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Liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance

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Neural Regeneration Research 2025年第3期20卷 695-714页

作者： Beibei Wu Yuqing Liu Hongli Li Lemei Zhu Lingfeng Zeng Zhen zhang weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental Disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： ABCA1 Alzheimer's disease amyloid-beta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli Li Jianhua Huang Di Zhao Lemei Zhu Zheyu zhang Min Yi weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

Chemical composition and size distribution of secondary organic aerosol formed from the photooxidation of isoprene

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Journal of Environmental Sciences 2009年第11期21卷 1525-1531页

作者： LIU Xianyun, zhang weijun, WANG Zhenya, ZHAO Weixiong, TAO Ling, YANG Xibin Laboratory of Environmental Spectroscopy, Anhui Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Hefei 230031, China. Laboratory of Environmental Spectroscopy Anhui Institute of Optics and Fine Mechanics Chinese Academy of Sciences Hefei 230031 China

Photooxidation of isoprene leads to the formation of secondary organic aerosol （SOA）. In this study, the chemical composition of SOA formed from OH-initiated photooxidation of isoprene has been investigated with gas chromatography/mass spectrometry （GC/MS） and a home-made aerosol time-of-fiight mass spectrometer. Sampling particles generated in a home-made smog chamber. The size distribution of SOA particles was detected by a TSI 3321 aerodynamic particle size spectrometer in real time. Results showed that SOA created by isoprene photooxidation was predominantly in the form of fine particles, which have diameters less than 2.5 μm. The obtained mass spectra of individual particles show that products of the OH-initiated oxidation of isoprene contain methyl vinyl ketone, methacrolein, formaldehyde, and some other hydroxycarbonyls. The possible reaction mechanisms leading to these products were also discussed.

关键词： secondary organic aerosols isoprene aerosol time-of-fiight mass spectrometer smog chamber size distribution

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乙醛二聚体内蓝移型氢键的理论研究

化学学报 2009年第7期67卷 599-606页

作者：杨颙张为俊安徽建筑工业学院材料与化学工程学院先进建筑材料安徽省重点实验室合肥230022 中国科学院安徽光学精密机械研究所环境光谱学实验合肥230031

利用理论方法研究了乙醛二聚体内的氢键.在MP2/6-31+G(d),B3LYP/6-31+G(d),B3LYP/6-311++G(d,p)和B3LYP/6-311++G(3df,2p)水平上,利用常规方法和均衡校正方法对3种稳定的乙醛二聚体进行了几何优化和振动频率计算.计算结果表明:在二聚体A... 详细信息

利用理论方法研究了乙醛二聚体内的氢键.在MP2/6-31+G(d),B3LYP/6-31+G(d),B3LYP/6-311++G(d,p)和B3LYP/6-311++G(3df,2p)水平上,利用常规方法和均衡校正方法对3种稳定的乙醛二聚体进行了几何优化和振动频率计算.计算结果表明:在二聚体A和C中乙醛中C—H键强烈收缩,存在显著的C—H…O蓝移型氢键.自然键轨道(NBO)分析表明,电子供体轨道和电子受体轨道之间相互作用的稳定化能、分子内电子密度重排、轨道再杂化和结构重组是决定氢键红移和蓝移的主要因素.其中,轨道间稳定化能属于键伸长效应,分子内电子密度重排、轨道再杂化和电子受体内部结构重组属于键收缩效应.在二聚体A和C中,由于键收缩效应处于优势地位导致C—H…O蓝移氢键存在.

关键词：红移型氢键蓝移型氢键电子密度拓扑分析自然键轨道分析

Effect of illumination intensity and light application time on secondary organic aerosol formation from the photooxidation of α-pinene

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Journal of Environmental Sciences 2009年第4期21卷 447-451页

作者： LIU Xianyun, zhang weijun, HUANG Mingqiang, WANG Zhenya, HAO Liqing, ZHAO Wenwu Laboratory of Environment Spectroscopy, Anhui Institute of Optics and Fine Mechanics, Chinese Academy of Sciences,Hefei 230031, China. Laboratory of Environment Spectroscopy Anhui Institute of Optics and Fine Mechanics Chinese Academy of Sciences Hefei 230031 China

Secondary organic aerosol （SOA） formation from hydroxyl radical （OH.） initiated photooxidation of α-pinene was investigated in a home-made smog chamber. The size distribution of SOA particles was measured using aerodynamic particle sizer spectrometer. The effects of illumination intensity and light application time on SOA formation for α-pinene were evaluated. Experimental results show that the concentration of SOA particles increased significantly with an increasing of illumination intensity, and the light application time, the concentration, and the size of SOA particles were also increased. In addition, the factors influencing the formation of SOA were discussed. In addition, this article compared the effect of α-pinene with that of toluene, and discussed the contribution of α-pinene to SOA formation.

关键词： α-pinene hydroxyl radical secondary organic aerosol size distribution

张维骏教授运用逍遥瓜蒌散治疗乳腺癌临证经验

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山西中医药大学学报 2023年第4期24卷 410-413页

作者：张丹娅唐娜张维骏山西中医药大学山西晋中030619

乳腺癌,中医学病名“乳岩”,病机多属本虚标实。因肝气郁滞、脾失健运,进而化生痰、瘀、毒,结于乳络,化生为癌。基于肝郁脾虚、痰瘀毒结的病机,导师张维骏教授将《傅青主女科》中的加减逍遥散与瓜蒌散化裁而成“逍遥瓜蒌散”,奏疏肝理... 详细信息

乳腺癌,中医学病名“乳岩”,病机多属本虚标实。因肝气郁滞、脾失健运,进而化生痰、瘀、毒,结于乳络,化生为癌。基于肝郁脾虚、痰瘀毒结的病机,导师张维骏教授将《傅青主女科》中的加减逍遥散与瓜蒌散化裁而成“逍遥瓜蒌散”,奏疏肝理气健脾、化痰散瘀解毒之功。在此方基础上,根据不同证型化裁施治,临床疗效肯定,体现了中医个体化诊疗的特色。同时也验证了《傅青主女科》以肝、脾为立足点治疗乳房诸疾的临床理论。

关键词：乳腺癌傅山逍遥瓜蒌散

张维骏教授运用泄水汤治疗原发性肝癌腹水经验

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山西中医药大学学报 2023年第2期24卷 184-187页

作者：唐娜张丹娅张维骏山西中医药大学山西晋中030619

肝癌腹水归属中医学“鼓胀”范畴,张维骏教授将鼓胀分为气滞湿阻、水湿困脾、湿热蕴结、肝脾血瘀、脾肾阳虚、肝肾阴虚6种证型,并在陈士铎《辨证录》中筛选出有效方剂“泄水至神汤”,以此为基础方,化裁为专方“泄水汤”治疗肝癌腹水,方... 详细信息

肝癌腹水归属中医学“鼓胀”范畴,张维骏教授将鼓胀分为气滞湿阻、水湿困脾、湿热蕴结、肝脾血瘀、脾肾阳虚、肝肾阴虚6种证型,并在陈士铎《辨证录》中筛选出有效方剂“泄水至神汤”,以此为基础方,化裁为专方“泄水汤”治疗肝癌腹水,方义健脾行气、益肾逐水,体现了中医辨病与辨证相结合的治疗特色,取得肯定疗效。

关键词：原发性肝癌腹水泄水汤

A New Offset Hatch Path Generation Algorithm for 3D Model Slicing in RP

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A New Offset Hatch Path Generation Algorithm for 3D Model Sl...

Economic, Energy, Exergy and Ecological（4E） Evaluation of a CCHP System Considering Feed-in Tariff

第五届全国表面工程学术会议

作者： Jiayi zhang, weijun Liu, Tianran Wang

＜正＞ Rapid Prototyping （RP） is a relatively novel technique to produce prototypes for industry in a shorter period of time. The filling method in our Directed Metal Deposition （DMD） rapid prototyping and manufacturing system directly influences the quality of prototypes. By investigating the geometric properties of domains in a slice, a new reconstruction algorithm of offset boundaries of the contours on STL solid data model slicing is introduced and a Limit for boundaries offsetting is put forth. By these new methods, we can fill regions by the offsetting lines of the boundaries. The performance of the proposed algorithm is discussed based on the connection angle along the path, continuous motion and the forces distributing. Based on the new algorithm, software is programmed in VC++. Its application is fast and efficient.

关键词： rapid prototyping slicing offset boundaries

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Economic, Energy, Exergy and Ecological（4E） Evaluation of ...