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工程建设与设计 2024年第17期 17-19页

作者：张为天中国建筑设计研究院北京100032

阐述“平疫结合”医疗建筑的含义以及建设“平疫结合”医疗建筑的必要性,基于“平疫结合”理念,从医疗工艺流程分析综合性医院改扩建的设计要点,从发热门诊、感染性疾病楼、综合诊疗中心等方面探讨细部建设与改扩建的策略及要点。

关键词：医疗建筑改扩建设计策略平疫结合

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利用中压制备液相色谱从蓝莓叶多酚中分离纯化绿原酸

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中国调味品 2024年第7期49卷 170-175页

作者：张芷瑜张天伟杨馥菡李会珍张志军中北大学化学与化工学院太原030051 中北大学晋中产业技术创新研究院山西晋中030600

该研究以蓝莓叶为试验材料,采用超声辅助纤维素酶的方法获得蓝莓叶多酚粗提物,然后利用中压制备液相色谱技术对粗提物进行分离纯化,分别考察不同流动相、进样量、流动相流速对绿原酸得率的影响。结果表明,最佳制备条件为乙腈-水溶液为... 详细信息

该研究以蓝莓叶为试验材料,采用超声辅助纤维素酶的方法获得蓝莓叶多酚粗提物,然后利用中压制备液相色谱技术对粗提物进行分离纯化,分别考察不同流动相、进样量、流动相流速对绿原酸得率的影响。结果表明,最佳制备条件为乙腈-水溶液为流动相、进样量6 mL、流动相流速10 mL/min,在此条件下,绿原酸得率为21.39%。经高效液相色谱分析,得到的绿原酸纯度可达94.98%。该方法能够快速、高效地分离蓝莓叶中的绿原酸。该方法为研究和应用蓝莓叶中活性成分提供了一种有效的手段。

关键词：蓝莓叶多酚中压制备液相色谱分离纯化绿原酸

维普期刊数据库博看期刊

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蓝莓果渣花色苷提取纯化工艺研究

中国调味品 2024年第3期49卷 175-181页

作者：张芷瑜张天伟杨馥菡李会珍张志军中北大学化学与化工学院太原030051 中北大学晋中产业技术创新研究院山西晋中030600

蓝莓果渣中的花色苷经超声辅助乙醇法进行提取,通过正交试验确定提取的最优条件为料液比1∶30(g/mL)、pH 3.0、乙醇体积分数50%、超声时间30 min,然后利用大孔树脂对粗提得到的花色苷进行分离纯化,对比了XDA-6、LX-16、LX-41、LX-180S、... 详细信息

蓝莓果渣中的花色苷经超声辅助乙醇法进行提取,通过正交试验确定提取的最优条件为料液比1∶30(g/mL)、pH 3.0、乙醇体积分数50%、超声时间30 min,然后利用大孔树脂对粗提得到的花色苷进行分离纯化,对比了XDA-6、LX-16、LX-41、LX-180S、LK825、DM216种大孔树脂的吸附和解吸效果。结果表明,LK825型大孔树脂的吸附率和解吸率分别为90.36%、90.19%,具有较强的吸附能力和较好的解吸性能,故选用LK825型大孔树脂进行纯化试验。LK825型大孔树脂静态试验的最优条件为吸附平衡时间7 h、解吸平衡时间5 h、提取液pH 3.0、解吸液pH 3.0、解吸液乙醇体积分数60%。动态试验的最优参数为上样流速1.0 mL/min、上样液体积22 BV、上样浓度1.0 mg/mL、洗脱流速1.5 mL/min、解吸液体积9 BV。纯化后蓝莓果渣花色苷的含量和色价分别是纯化前的12.8倍和17.9倍,纯度明显提高。

关键词：蓝莓果渣花色苷提取纯化

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Study of Surface Cell Madelung Constant and Surface Free Energy of Nanosized Crystal Grain

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Chinese Journal of Structural Chemistry 2005年第12期24卷 1369-1374页

作者： zhang wei-Jia WANG tian-Min CUI Min School of Science Beijng University of Aeronutics and Astronautics Beijing 100083 China

Surface cell Madelung constant is firstly defined in calculating surface free energy of nanosized crystal grains, which explains the physical performance of small crystals and may be great benefit to make surface analysis and study dynamics of crystal nucleus growth. A new approximative expression of surface energy and relevant thermodynamic data was used in this calculation. A new formula and computing method for calculating the Madelung constant a of any complex crystals is proposed, and surface free energies and surface electrostatic energies of nanosized crystal grains as well as Madelung constant of some complex crystals are theoretically calculated in this paper. The surface free energy of nanosized crystal grain TiO2 and surface electrostatic energy（absolute value） of nanosized crystal grain α-A12O3 are found to be the biggest among other crystal grains.

关键词： Madelung constant surface free energy nanosized crystal grain

Robust adaptive radar beamforming based on iterative training sample selection using kurtosis of generalized inner product statistics

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Journal of Systems Engineering and Electronics 2024年第1期35卷 24-30页

作者： tian Jing zhang wei School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China National Key Laboratory of Electromagnetic Space Security Chengdu 610036China

In engineering application,there is only one adaptive weights estimated by most of traditional early warning radars for adaptive interference suppression in a pulse reputation interval(PRI).Therefore,if the training samples used to calculate the weight vector does not contain the jamming,then the jamming cannot be removed by adaptive spatial *** the weight vector is constantly updated in the range dimension,the training data may contain target echo signals,resulting in signal cancellation *** cope with the situation that the training samples are contaminated by target signal,an iterative training sample selection method based on non-homogeneous detector(NHD)is proposed in this paper for updating the weight vector in entire range *** principle is presented,and the validity is proven by simulation results.

关键词： adaptive radar beamforming training sample selection non-homogeneous detector electronic jamming jamming suppression

Synthesis of protected (2S,4R)-2-amino-4-methyldecanoic acid, a proposed component of culicinins

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Chinese Chemical Letters 2008年第9期19卷 1068-1070页

作者： wei zhang tian tian Sun Duo Mei Jun Fei Wang Ying Xia Li Key laboratory of Marine Drugs The Ministry of Education of China School of Pharmacy Ocean University of China Qingdao 266003 China

The protected （2S,4R）-2-amino-4-methyldecanoic acid, a proposed component of culicinins has been synthesized over 10 steps and in total 28% yields using Wittig reaction and Schollkopf amino acid synthesis as key steps.

关键词： Synthesis Amino acid Schollkopf methodology Culicinins

Synthesis and Biological Activity of Novel Spin Labeled Derivatives of 4′-Demethyl-4-deoxypodophyllotoxin

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Chemical Research in Chinese Universities 2010年第5期26卷 753-756页

作者： XU Jing SUN Xiao-hua zhang Jia-qiang zhang Zhi-wei tian Xuan State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 P. R. China

Seven novel spin labeled derivatives of 4＇-demethyl-4-deoxypodophyllotoxin with nitroxyl radi- cals（TMHPO and TMPRO） were prepared and their cytotoxic and antioxidative activities were tested. Their cytotoxic activities were tested against two tumor cell lines（A-549 and HL-60） in vitro. Among them, five compounds show higher inhibition activity against A-549 cells compared with the clinical drug VP-16（2） and parent compound 4＇-demethyl-4-deoxypodophyllotoxin（DDPT, 6）. Compounds 8, 10 and 13 show excellent inhibition activity against HL-60 cells. Furthermore, the antioxidative activities of them were tested. All the seven spin labeled compounds show stronger antioxidative activity compared with VP-16（2） and DDPT（6）. The partition coefficients P of these derivatives were determined.

关键词： 4'-Demethyl-4-deoxypodophyllotoxin Nitroxyl radical Antiturnor activity Antioxidative activity

Selective adsorption of tetracycline by β-CD-immobilized sodium alginate aerogel coupled with ultrafiltration for reclaimed water

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Chinese Journal of Chemical Engineering 2024年第4期68卷 27-34页

作者： Xi Quan Jun zhang Linlin Yin wei Zuo Yu tian State Key Laboratory of Urban Water Resource and Environment(SKLUWRE) School of EnvironmentHarbin Institute of TechnologyHarbin 150090China

In this work,a novel composite material based on β-cyclodextrin-immobilized sodium alginate aerogel(β-CD/NaAlg) was developed utilizing cross-linker of epichlorohydrin and applied as an adsorbent to remove tetracycline antibiotics from reclaimed wastewater.A series of characterizations were utilized to confirm the successful synthesis of the adsorbent and this β-CD/NaAlg presented a three-dimensional network at the nanoscale or *** optimal conditions(pH=4,t=8 h,β-CD:NaAlg=9,adsorbent dosage = 1.5 g·L-1),the maximum removal rate of β-CD/NaAlg to tetracycline was 70%.The adsorption behavior of tetracycline on β-CD/NaAlg conformed to the Freundlich isotherm model(R2=0.9977) and the pseudo-second-order kinetic model(R^(2)=0.9993).Moreover,the adsorbent still removed 55.3% of tetracycline after five ***,the adsorbent was integrated with ultrafiltration to adsorb tetracycline antibiotics from simulated reclaimed wastewater,and the removal rate of tetracycline reached 78.9% within 2 *** existence of Cr(Ⅵ) had a negligible impact on tetracycline removal,while the presence of humic acid exhibited a promoting *** possible adsorption mechanisms were also elucidated through X-ray photoelectron spectroscopy and density functional theory *** summary,β-CD/NaAlg represents an environmentally friendly,efficient,and sustainable adsorbent for removing tetracycline antibiotics from reclaimed water.

关键词： b-CD/NaAlg aerogel Covalent grafting Tetracycline antibiotics Ultrafiltration Selective adsorption Reclaimed water

Resource-saving scheduling scheme for centralized target tracking in multiple radar system under automatic blanket jamming

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Chinese Journal of Aeronautics 2024年第5期37卷 349-362页

作者： Zhengjie LI Yujie wei Junwei XIE Haowei zhang Yu tian Air and Missile Defense College Air Force Engineering UniversityXi’an 710051China Air Force Xi’an Flying College Xi’an 710300China Air and Missile Defense Institute Air Force Research InstituteBeijing 100085China School of Economics and Management Beihang UniversityBeijing 100191China

This paper investigates the problem of Joint Radar Node Selection and Power Allocation(JRNSPA)in the Multiple Radar System(MRS)in the blanket jamming *** radar node independently tracks moving target and subsequently transmits the raw observation data to the fusion center,which formulates a centralized tracking network *** order to establish a practical blanket jamming environment,we suppose that each target carries the self-defense jammer which automatically implements blanket jamming to the radar nodes that exceed the preset interception ***,the Predicted Conditional Cramer-Rao Lower Bound(PC-CRLB)is derived and utilized as the tracking accuracy *** at ensuring both the tracking performance and the Low Probability of Intercept(LPI)performance,the resource-saving scheduling model is formulated to minimize the transmit power consumption while meeting the requirements of tracking ***,the Modified Zoutendijk Method Of Feasible Directions(MZMFD)-based two-stage solution technique is adopted to solve the formulated non-convex optimization *** results show the effectiveness of the proposed JRNSPA scheme.

关键词： Multiple Radar System(MRS) Centralized target tracking Resource scheduling Blanket jamming Low Probability of Intercept(LPI)

Regulating CRISPR/Cas9 Using Streptavidin-Biotin Interactions

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Chinese Journal of Chemistry 2024年第12期42卷 1387-1393页

作者： wei Shen wei Xiong Qianqian Qi Xingyu Liu Zhongpao Xie Yuanyuan zhang Jinxuan Hou tian tian Xiang Zhou College of Chemistry and Molecular Sciences Wuhan UniversityWuhanHubei 430072China Department of Thyroid&Breast Surgery Zhongnan Hospitalof Wuhan University Wuhan Hubei43001Chin

Comprehensive Summary Currently,CRISPR/Cas9 technology has found widespread applications across various ***,the utility of CRISPR/Cas9 is encumbered by issues pertaining to its reliability and safety,primarily stemming from the uncontrolled activity of the ***,the design and development of CRISPR/Cas9 systems with controllable activity is of paramount ***,characterized by its small molecular weight,and streptavidin,distinguished by its substantial spatial steric hindrance,can be harnessed as an ideal OFF switch(termed a"bioactivity brake")due to their interaction *** this work,we present a strategy that employs the streptavidin-biotin interaction as a"brake system"for CRISPR/Cas9,effectively allowing for the shutdown of the enzymatic activity of CRISPR/Cas9.

关键词： Streptavidin-biotin CRISPR/Cas9 CRISPR-OFF Guide RNA 2'-OH acylation Gene technology DNA cleavage