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Application of UiO-66 and its composites for remediation and resource recovery of typical environmental contaminants:a review

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Rare Metals 2024年第6期43卷 2498-2526页

作者： Hui-Min zhang Yun-Long wang Xin-feng Zhu zhen-zhen Huang dan-dan Pang Kai wang Chao-Hai wang Zhong-Xian Song shi-Qiang Yin Lin-Lin Chang Jin-Hui zhang School Infirmary Henan University of Urban ConstructionPingdingshan 467036China Faculty of Environmental and Municipal Engineering Henan Key Laboratory of Water Pollution Control and Rehabilitation TechnologyKey Laboratory of Carbon Emission Reduction and Combined Air Pollution Control TechnologyHenan University of Urban ConstructionPingdingshan 467036China School of Resources&Environment Collaborative Innovation Center of Coalbed Methane and Shale Gas for Central Plains Economic RegionHenan Polytechnic UniversityJiaozuo 454003China The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters Ministry of EducationGuangzhou Higher Education Mega CentreSouth China University of TechnologyGuangzhou 510006China

UiO-66 series metal-organic framework materials(MOFs)are typical porous materials assembled by Zr^(4+) with a large mass-to-nucleus ratio and terephthalic acid ligands,which form tetrahedral and octahedral cages arranged in a periodic triangular window *** to the strong interaction between Zr and O,UiO-66 series MOFs exhibit high thermal stability,structural stability,and chemical *** article mainly reviews the applications of UiO-66 and its composites in adsorption,photocatalysis,and resource utilization,while exploring the harm of pollutants to human health and the *** the first part,the differences in adsorption and removal mechanisms of liquid organic pollutants,heavy metals,and volatile organic compounds(VOCs)are *** results show that organic pollutants are mainly removed by physical adsorption,electrostatic interactions,hydrogen bonding,andπ-πinteractions,while heavy metals are mainly removed by chemical adsorption,electrostatic interactions,reduction,and *** are mainly removed by the pore volume and pore size structure of the *** catalysis can achieve non-toxic treatment of pollutants,and this study mainly focuses on UiO-based composite materials constructed by strategies such as semiconductor composites,ion doping,and metal/dye *** the second part,the synergistic effect between the components of UiO-based composite materials promotes the oriented and rapid separation and transfer of earriers at the material interface,thereby promoting the generation of active species such as h^(+),·O_(2)^(-) and·OH,and achieving rapid degradation of pollutants and detoxification of heavy *** the third part,heterojunctions can realize the resource utilization of pollutants in water and air,producing energy-type substances such as hydrogen and methanol while solving environmental *** addition,this article also summarizes the harm of common typical pollutants to the environment

关键词： UiO Adsorption Photocatalysis Environmental pollution Resource recovery

Effectiveness of Adherence to Standardized Hypertension Management by Primary Health Care Workers in China:a Cross-sectional Survey 3 Years after the Healthcare Reform

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Biomedical and Environmental Sciences 2016年第12期29卷 915-921页

作者： LI Yuan wang Jing Lei zhang xiao Chang LIU dan shi Wen Hui LIANG xiao feng WU Jing Division of NCD Control and Community Health Chinese Center for Disease Control and PreventionBeijing 102206China Center for Health Economics University of YorkHeslingtonYork YOIO 5DDUK

The standardized hypertension management provided by primary health care workers is an important part of China＇s recent health care reform efforts. Investigating 5,116 hypertensive patients from a cross-sectional survey conducted by the Chinese Center for Disease Control and Prevention in 2012, this study found that adherence to standardized hypertension management is associated with positive effects on hypertension- related knowledge, healthy lifestyle behavior, antihypertensive medical treatments, and blood pressure control. It will be necessary to provide primary health care workers with sufficient training and reasonable incentives to ensure the implementation and effectiveness of hypertension management.

关键词： Hypertension Primary health care Community health workers China

Chloroquine enhances the cytotoxicity of topotecan by inhibiting autophagy in lung cancer cells

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Chinese Journal of Cancer 2011年第10期30卷 690-700页

作者： Yao wang Rui-Qing Peng dan-dan Li Ya Ding xiao-Qi Wu Yi-Xin Zeng xiao-feng Zhu xiao-shi zhang State Key Laboratory of Oncology in South China Guangzhou Guangdong 510060 P. R. China Biotherapy Center Department of Experimental Research Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 P. R. China Department of Chemotherapy Zhongshan People＇s Hospital Zhongshan Guangdong 528403 P. R. China

Although the anti-malaria drug chloroquine(CQ) has been shown to enhance chemotherapy and radiation sensitivity in clinical trials,the potential mechanisms underlying this enhancement are still ***,we examined the relevant mechanisms by which the multipotent CQ enhanced the cytotoxicity of topotecan(TPT).The lung cancer cell line A549 was treated with TPT alone or TPT combined with CQ at non-cytotoxic *** viability was assessed using the MTT *** percentage of apoptotic cells and the presence of a side population of cells were both determined by flow *** and the expression of Bcl-2 family proteins were examined by Western *** accumulation of YFP-LC3 dots and the formation of acidic vesicular organelles were examined by confocal *** sensitized A549 cells to TPT and enhanced TPT-induced apoptosis in a Bcl-2 family protein-independent *** inhibited TPT-induced autophagy,which modified the cytotoxicity of ***,CQ failed to modify the transfer of TPT across the cytoplasmic membrane and did not increase lysosomal *** study showed that CQ at non-cytotoxic concentrations potentiated the cytotoxicity of TPT by interfering with autophagy,implying that CQ has significant potential as a chemotherapeutic enhancer.

关键词：细胞毒作用肺癌细胞自噬拓扑氯喹细胞毒性共聚焦显微镜 A549细胞

Clinical-radiomics predictors to identify the suitability of transarterial chemoembolization treatment in intermediate-stage hepatocellular carcinoma:A multicenter study

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Hepatobiliary & Pancreatic Diseases International 2023年第6期22卷 594-604页

作者： dan-dan wang Jin-feng zhang Lin-Han zhang Meng Niu Hui-Jie Jiang Fu-Cang Jia shi-Ting feng Department of Radiology the Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China Department of Breast Surgery Harbin Medical University Cancer HospitalHarbin 150081China Department of PET/CT the First Affiliated Hospital of Harbin Medical UniversityHarbin 150007China Department of Interventional Therapy the First Affiliated Hospital of China Medical UniversityShenyang 110001China Department of Radiology the First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China

Background: Although transarterial chemoembolization(TACE) is the first-line therapy for intermediatestage hepatocellular carcinoma(HCC), it is not suitable for all patients. This study aimed to determine how to select patients who are not suitable for TACE as the first treatment choice. Methods: A total of 243 intermediate-stage HCC patients treated with TACE at three centers were retrospectively enrolled, of which 171 were used for model training and 72 for testing. Radiomics features were screened using the Spearman correlation analysis and the least absolute shrinkage and selection operator(LASSO) algorithm. Subsequently, a radiomics model was established using extreme gradient boosting(XGBoost) with 5-fold cross-validation. The Shapley additive explanations(SHAP) method was used to visualize the radiomics model. A clinical model was constructed using univariate and multivariate logistic regression. The combined model comprising the radiomics signature and clinical factors was then established. This model’s performance was evaluated by discrimination, calibration, and clinical application. Generalization ability was evaluated by the testing cohort. Finally, the model was used to analyze overall and progression-free survival of different groups. Results: A third of the patients(81/243) were unsuitable for TACE treatment. The combined model had a high degree of accuracy as it identified TACE-unsuitable cases, at a sensitivity, specificity, and area under the receiver operating characteristic curve(AUC) of 0.759, 0.885, 0.906 [95% confidence interval(CI): 0.859-0.953] in the training cohort and 0.826, 0.776, and 0.894(95% CI: 0.815-0.972) in the testing cohort, respectively. Conclusions: The high degree of accuracy of our clinical-radiomics model makes it clinically useful in identifying intermediate-stage HCC patients who are unsuitable for TACE treatment.

关键词： Transarterial chemoembolization Hepatocellular carcinoma Radiomics Machine learning Prediction

Anti-obesity and Gut Microbiota Modulation Effect of Astragalus Polysaccharides Combined with Berberine on High-Fat Diet-Fed Obese Mice

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Chinese Journal of Integrative Medicine 2023年第7期29卷 617-625页

作者： YUE shi-jun wang Wen-xiao zhang Lei LIU Juan feng Wu-wen GAO Huan TANG Yu-ping YAN dan Beijing Key Laboratory of Bio-characteristic Profiling for Evaluation of Rational Drug Use Beijing Shijitan HospitalCapital Medical UniversityBeijing100038China Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility Shaanxi University of Chinese MedicineXi’an712046China Department of Pharmacy Beijing Friendship HospitalCaptical UniversityBeijing Institute of Clinical PharmacyBeijing100050China

Objective To investigate whether astragalus polysaccharides(APS)combined with berberine(BBR)can reduce high-fat diet(HFD)-induced obesity in *** Except for normal mice,32 HFD-induced obese mice were randomized into HFD,APS(1,000 mg/kg APS),BBR(200 mg/kg BBR),and APS plus BBR(1,000 mg/kg APS plus 200 mg/kg BBR)groups,*** 6-week treatment(once daily by gavage),the obesity phenotype and pharmacodynamic effects were evaluated by histopathological examination of epididymal fat,liver,and colon using hematoxylin-eosin staining and serum biochemical analyses by an automated chemistry *** feces were collected at the 12 th week,and taxonomic and functional profiles of gut microbiota were analyzed by 16S ribosomal ribonucleic acid(16S rRNA)*** Compared with HFD group,the average body weight of APS plus BBR group was decreased(Pdances of Bacteroides,which corresponded to the large increase of predicted bacterial genes involved in carbohydrate *** APS combined with BBR may synergistically reduce obesity and modulate the gut microbiota in HFD-fed mice.

关键词： Astragalus polysaccharides berberine obesity gut microbiota Bacteroides

Helicobacter pylori infection with atrophic gastritis: An independent risk factor for colorectal adenomas

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World Journal of Gastroenterology 2020年第37期26卷 5682-5692页

作者： Qin-Fen Chen xiao-Dong Zhou dan-Hong Fang En-Guang zhang Chun-Jing Lin xiao-zhen feng Na wang Jian-Sheng Wu dan wang Wei-Hong Lin Department of Physical Examination Medical Care Center The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Cardiovascular Medicine The Key Laboratory of Cardiovascular Diseases of WenzhouThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND The significance of Helicobacter pylori(***)infection and atrophic gastritis(AG)in the prevalence of colorectal adenomas has been examined in a limited number of ***,these studies reported disputed *** To investigate whether *** infection,AG,and ***-related AG increase the risk of colorectal *** This retrospective cross-sectional study included 6018 health-check *** relevant data for physical examination,laboratory testing,13C-urea breath testing,gastroscopy,colonoscopy and histopathological examination of gastric and colorectal biopsies were *** and multivariate logistic regression analyses were performed to determine the association between ***-related AG and colorectal *** Overall,1012 subjects(16.8%)were diagnosed with colorectal adenomas,of whom 143(2.4%)had advanced *** the enrolled patients,the prevalence of *** infection and AG was observed as 49.5%(2981/6018)and 10.0%(602/6018),*** with *** infection had an elevated risk of colorectal adenomas(adjusted odds ratio[OR]of 1.220,95%confidence interval(CI):1.053-1.413,P=0.008)but no increased risk of advance adenomas(adjusted OR=1.303,95%CI:0.922-1.842,P=0.134).AG was significantly correlated to an increased risk of colorectal adenomas(unadjusted OR=1.668,95%CI:1.352-2.059,P<0.001;adjusted OR=1.237,95%CI:0.988-1.549,P=0.064).*** infection accompanied by AG was significantly associated with an increased risk of adenomas(adjusted OR=1.491,95%CI:1.103-2.015,P=0.009)and advanced adenomas(adjusted OR=1.910,95%CI:1.022-3.572,P=0.043).CONCLUSION ***-related AG was associated with a high risk of colorectal adenomas and advanced adenomas in Chinese individuals.

关键词： Helicobacter pylori Gastritis Atrophy Adenomas Colorectal Health-check

The behavior of cesium adsorption on zirconyl pyrophosphate

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Nuclear Science and Techniques 2016年第3期27卷 74-79页

作者： feng-li song xiao-wei yang xiao-long li wei he dan lü ji que chun-long zhang shan-gui zhao shi-jun wang yun-tao liu Nuclear and Radiation Safety Center Ministry of Environmental ProtectionBeijing 100082China

Zirconyl pyrophosphate(ZrP_2O_7) was prepared and Cs adsorption behavior was *** show that the distribution coefficient of Cs adsorption on ZrP_2O_7 was about 2800 mL/*** exchange capacity of ZrP_2O_7 was0.35 mmol/*** dynamic tests,Cs can be separated from other fission products very well by ZrP_2O_*** ZrP_2O_7was stable both at high temperatures and in high concentration of nitric *** Cs adsorption by ZrP_2O_7 is a monolayer and chemical adsorption.

关键词：吸附行为磷酸锆铯动态测试分布系数交换能力裂变产物化学吸附

Engineering broad-spectrum disease-resistant rice by editing multiple susceptibility genes

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Journal of Integrative Plant Biology 2021年第9期63卷 1639-1648页

作者： Hui Tao Xuetao shi feng He dan wang Ning xiao Hong Fang Ruyi wang Fan zhang Min wang Aihong Li Xionglun Liu Guo-Liang wang Yuese Ning College of Agronomy Hunan Agricultural UniversityChangsha 410128China State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Department of Plant Pathology The Ohio State UniversityColumbusOH43210USA Institute of Agricultural Sciences for Lixiahe Region in Jiangsu Yangzhou 225009China

Rice blast and bacterial blight are important diseases of rice(Oryza sativa)caused by the fungus Magnaporthe oryzae and the bacterium Xanthomonas oryzae ***(Xoo),*** rice varieties for broadspectrum resistance is considered the most effective and sustainable approach to controlling both *** dominant resistance genes have been extensively used in rice breeding and production,generating diseaseresistant varieties by altering susceptibility(S)genes that facilitate pathogen compatibility remains ***,using CRISPR/Cas9 technology,we generated loss-of-function mutants of the S genes Pi21 and Bsr-d1 and showed that they had increased resistance to *** also generated a knockout mutant of the S gene Xa5 that showed increased resistance to ***,a triple mutant of all three S genes had significantly enhanced resistance to both *** and ***,the triple mutant was comparable to the wild type in regard to key agronomic traits,including plant height,effective panicle number per plant,grain number per panicle,seed setting rate,and thousand-grain *** results demonstrate that the simultaneous editing of multiple S genes is a powerful strategy for generating new rice varieties with broadspectrum resistance.

关键词： broad-spectrum resistance CRISPR/Cas9 gene editing Magnaporthe oryzae susceptibility gene Xanthomonas oryzae pv.oryzae

Single base substitution in Os CDC48 is responsible for premature senescence and death phenotype in rice

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Journal of Integrative Plant Biology 2016年第1期58卷 12-28页

作者： Qi-Na Huang Yong-feng shi xiao-Bo zhang Li-Xin Song Bao-Hua feng Hui-Mei wang Xia Xu xiao-Hong Li dan Guo Jian-Li Wu State Key Laboratory of Rice Biology China National Rice Research Institute Hangzhou 310006 China School of Life Sciences Hebei Normal University Shijiazhuang 050024 China

A premature senescence and death 128 （psd128） mutant was isolated from an ethyl methane sulfonate-induced rice IR64 mutant bank. The premature senescence phenotype appeared at the six-leaf stage and the plant died at the early heading stage, psd128 exhibited impaired chloroplast develop- ment with significantly reduced photosynthetic ability, chlorophyll and carotenoid contents, root vigor, soluble protein content and increased malonaldehyde content. Furthermore, the expression of senescence-related genes was significantly altered in psd128. The mutant trait was controlled by a single recessive nuclear gene. Using map- based strategy, the mutation Oryza sativa cell division cycle 48 （OsCDC48） was isolated and predicted to encode a putative AAA-type ATPase with 809 amino-acid residuals. A single base substitution at position C2347T in psd128 resulted in a premature stop codon. Functional complementation could rescue the mutant phenotype. In addition, RNA interference resulted in the premature senescence and death phenotype. OsCDC48 was expressed constitutively in the root, stem, leaf and panicle. Subcellular analysis indicated that OsCDC48：YFP fusion proteins were located both in the cytoplasm and nucleus. OsCDC48 was highly conserved with more than 90% identity in the protein levels among plant species. Our results indicated that the impaired function of OsCDC48 was responsible for the premature senescence and death phenotype.

关键词： Oryza sativa premature senescence and death AAA-ATPase OsCDC48