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Delivering quantum dots to lubricants: Current status and prospect

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Friction 2022年第11期10卷 1751-1771页

作者： wenling zhang Tianhao LI Rong AN Jiong WANG Yu TIAN School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China Herbert Gleiter Institute of Nanoscience School of Material Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China State Key Laboratory of Tribology Tsinghua UniversityBeijing 100084China

Very recently,two-dimensional quantum dots(2D QDs)have been pioneeringly investigated as lubricant additives,which exhibit superior friction-reducing and wear *** with 2D nanoparticles,2D QDs possess small size(~10 nm)and abundant active *** distinguished advantages enable them to quickly disperse into common lube mediums and maintain long-term storage *** good dispersion stability of 2D QDs not only effectively improves their embedding capacity,but also enables continuous supplements of lubricants during the sliding ***,2D QDs are attracting increasing research interest as efficient lubricants with desirable service *** this review,we focus on the latest studies of 2D QDs as liquid lubricant additives(both in polar and nonpolar mediums),self-lubricating solid coatings and gels,*** advanced strategies for synthesis and modification of 2D QDs are summarized.A comprehensive insight into the tribological behavior of a variety of 2D QDs together with the associated mechanism is reviewed in *** superior lubricating performances of 2D QDs are attributed to various mechanisms,including rolling effect,self-mending performance,polishing effect,tribofilm formation,nanostructure transfer and synergistic effects,*** for friction modulation of 2D QDs,including internal factors(surface modification,elemental doping)and extrinsic factors(counter surfaces,test conditions)are discussed,special attentions for achieving intelligent tribology toward superlubricity and bio-engineering,are also ***,the future challenges and research directions regarding QDs as lubricants conforming to the concept of“green tribology”toward a sustainable society are discussed.

关键词： quantum dots(QDs) design diversity dispersibility embedding stability lubrication

An asymptotic analysis method for the linearly shell theory

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Science China Mathematics 2006年第8期49卷 1009-1047页

作者： LI Kaitai zhang wenling HUANG Aixiang College of Sciences Xi'an Jiaotong University Xi'an 710049 China College of Sciences Xi'an Jiaotong University Xi'an 710049 China College of Sciences Xi'an Jiaotong University Xi'an 710049 China

In this paper, we consider a linearly elastic shell, i.e. a three-dimensional linearly elastic body with a small thickness denoted by 2ε, which is clamped along its part of the lateral boundary and subjected to the regular loads. In the linear case, one can use the two-dimensional models of Ciarlet or Koiter to calculate the displacement for the shell. Some error estimates between the approximate solution of these models and the three-dimensional displacement vector field of a flexural or membrane shell have been obtained. Here we give a new model for a linear and nonlinear shell, prove that there exists a unique solution U of the two-dimensional variational problem and construct a three-dimensional approximate solutions UKT(x,ξ) in terms of U: We also provide the error estimates between our model and the three-dimensional displacement vector field :‖u-UKT‖1,Ω≤C∈r,r=3/2, an elliptic membrane, r = 1/2, a general membrane, where C is a constant dependent only upon the data‖u‖3,Ω,‖UKT‖3,Ω,θ.

关键词： linear elastic shell, asymptotic expansion method.

Ionic liquids on uncharged and charged surfaces: In situ microstructures and nanofriction

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Friction 2022年第11期10卷 1893-1912页

作者： Rong AN Yudi WEI Xiuhua QIU Zhongyang DAI Muqiu WU Enrico GNECCO Faiz Ullah SHAH wenling zhang Herbert Gleiter Institute of Nanoscience School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China High Performance Computing Department National Supercomputing Center in ShenzhenShenzhen 518055China Otto Schott Institute of Materials Research(OSIM) Friedrich Schiller University JenaJena 07743Germany Chemistry of Interfaces LuleåUniversity of TechnologyLulea 97187Sweden School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China

In situ changes in the nanofriction and microstructures of ionic liquids(ILs)on uncharged and charged surfaces have been investigated using colloid probe atomic force microscopy(AFM)and molecular dynamic(MD)*** representative ILs,[BMIM][BF_(4)](BB)and[BMIM][PF_(6)](BP),containing a common cation,were selected for this *** torsional resonance frequency was captured simultaneously when the nanoscale friction force was measured at a specified normal load;and it was regarded as a measure of the contact stiffness,reflecting in situ changes in the IL microstructures.A higher nanoscale friction force was observed on uncharged mica and highly oriented pyrolytic graphite(HOPG)surfaces when the normal load increased;additionally,a higher torsional resonance frequency was detected,revealing a higher contact stiffness and a more ordered IL *** nanofriction of ILs increased at charged HOPG surfaces as the bias voltage varied from 0 to 8 V or from 0 to−8 *** simultaneously recorded torsional resonance frequency in the ILs increased with the positive or negative bias voltage,implying a stiffer IL layer and possibly more ordered ILs under these *** simulation reveals that the[BMIM]+imidazolium ring lies parallel to the uncharged surfaces preferentially,resulting in a compact and ordered IL *** parallel“sleeping”structure is more pronounced with the surface charging of either sign,indicating more ordered ILs,thereby substantiating the AFM-detected stiffer IL layering on the charged *** in situ observations of the changes in nanofriction and microstructures near the uncharged and charged surfaces may facilitate the development of IL-based applications,such as lubrication and electrochemical energy storage devices,including supercapacitors and batteries.

关键词： microstructure friction contact stiffness charged surfaces ionic liquids(ILs) molecular simulation

Probing the nanofriction of non-halogenated phosphonium-based ionic liquid additives in glycol ether oil on titanium surface

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Friction 2022年第2期10卷 268-281页

作者： Xiuhua QIU Linghong LU Zhenyu QU Jiongtao LIAO Qi FAN Faiz Ullah SHAH wenling zhang Rong AN Herbert Gleiter Institute of Nanoscience Department of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China Chemistry of Interfaces Lule?University of TechnologyLule?97187Sweden Department of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China

The nanofrictional behavior of non-halogentated phosphonium-based ionic liquids(ILs)mixed with diethylene glycol dibutyl ether in the molar ratios of 1:10 and 1:70 was investigated on the titanium(Ti)substrate using atomic force microscopy(AFM).A significant reduction is observed in the friction coefficientμfor the IL-oil mixtures with a higher IL concentration(1:10,μ~0.05),compared to that for the lower concentration 1:70(μ~0.1).AFM approaching force–distance curves and number density profiles for IL-oil mixtures with a higher concentration revealed that the IL preferred to accumulate at the surface forming IL-rich layered *** ordered IL-rich layers formed on the titanium surface facilitated the reduction of the nanoscale friction by preventing direct surface-to-surface ***,the ordered IL layers disappeared in the case of lower concentration,resulting in an incomplete boundary layers,because the ions were displaced by molecules of the oil during sliding and revealed to be less efficient in friction reduction.

关键词： ionic liquid nanofriction atomic force microscopy(AFM) ordering density

Emerging roles of activating transcription factor (ATF) family members in tumourigenesis and immunity: Implications in cancer immunotherapy

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Genes & Diseases 2022年第4期9卷 981-999页

作者： Meilin Chen Yijun Liu Yuqin Yang Yanbing Qiu Zhicheng Wang Xiaoxu Li wenling zhang Department of Medical Laboratory Science The Third Xiangya HospitalCentral South UniversityChangshaHunan 410013PR China

Activating transcription factors, ATFs, are a group of bZIP transcription factors that act as homodimers or heterodimers with a range of other bZIP factors. In general, ATFs respond to extracellular signals, indicating their important roles in maintaining homeostasis. The ATF family includes ATF1, ATF2, ATF3, ATF4, ATF5, ATF6, and ATF7. Consistent with the diversity of cellular processes reported to be regulated by ATFs, the functions of ATFs are also diverse. ATFs play an important role in cell proliferation, apoptosis, differentiation and inflammation-related pathological processes. The expression and phosphorylation status of ATFs are also related to neurodegenerative diseases and polycystic kidney disease. Various miRNAs target ATFs to regulate cancer proliferation, apoptosis, autophagy, sensitivity and resistance to radiotherapy and chemotherapy. Moreover, ATFs are necessary to maintain cell redox homeostasis. Therefore, deepening our understanding of the regulation and function of ATFs will provide insights into the basic regulatory mechanisms that influence how cells integrate extracellular and intracellular signals into genomic responses through transcription factors. Under pathological conditions, especially in cancer biology and response to treatment, the characterization of ATF dysfunction is important for understanding how to therapeutically utilize ATF2 or other pathways controlled by transcription factors. In this review, we will demonstrate how ATF1, ATF2, ATF3, ATF4, ATF5, ATF6, and ATF7 function in promoting or suppressing cancer development and identify their roles in tumour immunotherapy.

关键词： Anti-tumor effect ATF bZIP Cancer Immunity Tumorigenesis

The mechanisms of sorafenib resistance in hepatocellular carcinoma:theoretical basis and therapeutic aspects

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1713-1727页

作者： Weiwei Tang Ziyi Chen wenling zhang Ye Cheng Betty zhang Fan Wu Qian Wang Shouju Wang Dawei Rong F.P.Reiter E.N.De Toni Xuehao Wang Department of General Surgery Nanjing First HospitalNanjing Medical UniversityNanjingChina Hepatobiliary/Liver Transplantation Center The First Affiliated Hospital of Nanjing Medical UniversityKey Laboratory of Living Donor TransplantationChinese Academy of Medical SciencesNanjingChina Department of Gastroenterology The First Affiliated Hospital of Nanjing Medical UniversityNanjingChina Michael G.DeGroote School of Medicine McMaster UniversityHamiltonONCanada Department of Radiology The First Affiliated Hospital of Nanjing Medical UniversityNanjingChina Department of Medicine II University HospitalLMUMunichGermany Liver Center Munich University HospitalLMUMunichGermany

Sorafenib is a multikinase inhibitor capable of facilitating apoptosis,mitigating angiogenesis and suppressing tumor cell *** late-stage hepatocellular carcinoma(HCC),sorafenib is currently an effective first-line ***,the development of drug resistance to sorafenib is becoming increasingly *** study aims to identify factors contributing to resistance and ways to mitigate *** studies have shown that epigenetics,transport processes,regulated cell death,and the tumor microenvironment are involved in the development of sorafenib resistance in HCC and subsequent HCC *** study summarizes discoveries achieved recently in terms of the principles of sorafenib resistance and outlines approaches suitable for improving therapeutic outcomes for HCC patients.

关键词： sorafenib therapeutic hepatocellular

Nasopharyngeal carcinoma:Advances in genomics and molecular genetics

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Science China(Life Sciences) 2011年第10期54卷 966-975页

作者： ZENG ZhaoYang HUANG HongBin zhang wenling XIANC Bo ZHOU Ming ZHOU YanHong MA Jian YI Mei LI XiaYu LI XiaoLing XIONG Wei LI GuiYuan Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education of China Central South University Changsha 410078 China Key Laboratory of Carcinogenesis of Ministry of Health of China Central South University Changsha 410078 China Disease Genome Research Center Central South University Changsha 410078 China Cancer Research Institute Central South University Changsha 410078 China Xiangya Hospital Central South University Changsha 410078 China

Nasopharyngeal carcinoma （NPC） is a squamous-cell carcinoma that arises in the epithelial lining of the nasopharynx [1]. This neoplasm has a notable ethnic and geographic distribution, being of high prevalence in southern China but rare in other parts of the world [2]. Familial clustering of NPC has been observed in diverse populations [3]. Elevated levels of circulating free Epstein-Barr virus （EBV） DNA and EBV-related antibodies in sera, as well as EBV DNA in tumor ceils, have been consistently detected in individuals with NPC [4,5].

关键词：鼻咽癌分子遗传学基因组学全国人民代表大会病毒DNA EB病毒鳞状细胞癌地域分布

Long non-coding RNAs in cancer

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Science China(Life Sciences) 2012年第12期55卷 1120-1124页

作者： GONG ZhaoJian zhang ShanShan zhang wenling HUANG HongBin LI Qiao DENG Hao MA Jian ZHOU Ming XIANG Juan Juan WU MingHua LI XiaYu XIONG Wei LI XiaoLing LI Yong ZENG ZhaoYang LI GuiYuan Hunan Key Laboratory of Nonresolving Inflammation and Cancer Disease Genome Research Center the Third Xiangya Hospital Central South University Changsha 410013 China Key Laboratory of Carcinogenesis of Ministry of Health Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education Cancer Research Institute Central South University Changsha 410078 China Department of Stomatology the Second Xiangya Hospital Central South University Changsha 410011 China Department of Stomatology Xiangya Hospital Central South University Changsha 410008 China Key Laboratory of lnformation System Engineering National University of Defense Technology Changsha 410073 China Department of Biochemistry and Molecular Biology Center for Genetics and Molecular Medicine School of Medicine University of Louisville Louisville KY 40202 USA

Long non-coding RNAs （lncRNAs） are a group of RNA transcripts that exceed 200 nt in length, yet lack significant open reading frames （ORFs） [1-4]. In contrast to small non-coding RNAs （ncRNAs）, such as microRNAs （miR- NAs） [4-23], small interfering RNAs （siRNAs） [24-31] and transfer RNAs （tRNAs） [32-34], there are thousands of IncRNA genes discovered during the past three years in the human genome and most of their functions remain elusive. The long nucleotide chain of lncRNAs can either form a complex spatial structure and interact with protein factors, or provide a large segment for the concurrent binding of many molecules that collectively participate in genomic imprinting, X-chromosome silencing, chromosome modifi- cation, intranuclear transport, transcriptional activation and interference, thereby regulating cell growth, differentiation, development, senescence and death [35].

关键词：非编码RNA tRNA基因 siRNAs 癌症小分子RNA 转录激活开放阅读框转移RNA

佛经文本与艺术遗存所呈现的古代文化交流——以月光王本生为例

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敦煌研究 2019年第1期 7-19页

作者：张文玲台北故宫博物院

流传至今的佛经故事,数量众多,但并非大多数的佛经故事都还留存与之相关的多种语文佛经文本和艺术遗存,月光王本生是少数中的一例。对流传至今与月光王本生相关的佛经文本与艺术遗存的研究表明:1.月光王本生文本应出现于贵霜王朝时期,... 详细信息

流传至今的佛经故事,数量众多,但并非大多数的佛经故事都还留存与之相关的多种语文佛经文本和艺术遗存,月光王本生是少数中的一例。对流传至今与月光王本生相关的佛经文本与艺术遗存的研究表明:1.月光王本生文本应出现于贵霜王朝时期,而最早的月光王本生内容,很可能出现在由根本说一切有部约在公元200—350年间所完成的《天譬喻》中;2.虽然大约完成于公元200—350年间的《天譬喻》文本已不存,但其内容应可从目前所存2—3世纪的犍陀罗浮雕以及现存月光王本生中年代最早(公元251年)的《六度集经》卷1的内容得其梗概;3.根本说一切有部所传月光王一切施的思想、犍陀罗地区所创造出来的图像造型(挥刀欲砍的婆罗门、屈身甘心舍头的月光王)以及克孜尔壁画中跪捧七宝头的大月大臣,都见于敦煌莫高窟第275窟的月光王本生壁画,从中可以看出古代佛教世界中的东西文化交流。

关键词：月光王本生贵霜犍陀罗艺术遗存莫高窟东西文化交流