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Preparation of β-Cyclodextrin Modified FusedSilica Capillary and Its Application inCapillary Electrophoresis Enantiom eric Separation

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Chemical Research in Chinese Universities 1999年第3期15卷 232-237页

作者： zhang xin-xiang HONG Feng BAI Jing CHANG Wen-bao CI Yun-xiang College of Chemistry Peking UniversityBeijing 100871P.R.China

A simple type of chiral selector immobilized capillaries was prepared and applied to the separation of some enantiomers by capillary electrophoresis(CE) without chiral selective reagents in a buffer solution. β Cyclodextrin (CD) was bonded to the inner wall of fused silica capillary with the aid of 3 (2 cyclooxypropoxyl) propyl trimethoxy silane or 3 aminopropyltriethoxyl silane as bridge. The synthesis conditions such as reaction temperature, reaction ratios, solvents were optimized. The stability and reproducibility of the CD modified capillaries were studied under different operation conditions. It is satisfactory to apply the capillary to the chiral separation of d,l adrenaline and the atracurium besilate diastereoisomers under the optimized conditions.

关键词： U-cyclodextrin-immobilized capillary Capillary electrophoresis Enantiomeric separation

Determination　of　Trace　Amounts　of　Cobalt　and　Copper　by　High　Performance　Liquid　Chromatography　with　Indigo　Carmine　Chemiluminescence　Detection

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Chemical Research in Chinese Universities 1996年第4期12卷 348-353页

作者： zhang xin-xiang CHENG Jie-ke and ZENG Yun-e(Department of Chemistry,Wuhan University,Wuhan,430072) WUHAN UNIV DEPT CHEMWUHAN 430072PEOPLES R CHINA

A post-column reaction chemiluminescence detection method in ion chromatography is described in this *** chemiluminescence system was indigo cramine-hydrogen peroxide. The chemiluminescence reaction conditions and the separation conditions of Co and Cu in chromatography were *** detection limits were 1.0 and 2.0×10-8 g/mL for Co and Cu respectively.

关键词： s:Chemiluminescehce detection HPLC Cobalt Copper Indigo Carmine

Effects of Bulky LATP in PEO-based Hybrid Solid Electrolytes

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Chinese Journal of Structural Chemistry 2020年第11期39卷 1941-1948页

作者： XUE Xi-Lai zhang xiang-xin LIN Jun-Hong CHEN Su-Jing CHEN Yuan-Qiang LIU Yong-Chuan zhang Yi-Ning Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Beijing 100049China Dalian National Laboratory for Clean Energy Chinese Academy of SciencesDalian 161000China

Solid polymer electrolytes(SPEs) have been considered as the spotlight in recent years due to their high safety, non-flammability and good flexibility. Nonetheless, high crystallinity of polymer matrix leads to low ionic conductivity at ambient conditions and retards the practical applications of SPEs. Herein, we report hybrid solid electrolytes(HSE) containing bulky LATP in poly(ethylene oxide)(PEO) matrix, which significantly enhances the electrochemical properties. LATP has been easily obtained by an accessible solid-state method. The solid electrolyte based on 20 wt% LATP in PEO polymer matrix(abbreviated as PEO-20) exhibits an ionic conductivity of 2.1 ×10-5 S·cm-1 at 30 ℃, an order of magnitude higher than 2.9 × 10-6 S·cm-1 of the pristine PEO solid electrolyte(abbreviated as PEO-0), mainly resulting from the decline of crystallinity in polymer matrix. The electrochemical window of PEO-20 can reach 4.84 V at room temperature, compared with 4.40 V for PEO-0, which could be compatible with high-voltage cathode materials.

关键词： hybrid solid electrolytes bulky LATP polyethylene oxide

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan zhang xin Liu Jian zhang Ya Gao Shuyue Li Cui Chang xiang Liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

亲和毛细管电泳法和荧光法研究氟喹诺酮类药物与牛血清白蛋白的相互作用

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高等学校化学学报 2008年第4期29卷 694-699页

作者：张黎伟张新祥北京大学化学与分子工程学院北京100871

分别采用亲和毛细管电泳法和荧光法对6种氟喹诺酮类药物(司帕沙星、洛美沙星、左氧氟沙星、诺氟沙星、培氟沙星和氟罗沙星)与牛血清白蛋白的相互作用进行考察.结合比均为1∶1,结合常数在104L/mol量级,热力学参数表明体系间的相互作用力... 详细信息

分别采用亲和毛细管电泳法和荧光法对6种氟喹诺酮类药物(司帕沙星、洛美沙星、左氧氟沙星、诺氟沙星、培氟沙星和氟罗沙星)与牛血清白蛋白的相互作用进行考察.结合比均为1∶1,结合常数在104L/mol量级,热力学参数表明体系间的相互作用力以范德华作用力和氢键力为主.另外,亲和毛细管电泳实验结果表明,缓冲溶液pH值和离子强度增大会造成结合常数在一定程度上的减小,使相互作用减弱.同时,荧光猝灭实验结合紫外光谱扫描说明体系间为静态猝灭.所得到的数据对进一步研究氟喹诺酮类药物的作用机理、提高药效和开发新一代氟喹诺酮类药物具有一定的参考意义.

关键词：亲和毛细管电泳荧光光谱法氟喹诺酮牛血清白蛋白相互作用

Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats

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Neural Regeneration Research 2025年第5期20卷 1495-1504页

作者： Yunting xiang xiangxin xing Xuyun Hua Yuwen zhang xin Xue Jiajia Wu Mouxiong Zheng He Wang Jianguang Xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University) Ministry of EducationShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected ***,differences among reconstruction strategies at the brain network level have not been *** study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve ***–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper ***-state brain functional magnetic resonance imaging was obtained 7 months after *** independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the *** in intra-network resting-state functional connectivity were compared among the *** muscle reinnervation was assessed by behavioral observation(elbow flexion)and *** results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural *** repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor *** thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve *** areas related to cognition and emotion were enhanced after end-to-side nerve *** study revealed important brain networks related to different nerve *** networks may be potential targets for enhancing motor recovery.

关键词： brain functional networks end-to-end nerve transfer end-to-side nerve transfer independent component analysis nerve repair peripheral plexus injury resting-state functional connectivity

商业模式创新驱动技术创新的实现机理研究——基于软件业的多案例扎根分析

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科学学研究 2015年第4期33卷 616-626页

作者：张新香中南财经政法大学信息与安全工程学院湖北武汉430073

技术创新与商业模式创新交互驱动,考虑已有的文献多侧重技术创新驱动商业模式创新的研究,本文聚焦于商业模式创新驱动技术创新实现机理的探讨。收集整理20家中外软件企业样本案例资料,开展多案例扎根分析,挖掘商业模式创新驱动技术创新... 详细信息

技术创新与商业模式创新交互驱动,考虑已有的文献多侧重技术创新驱动商业模式创新的研究,本文聚焦于商业模式创新驱动技术创新实现机理的探讨。收集整理20家中外软件企业样本案例资料,开展多案例扎根分析,挖掘商业模式创新驱动技术创新的内在机理和实现途径。研究结论显示:产品/服务创新和市场定位创新作为商业模式定位创新,产业链重定位和网络生态系统构建作为商业模式营运创新,合并盈利创新构成商业模式创新的主体内容。主体内容形成关键动因,加上商业模式创新所处现实情境的逼迫,商业模式创新终极目标的激励,共同促使软件业积极实施技术创新。

关键词：商业模式创新技术创新扎根理论实现机制

Bilevel Optimal Scheduling of Island Integrated Energy System Considering Multifactor Pricing

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Energy Engineering 2025年第1期122卷 349-378页

作者： xin zhang Mingming Yao Daiwen He Jihong zhang Peihong Yang Xiaoming zhang School of Automation and Electrical Engineering Inner Mongolia University of Science and TechnologyBaotou014010China

In this paper,a bilevel optimization model of an integrated energy operator(IEO)–load aggregator(LA)is constructed to address the coordinate optimization challenge of multiple stakeholder island integrated energy system(IIES).The upper level represents the integrated energy operator,and the lower level is the electricity-heatgas load *** to the benefit conflict between the upper and lower levels of the IIES,a dynamic pricing mechanism for coordinating the interests of the upper and lower levels is proposed,combined with factors such as the carbon emissions of the IIES,as well as the lower load interruption *** price of selling energy can be dynamically adjusted to the lower LA in the mechanism,according to the information on carbon emissions and load interruption *** benefits and win-win situations are achieved between the upper and lower ***,CPLEX is used to iteratively solve the bilevel optimization *** optimal solution is selected according to the joint optimal discrimination *** results indicate that the sourceload coordinate operation can reduce the upper and lower operation *** the proposed pricingmechanism,the carbon emissions and load interruption power of IEO-LA are reduced by 9.78%and 70.19%,respectively,and the capture power of the carbon capture equipment is improved by 36.24%.The validity of the proposed model and method is verified.

关键词： Bilevel optimal scheduling load aggregator integrated energy operator carbon emission dynamic pricing mechanism

Performance Analysis of Optical Code Division Multiple Access System Based on Carrier-suppressed and Single Sideband Return-to-zero Codes

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Semiconductor Photonics and Technology 2008年第2期14卷 75-79页

作者： LI Jie zhang Qi xin xiang-jun WANG Kui-ru YU Chong-xiu zhang Jin-long （School of Electronic Engineering Beijing University of Posts andTelecommunications Key Laboratory of Optical Communication and Lightwave Technology of Ministry of Education Beijing 100876 CHN

Researched is the generation method about carrier-suppressed return-to-zero（CS-RZ） and single sideband return-to-zero（SSB-RZ） formats. The performance is simulated and analyzed when both CS-RZ and SSB-RZ formats are used respectively in symbol overlapping fast frequency hop optical code division multiple access（SO-FFH-OCDMA） system at the transmission rate of 10 Gb/s. The simulation demonstrates that both formats are applicable in OCDMA system. For the system using either CS-RZ or SSB-RZ, Q factor degrades with the increase of transmission distance and increases with the increase of input power. Moreover, the performance of SO-FFH-OCDMA system with CS-RZ is better than that of SSP,-RZ at the same transmission distance and input power.

关键词： SO-FFH-OCDMA CS-RZ SSB-RZ