wang Wenjing Bao Lei Wang Jianhua Qu Ying zhang School of Resources and Environment Northeast Agricultural UniversityHarbin 150030China

Di(2-ethylhexyl)phthalate(DEHP),a complex structure with high toxicity,is a common organic *** study investigated the effects of fresh biochar(FBC),and freeze-thaw cycled aged biochar(FTC-BC)on DEHP-contaminated soils using a pot *** specific surface area of FBC increased from 145.20 to 303.50 m~2/g,and oxygen-containing functional groups increased from 1.26 to 1.48 mol/g after freeze-thaw cycles,greatly enhancing the adsorption of DEHP by biochar in the *** comprehensive radar chart evaluation showed that FBC and FTC-BC reduced DEHP growth stress and improved the soil *** with FBC,FTC-BC performed better in protecting the normal growth of pakchoi and improving soil *** addition,the application of biochar increased the diversity and abundance of bacteria in the DEHP-contaminated soil and changed the composition of the soil bacterial *** partial least squares path model(PLS-PM)showed that adding biochar as a soil remediation agent significantly positively impacted soil nutrients and indirectly reduced the DEHP levels in soil and plants by increasing soil microbial *** with FBC,FTC-BC creates a more satisfactory living environment for microorganisms and has a better effect on the degradation of DEHP in the *** study provides a theoretical basis for future biochar remediation of DEHP-contaminated soils in cold high-latitude regions.

关键词： DEHP Freeze-thaw cycles Biochar Soil restoration

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Deep transfer network of heterogeneous domain feature in machine translation

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High-Confidence Computing 2022年第4期2卷 8-13页

作者： Yupeng Liu Yanan zhang xiaochen zhang Harbin University of Science and Technology Harbin 150080China Heilongjiang Institute of Technology Harbin 150050China

In order to address the shortcoming of feature representation limitation in machine translation(MT)system,this paper presents a feature transfer method in *** feature transfer of the decoding process considered not only their own translation system,but also transferred knowledge of another translation *** domain meta feature and the objective function of domain adaptation are used to better model the domain transfer *** this paper,extensive experiments and comparisons are *** experiment results show that the proposed model has a significant improvement in domain transfer *** first model has better performance than baseline system,which improves 3.06 BLEU score on the news test set,improves 3.27 BLEU score on the education test set,and improves 3.93 BLEU score on the law test set;The second model improves 3.16 BLEU score on the news test set,improves 3.54 BLEU score on the education test set,and improves 4.2 BLEU score on the law test set.

关键词： Neural translation model Deep transfer network Heterogeneous domain Meta feature

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110kV双回路新型复合横担输电塔受力性能研究

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山西建筑 2024年第15期50卷 45-49页

作者：柴少磊王柄楠张晓晨徐波李燕李明星国网宁夏电力有限公司宁夏银川750001 西安建筑科技大学土木工程学院陕西西安710055

为研究110kV带二分拉杆的FRP复合横担双回路输电塔受力性能,采用有限元软件ANSYS建立复合横担塔分析模型,了解不同工况下输电塔的受力状态,对整塔位移和杆件轴力进行分析,得到各种荷载组合情况下的塔体受力情况,并与角钢塔对比。结果表... 详细信息

为研究110kV带二分拉杆的FRP复合横担双回路输电塔受力性能,采用有限元软件ANSYS建立复合横担塔分析模型,了解不同工况下输电塔的受力状态,对整塔位移和杆件轴力进行分析,得到各种荷载组合情况下的塔体受力情况,并与角钢塔对比。结果表明:复合横担塔以90°大风工况为控制工况;各工况作用下,钢构件的最大应力约为300MPa,位于塔腿主材处,复合材的最大应力约141MPa,位于复合材料拉杆处,塔体应力在安全裕度内,满足强度要求。

关键词： 110kV 输电塔双回路复合横担

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Run-and-Tumble Dynamics and Mechanotaxis Discovered in Microglial Migration

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Research 2024年第2期2023卷 95-103页

作者： Yiyu zhang Da Wei xiaochen Wang Boyi Wang Ming Li Haiping Fang Yi Peng Qihui Fan Fangfu Ye Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Wenzhou Institute University of Chinese Academy of SciencesWenzhouZhejang 325000China Songshan Lake Materials Laboratory DongguanGuangdong 523808China School of Science East China University of Science and TechnologyShanghai 200237China Oujang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)WenzhouZhejiang 325000China

Microglia are resident macrophage cells in the central nervous system that search for pathogens or abnormal neural activities and migrate to resolve the *** effective search and targeted motion of macrophages mean dearly to maintaining a healthy brain,yet little is known about their migration *** this work,we study microglial motion with and without the presence of external *** discover that the cells are promptly attracted by the applied forces(i.e.,mechanotaxis),which is a tactic behavior as yet unconfirmed in ***,in both the explorative and the targeted migration,microglia display dynamics that is strikingly analogous to bacterial run-and-tumble motion.A closer examination reveals that microglial run-and-tumble is more sophisticated,e.g.,they display a short-term memory when tumbling and rely on active steering during runs to achieve mechanotaxis,probably via the responses of mechanosensitive ion *** differences reflect the sharp contrast between microglia and bacteria cells(eukaryotes ***)and their environments(compact tissue ***).Further analyses suggest that the reported migration dynamics has an optimal search efficiency and is shared among a subset of immune cells(human monocyte and macrophage).This work reveals a fruitful analogy between the locomotion of 2 remote systems and provides a framework for studying immune cells exploring complex environments.

关键词： analogy closer prompt

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A high-sensitive and self-selective humanoid mechanoreceptor for spatiotemporal tactile stimuli cognition

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Nano Research 2024年第5期17卷 4400-4409页

作者： Shuxin Bi Xuan Zhao Fangfang Gao xiaochen Xun Bin Zhao Liangxu Xu Tian Ouyang Qingliang Liao Yue zhang Academy for Advanced Interdisciplinary Science and Technology Beijing Advanced Innovation Center for Materials Genome EngineeringUniversity of Science and Technology(Beijing)Beijing 100083China Key Laboratory of Advanced Materials and Devices for Post-Moore Chips Ministry of EducationBeijing Key Laboratory for Advanced Energy Materials and TechnologiesSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

The cognition of spatiotemporal tactile stimuli,including fine spatial stimuli and static/dynamic temporal stimuli,is paramount for intelligent robots to feel their surroundings and complete manipulation ***,current tactile sensors have restrictions on simultaneously demonstrating high sensitivity and performing selective responses to static/dynamic stimuli,making it a challenge to effectively cognize spatiotemporal tactile ***,we report a high-sensitive and self-selective humanoid mechanoreceptor(HMR)that can precisely respond to spatiotemporal tactile *** HMR with PDMS/chitosan@CNTs(PDMS:polydimethylsiloxane;CNT:carbon nanotube)graded microstructures and polyurethane hierarchical porous spacer exhibits high sensitivity of 3790.8 kPa^(-1).The HMR demonstrates self-selective responses to static and dynamic stimuli with mono signal through the hybrid of piezoresistive and triboelectric ***,it can respond to spatiotemporal tactile stimuli and generate distinguishable and multi-type characteristic *** the assistance of the convolutional neural network,multiple target objects can be easily identified with a high accuracy of 99.1%.This work shows great potential in object precise identification and dexterous manipulation,which is the basis of intelligent robots and natural human-machine interactions.

关键词： mechanoreceptors self-selective high-sensitive spatiotemporal tactile stimuli cognition sensors

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Oncogenic β-catenin-driven liver cancer is susceptible to methotrexate-mediated disruption of nucleotide synthesis

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Chinese Medical Journal 2024年第2期137卷 181-189页

作者： Fangming Liu Yuting Wu Baohui zhang Shuhui Yang Kezhuo Shang Jie Li Pengju zhang Weiwei Deng Linlin Chen Liang Zheng xiaochen Gai Hongbing zhang Department of Physiology State Key Laboratory of Common Mechanism Research for Major DiseasesHaihe Laboratory of Cell EcosystemInstitute of Basic Medical Sciences and School of Basic MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Department of Physiology Institute of Basic Medical Sciences and School of Basic MedicineGraduate School of Peking Union Medical CollegeChinese Academy of Medical SciencesBeijing100005China Department of Physiology School of Life ScienceChina Medical UniversityShenyangLiaoning 110122China School of Life Sciences Westlake UniversityHangzhouZhejiang 310024China Key Laboratory of Pediatric Hematology and Oncology Ministry of HealthInstitute of Pediatric Translational MedicineShanghai Children’s Medical CenterShanghai Jiao Tong School of MedicineShanghai 200127China

Background:Liver cancer is largely resistant to *** study aimed to identify the effective chemotherapeutics forβ-catenin-activated liver cancer which is caused by gain-of-function mutation of catenin beta 1(CTNNB1),the most frequently altered proto-oncogene in hepatic ***:Constitutiveβ-catenin-activated mouse embryonic fibroblasts(MEFs)were established by deleting exon 3(β-catenin^(Δ(ex3)/+)),the most common mutation site in CTNNB1 gene.A screening of 12 widely used chemotherapy drugs was conducted for the ones that selectively inhibitedβ-catenin^(Δ(ex3)/+)but not for wild-type *** metabolomics was carried out to examine the alterations of metabolites in nucleotide *** efficacy and selectivity of methotrexate(MTX)onβ-catenin-activated human liver cancer cells were determined in ***-deficient nude mice subcutaneously inoculated withβ-catenin wild-type or mutant liver cancer cells and hepatitis B virus(HBV);β-catenin^(lox(ex3)/+)mice were used,respectively,to evaluate the efficacy of MTX in the treatment ofβ-catenin mutant liver ***:MTX was identified and validated as a preferential agent against the proliferation and tumor formation ofβ-catenin-activated *** nucleotide synthesis was the major metabolic aberration inβ-catenin-active cells,and this alteration was also the target of ***,MTX abrogated hepatocarcinogenesis of HBV;β-catenin^(lox(ex3)/+)mice,which stimulated concurrent Ctnnb1-activated mutation and HBV infection in liver ***:MTX is a promising chemotherapeutic agent forβ-catenin hyperactive liver *** repurposing MTX has the advantages of lower risk,shorter timelines,and less investment in drug discovery and development,a clinical trial is warranted to test its efficacy in the treatment ofβ-catenin mutant liver cancer.

关键词： Liver cancer β-catenin Methotrexate Nucleotide synthesis Chemotherapy

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The characterization of protein lactylation in relation to cardiac metabolic reprogramming in neonatal mouse hearts

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Journal of Genetics and Genomics 2024年第7期51卷 735-748页

作者： Tongyu zhang Yingxi Zhu xiaochen Wang Danyang Chong Haiquan Wang Dandan Bu Mengfei Zhao Lei Fang Chaojun Li Ministry of Education Key Laboratory of Model Animals for Disease Study Model Animal Research CenterMedical School of Nanjing UniversityNational Resource Center for Mutant MiceNanjingJiangsu 210093China State Key Laboratory of Reproductive Medicine and Offspring Health China International Joint Research Center on Environment and Human HealthCenter for Global HealthSchool of Public HealthGusu SchoolNanjing Medical UniversityNanjingJiangsu 211166China

In mammals,the neonatal heart can regenerate upon injury within a short time after birth,while adults lose this *** reprogramming has been demonstrated to be critical for cardiomyocyte proliferation in the neonatal ***,we reveal that cardiac metabolic reprogramming could be regulated by altering global protein *** performing 4D label-free proteomics and lysine lactylation(Kla)omics analyses in mouse hearts at postnatal days 1,5,and 7,2297 Kla sites from 980 proteins are identified,among which 1262 Kla sites from 409 proteins are *** clustering analysis reveals that the proteins with altered Kla sites are mainly involved in metabolic *** expression and Kla levels of proteins in glycolysis show a positive correlation while a negative correlation in fatty acid ***,we verify the Kla levels of several differentially modified proteins,including ACAT1,ACADL,ACADVL,PFKM,PKM,and ***,our study reports a comprehensive Kla map in the neonatal mouse heart,which will help to understand the regulatory network of metabolic reprogramming and cardiac regeneration.

关键词： Lactylation Metabolicrep rogramming Postnatal heart regeneration Cell proliferation

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Recent progress in functional metal-organic frameworks for bio-medical application

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Regenerative Biomaterials 2024年第2期3卷 37-54页

作者： Wenwen Chai xiaochen Chen Jing Liu Liyan zhang Chunyu Liu Li Li John Robert Honiball Haobo Pan Xu Cui Deping Wang School of Materials Science and Engineering Tongji UniversityShanghai 201804China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China Department of Orthopaedics&Traumatology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina

Metal-organic frameworks(MOFs)have a high specific surface area,adjustable pores and can be used to obtain functional porous materials with diverse and well-ordered structures through coordination and self-assembly,which has intrigued wide interest in a broad range of *** the arena of biomedical engineering,the functionalized modification of MOFs has produced drug carriers with excellent dispersion and functionalities such as target delivery and response release,with promising applications in bio-detection,disease therapy,tissue healing,and other *** review summa-rizes the present state of research on the functionalization of MOFs by physical binding or chemical cross-linking of small *** *** hvdrogels and evaluates the role and approach of MOFs functionalization in boosting the reactivity of *** this basis,research on the application of functionalized MOFs composites in biomedical engineering fields such as drug delivery,tissue repair,disease treatment,bio-detection and imaging is surveyed,and the development trend and application prospects of functionalized MOFs as an important new class of biomedical materials in the biomedical field are anticipated,which may provide some inspiration and reference for further development of MOF for bio-medical applications.

关键词： metal-organic frameworks porous functionalization tissue repair disease treatment

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Research on Monitoring and Earlywarning System of Marine Organisms for the Intake of Nuclear PowerPlants

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Animal Husbandry and Feed Science 2018年第4期10卷 236-240页

作者： lu hairong meng yahui zhang xiaochen duan yongbo Suzhou Nuclear Power Research Institute Co. Ltd. Suzhou 215004 China 不详

An monitoring and earlywarning system is proposed for marine organisms and the cause of water intake blockage is analyzed. Based onthe intelligent sensing technology, computer software and hardware technology and digital signal processing technology, the buoy monitoring platformsystem is developed by internet of things technology, cloud computing and the application of large data. Remote realtime monitoring of aquatic organisms and foreign bodies is realized based on underwater acoustic detection and low light imaging technology. Data processing center is established to store, analyze and process monitoring information and display it in real time, and provide emergency decision support. Through development and test of relevant key equipments, the reliability of cold source system of nuclear power plants is improved, which effectively reduces theinfluence of marine biological invasion on security and economic operation of the units.

关键词： Water intake of nuclear power plants Marine biological invasion Monitoring and early warning

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