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黄原胶基新型伤口敷料研究进展

中国医疗美容 2024年第1期14卷 103-106页

作者：何琴张晓南重庆医科大学附属口腔医院口腔疾病与生物医学重庆市重点实验室重庆市高校市级口腔生物医学工程重点实验室重庆401147

黄原胶在生物医疗领域具有重要的价值。黄原胶基伤口敷料在伤口愈合领域作为一种新兴材料被设计成多种敷料类型。文章主要阐述以黄原胶为基质的水凝胶类,3D打印类,复合海绵类等新型伤口敷料,并总结用于伤口愈合的最新进展。黄原胶基伤... 详细信息

黄原胶在生物医疗领域具有重要的价值。黄原胶基伤口敷料在伤口愈合领域作为一种新兴材料被设计成多种敷料类型。文章主要阐述以黄原胶为基质的水凝胶类,3D打印类,复合海绵类等新型伤口敷料,并总结用于伤口愈合的最新进展。黄原胶基伤口敷料具有优异的促进伤口愈合能力。然而每种敷料都存在不足,因此为满足伤口愈合过程的需求,黄原胶基伤口敷料需要得到更广泛的关注和拓展研究。

关键词：黄原胶伤口敷料伤口愈合水凝胶 3D打印伤口敷料

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冠心病瘀毒证的分子生物学研究现状

时珍国医国药 2024年第2期35卷 400-403页

作者：刘昕怡张晓囡李晓雅刘龙涛北京中医药大学研究生院北京100029 中国中医科学院西苑医院北京100091 国家中医心血管病临床医学研究中心北京100091

冠心病瘀毒证是基于冠心病稳定期向不稳定期转变的病机演变理论,与血管内皮功能障碍、血液流变学、血小板功能及凝血-纤溶系统功能异常,脂代谢紊乱,炎症反应及肠道菌群失调等密切相关。该文从理化指标和分子生物学方面探讨冠心病“因瘀... 详细信息

冠心病瘀毒证是基于冠心病稳定期向不稳定期转变的病机演变理论,与血管内皮功能障碍、血液流变学、血小板功能及凝血-纤溶系统功能异常,脂代谢紊乱,炎症反应及肠道菌群失调等密切相关。该文从理化指标和分子生物学方面探讨冠心病“因瘀致毒,因毒致变”的证候本质,旨在为瘀毒证客观化提供参考,同时为进一步完善中西医结合诊治冠心病-瘀毒证提供思路和方法。

关键词：冠心病瘀毒证分子生物学病机

用于颅颌面骨缺损修复的骨组织工程支架研究进展

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中国医疗美容 2024年第3期14卷 109-114页

作者：朱俊霖张晓南重庆医科大学附属口腔医院口腔疾病与生物医学重庆市重点实验室重庆市高校市级口腔生物医学工程重点实验室重庆401147

颌面部骨骼是具有咀嚼运动、机械承重和支持软组织以维持面部美观等多功能的器官,颌骨缺损会导致面部畸形和颌骨功能的丧失,严重影响患者的生活质量。超过临界尺寸的骨组织无法自行修复与再生,往往需要通过骨移植材料的植入来恢复功能... 详细信息

颌面部骨骼是具有咀嚼运动、机械承重和支持软组织以维持面部美观等多功能的器官,颌骨缺损会导致面部畸形和颌骨功能的丧失,严重影响患者的生活质量。超过临界尺寸的骨组织无法自行修复与再生,往往需要通过骨移植材料的植入来恢复功能。考虑到自体移植和同种异体移植技术的缺点(如发病率高、失败率高和宿主排斥),骨组织工程已被广泛应用为治疗骨缺损的一种策略。有机高分子聚合物与钛合金由于其生物相容性佳在骨组织工程中被使用较多,不同材料表面改性方法被应用在骨组织工程支架上以改进其生物学相容性以及实现功能化。此外,不同的骨组织工程支架制造方式对支架性能存在巨大影响,尤其体现在精确度,经济性,制造速度方面。因此,本文旨在综述应用于颌面部骨缺损修复的骨组织工程支架的研究进展,尤其集中于材料分类以及制造方法方面,并探讨和展望其发展方向。

关键词：骨组织工程颅颌面骨缺损生物材料增材制造静电纺丝

血清ESM-1对非小细胞肺癌的诊断及预后价值

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中国老年学杂志 2024年第7期44卷 1574-1576页

作者：张玉敏张小楠高秀娟鞠思敏李玉柱周琪唐山市人民医院检验科河北唐山063000 唐山市人民医院肿瘤内科河北唐山063000 唐山市人民医院放射科河北唐山063000 唐山市人民医院保健室河北唐山063000

目的探讨内皮细胞特异性分子(ESM)-1对非小细胞肺癌(NSCLC)的诊断及预后价值。方法选取NSCLC患者73例为肺癌组和同期40例健康体检者为对照组,采用酶联免疫吸附试验(ELISA)检测血清ESM-1水平,采用Mann-Whitney U检验比较两组患者基本... 详细信息

目的探讨内皮细胞特异性分子(ESM)-1对非小细胞肺癌(NSCLC)的诊断及预后价值。方法选取NSCLC患者73例为肺癌组和同期40例健康体检者为对照组,采用酶联免疫吸附试验(ELISA)检测血清ESM-1水平,采用Mann-Whitney U检验比较两组患者基本特征、ESM-1水平差异,通过受试者工作特征(ROC)曲线分析血清ESM-1对NSCLC的诊断价值,采用Kaplan-Meier法描述生存曲线、Log-Rank检验比较各组生存特征,采用单因素和多因素Cox比例风险模型分析不同预后因素对生存时间的意义。结果肺癌组血清ESM-1水平高于对照组,差异具有统计学意义(P0.05);通过ROC曲线分析显示,血清ESM-1对NSCLC的诊断阈值为18.34 ng/ml,曲线下面积(AUC)为0.955,敏感度为86.3%,特异性为92.0%,阳性预测值为94.0%,阴性预测值为82.1%;不同年龄、性别、病理类型的NSCLC患者血清ESM-1水平比较均无统计学差异(P>0.05);Ⅲ~Ⅳ期患者的血清ESM-1水平明显高于Ⅰ~Ⅱ期患者,有远处转移患者的血清ESM-1水平明显高于无远处转移者(P<0.05);ESM-1高水平的NSCLC患者的生存时间明显低于ESM-1水平低的NSCLC患者(P=0.003),单因素分析显示,生存时间与病理类型(P=0.013)、TNM分期(P=0.001)、ESM-1水平(P=0.003)相关,但与年龄(P=0.752)、性别(P=0.393)无关。Cox回归分析显示,病理类型(HR:0.173,95%CI:0.040~0.739,P=0.018)、TNM分期(HR:2.046,95%CI:1.166~3.589,P=0.013)、ESM-1水平(HR:2.466,95%CI:1.012~6.661,P=0.049)是NSCLC生存时间的独立预后指标。结论血清ESM-1对NSCLC的诊断具有一定的价值,可能成为NSCLC患者预后的一种新的肿瘤生物标志物。

关键词：非小细胞肺癌内皮细胞特异性分子1 诊断

基于数据挖掘陈可冀院士治疗高血压病用药规律及机制研究

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中国中西医结合杂志 2024年第4期44卷 469-474页

作者：于宗良王泽平张晓囡李晓雅刘龙涛中国中医科学院西苑医院心血管病中心北京100091 国家中医心血管病临床医学研究中心北京100091 北京中医药大学研究生院北京100029

高血压病以体循环动脉压升高为主要临床表现,是急性心肌梗死、急性脑出血、脑梗死等危急重症的重要危险因素^([1])。最新研究显示,我国高血压病患者约2.45亿,控制率仅为16.8%^([2,3])。研究表明,中药降压疗效显著,在多靶点稳定降压的同... 详细信息

高血压病以体循环动脉压升高为主要临床表现,是急性心肌梗死、急性脑出血、脑梗死等危急重症的重要危险因素^([1])。最新研究显示,我国高血压病患者约2.45亿,控制率仅为16.8%^([2,3])。研究表明,中药降压疗效显著,在多靶点稳定降压的同时,能够有效保护靶器官^([4-6])。然而,中医临证组方繁杂,用药规律总结主观性较强,名老中医经验传承受到严峻挑战。通过中医传承辅助平台,能够系统分析、总结名老中医处方规律^([7, 8]),对于中医药传承发展和居民卫生健康具有重要意义^([9,10])。

关键词：中医传承辅助平台用药规律急性心肌梗死体循环动脉压高血压病患者危急重症急性脑出血多靶点

Water quality, agriculture and food safety in China:Current situation, trends, interdependencies, and management

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Journal of Integrative Agriculture 2015年第11期14卷 2365-2379页

作者： zhang xiao-nan GUO Qiu-ping SHEN xiao-xue YU Sheng-wen QIU Guo-yu Shenzhen Engineering Laboratory for Water Desalinization with Renewable Energy School of Environment and EnergyPeking University Chinese Academy for Environmental Planning

Water quality in China is becoming a severe challenge for agriculture and food safety, and it might also impact health of population via agriculture and food. Thus, it is causing widespread concern. Based on extensive literatures review and data mining, current situation of water pollution in China and its effects on food safety were analyzed. The 2nd National Water Resource Survey in China show that the surface water all over the country was under slight pollution and about 60% of groundwater is polluted. Drinking water quality is basically guaranteed in urban area but it is worrisome in rural areas. In addition, China is the largest consumer of fertilizer and pesticide in the world and the amounts of application still show increasing trends. Fertilizers and pesticides are the most important sources of pollution, which affect human health as persistent organic pollutants and environmental endocrine disruptors. Eutrophication of surface water and nitrate pollution of groundwater are serious threats to drinking water safety. Sewage irrigation is becoming a pollution source to China＇s water and land because of lacking of effective regulations. Although, with the advance in technology and management level, control of nitrogen and phosphorus emissions and reducing water pollution is still a major challenge for China.

关键词： agriculture drinking water eutrophication fertilizer food safety groundwater heavy metals microcystin nitrate pesticide pollution water quality

Shengmai San for Treatment of Cardiotoxicity from Anthracyclines:A Systematic Review and Meta-Analysis

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Chinese Journal of Integrative Medicine 2022年第4期28卷 374-383页

作者： zhang xiao-nan LI Yan-yang zhang Yuan-hui zhang Wan-qin ZHU Ya-ping zhang Jun-ping LV Shi-chao LIU Long-tao National Clinical Research Center for Chinese Medicine Cardiology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091China Tianjin Medical University Cancer Institute and Hospital Tianjin300060China First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin300112China

Objective:To systematically evaluate the efficacy of Shengmai San in patients with cardiotoxicity of ***:Randomized controlled trials(RCTs)were identified by searching China National Knowledge Infrastructure(CNKI),Wanfang Database,Chinese Biomedical Literature Database(CBM),Pub Med,Cochrane Library,and Embase Databases from the inceptions until December *** Cochrane Handbook was used to evaluate the risk of bias in the included *** analysis was conducted using Rev Man 5.3 ***:Totally 19 RCTs with 2,331 participants were included in this *** showed that in improving arrhythmia(13 RCTs,n=1,877,RR=0.37,95%CI 0.25 to 0.52,P<0.00001),the treatment group was superior to the control *** terms of reducing left ventricular end-diastolic diameter(LVEDD,2 RCTs,n=128,MD=-0.79,95%CI-0.93 to-0.65,P<0.00001)and left ventricular end systolic diameter(LVESD,2 RCTs,n=128,MD=-0.58,95%CI-0.82 to-0.35,P<0.00001),the treatment group was also better than the control *** reducing myocardial enzymes such as creatine kinase(CK)[(3 RCTs,n=256,SMD=-0.80,95%CI-1.16 to-0.44,P<0.0001),(2 RCTs,n=126,SMD=-0.62,95%CI-0.98 to-0.26,P=0.0007)],the treatment group was superior to the control ***:Shengmai San has a positive effect on the treatment of cardiotoxicity from ***,in the future,it is still necessary to conduct high-quality RCTs to verify its efficacy.

关键词： Shengmai San anthracyclines cardiotoxicity systematic review meta-analysis

Rupintrivir is a promising candidate for treating severe cases of Enterovirus-71 infection

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World Journal of Gastroenterology 2010年第2期16卷 201-209页

作者： zhang, xiao-nan Song, Zhi-Gang Jiang, Ting Shi, Bi-Sheng Hu, Yun-Wen Yuan, Zheng-Hong Shanghai Publ Hlth Clin Ctr Res Unit Shanghai 201508 Peoples R China Fudan Univ Shanghai Med Coll Key Lab Med Mol Virol Shanghai 200032 Peoples R China

AIM:To evaluate the suitability of rupintrivir against Enterovirus 71(EV71)induced severe clinical symptoms using computational methods. METHODS:The structure of EV71 3C protease was predicted by homology *** binding free energies between rupintrivir and EV71 3C and human rhinovirus 3C protease were computed by molecular dynamics and molecular mechanics Poisson-Boltzmann/ surface area and molecular mechanics generalized-born/ surface area ***71 3C fragments obtained from clinical samples collected during May to July 2008 in Shanghai were amplified by reverse-transcription and polymerase chain reaction and sequenced. RESULTS:We observed that rupintrivir had favorable binding affinity with EV71 3C protease(-10.76 kcal/mol). The variability of the 3C protein sequence in isolates of various outbreaks,including those obtained in our hospital from May to July 2008,were also analyzed to validate the conservation of the drug binding pocket. CONCLUSION:Rupintrivir,whose safety profiles had been proved,is an attractive candidate and can be quickly utilized for treating severe EV71 infection.

关键词： Rupintrivir Hand foot and mouth disease Molecular mechanics Poisson-Boltzmann/surface area Molecular mechanics Generalized-Born/surface area Homology modeling Picornavirus

Carbon coated LaFe_(0.92)Pd_(0.08)O_(3) composites for catalytic transfer hydrogenation:Balance in the ability of substrates adsorption and conversion

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nano Research 2024年第5期17卷 3724-3732页

作者： Bowen Wang nan zhang Ping xiao Jian zhang Sónia A.C.Carabineiro Junjiang Zhu Hubei Key Laboratory of Biomass Fibers and Eco-dyeing&Finishing College of Chemistry and Chemical EngineeringWuhan Textile UniversityWuhan 430200China College of Chemistry and Materials Engineering Wenzhou UniversityWenzhou 325035China LAQV-REQUIMTE Department of ChemistryNOVA School of Science and TechnologyUniversidade NOVA de LisboaLargo da Torre2829-516 CaparicaPortugal

Catalytic transfer hydrogenation(CTH)is a green and efficient pathway for selective hydrogenation of unsaturated aldehydes and ***,managing the abilities of solid catalysts to adsorb substrates and to convert them into desired products is a challenging ***,we report the synthesis of carbon coated LaFe_(0.92)Pd_(0.08)O_(3) composites(LFPO-8@C)for CTH of benzaldehyde(BzH)into benzyl alcohol(BzOH),using isopropanol(IPA)as hydrogen *** coating with carbon improves the ability to adsorb/transfer reactants from solution to active sites,and the doping of Pd2+at Fe3+site strengthens the ability of LaFeO_(3) to convert BzH into BzOH.A balanced point between them(i.e.,abilities to adsorb BzH and to convert BzH into BzOH)is obtained at LFPO-8@C,which exhibits a BzOH formation rate of 3.88 mmol·gcat^(-1)·h^(-1) at 180℃ for 3 h,which is 1.50 and 2.72 times faster than those of LFPO-8 and LaFeO_(3)@C.A reaction mechanism is proposed,in which the acidic sites(e.g.,Fe^(4+),oxygen vacancy)are used for the activation of C=O bond of BzH and O-H bond of IPA,and the basic sites(e.g.,lattice oxygen)for the activation ofα-H(O-H)bond of IPA.

关键词： LaFe_(0.92)Pd_(0.08)O_(3) porous carbon catalytic transfer hydrogenation isopropanol reaction mechanism