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Global burden of viral infectious diseases of poverty based on Global Burden of Diseases Study 2021

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贫困所致传染病(英文) 2024年第5期13卷 53-67页

作者： Li xin-Chen zhang Yan-Yan zhang Qi-Yu Liu Jing-Shu Ran Jin-Jun Han Le-Fei zhang xiao-xi School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai People’s Republic of China Institute of One Health Shanghai Jiao Tong University Shanghai People’s Republic of China School of Public Health Shanghai Jiao Tong University School of Medicine Shanghai People’s Republic of China

Background Viral infectious diseases of poverty (vIDPs) remain a significant global health challenge. Despite their profound impact, the burden of these diseases is not comprehensively quantified. This study aims to analyze the global burden of six major vIDPs, including coronavirus disease 2019 (COVID-19), HIV/AIDS, acute hepatitis, dengue, rabies, and Ebola virus disease (EVD), using data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 (GBD 2021).Methods Following the GBD 2021 framework, we analyzed the incidence, mortality, and disability-adjusted life years (DALYs) of the six vIDPs across 204 countries and territories from 1990 to 2021. We examined the association between the Socio-Demographic Index (SDI) and the burden of vIDPs. All estimates were reported as numbers and rates per 100,000 population, calculated using the Bayesian statistical model employed by GBD 2021, with 95% uncertainty intervals (UI).Results In 2021, vIDPs caused approximately 8.7 million deaths and 259.2 million DALYs, accounting for 12.8% and 9.0% of the global all-cause totals, respectively. Globally, the burden of vIDPs varied significantly: COVID-19 caused around 7.9 million (95% UI: 7.5, 8.4) deaths and 212.0 million (95% UI 197.9, 234.7) DALYs in 2021. Acute hepatitis had the second-highest age-standardized incidence rate, with 3411.5 (95% UI: 3201.8, 3631.3) per 100,000 population, while HIV/AIDS had a high age-standardized prevalence rate, with 483.1 (95% UI: 459.0, 511.4) per 100,000 population. Dengue incidence cases rose from 26.5 million (95% UI: 3.9, 51.9) in 1990 to 59.0 million (95% UI: 15.5, 106.9) in 2021. Rabies, although reduced in prevalence, continued to pose a significant mortality risk. EVD had the lowest overall burden but significant outbreak impacts. Age-standardized DALY rates for vIDPs were significantly negatively correlated with SDI: acute hepatitis (r = -0.8,P < 0.0001), rabies (r = -0.7,P < 0.0001), HIV/AIDS (r = -0.6,P < 0.0001), C

关键词： Viral infectious diseases of poverty Global Burden of Disease 2021 Disability-adjusted life years Socio-Demographic Index

Citrate versus unfractionated heparin for anticoagulation in continuous renal replacement therapy

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Chinese Medical Journal 2013年第7期126卷 1344-1349页

作者： LIAO Yu-jie zhang Ling ZENG xiao-xi FU Ping Division of Nephrology West China Hospital of Sichuan University Chengdu Sichuan 610041 China

Background Unfractionated heparin is the most commonly used anticoagulant in continuous renal replacement therapy （CRRT）, but it can increase the risk of bleeding. Citrate is a promising substitute. Our study was to assess the efficacy and safety of citrate versus unfractionated heparin in CRRT. Methods We searched the MEDLINE, the EMBASE, the Cochrane Central Register of Controlled Trials, and the China National Knowledge Infrastructure Database until up to November 2011 for randomized controlled trials comparing citrate with unfractionated heparin in adult patients with acute kidney injury prescribed CRRT. The primary outcome was mortality and the secondary outcomes included circuit survival, control of uremia, risk of bleeding, transfusion rates, acid-base statuses, and disturbance of sodium and calcium homeostasis. Results Four trials met the inclusion criteria. Meta-analysis found no significant difference between two anticoagulants on mortality. Less bleeding and more hypocalcemic episodes were with citrate. Citrate was superior or comparable to unfractionated heparin in circuit life. Conclusions Citrate anticoagulation in CRRT seems to be superior in reducing bleeding risk and with a longer or similar circuit life, although there is more metabolic derangement. Mortality superiority has not been approved.

关键词： continuous renal replacement therapy anticoagulation citrate unfractionated heparin meta-analysis

Molecular Epidemiological Analysis of Group A Streptococci Isolated from Children in Chaoyang District of Beijing, 2011:emm Types, Virulence Factor Genes and Erythromycin Resistant Genes

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Biomedical and Environmental Sciences 2013年第9期26卷 782-784页

作者： WANG Hai Bin SONG Yan Yan YOU Yuan Hai WANG Heng Wei HAN Qin Hua ZHAO Jian Hong zhang xiao xi Laboratory of Microbiology Chaoyang District Center for Disease Control and Prevention Department of Diagnosis National Institute for Communicable Disease Control and Prevention Chinese Center for DiseaseControl and Prevention State Key Laboratory for Infectious Disease Prevention and Control

Group A streptococcus （GAS） causes a wide range of diseases in the human population. GAS diseases are more common in children than in adults, with clinical manifestations ranging from pharyngitis and impetigo to invasive infections and post streptococcal sequelae, such as acute rheumatic fever and acute post-streptococcal glomerulonephritis[1]. GAS harbors a host of virulence factors that contribute to its complex pathogenicity and differences in the disease severity and frequency. M protein, one of the major virulence factors, is encoded by the emm gene induces a type of specific host immune response and confers antiphagocytic properties.

关键词： Virulence Factor Genes and Erythromycin Resistant Genes emm Types Molecular Epidemiological Analysis of Group A Streptococci Isolated from Children in Chaoyang District of Beijing GAS

A mobile mass - a left atrial undifferentiated sarcoma mimicking myxoma： a case report

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Chinese Medical Journal 2008年第14期121卷 1339-1341页

作者： SHAO Huan-zhang xiao xi-jun ZHU Peng QIAN Yong-jun YUAN Hong-sheng Department of Cardiovascular Surgery West China Hospital Sichuan University Chengdu Sichuan 610041 China

The incidence of primary cardiac tumors is extremely low, ranging from 0.0017% to 0.019%.^1 Primarytumors can be categorized into benign or malignant tumors, in which 75% of primary tumors are benign with myxomas comprising 50% of the cases. On the other hand, malignant tumors constitute less than 25% of primary cardiac neoplasms and are manifested predominantly as sarcoma in various forms.

关键词： heart neoplasms myxoma sarcoma surgery.

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对公司人格否认制度具体适用的思考

河北学刊 2007年第4期27卷 179-181页

作者：张小溪南开大学经济学院天津300071

作为现代公司制度的一项重要内容,公司人格否认制度已被2006年开始实行的新《公司法》明确规定下来。该制度虽被称为"公司人格否认",但却是以无视公司人格的方法,阻止公司独立人格的滥用。因此,它实际上是《公司法》的一项补充性制度。... 详细信息

作为现代公司制度的一项重要内容,公司人格否认制度已被2006年开始实行的新《公司法》明确规定下来。该制度虽被称为"公司人格否认",但却是以无视公司人格的方法,阻止公司独立人格的滥用。因此,它实际上是《公司法》的一项补充性制度。本文在对公司法理论及国外司法实践进行考察后认为,在中国今后的司法实践中,公司人格否认需要得到相当谨慎的适用。

关键词：公司人格否认法人人格有限责任

Immune mechanism and clinical significance of macrophage to medullary hematopoietic injury of immune-related hematocytopenia patients

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Chinese Medical Journal 2013年第24期126卷 4696-4702页

作者： SUN Li-fei HAN Bing WU Qiang-qiang zhang xiao-xi DU Yan-hui WANG Gui-chen zhang Jin-biao zhang Yan Department of Tumor Research and Treatment Centricity People'sLiberation Army No. 148 Hospital Zibo Shandong 255300 China

Background Immune-related hematocytopenia （IRH） is considered to be related with the production of autoantibody, as well as the activation of humoral immunity which is stimulated by B lymphocyte. This study aimed to observe the levels of various cytokines in the blood serum and the in situ active state of macrophage （Me） in the medullary hematopoietic microenvironment of IRH patients, and to probe into the immune mechanism and clinical significance of Me in hematopoietic cell injury. Methods ELISA is used to detect the IL-4, IL-6, IL-12, IL-17, and IFN-y levels in the peripheral blood serum of 376 patients in pre- and post-therapy. Cytochemistry and cell immunochemistry methods are used to observe the peroxidase （POX）, nonspecific esterase （NSE）, hemosiderin granules, and HLA-DR activity of Me in the bone marrow of patients. Immunofluorescence is used to observe the expression of hemocyte antihuman globulin IgG antibody, lymphocytes CD4 molecule, Me membrane Fcyllreceptor （FcyllR）, mannitose receptor （MR）, IFN-y, ICAM-1, IL-12, and IL-17A and the formation mechanism of antibody-dependent cell-mediated cytotoxicity （ADCC） hematopoietic cell islands （HI） in the medullary hematopoietic microenvironment of patients. Glucocorticoid is used for treatment on the basis of anti-infection therapy, and gamma globulin stoss therapy is used for the appearance of ADCC-type HI or serious Me bloodthirsty phenomenon; if necessary, association of Cyclosporine A （CsA） should be used and chalybeate should be supplemented. Results In the patient group, the levels of IL-4, IL-6, IL-12, IL-17, and IFN-y were increased. After treatment, the cytokine levels gradually became normal. The activated Me in the marrow highly expressed NSE and POX, and Me swallowed more hemosiderin particles, but the iron in the cytoplasm of immature erythrocytes decreased. The activated Me expressed HLA-DR, MR, ICAM-1, IFN-y, and IL-12. For patients with humoral immunity activation and bacterial infection, Me wea

关键词： macrophage immune-related hematocytopenia antibody-dependent cell-mediated cytotoxicity effect Fcy receptor, intercellular adhesion molecule-l interferon-y," interleukin-17A

Detection of recent HIV-1 infections among men who have sex with men in Beijing during 2005-2006

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Chinese Medical Journal 2008年第12期121卷 1105-1108页

作者： LI Shen-wei zhang xiao-yan LI xin-xu WANG Min-jie LI Dong-liang RUAN Yu-hua zhang xiao-xi SHAO Yi-ming State Key Laboratory for Infectious Disease Prevention and Control National Center for AIDS/STD Control and Prevention China CDC Beijing 100050 China Chaoyang District Center for AIDS/STD Control and Prevention Beijing 100021 China

Background Men who have sex with men （MSM） have become one of the most risky populations for HIV infection in China. Though several cross-sectional sero-prevalence studies have been conducted, the annual HIV incidence remains unknown in this population.Methods We applied IgG-capture BED-enzyme immunoassay （BED-CEIA） to define the recent HIV-1 infections among MSM in Beijing in the years 2005 and 2006 and the annual HIV incidence was estimated.Results Overall, 1067 MSM samples were collected, including 526 samples in the year 2005 and 541 in 2006. In 2005, of 17 HIV seropositive samples, 7 were identified as recent HIV-1 infections and the estimated HIV infection incidence was 2.9% per year （95% CI, 0.8%-5.0%）. In 2006, of 26 HIV seropositive samples, 9 were identified as recent HIV-1 infections and the estimated annual incidence was 3.6% （95% CI, 1.3%-5.9%）, which was 0.7% higher than that in 2005. Individuals engaging in male group sexual intercourse （5.17% vs 0.87%, P=0.019） and having receptive anal sexual intercourse more than five times （2.79% vs 0.33%, P=0.047） in the past 6 months significantly increase the risk of being infected by HIV-1.Conclusions A high level of annual HIV-1 infection incidence was observed among MSM in Beijing for the consecutive years 2005 and 2006 with a continuous increasing trend. The rising incidence and related high risk behavior among MSM alarmed the health authorities and calls for more effective intervention strategies among this population.

关键词： HIV-1 men who have sex with men HIV incidence IgG-capture BED-enzyme immunoassay

Lipid levels and insulin resistance markers in patients with colorectal cancer:Propensity score matching analysis

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 130-142页

作者： Ren-Hao Hu Dong-Yi Yan Ke-Hui zhang Di zhang xi-Mao Cui xiao-Hua Jiang Shun zhang Department of Gastrointestinal Surgery Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China School of Medicine Tongji UniversityShanghai 200092China Department of Emergency Medicine Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China

BACKGROUND Colorectal cancer(CRC)is a prevalent malignant neoplasm characterized by subtle early *** To investigate the correlation among serum lipid profiles,the triglyceride-glucose(TyG)index,and the atherosclerotic index(AI)in patients with ***,it explored the clinical diagnostic utility of combining serum lipids with cancer antigens in the context of *** A retrospective analysis encompassed 277 patients with CRC and 1034 healthy *** Following propensity score matching,patients with CRC exhibited significantly reduced levels of serum triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol,and low-density lipoprotein cholesterol(LDL-C),as well as a diminished TyG ***,they displayed elevated AI levels compared to their healthy *** in advanced stages exhibited lower serum levels of TG,TC,and LDL-C compared to those in early *** with positive lymph node metastasis demonstrated reduced levels of TG,LDL-C,and the TyG *** operating characteristic analysis revealed that the combination of the TyG index,carcinoembryonic antigen,and carbohydrate antigen 19-9 yielded the highest positive prediction rate for CRC at 75.3%.CONCLUSION Preoperative serum lipid profiles exhibit a robust association with patients with *** concurrent assessment of multiple serum lipids and cancer antigens effectively enhances the diagnostic accuracy for CRC.

关键词： Colorectal cancer Serum lipids Triglyceride-glucose index Atherosclerotic index Diagnostic marker

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磷酸酯中结合磷与无机磷的分析测定

精细化工 2001年第3期18卷 178-180页

作者：张小希胡天戈吉林化学工业集团公司助剂厂吉林吉林132022 吉林化学工业集团公司研究院吉林吉林132021

将试样在硝酸、硫酸、高氯酸中分解 ,用钒钼酸铵法以 72 1型分光光度计测定阴离子表面活性剂磷酸酯中的无机磷、结合磷的质量。

关键词：磷酸酯钒钼酸铵法无机磷结合磷测定阴离子表面活性剂