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Anti-diabetic effects of cinnamaldehyde and berberine and their impacts on retinol-binding protein 4 expression in rats with type 2 diabetes mellitus

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Chinese Medical Journal 2008年第21期121卷 2124-2128页

作者： zhang wei xu yan-cheng guo fang-jian meng ye li ming-li Department of Endocrinology Zhongnan Hospital ot Wunan University Wuhan Hubei 430071 China

Background Retinol binding protein 4 （RBP4）, as an adipocyte secreted cytokine, was recently found to be inversely correlated with expression of glucose transporter 4 （GLUT4） in insulin resistance （IR） state and to have an intimate relationship with IR and type 2 diabetes mellitus （T2DM）. The present study aimed to evaluate the anti-diabetic efficacy of cinnamaldehyde （Cin）, berberine （Ber）, and metformin （Met） as well as their impacts on the RBP4-GLUT4 system. Methods Rat models of T2DM were established by combination of intraperitoneal injection of low-dose streptozotocin and high fat diet induction. Rats were divided into five groups： the control group, the diabetes group, the diabetes＋Ber group, the diabetes＋Cin group, and the diabetes＋Met group. Western blotting was used to detect the serum or tissue RBP4 and GLUT4 protein levels. Results After treatment for four weeks, both Cin and Ber displayed significant hypolipidemic, hypoglycemic, and insulin sensitizing functions （P 〈0.01） compared with the control group. Their effects on lowering fasting plasma glucose （FPG）, low density lipoprotein-cholesterol （LDL-C） and homeostasis model assessment of insulin resistance （HOMA-IR） seem even better than that of Met. Cin and Ber markedly lowered serum RBP4 levels and up-regulated the expression of tissue GLUT4 protein, and Cin seemed more notable in affecting these two proteins. Conclusions Both Cin and Ber display an exciting anti-diabetic efficacy in this study and may be of great value for the treatment of type 2 diabetes. Their mechanisms involve the RBP4-GLUT4 system, during which the serum RBP4 levels are lowered and the expression of tissue GLUT4 protein is up-regulated.

关键词： cinnamaldehyde berberine type 2 diabetes meUitus insulin resistance retinol binding protein 4 glucose transporter 4

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Milestone progress of the HEPS booster commissioning

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Nuclear Science and Techniques 2024年第1期35卷 170-177页

作者： Yue-Mei Peng jian-She Cao Jin-Hui Chen Hai-Yi Dong Ping He Yi Jiao ling Kang Wen Kang jian li Jing-Yi li guo-Ping lin fang liu Feng-li Long Cai meng Xin Qi Hua-Min Qu yan-Feng Sui Sheng Wang Gang xu Qiang ye Jing zhang Pei zhang wei-Min Pan Key Laboratory of Particle Acceleration Physics and Technology Institute of High Energy PhysicsChinese Academy of Sciences19B Yuquan RoadShijingshan DistrictBeijing 100049China University of the Chinese Academy of Sciences 19A Yuquan RoadShijingshan DistrictBeijing 100049China

The high-energy photon source(HEPS)is the first fourth-generation synchrotron light source facility in *** HEPS injector consists of a linear accelerator(linac)and a full energy *** booster captures the electron beam from the linac and increases its energy to the value required for the storage *** full-energy beam could be injected to the storage ring directly or after“high-energy accumulation.”On November 17,2023,the key booster parameters successfully reached their corresponding target *** milestone results were achieved based on numerous contributions,including nearly a decade of physical design,years of equipment development and installation,and months of beam *** measured at the extraction energy of 6 GeV,the averaged beam current and emittance reached 8.57 mA with 5 bunches and 30.37 nm rad with a single-bunch charge of 5.58 nC,compared with the corresponding target values of 6.6 mA and 35 nm rad,*** paper presents the physical design,equipment development,installation,and commissioning process of the HEPS booster.

关键词： High energy photon source Booster Beam commissioning

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The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-Yun Zhao Shao-lin Xiong Xiang-yang Wen Xin-Qiao li Ce Cai Shuo Xiao Qi Luo Wen-Xi Peng Dong-Ya guo Zheng-Hua An Ke Gong Jin-Yuan liao yan-Qiu zhang Yue Huang Lu li Xing Wen Fei zhang Jing Duan Chen-wei Wang Dong-li Shi Peng zhang Qi-Bin Yi Chao-yang li yan-Bing xu Xiao-Hua liang Ya-Qing liu Da-li zhang Xi-Lei Sun Fan zhang Gang Chen Huan-Yu Wang Sheng yang Xiao-Jing liu Min Gao Mao-Shun li Jin-Zhou Wang Xing Zhou Yi Zhao Wang-Chen xue Chao Zheng Jia-Cong liu Xing-Bo Han Jin-ling Qi Jia Huang Ke-Ke zhang Can Chen Xiong-Tao yang Dong-Jie Hou Yu-Sa Wang Rui Qiao Xiang Ma Xiao-Bo li Ping Wang Xin-Ying Song li-ming Song Shi-Jie Zheng Bing li Hong-Mei zhang Yue Zhu wei Chen jian-jian He Zhen zhang Jin Hou Hong-Jun Wang yan-Chao Hao Xiang-Yu Wang Zong-Yuan yang Zhi-Long Wen Zhi Chang Yuan-Yuan Du Rui Gao Xiao-Fei Lan yan-guo li Gang li xu-fang li fang-Jun Lu Hong Lu Bin meng Feng Shi Hui Wang Hui-Zhen Wang Yu-Peng xu Jia-wei yang xue-Juan yang Shuang-Nan zhang Chao-Yue zhang cheng-Mo zhang Zhi-cheng Tang cheng cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun University of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

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The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-li Luo Yong-Heng Zhao Gang Zhao li-Cai Deng Xiao-wei liu Yi-Peng Jing Gang Wang Hao-Tong zhang jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu guo-Ping li Zhong-Rui Bai Yue Wu yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan Chen jian-Jun Chen Kun-Xin Chen li Chen xue-Lei Chen Xiao-yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-wei Fan Lei Feng jian-Ning Fu Peng Gao xue-Fei Gong Bo-Zhong Gu yan-Xin guo Zhan-Wen Han Bo-liang He Jin-liang Hou Yong-Hui Hou Wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei Jia fang-Hua jiang Xiang jiang Zhi-Bo jiang Ge Jin Xiao Kong xu Kong Ya-Juan Lei Ai-Hua li Chang-Hua li Guang-wei li Hai-Ning li jian li Qi li Shuang li Sha-Sha li Xin-Nan li yan li Yin-Bi li ye-Ping li Yuan liang Chien-cheng lin Chao liu Gen-Rong liu Guan-Qun liu Zhi-Gang liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi Yong-Jun Qi Shi-Yin Shen Huo-ming Shi Jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang Qing-Sheng Tao Yuan Tian Dan Wang Da-Qi Wang Feng-Fei Wang guo-Min Wang Hai Wang Hong-Chi Wang jian Wang Jia-Ning Wang jian-ling Wang jian-Ping Wang Jun-Xian Wang Lei Wang meng-Xin Wang Shou-Guan Wang Shu-Qing Wang Xia Wang Ya-Nan Wang You Wang Yue-Fei Wang You-Fen Wang Peng wei ming-Zhi wei Hong Wu Ke-Fei Wu xue-Bing Wu Yu-Zhong Wu Xiao-Zheng Xing ling-Zhe xu Xin-Qi xu yan xu Tai-Sheng yan De-Hua yang Hai-Feng yang Hui-Qin yang ming yang Zheng-Qiu Yao Yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan wei-Min Yuan Chao Zhai En-Peng zhang Hua-wei zhang jian-Nan zhang li-Pin zhang wei zhang Yong zhang yan-Xia zhang Zheng-Chao zhang ming Zhao fang Zhou xu Zhou Jie Zhu Yong-Tian Zhu Si-cheng Zou fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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Data release of the LAMOST pilot survey

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Research in Astronomy and Astrophysics 2012年第9期12卷 1243-1246页

作者： A-li Luo Hao-Tong zhang Yong-Heng Zhao Gang Zhao Xiang-Qun Cui guo-Ping li Yao-Quan Chu jian-Rong Shi Gang Wang jian-Nan zhang Zhong-Rui Bai Xiao-yan Chen Feng-Fei Wang yan-Xin guo jian-Jun Chen Bing Du Xiao Kong Ya-Juan Lei Yin-Bi li Yi-Han Song Yue Wu yan-Xia zhang Xin-lin Zhou fang Zuo Peng Du lin He Wen Hou Yi-Qiao Dong jian li Guang-wei li Shuang li Jing Song Yuan Tian meng-Xin Wang Yong-Hui Hou Zhi-Ying Huo Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Lei Jia fang-Hua jiang Xiang jiang Zi-Bo jiang Ge Jin Ai-Hua li Qi li Yin-Dun Mao Zheng-Hong Tang Qing-Sheng Tao liang-Ping Tu Da-Qing Wang Dan Wang jian-Ping Wang Lei Wang Shou-Guan Wang Shu-Qing Wang Ya-Nan Wang You Wang Yue-Fei Wang ming-Zhi wei Xiang-Xiang xue Xiao-Zheng Xing ling-Zhe xu Xin-Qi xu yan xu De-Hua yang Shi-Hai yang Zheng-Qiu Yao Yong Yu Hui Yuan Chao Zhai En-Peng zhang Jing zhang li-Ping zhang weizhang Yong zhang Zhen-Chao zhang ming Zhao fang Zhou Yong-Tian Zhu Jie Zhu Si-cheng Zou National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China lal @ lamost o rg Nanjing Institute of Astronomical Optics and Technology National Astronomical ObservatoriesChinese Academy of Sciences Nanjing 210042 China University of Science and Technologyof China Hefei 230026 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Architecture Design and Research Chinese Academy of Sciences Beijing 100190China

This paper describes the data release of the LAMOST pilot survey, which includes data reduction, calibration, spectral analysis, data products and data access. The accuracy of the released data and the information about the FITS headers of spectra are also introduced. The released data set includes 319 000 spectra and a catalog of these objects.

关键词： techniques: spectroscopic survey — data reduction — data release

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Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

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Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-Xin liu Yue Huang Guang-cheng Xiao Qing-Cui Bu Jin-Lu Qu Shu zhang Shuang-Nan zhang Shu-Mei Jia fang-Jun Lu Xiang Ma lian Tao wei zhang li Chen li-ming Song Ti-Pei li Yu-Peng xu xue-Lei Cao Yong Chen Cong-Zhan liu Ce Cai Zhi Chang Gang Chen Tian-Xiang Chen Yi-Bao Chen Yu-Peng Chen wei Cui wei-wei Cui Jing-Kang Deng Yong-wei Dong Yuan-Yuan Du Min-xue Fu Guan-Hua Gao He Gao Min Gao ming-Yu Ge Yu-Dong Gu Ju Guan cheng-cheng guo Da-wei Han Jia Huo Lu-Hua jiang wei-Chun jiang Jing Jin Yong-Jie Jin ling-Da Kong Bing li cheng-Kui li Gang li Mao-Shun li wei li Xian li Xiao-Bo li xu-fang li yang-guo li Zheng-wei li Xiao-Hua liang Jing-Yuan liao Bai-Sheng liu guo-Qing liu Hong-wei liu Xiao-Jing liu Yi-Nong liu Bo Lu xue-Feng Lu Qi Luo Tao Luo Bin meng Yi Nang jian-Yin Nie Ge Ou Na Sai Ren-cheng Shang Xin-Ying Song liang Sun Ying Tan You-li Tuo Chen Wang guo-Feng Wang Juan Wang ling-Jun Wang Weng-Shuai Wang Yu-Sa Wang Xiang-yang Wen Bai-yang Wu Bo-Bing Wu Mei Wu Shuo Xiao Shao-lin Xiong He xu Jia-wei yang Sheng yang yan-Ji yang Yi-Jung yang Qi-Bin Yi Qian-Qing Yin Yuan You Ai-Mei zhang cheng-Mo zhang Fan zhang Hong-Mei zhang Juan zhang Tong zhang Wan-Chang zhang Wen-Zhao zhang Yi zhang Yi-Fei zhang Yong-Jie zhang Yuan-Hang zhang Yue zhang Zhao zhang Zhi zhang Zi-liang zhang Hai-Sheng Zhao Xiao-Fan Zhao Shi-Jie Zheng Yao-Guang Zheng Deng-Ke Zhou jian-Feng Zhou Yu-xuan Zhu Ren-lin Zhuang Yue Zhu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics Sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–031

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Advances in nuclear detection and readout techniques

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Nuclear Science and Techniques 2023年第12期34卷 281-358页

作者： Rui He Xiao‑yang Niu Yi Wang Hong‑wei liang Hong‑Bang liu ye Tian Hong‑lin zhang Chao‑Jie Zou Zhi‑Yi liu Yun‑Long zhang Hai‑Bo yang Ju Huang Hong‑Kai Wang wei‑Jia Han Bei Cao Gang Chen Cong Dai li‑Min Duan Rui‑Rui Fan fang‑Fa Fu jian‑Hua guo Dong Han wei jiang Xian‑Qin li Xin li Zhuo‑Dai li Yu‑Tie liang Shun liao De‑xu lin cheng‑ming liu guo‑Rui liu Jun‑Tao liu Ze Long meng‑Chen Niu Hao Qiu Hu Ran Xiang‑ming Sun Bo‑Tan Wang Jia Wang Jin‑Xiang Wang Qi‑lin Wang Yong‑Sheng Wang Xiao‑Chuan Xia Hao‑Qing Xie He‑Run yang Hong Yin Hong Yuan Chun‑Hui zhang Rui‑Guang Zhao Ran Zheng cheng‑Xin Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China Key Laboratory of Particle and Radiation Imaging Department of Engineering PhysicsTsinghua UniversityBeijing 100084China School of Integrated Circuits Dalian University of TechnologyDalian 116020China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Electronic Engineering School Heilongjiang UniversityHarbin 150080China Spallation Neutron Source Science Center Dongguan 523803China Micro‑electronic Department Harbin Institute of TechnologyHarbin 150001China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210034China liaoning Academy of Materials Shenyang 110167China Istituto Nazionale di Fisica Nucleare Sezione di PerugiaPerugiaItaly School of Mathematics and Physics Chengdu University of TechnologyChengdu 620035China PLAC Key Laboratory of Quark and Lepton Physics(MOE)Central China Normal UniversityWuhan 430079China School of Electronics and Information Northwestern Polytechnical UniversityXi’an 710129China State Key Lab of Superhard Materials College of PhysicsJilin UniversityChangchun 130012China School of Computer Science Northwestern Polytechnical UniversityXi’an 710129China

“A Craftsman Must Sharpen His Tools to Do His Job,”said *** detection and readout techniques are the foundation of particle physics,nuclear physics,and particle astrophysics to reveal the nature of the ***,they are being increasingly used in other disciplines like nuclear power generation,life sciences,environmental sciences,medical sciences,*** article reviews the short history,recent development,and trend of nuclear detection and readout techniques,covering Semiconductor Detector,Gaseous Detector,Scintillation Detector,Cherenkov Detector,Transition Radiation Detector,and Readout *** explaining the principle and using examples,we hope to help the interested reader underst and this research field and bring exciting information to the community.

关键词： Silicon detector Wide bandgap detector Time projection chamber(TPC) Multigap resistive plate chamber detector(MRPC) Scintillation detector Calorimeters Cherenkov detector Transition radiation detector Artificial intelligence Trigger-less readout

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Efficacy and safety of Shenyankangfu Tablet,a Chinese patent medicine,for primary glomerulonephritis:A multicenter randomized controlled trial

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Journal of Integrative Medicine 2021年第2期19卷 111-119页

作者： Jie Wu Shu-wei Duan Hong-tao yang Yue-yi Deng wei li Ya-ni He Zhao-hui Ni Yong-li Zhan Shan lin Zhi-yong guo Jun Zhu Jing-ai fang xu-sheng liu li-hua Wang Rong Wang Nian-song Wang Xiao-hong cheng li-qun He Ping Luo Shi-ren Sun Ji-feng Sun Ai-ping Yin Geng-ru jiang Hong-yu Chen Wen-hu liu Hong-li lin meng liang Lu Ma ming Chen li-qun Song jian Chen Qing Zhu Chang-ying Xing Yun li Ji-ning Gao Rong-shan li Ying li Hao zhang Ying Lu Qiao-ling Zhou Jun-zhou Fu Qiang He Guang-yan Cai Xiang-mei Chen Department of Nephrology Chinese People’s Liberation Army General HospitalChinese People’s Liberation Army Institute of NephrologyState Key Laboratory of Kidney Diseases(2011DAV00088)National Clinical Research Center for Kidney DiseasesBeijing 100853China Department of Nephrology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300192China Department of Nephrology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Nephrology Shandong University of Traditional Chinese Medicine Affiliated HospitalJinan 250011.Shandong ProvinceChina Department of Nephrology Daping HospitalArmy Medical UniversityChongqing 400042China Department of Nephrology Renji HospitalShanghai Jiao Tong UniversityShanghai 200127China Department of Nephrology Guang’anmen HospitalChina Academy of Traditional Chinese Medical SciencesBeijing 100053China Department of Nephrology Tianjin Medical University General HospitalTianjin 300052China Department of Nephrology Changhai Hospital of ShanghaiNaval Medical UniversityShanghai 200433China Department of Nephrology West China HospitalChengdu 610083Sichuan ProvinceChina Department of Nephrology First Affiliated Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Nephrology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of Nephrology Shanxi Medical University Second Affiliated HospitalTaiyuan 030001Shanxi ProvinceChina Department of Nephrology Shandong Provincial HospitalJinan 250021Shandong ProvinceChina Department of Nephrology and Rheumatology Affiliated Sixth People’s HospitalShanghai Jiao Tong UniversityShanghai 200233China Department of Nephrology Shaanxi Traditional Chinese Medicine HospitalXi'an 710003Shaanxi ProvinceChina Department of Nephrology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 200021China Department of Nephrology Jilin University Se

Background:Shenyankangfu Tablet(SYKFT)is a Chinese patent medicine that has been used widely to decrease proteinuria and the progression of chronic kidney ***:This trial compared the efficacy and safety of SYKFT,for the control of proteinuria in primary glomerulonephritis patients,against the standard drug,losartan ***,setting,participants and intervention:This was a multicenter,double-blind,randomized,controlled clinical *** glomerulonephritis patients,aged 18-70 years,with blood pressure≤140/90 mmHg,estimated glomerular filtration rate(eGFR)>45 mL/min per 1.73 ㎡,and 24-hour proteinuria level of 0.5-3.0 g,were recruited in 41 hospitals across 19 provinces in China and were randomly divided into five groups:SYKFT,losartan potassium 50 mg or 100 mg,SYKFT plus losartan potassium 50 mg or 100 *** outcome measu res:The primary outcome was change in the 24-hour proteinuria level,after 48 weeks of ***:A total of 735 participants were *** percent decline of urine protein quantification in the SYKFT group after 48 weeks was 8.78%±2.56%(P=0.006)more than that in the losartan 50 mg group,which was 0.51%±2.54%(P=1.000)less than that in the losartan 100 mg *** with the losartan potassium 50 mg group,the SYKFT plus losartan potassium 50 mg group had a 13.39%±2.49%(Pline did not change statistically *** average change in TCM syndrome score between the patients who took SYKFT(-3.00[-6.00,-2.00])and who did not take SYKFT(-2.00[-5.00,0])was statistically significant(P=0.003).No obvious adverse reactions were observed in any ***:SYKFT decreased the proteinur

关键词： Herbal medicine,Chinese Shenyankangfu Tablet Primary glomerulonephritis Randomized controlled trial Double blind Double dummy

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桂皮醛抗糖尿病作用及其分子机制

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中华糖尿病杂志 2009年第6期1卷 -页

作者：张维徐焱成郭方健李鸣一孟晔夏茜娅武汉大学中南医院内分泌科 430071

目的观察桂皮醛抗糖尿病的效果并探讨其药理机制.方法将清洁级雄性Wistar大鼠40只分为正常对照组(8只,普通饮食),其余32只大鼠予高脂高糖饮食、链脲佐菌素,造成2型糖尿病成模大鼠(24只),分为糖尿病对照组、二甲双胍治疗组(200 mg·kg-... 详细信息

目的观察桂皮醛抗糖尿病的效果并探讨其药理机制.方法将清洁级雄性Wistar大鼠40只分为正常对照组(8只,普通饮食),其余32只大鼠予高脂高糖饮食、链脲佐菌素,造成2型糖尿病成模大鼠(24只),分为糖尿病对照组、二甲双胍治疗组(200 mg·kg-1·d-1)和桂皮醛治疗组(40 mg·kg-1·d-1),每组8只.经药物干预4周后测各组体质量、空腹血糖、血脂、空腹血胰岛素并计算胰岛素抵抗指数(HOMA-IR),采用Western blot对血清及组织的视黄醇结合蛋白4(RBP4)、葡萄糖转运载体4(GLUT4)蛋白水平进行分析,免疫组织化学染色分析组织p85α和胰岛素受体底物1(IRSI)蛋白表达水平.结果与糖尿病对照组比较,桂皮醛降糖、降脂、提高胰岛素敏感性效果明显[空腹血糖:(22.7±4.0)比(7.5±1.5)mmol/L;甘油三酯:(1.53±0.13)比(0.77±0.15)mmol/L;HOMA-IR:8.0±3.0比61.2±12.1,P<0.01];糖尿病组血清RBP4升高了1.68倍,GLUT4蛋白水平与正常对照组比较下调了33%～44%,差异有统计学意义(P<0.05);与糖尿病组比较,桂皮醛明显降低了(28.6%)血清RBP4水平(P<0.05),下调肌肉p85a蛋白表达(0.51±0.05比0.43±0.04,P<0.05),同时上调IRSl蛋白表达(0.52±0.05比0.03±0.06,P<0.05),肝脏、肌肉和脂肪组织的GLUT4蛋白表达升高.结论桂皮醛具有良好的降糖调脂、提高胰岛素敏感性的效果,其药理机制与降低血清RBP4水平以及调节肌肉组织p85α和IRSI蛋白表达有关.

关键词：桂皮醛糖尿病,2型视黄醇结合蛋白4 P13K调节亚基p85α 胰岛素受体底物1

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Consensus statement on layout and delivery of automatic external defibrillator in China

引用

Journal of Hainan Medical University 2020年第15期26卷 18-23页

作者： Yu Cao Song Chen yan-Fen Chai Xiao-Hui Chen Yu-guo Chen Shao-Wen cheng Wen-wei cheng Bang-Han Ding yang Deng Jie Fu Bang-jiang fang Mai-Ying Fan li Gui Ping Gong wei guo Shu-Bin guo liang Huang Ji-Yuan Han Zhong Ji Xian-Fei Ji Xin-Cai Ji Hong-xu Jin Xin-Jun jiang Wang-Xiang jiang Jia-liang liu Xiao-Ran liu Zhi liu Chuan-Zhu Lv Feng Lu Tan-Shi li Xin li Yong li Shang-Lun li Shuang-ming li Xiao-Gang li Bao-Jun li Pei-Wu li Chun-Sheng li Zhi-Jun li Chang-Luo li Xiang-Min li Yin-Ping li Zong-Jun Lu Zu-xun Lu Zhong-Qiu Lu Zhi-Qian Luo Xiao-Xing liao jian-Bo Lei Tao Ma Yu Ma Yue-Feng Ma Qing-Bian Ma lin-Hao Ma Jun-Qi Ma Shi-Nan Nie Jie-Miao Ou-yang Peng Peng Qiao Pei Shu-ming Pan guo-Zhong Qing li-Jie Qin Wu-Ying Qiao Fei Shao wei Song Xing-Yue Song Zhen-Ju Song Rong-Ju Sun De-Ya Shang Du-Juan Sha Gui-Lan Tao guo-Gang Tian Ying-Ping Tian jian-Guang Tian Chao-yang Tong Zi-Ren Tang meng-Xiong Tang guo-Ping Wu Zhi Wan Tao Wang Xin Wang Peng Wang Zhong Wang Tong Wang Ri-Xing Wang Yi-Xin Wang Xiao-Dan Wang ling Wu wei wei Hua Xiang Feng xu Jun xu Jie xu Miao-Rong Xie Shuo-Gui xu Tie xu Feng Yu Wen Yi li-Shan yang Shi-Jiao yan Jin-jian Yao Shou-Chun yan xue-Zhong Yu Xian-Zhi ye Xian-liang yan Fu-Bing Zhou Rong-Bin Zhou ming Zhou Qiang Zhou Jin Zhou Ping Zhou Chang-Ju Zhu Hua-Dong Zhu Ji-Hong Zhu Hong zhang Mao zhang Hua zhang Na zhang guo-Qiang zhang guo-Xiu zhang Jin-Song zhang Wen-Wu zhang Wen-Zhong zhang jian-Feng zhang Yi-Min Zhu Jun Zeng Yuan Zheng Zhi-Jie Zheng Shen Zhao yan Zhao Min Zhao Bin Zhao Xiao-Dong Zhao Xiao-Jing Zhao Hong-Ke Zeng Sheng-Qiang Zou The Chinese Society of Emergency Medicine Research Unit of Island Emergency Medicine Chinese Academy of Medical SciencesHainan Medical University Key Laboratory of Emergency and Trauma of Ministry of Education Hainan Medical UniversityHaikouHainanChina Emergency and Trauma College Hainan Medical UniversityHaikouHainanChina Department of Emergency Hainan Clinical Research Center for Acute and Critical DiseasesThe Second Affiliated Hospital of Hainan Medical UniversityHaikouHainanChina Key Laboratory of Hainan Trauma and Disaster Rescue Key Laboratory of Trauma of Hainan Medical University

*** Sudden cardiac death(SCD)refers to sudden death due to a variety of cardiac *** is manifested as a sudden loss of consciousness,cardiac arrest,and respiratory arrest and generally shows early symptoms that are atypical and not easily detected[1].According to a recent study,nearly 544000 patients suffer from SCD every year in China[2].

关键词： cardiac death respiratory

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