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Comparable anti-CMV responses of transplant donor and third-party CMV-specific T cells for treatment of CMV infection after allogeneic stem cell transplantation

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Cellular & Molecular Immunology 2022年第4期19卷 482-491页

作者： Xu-ying pei Xue-Fei liu xiang-yu Zhao meng Lv xiao-dong Mo ying-Jun Chang Qian-Nan Shang yu-Qian sun yu-hong chen Lan-Ping Xu yu Wang xiao-Hui zhang Kai-Yan liu xiao-Jun Huang Peking University People’s Hospital Peking University Institute of HematologyNational Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijing100044China Peking-Tsinghua Center for Life Sciences Beijing100871China

Adoptive transfer of cytomegalovirus(CMV)-specific cytotoxic T lymphocytes(CMV-CTLs)from original transplant donors or third-party donors was effective for the treatment of CMV infection after allogenic stem cell transplantation(allo-SCT),but the antiviral activity of CMV-CTL types has not been *** determine whether third-party CMV-CTLs provide comparable long-term antiviral efficacy to transplant donor CMV-CTLs,we first compared the antiviral abilities of transplant donors and third-party CMV-CTLs for treatment of CMV infection in two mouse models,compared the in vivo recovery of CMV-specific immunity,and analyzed the underlying mechanisms driving sustained antiviral *** results showed that both donor and third-party CMV-CTLs effectively combated systemic CMV infection by reducing CMV pathology and tumor burden 28 days *** in vivo recovery of CMV-specific immunity after CMV-CTL infusion was comparable in both groups.A detailed analysis of the source of recovered CMV-CTLs showed the proliferation and expansion of graft-derived endogenous CMV-CTLs in both *** clinical study,which enrolled 31 patients who received third-party CMV-CTLs and 62 matched pairs of individuals who received transplant donor CMV-CTLs for refractory CMV infection,further showed that adoptive therapy with donor or third-party CMV-CTLs had comparable clinical responses without significant therapy-related *** observed strong expansion of CD8+tetramer+T cells and proliferation of recipient endogenous CMV-CTLs after CMV-CTL infusion,which were associated with a reduced or cleared viral *** data confirmed that adoptive therapy with third-party or transplant donor CMV-CTLs triggered comparable antiviral responses to CMV infection that might be mediated by restoration of endogenous CMV-specific immunity.

关键词： Allogeneic stem cell transplantation CMV-specific cytotoxic T lymphocytes Transplant donor Third party donor Immunotherapy

Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield

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Molecular Plant 2022年第8期15卷 1310-1328页

作者： Baosheng Liao xiaofeng Shen Li xiang Shuai Guo Shiyu chen ying meng yu Liang Dandan Ding Junqi Bai dong zhang Tomasz Czechowski Yi Li Hui Yao Tingyu Mai Caroline Howard Chao sun Haitao liu Jiushi liu Jin pei Jihai Gao Jigang Wang xiaohui Qiu Zhihai Huang hongyi Li Ling yuan Jianhe Wei lan Graham Jiang Xu Boli zhang Shilin chen Instituteof ChineseMateria Medica China Academyof ChineseMedical SciencesBeijing 100700China Key Laboratory of Quality Evaluation of Chinese Medicine of the Guangdong Provincial Medical Products Administration the Second Clinical CollegeGuangzhou Universityof ChineseMedicineGuangzhou510006China Institute of Medicinal Plant Development Chinese Academy of Medical SciencesBeijing 100193China Artemisinin Research.Center China Academy of Chinese Medical SciencesBeijing 100700China Pharmacy College Chengdu University of Traditional Chinese MedicineChengdu 611137China Centre for Novel Agricultural Products Department of BiologyUniversity of YorkYorkUK Wellcome Sanger Institute Wellcome Trust Genome CampusHinxton CB101RQUK Kentucky Tobacco Research and Development Center University of KentuckyLexingtonKY 40546USA Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement&Guangdong Provincial Key Laboratory of Applied Botany South China Botanical GardenChineseAcademyof SciencesGuangzhou 510520China School of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjin 300193China chengdu University of Traditional Chinese Medicine Chengdu 611137China

Artemisia annua is the major natural source of artemisinin,an anti-malarial medicine commonly used ***,we present chromosome-level haploid maps for two *** strains with different artemisinin contents to explore the relationships between genomic organization and artemisinin ***-fidelity sequencing,optical mapping,and chromatin conformation capture sequencing were used to assemble the heterogeneous and repetitive genome and resolve the haplotypes of *** 5o,ooo genes were annotated for each haplotype genome,and a triplication event that occurred approximately 58.12million years ago was examined for the first time in this species.A total of 3,903,467-5,193,414 variants(SNPs,indels,and structural variants)were identified in the 1.5-Gb genome during pairwise comparison between haplotypes,consistent with the high heterozygosity of this *** analyses revealed a correlation between artemisinin concents and the copy number of amorpha-4,11-dienes *** correlation was further confirmed by resequencing of *** samples with varied artemisinin *** consensus sequencing of transcripts facilitated the detection of paralog ***,our study provides chromosome-level allele-aware genome assemblies for two *** strains and new insights into the biosynthesis of artemisinin and its regulation,which will contribute to conquering malaria worldwide.

关键词： Artemisia annua artemisinin haplotype chromosome amorpha-4 11-diene synthase copy number variation

Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3009-3018页

作者： Jun liu Dan-Dan Li Wei dong yu-Qi liu Yang Wu Da-Xuan Tang Fu-Chun zhang meng Qiu Qi Hua Jing-yu He Jun Li Bai Du Ting-Hai Du Lin-Lin Niu Xue-Jun Jiang Bo Cui Jiang-Bin chen Yang-Gan Wang Hai-Rong Wang Qin yu Jing He Yi-Lin Mao xiao-Fang Bin yue Deng yu-Dan Tian Qing-Hua Han Da-Jin liu Li-Qin Duan Ming-Jun Zhao Cui-ying zhang Hai-ying Dai Ze-Hua Li ying xiao You-Zhi Hu xiao-yu Huang Kun xing xin Jiang Chao-Feng liu Jing An Feng-Chun Li Tao Tao Jin-Fa Jiang ying Yang Yao-Rong dong Lei zhang Guang Fu ying Li Shu-Wei Huang Li-Ping Dou Lan-Jun sun ying-Qiang Zhao Jie Li yun xia Jun liu Fan liu Wen-Jin He ying Li Jian-Cong Tan Yang Lin Ya-Bin Zhou Jian-Fei Yang Guo-Qing Ma Hui-Jun chen He-Ping liu Zong-Wu liu Jian-xiong liu xiao-Jia Luo xiao-hong Bin Ya-Nan yu Hai-xia Dang Bing Li Fei Teng Wang-Min Qiao xiao-Long Zhu Bing-Wei chen Qi-Guang chen Chun-Ti Shen yong-Yan Wang yun-Dai chen Zhong Wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijingChina Department of Geratology Peking University Third HospitalBeijingChina Department of Cardiology Xuan Wu HospitalCapital Medical UniversityBeijingChina Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Cardiology First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenanChina Department of Cardiology Wuhan University Renmin HospitalWuhanHubeiChina Department of Cardiology Wuhan University Zhongnan HospitalWuhanHubeiChina Affiliated Zhongshan Hospital of Dalian University DalianLiaoningChina Department of Cardiology Second Affiliated Hospital to Hunan University of Chinese MedicineChangshaHunanChina Department of Cardiology First Affiliated Hospital to Changchun University of Chinese MedicineChangchunJilinChina Department of Cardiology First Affiliated Hospital to Shanxi Medical UniversityTaiyuanShanxiChina Department of Cardiology Affiliated Hospital of Shanxi University of Chinese MedicineXianyangShanxiChina Department of Cardiology Changsha Central HospitalChangshaHunanChina Department of Cardiology Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina Department of Cardiology Shanxi Provincial People's HospitalXi'anShanxiChina Department of Cardiology Shanxi Province Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Xi'an City Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Shanghai Tongji HospitalShanghaiChina Department of Cardiology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghaiChina Department of Cardiology The First Hospital of ChangshaChangshaHunanChina Department of Cardiology Xinhua Hospi

It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart ***,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and *** performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by ***,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol *** assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear *** study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target

关键词： angina injection sketch

Paired quasi-periodic pulsations of hard X-ray emission in a solar flare

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Science China(Physics,Mechanics & Astronomy) 2023年第5期66卷 195-206页

作者： Hai-Sheng Zhao dong Li Shao-Lin xiong Yan-Qiu zhang Yang su Wei chen Yi Zhao xiao-Bo Li Jia-Cong liu Wen-xi Peng Rui Qiao xin-Qiao Li xiang-Yang Wen Li-Ming Song Shi-Jie Zheng xin-ying Song xiao-yun Zhao yue Huang Shuang-Nan zhang Shuo xiao Ce Cai Zheng-Hua An Can chen Gang chen Wei chen Yan-Qi Du Min Gao Ke Gong dong-Ya Guo Zhi-Wei Guo Jian-Jian He Bin Li Chao Li Chao-Yang Li Gang Li Jian-Hui Li Lu Li Qing-xin Li Yan-Guo Li Jing Liang xiao-Hua Liang Jin-yuan Liao xiao-Jing liu Ya-Qing liu Qi Luo xiang Ma Bin meng Ge Ou dong-Li Shi Jing-Yan Shi Gong-xing sun xi-Lei sun You-Li Tuo chen-Wei Wang Hui Wang Jin Wang Jin-Zhou Wang Ping Wang Wen-Shuai Wang hong Wu Sheng-Lun xie Yan-Bing Xu yu-Peng Xu Wang-chen Xue Sheng Yang Min Yao Jian-ying Ye Qi-Bin Yi Chao-yue zhang Da-Li zhang Fan zhang Fei zhang hong-Mei zhang Kai zhang Peng zhang xiao-Lu zhang Zhen zhang Guo-ying Zhao Shi-Yi Zhao Chao Zheng xing Zhou yue Zhu Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China Department of Astronomy Beijing Normal UniversityBeijing 100875China School of Computing and Artificial Intelligence Southwest Jiaotong UniversityChengdu 611756China Physics and Space Science College China West Normal UniversityNanchong 637002China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Institute of Astrophysics Central China Normal UniversityWuhan 430079China School of Physics Changchun University of Science and TechnologyChangchun 130022China College of Physics and Engineering Qufu Normal UniversityQufu 273165China College of Physics Sciences&Technology Hebei UniversityBaoding 071002China

We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)during the flare event on 2022 April 21 at 01:52 *** subpeaks with durations of 4-6 s have been detected in the hard X-ray precursor phase,and the key feature is that they appear in pairs and seem like double-peak *** subpeaks are rarely observed in hard X-ray band and confirmed by the microwave obtained by Nobeyama Radio Polarimeters(NoRP)and Radio Solar Telescope Network(RSTN).While an exponential function can describe the continuum component of the time profile from the precursor to part of the impulsive *** periods of quasi-periodic pulsations(QPPs)are detected to be about 7.3 and 12.8 s for the precursor and impulsive phase,respectively,with at least 95%confidence *** paired QPPs are assumed to be double-peak QPPs and then the scenario of current loop coalescence model is found to be in good agreement with our *** precursor phase can be interpreted as the oscillating coalescence of two islands,while the impulsive phase can be interpreted as more islands to coalesce one by one to form larger islands.

关键词： solar flare QPPs loop coalescence circular-ribbon flare

The Lyman-alpha Solar Telescope(LST) for the ASO-S mission——Ⅱ. design of LST

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Research in Astronomy and Astrophysics 2019年第11期19卷 33-48页

作者： Bo chen Hui Li Ke-Fei Song Quan-Feng Guo pei-Jie zhang Ling-Ping He Shuang Dai xiao-dong Wang Hai-Feng Wang Chun-Long liu hong-Ji zhang Guang zhang yunqi Wang Shi-Jie liu hong-xin zhang Lei liu Shi-Lei Mao Yang liu Jia-Hao Peng Peng Wang Liang sun Yang liu Zhen-Wei Han Yan-Long Wang Kun Wu Guang-xing Ding Peng Zhou xin Zheng Ming-Yi xia Qing-Wen Wu Jin-Jiang xie Ya chen Shu-Mei Song hong Wang Bo Zhu Chang-Bo Chu Wen-Gang Yang Li Feng yu Huang Wei-Qun Gan ying Li Jing-Wei Li Lei Lu Jian-Chao Xue Bei-Li ying Ming-Zhe sun cheng Zhu Wei-Min Bao Lei Deng Zeng-Shan Yin Changchun Institute of Optics FineMechanics and PhysicsChinese Academy of SciencesChangchun 130033China State Key Laboratory of Applied Optics Changchun 130033China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210034China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’an 710119China Shandong University Weihai 264209China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201210China

As one of the three payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is composed of three instruments:a Solar Corona Imager(SCI),a LyαSolar Disk Imager(SDI)and a full-disk White-light Solar Telescope(WST).When working in-orbit,LST will simultaneously perform high-resolution imaging observations of all regions from the solar disk to the inner corona up to 2.5 R⊙(R⊙stands for the mean solar radius)with a spatial resolution of 4.8′′and 1.2′′for coronal and disk observations,respectively,and a temporal resolution of 30–120 s and 1–120 s for coronal and disk observations,*** maximum exposure time can be up to20 s due to precise pointing and image stabilization *** the three telescopes of LST,SCI is a dual-waveband coronagraph simultaneously and independently observing the inner corona in the HI Lyα(121.6±10 nm)line and white light(WL)(700±40 nm)wavebands by using a narrowband Lyαbeam splitter and has a field of view(FOV)from 1.1 to 2.5 R⊙.The stray-light suppression level can attainxis two-mirror reflective structure with an FOV up to 1.2 R⊙,covering the inner coronal edge area and relating to coronal *** present the up-to-date design for the LST payload.

关键词： telescopes—instrumentation high angular resolution—sun flares—sun coronal mass ejections(CMEs)—sun UV radiation

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Biomarkers of aging

Science China(Life Sciences) 2023年第5期66卷 893-1066页

作者： Aging Biomarker Consortium Hainan Bao Jiani Cao mengting chen Min chen Wei chen xiao chen Yanhao chen yu chen yutian chen Zhiyang chen Jagadish K Chhetri yingjie Ding Junlin Feng Jun Guo mengmeng Guo Chuting He yujuan Jia Haiping Jiang ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng liu xiaoqian liu Zuojun liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie xinhua Qiao xinpei sun xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang yuhan Wang Rimo Wu Kai xia Fu-Hui xiao Lingyan Xu yingying Xu Haoteng Yan Liang Yang Ruici Yang yuanxin Yang Yilin ying Le zhang Weiwei zhang Wenwan zhang xing zhang Zhuo zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang chen Guobing chen Hou-Zao chen Jun chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li xin Li Baohua liu Feng liu Lin liu Qiang liu Qiang liu xingguo liu yong liu xianghang Luo Shuai Ma xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve sun yu sun Mei Tian Shusen Wang Si Wang xia Wang xiaoning Wang Yan-Jiang Wang yunfang Wang Catherine CL Wong Andy Peng xiang Yichuan xiao Zhengwei xie Daichao Xu Jing Ye Rui yue Cuntai zhang hongbo zhang Liang zhang Weiqi zhang yong zhang yun-Wu zhang Zhuohua zhang Tongbiao Zhao yuzheng Zhao Dahai Zhu Weiguo Zou Gang pei Guang-Hui liu Aging Biomarker Consortium(ABC) Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Aging Biology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Clinic Center of Human Gene Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Clinical Research Center of Metabolic and Cardiovascular Disease Huazhong University of Science and TechnologyWuhan 430022China Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging Huazhong University of Science and TechnologyWuhan 430022China Stem Cell Translational Research Center Tongji HospitalTongji University School of MedicineShanghai 200065China Department of Nuclear Medicine Daping HospitalThird Military Medical UniversityChongqing 400042China CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Shanghai Key Laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China The Department of Endovascular surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Ageing and Regenerative MedicineJ

Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological *** a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly *** immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this ***,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory *** fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.

关键词： aging senescence biomarker clock

The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： xiao-yun Zhao Shao-Lin xiong xiang-Yang Wen xin-Qiao Li Ce Cai Shuo xiao Qi Luo Wen-xi Peng dong-Ya Guo Zheng-Hua An Ke Gong Jin-yuan Liao Yan-Qiu zhang yue Huang Lu Li xing Wen Fei zhang Jing Duan chen-Wei Wang dong-Li Shi Peng zhang Qi-Bin Yi Chao-Yang Li Yan-Bing Xu xiao-Hua Liang Ya-Qing liu Da-Li zhang xi-Lei sun Fan zhang Gang chen Huan-yu Wang Sheng Yang xiao-Jing liu Min Gao Mao-Shun Li Jin-Zhou Wang xing Zhou Yi Zhao Wang-chen Xue Chao Zheng Jia-Cong liu xing-Bo Han Jin-Ling Qi Jia Huang Ke-Ke zhang Can chen xiong-Tao Yang dong-Jie Hou yu-Sa Wang Rui Qiao xiang Ma xiao-Bo Li Ping Wang xin-ying Song Li-Ming Song Shi-Jie Zheng Bing Li hong-Mei zhang yue Zhu Wei chen Jian-Jian He Zhen zhang Jin Hou hong-Jun Wang Yan-Chao Hao xiang-yu Wang Zong-yuan Yang Zhi-Long Wen Zhi Chang yuan-yuan Du Rui Gao xiao-Fei Lan Yan-Guo Li Gang Li Xu-Fang Li Fang-Jun Lu hong Lu Bin meng Feng Shi Hui Wang Hui-Zhen Wang yu-Peng Xu Jia-Wei Yang Xue-Juan Yang Shuang-Nan zhang Chao-yue zhang cheng-Mo zhang Zhi-cheng Tang cheng cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun University of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

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Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-xin liu yue Huang Guang-cheng xiao Qing-Cui Bu Jin-Lu Qu Shu zhang Shuang-Nan zhang Shu-Mei Jia Fang-Jun Lu xiang Ma Lian Tao Wei zhang Li chen Li-Ming Song Ti-pei Li yu-Peng Xu Xue-Lei Cao yong chen Cong-Zhan liu Ce Cai Zhi Chang Gang chen Tian-xiang chen Yi-Bao chen yu-Peng chen Wei Cui Wei-Wei Cui Jing-Kang Deng yong-Wei dong yuan-yuan Du Min-Xue Fu Guan-Hua Gao He Gao Min Gao Ming-yu Ge yu-dong Gu Ju Guan cheng-cheng Guo Da-Wei Han Jia Huo Lu-Hua Jiang Wei-Chun Jiang Jing Jin yong-Jie Jin Ling-Da Kong Bing Li cheng-Kui Li Gang Li Mao-Shun Li Wei Li xian Li xiao-Bo Li Xu-Fang Li Yang-Guo Li Zheng-Wei Li xiao-Hua Liang Jing-yuan Liao Bai-Sheng liu Guo-Qing liu hong-Wei liu xiao-Jing liu Yi-Nong liu Bo Lu Xue-Feng Lu Qi Luo Tao Luo Bin meng Yi Nang Jian-Yin Nie Ge Ou Na Sai Ren-cheng Shang xin-ying Song Liang sun ying Tan You-Li Tuo chen Wang Guo-Feng Wang Juan Wang Ling-Jun Wang Weng-Shuai Wang yu-Sa Wang xiang-Yang Wen Bai-Yang Wu Bo-Bing Wu Mei Wu Shuo xiao Shao-Lin xiong He Xu Jia-Wei Yang Sheng Yang Yan-Ji Yang Yi-Jung Yang Qi-Bin Yi Qian-Qing Yin yuan You Ai-Mei zhang cheng-Mo zhang Fan zhang hong-Mei zhang Juan zhang Tong zhang Wan-Chang zhang Wen-Zhao zhang Yi zhang Yi-Fei zhang yong-Jie zhang yuan-Hang zhang yue zhang Zhao zhang Zhi zhang Zi-Liang zhang Hai-Sheng Zhao xiao-Fan Zhao Shi-Jie Zheng Yao-Guang Zheng Deng-Ke Zhou Jian-Feng Zhou yu-Xuan Zhu Ren-Lin Zhuang yue Zhu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics Sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–031

Was Wuhan the early epicenter of the COVID-19 pandemic?——a critique

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National Science Review 2023年第4期10卷 19-21页

作者： Yanan Cao Lingling chen Hua chen yupeng Cun xiaofeng Dai hongli Du Feng Gao Fengbiao Guo Yalong Guo pei Hao Shunmin He Shunping He xiongLei He Zheng Hu Boon-Peng Hoh xin Jin Qian Jiang Qinghua Jiang Asifullah Khan hong-Zhi Kong Jinchen Li Shuai cheng Li ying Li Qiang Lin Jianquan liu Qi liu Jian Lu Xuemei Lu Shujin Luo Qinghua Nie Zilong Qiu Tieliu Shi xiaofeng Song Jianzhong su Sheng-ce Tao Chaolong Wang Chuan-Chao Wang Guo-dong Wang Jiguang Wang Qi Wu Shaoyuan Wu Shuhua Xu yu Xue Wenjun Yang Zhaohui Yang Kai Ye yuan-Nong Ye Li yu Fangqing Zhao Yiqiang Zhao Weiwei Zhai Dandan zhang Liye zhang Houfeng Zheng Qi Zhou Tianqi Zhu Ya-ping zhang Ruijin Hospital Shanghai Jiao Tong University College of Life Science and Technology Guangxi University Beijing Institute of Genomics Chinese Academy of Sciences Children's Hospital of Chongqing Medical University Wuxi School of Medicine Jiangnan University School of Biology and Biological Engineering South China University of Technology Department of Physics School of ScienceTianjin University School of Pharmaceutical Sciences Wuhan University Institute of Botany Chinese Academy of Sciences Institut Pasteur of Shanghai Chinese Academy of Sciences Institute of Biophysics Chinese Academy of Sciences Institute of Hydrobiology Chinese Academy of Sciences School of Life Sciences Sun Yat-sen University Institute of Synthetic Biology Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences Faculty of Medicine and Health Sciences University College Sedaya International School of Medicine South China University of Technology Department of Medical Genetics Capital Institute of Pediatrics School of Life Science and Technology Harbin Institute of Technology Department of Biochemistry Abdul Wali Khan University xiangya Hospital Central South University Department of Computer Science City University of Hong Kong College of Life Science and Technology Foshan University South China Sea Institute of Oceanology Chinese Academy of Sciences College of Ecology Lanzhou University School of Life Sciences and Technology Tongji University School of Life Sciences Peking University Kunming Institute of Zoology Chinese Academy of Sciences College of Animal Science South China Agricultural University Institute of Neuroscience Chinese Academy of Sciences School of Life Sciences East China Normal University Nanjing University of Aeronautics and Astronautics Wenzhou Institute University of Chinese Academy of Sciences Institute of Systems Biomedicine Shanghai Jiao Tong University Tongji Medical College Huazhong University of Science and Technology School of Life Sciences Xiamen University Division of Life Science and Department of

Recently, Worobey et al.(2022) published a report entitled ‘The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic’ that succinctly summarizes their study [1]. A pre-print version of this study had earlier elicited a series of highprofile media coverages [2,3]. All these reports deliver a social-political message that the Huanan market is the epicenter of COVID-19.

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