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Decoding the complexity of metastasis

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Cancer Biology & Medicine 2022年第3期19卷 284-288页

作者： Yingcheng wu tiancheng zhang Xiaoming zhang Qiang Gao Department of Liver Surgery and Transplantation Key Laboratory of Carcinogenesis and Cancer Invasion(Ministry of Education)Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghai 200032China The Center for Microbes Development and HealthKey Laboratory of Molecular Virology and ImmunologyInstitute Pasteur of ShanghaiChinese Academy of SciencesShanghai 200031China Key Laboratory of Medical Epigenetics and Metabolism Institutes of Biomedical SciencesFudan UniversityShanghai 200032China State Key Laboratory of Genetic Engineering Fudan UniversityShanghai 200433China

Cancer metastasis remains one of the most confounding questions in oncology1,*** current cutting-edge techniques enable very early detection of tumors,profiling whether a tumor has already begun to spread and where it has attempted to colonize remains a major ***,metastatic seeding events exhibit remarkable temporal and spatial heterogeneity,wherein the origin(primary site)and destination(metastatic site)are highly *** example,liver metastasis is particularly common and remains a leading cause of mortality3.

关键词： metastasis mortality founding

基于“阴平阳秘”范式的沈氏女科“加一味”用药法研究

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中华中医药杂志 2024年第9期39卷 5012-5014页

作者：尉万春张志明伍国强李成卫甘肃省甘谷县人民医院天水741200 甘肃省中医院兰州730050 兰州理工大学生命科学与工程学院兰州730050 北京中医药大学中医学院北京100029

沈氏女科第十九代传人沈绍功教授临证常用以“阴平阳秘”为范式的“调平”用药法,即“加一味”策略。“加一味”用药法基于辨证论治法则,在均衡五脏、防范风险、提升疗效等方面起到了积极的作用。文章借助人体的“阴平阳秘”生理范式,... 详细信息

沈氏女科第十九代传人沈绍功教授临证常用以“阴平阳秘”为范式的“调平”用药法,即“加一味”策略。“加一味”用药法基于辨证论治法则,在均衡五脏、防范风险、提升疗效等方面起到了积极的作用。文章借助人体的“阴平阳秘”生理范式,从“寒者热之,热者寒之”,反向“加一味”调平;“虚则补之,实则泻之”,全程“加一味”顾护正气;“阴中求阳,阳中求阴”,“加一味”疏利和间治并举三个方面系统阐释沈氏女科“加一味”用药法的内涵及方法,为拓展中医药临证辨治方法论拓宽思路。

关键词：阴平阳秘沈氏女科加一味调平

Evaluation of FY-3B Reprocessed OLR Data in the Asian–Australian Monsoon Region during 2011–2019:Comparison with NOAA OLR

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Journal of Meteorological Research 2021年第6期35卷 964-974页

作者： Lin LIU wanchun zhang Wen CHEN Renguang wu Lin WANG State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081 National Satellite Meteorological Center China Meteorological AdministrationBeijing 100081 Center for Monsoon System Research Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100190 School of Earth Sciences Zhejiang UniversityHangzhou 310027

The present study evaluates spatial and temporal characteristics of the Fengyun-3 B(FY-3 B)’s outgoing longwave radiation(OLR)data based on NOAA OLR data and the GPCP(Global Precipitation Climatology Project)precipitation data over the Asian-Australian region during *** terms of climatological distribution patterns and interannual standard deviation,FY-3 BOLR are quite consistent with NOAA OLR,with annual and seasonal pattern correlation coefficients all exceeding *** are some discrepancies in the OLR magnitude between FY-3 B and NOAA,especially for the OLR climatology;the climatological OLR from FY-3 B are systematically larger than those from NOAA over the whole study *** addition,examination of the temporal correlation coefficients between OLR and precipitation over the Asian-Australian monsoon(AAM)region reveals that both of the OLR datasets have captured the widespread negative correlation with precipitation,and FY-3 BOLR exhibits a stronger relationship to precipitation over ***,FY-3 BOLR exhibits better responses to the precipitation anomalies over India during the extreme El Nino and La Nina *** results suggest that the FY-3 B OLR dataset is of high quality and worthy of further global application.

关键词： Fengyun-3B outgoing longwave radiation precipitation Asian–Australian monsoon data evaluation

Impacts of soil organic matter, pH and exogenous copper on sorption behavior of norfloxacin in three soils

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Journal of Environmental Sciences 2009年第5期21卷 632-640页

作者： zhang Jie LI Zhaojun GE Gaofei SUN wanchun LIANG Yongchao wu Laosheng College of Natural Resources and Environmental Sciences Nanjing Agricultural University Nanjing 210095 China Ministry of Agriculture Key Laboratory of Crop Nutrition and Fertilization Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences Beijing 100081 China Key Laboratory of Oasis Eco-Agriculture and College of Agriculture Shihezi University Shihezi 832003 China Department of Environmental Sciences University of California Riverside Riverside CA 92521 USA

Norfloxacin sorption and the factors （soil organic matter （SOM）, pH, and exogenous copper （Cu） influencing the sorption were investigated in a black soil （soil B）, a fluvo-aquic soil （soil F）, and a red soil （soil R）. With increasing norfloxacin concentrations, sorption amount of norfloxacin increased in both the bulk soils and their SOM-removed soils, but the sorption capacity of SOM-removed soils was higher than that of their corresponding bulk soils, indicating that the process of norfloxacin sorption in soil was influenced by the soil properties including SOM. The sorption data in all bulk soils and SOM-removed soils were fitted to Freundlich and Langmuir models. The correlation coefficients suggested that the experimental data fitted better to Freundlich equation than to Langmuir equation. Furthermore, the data from soil F and SOM-removed F could not be described by Langmuir equation. The norfloxacin sorption amount decreased in soil B and soil F, whereas it increased in soil R as solution pH increased. The maximum KD and Koc were achieved in soil R when the equilibrium solution pH was 6. The norfloxacin sorption was also influenced by the exogenous Cu^2＋, which depended on the soil types and Cu^2＋ concentrations. With increasing Cu^2＋ concentrations in solution, generally, sorption amount, KD and Koc for norfloxacin in soils increased and were up to a peak at 100 mg/L Cu^2＋, and then the sorption amount decreased regardless of norfloxacin levels.

关键词： copper norfloxacin pH soil organic matter sorption

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陆相断陷湖盆页岩油开发技术迭代与发展方向

石油勘探与开发 2024年第4期51卷 865-877页

作者：孙焕泉王海涛杨勇吕琦张峰刘祖鹏吕晶陈天成蒋廷学赵培荣吴世成中国石油化工集团有限公司北京100728 中国石化石油勘探开发研究院北京102206 中国石化胜利油田分公司山东东营257000 中国石化油田勘探开发事业部北京100728 中石化石油工程技术研究院有限公司北京102206

对比、借鉴美国页岩油开发钻井技术、压裂技术、井网部署模式迭代历程及成效,围绕济阳陆相断陷湖盆页岩油地质特点和开发难点,通过开发技术、钻井技术和压裂技术的创新、迭代,初步形成了适合陆相断陷湖盆页岩油地质特征的开发技术体系,... 详细信息

对比、借鉴美国页岩油开发钻井技术、压裂技术、井网部署模式迭代历程及成效,围绕济阳陆相断陷湖盆页岩油地质特点和开发难点,通过开发技术、钻井技术和压裂技术的创新、迭代,初步形成了适合陆相断陷湖盆页岩油地质特征的开发技术体系,支撑了页岩油产量快速增长,降低了开发投资成本。通过与美国页岩油开发技术对比,提出了陆相断陷湖盆页岩油开发技术迭代的发展方向:持续强化整体立体开发,提高工程技术精细程度,完善工程技术指标体系,加快工程装备智能优化,探索应用复杂结构井,形成从设计到实施的全流程一体化质量管理体系,不断创新陆相断陷湖盆页岩油开发理念与技术,推动实现陆相断陷湖盆页岩油规模效益开发和高质量发展。

关键词：页岩油陆相断陷湖盆济阳坳陷钻井压裂开发技术迭代发展方向

Evaluation of the Madden–Julian Oscillation in Fengyun-3B Polar-Orbiting Satellite Reprocessed OLR Data

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Journal of Meteorological Research 2022年第6期36卷 931-946页

作者： Hainan GONG wanchun zhang Ling SUN Zizhen DONG Peng zhang Lin WANG Wen CHEN Renguang wu Center for Monsoon System Research Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100190 National Satellite Meteorological Centre China Meteorological AdministrationBeijing 100081 School of Earth Sciences Yunnan UniversityKunming 650500 School of Earth Sciences Zhejiang UniversityHangzhou 310058

The present study compares the spatial and temporal characteristics of the Madden-Julian Oscillation(MJO)in Fengyun-3B(FY-3B)polar-orbiting satellite reprocessed outgoing longwave radiation(OLR)data and NOAA OLR data during *** spatial distributions of climatological mean and intraseasonal standard deviation of FY-3B OLR during boreal winter(November-April)and boreal summer(May-October)are highly consistent with those of NOAA *** FY-3B and NOAA OLRs display highly consistent features in the wavenumber-frequency spectra,the occurrence frequency of MJO active days,the eastward propagation of MJO along the equator,and the interannual variability of MJO according to diagnoses using the all-season multivariate EOF *** results indicate that the FY-3B OLR produced by the polar-orbiting satellites is of high quality and worthy of global application.

关键词： Fengyun-3B outgoing longwave radiation Madden–Julian Oscillation multivariate empirical orthogonal function data evaluation

Fretting corrosion of surgical 316L stainless steel in saline solutions

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International Journal of Minerals,Metallurgy and Materials 1997年第3期11卷 18-21页

作者： BAI Zhijun wu Yinshun zhang tiancheng LIU Qiang (Material Science and Engineering School, University of Science and Technology Beijing, Beijing 100083, China)

A new simulation system for the laboratory investigation of fretting wear is developed. It consist of a mechanism device, a electrochemical cell and a datum acqulsition and process software. Fretting of surgical 316L stainlesssteel in saline is studied. The results show that electrochemical corrosion is enhanced by fretting and anodic currentdensity under fretting is 100 times than static condition. Fretting corrosion is a mechanic -elec trochemical al Process.

关键词： fretting system 316L sninless steel saline solution

二甲双胍对2型糖尿病患者脊柱内固定手术后远期功能的影响:一项回顾性研究

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空军军医大学学报 2024年第4期45卷 440-445,449页

作者：郝凯利王天吉马田成张扬赵雄吴子祥冯亚非雷伟空军军医大学西京医院骨科陕西西安710032

目的探讨二甲双胍对2型糖尿病(T2DM)患者脊柱内固定手术后远期功能的影响。方法选取2011年1月至2022年1月在空军军医大学西京医院骨科行脊柱内固定手术的T2DM患者,根据降糖药物的不同,将患者分为二甲双胍组和胰岛素组。收集患者的病... 详细信息

目的探讨二甲双胍对2型糖尿病(T2DM)患者脊柱内固定手术后远期功能的影响。方法选取2011年1月至2022年1月在空军军医大学西京医院骨科行脊柱内固定手术的T2DM患者,根据降糖药物的不同,将患者分为二甲双胍组和胰岛素组。收集患者的病历资料和生活质量、脊柱功能及疼痛的评估资料,采用t检验、单因素方差分析、Mann-Whitney U检验、Kruskal-Wallis H检验、χ^(2)检验和多元线性回归分析进行数据比较和分析。结果共纳入患者204例,其中二甲双胍组108例(52.94%),胰岛素组96例(47.06%)。术后远期功能评估,相对于胰岛素,二甲双胍的使用可显著提高患者健康调查简表生理机能维度评分(75.14分vs 65.36分,P<0.05)和一般健康状况维度评分(58.02分vs 48.08分,P<0.05),同时显著降低颈椎功能障碍指数或Oswestry功能障碍指数(15.93 vs 23.16,P<0.05)。此外,空腹血糖或餐后血糖越高、手术节段越多和体质量指数越大是影响患者术后远期功能的危险因素(P<0.05);在手术方式方面,相对于颈前路椎间盘切除融合术,腰椎后路椎间融合术是影响患者术后远期功能的危险因素(P<0.05)。结论相对于胰岛素,二甲双胍的使用可有效改善T2DM患者脊柱内固定手术后的远期功能。

关键词：二甲双胍 2型糖尿病脊柱内固定手术术后远期功能

Efficient induction of neural progenitor cells from human ESC/iPSCs on Type I Collagen

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Science China(Life Sciences) 2021年第12期64卷 2100-2113页

作者： Pengfei Liu Shubin Chen Yaofeng Wang Xiaoming Chen Yiping Guo Chunhua Liu Haitao Wang Yifan Zhao Di wu Yongli Shan Jian zhang Chuman wu Dongwei Li Yanmei zhang tiancheng Zhou Yaoyu Chen Xiaobo Liu Chenxu Li Lihui Wang Bei Jia Jie Liu Bo Feng Jinglei Cai Duanqing Pei CAS Key Laboratory of Regenerative Biology Guangdong Provincial Key Laboratory of Stem Cell and Regenerative MedicineGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China Ambulatory Surgical Center The 2nd Clinical medical College(Shenzhen People’s Hospital)of Jinan UniversityThe 1st Affiliated Hospitals of Southern University of Science and TechnologyShenzhen 518020China Integrated Chinese and Western Medicine Postdoctoral Research Station Jinan UniversityGuangzhou 510632China Bioland Laboratory Guangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhou 510005China School of Biomedical Sciences The Chinese University of Hong KongHong Kong SARChina Centre for Regenerative Medicine and Health Hong Kong Institute of Science&InnovationChinese Academy of SciencesHong Kong SARChina Department of Regenerative Medicine School of Pharmaceutical ScienceJilin UniversityChangchun 130012China Department of Pathology Medical CollegeJinan UniversityGuangzhou 510632China The Center for Prenatal and Hereditary Disease Diagnosis Department of Obstetrics and GynecologyNanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Obstetrics and Gynecology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China

A stable,rapid and effective neural differentiation method is essential for the clinical applications of human embryonic stem cells(ESCs)or induced pluripotent stem cells(iPSCs)in treating neurological disorders and ***,we established a novel and robust monolayer differentiation method to produce functional neural progenitor cells(NPCs)from human ESC/iPSCs on Type I *** derived cells not only displayed the requisite markers,but also behaved similarly to classic NPCs both in vitro and in *** transplantation into traumatic brain injury model,the derived NPCs facilitated recovery from *** also found that SMAD signaling stayed down throughout the differentiation process on Type I Collagen,and the pluripotent signals were rapidly downregulated along with raising up of neural early markers on the third ***,ATAC-seq data showed the related mediation of distinct transcriptome and global chromatin dynamics during NPC ***,our results thus provide a convenient way to generate NPCs from human ESC/iPSCs for neural diseases’treatment.

关键词： ESCs iPSCs NPCs neural differentiation Type I Collagen