检索结果-南通市图书馆

Gene therapy for monogenic disorders: challenges, strategies, and perspectives

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第2期51卷 133-143页

作者： yi zhang Zhi-ying Wu Department of Medical Genetics and Center for Rare Diseases Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Department of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Key Laboratory of Medical Neurobiology of Zhejiang Province HangzhouZhejiang 310009China

Monogenic disorders refer to a group of human diseases caused by mutations in single genes. While disease-modifying therapies have offered some relief from symptoms and delayed progression for some monogenic diseases, most of these diseases still lack effective treatments. In recent decades, gene therapy has emerged as a promising therapeutic strategy for genetic disorders. Researchers have developed various gene manipulation tools and gene delivery systems to treat monogenic diseases. Despite this progress, concerns about inefficient delivery, persistent expression, immunogenicity, toxicity, capacity limitation, genomic integration, and limited tissue specificity still need to be addressed. This review gives an overview of commonly used gene therapy and delivery tools, along with the challenges they face and potential strategies to counter them.

关键词： Gene therapy Monogenic diseases Geneediting Genedelivery Challenges

Recent progress and strategies of cathodes toward polysulfides shuttle restriction for lithium-sulfur batteries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第9期43卷 4132-4161页

作者： Xing-You Rao Shuang-Fei xiang Jian Zhou Zhen zhang xiang-Yu Xu Yuan-Yuan Xu Xin-Chi Zhou Zheng-Dao Pan Su-Chong Tan Shi-Xing Dong Zhou-Lu Wang Yu-Tong Wu Yun-Lei Zhou xiang Liu yi zhang Shan Jiang School of Energy Sciences and Engineering Nanjing Tech UniversityNanjing 211816China School of Materials Science and Engineering and Institute of Smart Fiber Materials Zhejiang Sci-Tech UniversityHangzhou 310018China JiangSu Sailboat Petrochemical Co. LtdLianyungang 222000China Hangzhou Institute of Technology Xidian UniversityHangzhou 311200China

Lithium-sulfur batteries(LSBs)have already developed into one of the most promising new-generation high-energy density electrochemical energy storage systems with outstanding features including high-energy density,low cost,and environmental ***,the development and commercialization path of LSBs still presents significant limitations and challenges,particularly the notorious shuttle effect triggered by soluble longchain lithium polysulfides(LiPSs),which inevitably leads to low utilization of cathode active sulfur and high battery capacity degradation,short cycle life,*** research efforts have been conducted to develop various sulfur host materials capable of effectively restricting the shuttle *** review firstly introduces the fundamental electrochemical aspects of LSBs,followed by a comprehensive analysis of the mechanism underlying the shuttle effect in Li–S batteries and its profound influence on various battery components as well as the overall battery ***,recent advances and strategies are systematically reviewed,including physical confinement,chemisorption,and catalytic conversion of sulfur hosts for restricting LiPSs shuttle *** interplay mechanisms of sulfur hosts and LiPSs are discussed in detail and the structural advantages of different host materials are ***,key insights for the rational design of advanced host materials for LSBs are provided,and the upcoming challenges and the prospects for sulfur host materials in lithium-sulfur batteries are also explored.

关键词： Lithium-sulfur batteries Polysulfides Shuttle effect Host

Feature-Grounded Single-Stage Text-to-Image Generation

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tsinghua Science and Technology 2024年第2期29卷 469-480页

作者： Yuan Zhou Peng Wang Lei xiang Haofeng zhang School of Artificial Intelligence Nanjing University of Information Science and TechnologyNanjing 210044China School of Computer Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China

Recently,Generative Adversarial Networks(GANs)have become the mainstream text-to-image(T2I)***,a standard normal distribution noise of inputs cannot provide sufficient information to synthesize an image that approaches the ground-truth image ***,the multistage generation strategy results in complex T2I ***,this study proposes a novel feature-grounded single-stage T2I model,which considers the“real”distribution learned from training images as one input and introduces a worst-case-optimized similarity measure into the loss function to enhance the model's generation *** results on two benchmark datasets demonstrate the competitive performance of the proposed model in terms of the Frechet inception distance and inception score compared to those of some classical and state-of-the-art models,showing the improved similarities among the generated image,text,and ground truth.

关键词： text-to-image(T2I) feature-grounded single-stage generation Generative Adversarial Network(GAN)

Effect of heat treatment on microstructure and mechanical properties of selective laser-melted PH13-8Mo stainless steel

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2024年第4期31卷 945-955页

作者： Yuan zhang xiang Liu Chang-jun Wang Chang Liu School of Material Science and Engineering Kunming University of Science and TechnologyKunming 650093YunnanChina Central Iron&Steel Research Institute Co. Ltd.Beijing 100081China

PH13-8Mo stainless steel powder with high sphericity and well fluidity was prepared by the plasma rotating electrode *** formed parts with ultra-high purity were manufactured by selective laser *** tensile and impact mechanical properties of the printed parts under three heat treatment regimes were compared to those without heat *** microstructure,grain orientation and phase composition were characterized by electron-backscatter diffraction,X-ray diffraction and transmission electron *** characterization results reveal that the addition of heat treatment makes the grains enlarge,and after different heat treatments,the average grain size from 1.51μm in the printed state increases to 2.78,3.09 and 2.06μm,*** formed parts are mainly composed of martensite and retained ***,the NiAl and M23C precipitates form,which are the major strengthening phases of PH13-8Mo stainless *** optimal heat treatment process is 925℃×1 h water cooling(WC)+0℃×2 h air cooling(AC)+540℃×4 h *** this heat treatment process,PH13-8Mo formed parts have the optimal comprehensive mechanical properties:the tensile strength,yield strength and impact energy KU2 are 1492 MPa,1432 MPa and 63 J,*** strengthening and toughening via heat treatment are mainly attributed to dislocation strengthening,the formation of NiAl and M23Co precipitates and the change of volume fraction of the retained austenite.

关键词： High-strength stainless steel-Selective laser melting-Heat treatment Microstructure Mechanical property

Near real-time gravitational wave data analysis of the massive black hole binary with TianQin

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 175-186页

作者： Hong-Yu Chen xiang-Yu Lyu En-Kun Li yi-Ming Hu MOE Key Laboratory of TianQin Mission TianQin Research Center for Gravitational Physics&School of Physics and AstronomyFrontiers Science Center for TianQinGravitational Wave Research Center of CNSASun Yat-sen University(Zhuhai Campus)Zhuhai 519082China

Space-borne gravitational wave(GW)detectors can detect the merger of massive black *** early warning and localization of GW events before merging can be used to inform electromagnetic telescopes and conduct multimessenger ***,this requires real-time data transmission and analysis *** geocentric orbit of the space-borne GW detector Tian Qin makes it possible to conduct real-time data *** this study,we develop a search and localization pipeline for massive black hole binaries(MBHBs)with Tian Qin under both regular and real-time data transmission *** demonstrate that,with real-time data transmission,MBHBs can be accurately localized on the *** the approaching merger,each analysis can be finished in only 40 *** an MBHB system at a distance of 1 Gpc,if we receive data every hour,then we can pinpoint its location to within less than 1 deg^(2)on the final day before the merger.

关键词： gravitational wave detectors and experiments black holes data analysis algorithms and implementation data management

A high-entropy-designed cathode with V^(5+)-V^(2+) multi-redox for high energy density sodium-ion batteries

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第10期97卷 429-437,I0008页

作者： xiang Ding Xiaofen Yang yibing Yang Liangwei Liu yi Xiao Lili Han College of Chemistry and Materials Science Fujian Normal University.Fuzhou 350007FujianChina State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002FujianChina

Na_(3)V_(2)(PO_(4))_(3)(NVP)is gifted with fast Na^(+)conductive NASICON *** it still suffers from low electronic conductivity and inadequate energy ***,a high-entropy modification strategy is realized by doping V^(3+)site with Ga^(3+)/Cr^(3+)/Al^(3+)/Fe^(3+)/In^(3+)simultaneously(***_(3)V_(2-x)(GaCrAlFeIn)_x(PO_(4))_(3);x=0,0.04,0.06,and 0.08)to stimulate the V^(5+)■V^(2+)reversible multi-electron *** configuration high-entropy can effectively suppress the structural collapse,enhance the redox reversibility in high working voltage(4.0 V),and optimize the electronic induced *** in-situ X-ray powder diffraction and in-situ electrochemical impedance spectroscopy tests efficaciously confirm the robust structu ral recovery and far lower polarization throughout an entire charge-discharge cycle during 1.6-4.3 V,***,the density functional theory calculations clarify the stronger metallicity of high-entropy electrode than the bare that is derived from the more mobile free electrons surrounding the vicinity of Fermi *** grace of high-entropy design and multi-electron transfer reactions,the optimal Na_(3)V_(1.7)(GaCrAlFeIn)_(0.06)(PO_(4))_(3)can exhibit perfect cycling/rate performances(90.97%@5000 cycles@30 C;112 mA h g^(-1)@10 C and 109 mA h g^(-1)@30 C,2.0-4.3 V).Furthermore,it can supply ultra-high185 mA h g^(-1)capacity with fa ntastic energy density(522 W h kg^(-1))in half-cells(1.4-4.3 V),and competitive capacity(121 mA h g^(-1))as well as energy density(402 W h kg^(-1))in full-cells(1.6-4.1 V),demonstrating enormous application potential for sodium-ion batteries.

关键词： Na_(3)V_(2)(PO_(4))_(3) High-entropy V^(5+)■V^(2+)multi-redox High energy density Sodium-ion batteries

Knockout of OsSPL10 confers enhanced glufosinate resistance in rice

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Plant Communications 2024年第2期5卷 7-10页

作者： Jin-Qiu Xia Qin-Yu Liang Da-Yu He Zheng-yi zhang Jie Wu Jing zhang Ping-Xia Zhao Zi-Sheng zhang Cheng-Bin xiang Division of Life Sciences and Medicine Division of Molecular&Cell BiophysicsHefei National Science Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaThe Innovation Academy of Seed DesignChinese Academy of SciencesHefeiAnhui Province 230027China

Dear Editor,Rice(Oryza sativa L.)is one of the world’s major food crops,feeding more than half of the global *** reduce labor and production costs,direct seeding is becoming popular for rice cultivation,but weeds have become a serious problem(Jin et al.,2022).Chemical herbicides are one of the most effective ways to control ***,the development of herbicide-resistant rice has great significance for modern rice production.

关键词： crops population. weed

An analytical model of hot rolling force for a thick plate by combining globally optimal approximation yield criterion and egg-circular velocity field

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2024年第3期31卷 647-659页

作者： Shun-hu zhang yi zhang Wen-hao Tian Yan Li Shagang School of Iron and Steel Soochow UniversitySuzhou 215021JiangsuChina

For the sake of solving the problem that it is difficult to be integrated for the Mises specific plastic power due to its nonlinearity,a new linear criterion,named the globally optimal approximation criterion,is constructed by the polygonal approximation to the Mises *** new criterion is proved to be the linear function of the principal stress componentsσ1,σ2 andσ3 and the trajectory of it on theπ-plane is a non-equiangular but equilateral dodecagon intersecting the Mises *** theoretical results of the current criterion described by the Lode stress parameters are in excellent accordance with the experimental ***,according to the trend that the metallic flow velocity between rollers aggrandizes gradually from the inlet to the outlet during the hot rolling of a thick plate,a biomimetic velocity field is proposed in which the horizontal velocity component fits the egg-circular curve *** velocity field and its simulated results agree quite ***,using the determined linear criterion,energy analysis of the constructed velocity field is utilized to obtain the interior deformation power,while the vector decomposition approach is utilized to obtain the frictional power and shear *** this basis,the overall power is obtained and the analytical solutions are generated for the rolling torque,rolling force and the coefficient of the stress state under different egg curves by minimizing the neutral ***,the parameter optimization of the characteristic parameterρwhich affects the slope of the egg-circular curve is carried out and the best egg-circular curve which can minimize the energy consumption is *** best agreement between the theoretical and observed values of rolling force and rolling torque is under this curve,and the mean relative errors of the rolling torque and rolling force are no more than 2.93%,while the maximum error is no more than 8.35%.

关键词： yield criterion Plastic deformation Rolling force Velocity field Analytical solution

Churning loss characteristics of a wet three-phase high-speed reluctance motor

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第3期25卷 251-267页

作者： Zhenzhou zhang Mingzhu DAI Chenchen zhang yi CHEN Bin MENG College of Mechanical Engineering Zhejiang University of TechnologyHangzhou 310023China

With the increasing requirements of electro-hydrostatic actuators(EHAs)for power,volume,and pressure,there is a growing tendency in the industry to combine the motor and pump to form a so-called'motor pump'to improve the *** this paper,a novel structure for a wet three-phase high-speed reluctance motor pump is proposed,which can further improve integration by removing the dynamic seal on the pump shaft,thereby avoiding the problems of dynamic seal wear and oil leakage and improving heat dissipation under high-speed working ***,after the motor is wetted,the churning loss caused by immersion of the rotor in the oil causes additional fluid resistance *** on fundamental fluid mechanics,an analytical model of the churning torque of a wet motor was *** verify the accuracy of the analytical model,a simulation model of churning loss was established based on computational fluid dynamics(CFD),and the churning torque and flow field state were ***,an experimental prototype was designed and manufactured,and a test bench for churning loss was *** oil churning torque was measured at different speeds and *** results from the analytical,simulation,and experimental models agreed *** experimental results validated the analytical model and CFD *** research provides a practical method for calculating the churning loss and serves as guidance for future optimization of churning loss reduction.

关键词： Motor pump Wet motor Churning loss Analytical model Computational fluid dynamics(CFD)