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Chinese Journal of Natural Medicines 2018年第4期16卷 293-301页

作者： zhang Yue zhang Xi-tong zhang Qi WANG Bing ZHANG Tong Experiment Center for Teaching and Learning Shanghai University of Traditional Chinese Medicine School of Pharmacy Shanghai University of Traditional Chinese Medicine

In the present study, a gastric retention floating system for Brucea javanica oil, composed of alginate and carrageenan, was prepared using ionotropic gelation. Parameters for floatability, drug load, encapsulation efficiency, bead morphology, in vitro release, and in vivo gastric retention were evaluated. The optimized formulation via Box–Behnken design consisted of 1.7% alginate(W/V), 1.02% carrageenan(W/V), 1.4% CaCO_3(W/V), and a gelling bath of pH 0.8. The alginate–carrageenan–Brucea javanica oil beads had a porous structure and exhibited up to 24 h of in vitro floatability with a load capacity of 45%–55% and an encapsulation efficiency of 70%–80%. A 6-h sustained release was observed in vitro. The beads had a prolonged gastric retention(> 60% at 6 h) in fasted rats, compared to non-floating beads(15% at 6 h), as measured by gamma scintigraphy with single-photon emission tomography/computed tomography(SPET/CT). In conclusion, the alginate–carrageenan–Brucea javanica oil system showed enhanced oil encapsulation efficiency, excellent floating and gastric retention abilities, and a favorable release behavior.

关键词： Brucea javanica oil Simaroubaceae Alginate–carrageenan beads Gastric retention Box–Behnken design SPET/CT

Persistently explore new understandings of Greenland Ice Sheet ablation

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Advances in Polar Science 2023年第3期34卷 155-157页

作者： XIAO Cunde ZHANG Tong State Key Laboratory of Earth Surface Processes and Resources Ecology Beijing Normal UniversityBeijing 100871China

Greenland and Antarctic ice sheets are the largest potential contributors to global sea level rise(GSLR),amounting to more than 64 m of sea level equivalence(SLE).Between the two,Greenland Ice Sheet(GrIS)alone compris... 详细信息

关键词： Greenland Ice Sheet(GrIS) global sea level rise dynamics ablation ice discharge

张培彤应用六君二母汤治疗晚期恶性淋巴瘤验案三则

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中国中医药信息杂志 2017年第1期24卷 110-113页

作者：张天博张培彤北京中医药大学北京100029 中国中医科学院广安门医院北京100053

恶性淋巴瘤来源于淋巴网状组织,与免疫关系密切,主要发生于淋巴结,也可发生于淋巴结外和非淋巴组织。西医治疗恶性淋巴瘤常在化疗和放疗后很快复发。中医药不仅在放化疗期间可起到减毒增效作用,对防治放化疗后的复发及转移也有很好作用... 详细信息

恶性淋巴瘤来源于淋巴网状组织,与免疫关系密切,主要发生于淋巴结,也可发生于淋巴结外和非淋巴组织。西医治疗恶性淋巴瘤常在化疗和放疗后很快复发。中医药不仅在放化疗期间可起到减毒增效作用,对防治放化疗后的复发及转移也有很好作用。中国中医科学院广安门医院肿瘤科张培彤教授运用六君二母汤化裁,对恶性淋巴瘤有较好的疗效。本文总结了张教授运用六君二母汤化裁的临床经验。

关键词：名医经验张培彤六君二母汤恶性淋巴瘤医案

Roadmap to tackle antibiotic resistance in the environment under the One Health framework

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mLife 2023年第3期2卷 224-228页

作者： Liguan Li tong zhang Environmental Microbiome Engineering and Biotechnology Laboratory Center for Environmental Engineering ResearchDepartment of Civil EngineeringThe University of Hong KongHong KongChina

Antibiotic resistance has been recognized as a major challenge worldwide for humans.“One Health”has been recognized as a key concept for containment of antibiotic resistance.Under the framework,the role of the environment in the development of antibiotic resistance genes(ARGs)has become increasingly obvious.Despite numerous efforts,response to antibiotic re-sistance is considered to be inadequate,which is probably due to the lack of a clear roadmap.Here,we propose a“One Health”roadmap to combat antibiotic resistance in the environment through(1)understanding environmental resistome.The environmental gene pool has long been recognized as the single largest reservoir of both known and novel ARGs.(2)Standardizing ARG quantification.Systematic joint efforts based on standardized quantification are urgently needed to un-derstand the true tempospatial profiles of the environmental resistome.(3)Identifying mechanisms of resistome development.Horizontal gene transfer and co-selection have been recognized as the two main mechanisms contributing to the environmental resistome.(4)Establishing a risk-assessment framework.The first critical step for large-scale cost-effective targeted ARG management in the environment is the risk assessment to identify the priority ARGs for control.(5)Formulating regulatory standards.By correlating the environmental ARG profile with public health,we may identify the indicator ARGs that can be integrated into current environmental quality standards.(6)Developing control strategies.Systematic analysis of available control technologies is required to identify the most feasible ones to curtail the spread of ARGs in the environment.The proposed roadmap under the“One Health”framework provides a guide to tackle antibiotic resistance in the environment.

关键词： antibiotic resistance environment One Health roadmap

Discovering the next decade’s synthetic biology research trends with ChatGPT

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Synthetic and Systems Biotechnology 2023年第2期8卷 220-223页

作者： Yaojun tong Lixin zhang State Key Laboratory of Microbial Metabolism Joint International Research Laboratory of Metabolic and Developmental SciencesSchool of Life Sciences and TechnologyShanghai Jiao Tong UniversityShanghai200240China State Key Laboratory of Bioreactor Engineering School of BiotechnologyEast China University of Science and Technology(ECUST)Shanghai200237China

ChatGPT,a conversational AI(Artificial Intelligence)model devel-oped and recently released by OpenAI(https://***/),caused quite a stir.However,the debate of AI never fades^([1–5]),it has been pushed to a peak by ChatGPT.We hear so much from social media that AI may cause bad consequences on society,for example causing a wave of unemployment in many areas,and for research it might compromise the current transparent science if not use it properly^([6]).

关键词： properly consequences GPT

Multistage Formation of Neoarchean Potassic Meta-Granites and Evidence for Crustal Growth on the North Margin of the North China Craton

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Journal of Earth Science 2023年第3期34卷 658-673页

作者： Xiaowei zhang Huafeng zhang Ying tong Laboratory of National Land Space Planning and Disaster Emergency Management of Inner Mongolia Chifeng UniversityChifeng 024000China Beijing SHRIMP Center Institute of GeologyChinese Academy of Geological SciencesBeijing 100037China School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China Key Laboratory of Earthprobe and Geodynamics Chinese Academy of Geological SciencesBeijing 100037China

The North China Craton(NCC)is one of the most complex cratons in the world.It underwent a series of tectonothermal events during the Neoarchean-Paleoproterozoic.The petrogenesis of potassic granitoids,the timing,and the style of Archean crustal growth are still debated.Systematic field and petrological stdudies on the potassic meta-granites from the Guyang-Chayouzhongqi region were carried out.New U-Pb ages,zircon Lu-Hf isotopic analyses,and whole-rock geochemical data were obtained.Two groups(~2.7 Ga and~2.5 Ga)of potassic meta-granites were recognized.The~2.7 Ga meta-granites are mainly A2-type,with variableεHf(t)values(-8.4 to+3.3)and Archean one stage model ages(T_(DM)=~3.0 Ga),indicating that their source was derived from ancient anatectic TTG-like granite and depleted mantle,which suggests that thin crust had formed in the Guyang-Chayouzhongqi region by~3.0 Ga.Similar to the K-rich granites in the NCC,most of the~2.5 Ga potassic meta-granites are typical of A1-type granite,and are enriched in Sm and Gd and depleted in Nb,Ta,P,and Ti.The ages and isotopic data indicate that the~2.5 Ga meta-granites were generated from juvenile crustal sources with Neoarchean TTGs.The overall zircon U-Pb and Hf isotopic data furthermore suggested that the~2.7 Ga event is the most important stage of magmatic accretion in the NCC,similar to other cratons.In contrast,reworking or metamorphic alteration was the main crustal process in the NCC at~2.5 Ga.

关键词： zircon U-Pb age Lu-Hf isotope geochemistry potassic meta-granite crustal growth North China Craton

Data-driven glass-forming ability criterion for bulk amorphous metals with data augmentation

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Journal of Materials Science & Technology 2022年第26期121卷 99-104页

作者： Jie Xiong tong-Yi zhang School of Materials Science and Engineering Harbin Institute of TechnologyShenzhen 518000China Hong Kong University of Science and Technology(Guangzhou) Guangzhou 511400China Material Genome Institute Shanghai UniversityShanghai 200444China

A data augmentation technique is employed in the current work on a training dataset of 610 bulk metallic glasses(BMGs),which are randomly selected from 762 collected data.An ensemble machine learning(ML)model is developed on augmented training dataset and tested by the rest 152 data.The result shows that ML model has the ability to predict the maximal diameter Dmaxof BMGs more accurate than all reported ML models.In addition,the novel ML model gives the glass forming ability(GFA)rules:average atomic radius ranging from 140 pm to 165 pm,the value of TT/(T-T)(T-T)being higher than 2.5,the entropy of mixing being higher than 10 J/K/mol,and the enthalpy of mixing ranging from-32 k J/mol to-26 k J/mol.ML model is interpretative,thereby deepening the understanding of GFA.

关键词： Materials informatics Glass-forming ability Data augmentation Model interpretation Meta-ensemble model

DGMP: Identifying Cancer Driver Genes by Jointing DGCN and MLP from Multi-omics Genomic Data

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Genomics, Proteomics & Bioinformatics 2022年第5期20卷 928-938页

作者： Shao-Wu zhang Jing-Yu Xu tong zhang MOE Key Laboratory of Information Fusion Technology School of AutomationNorthwestern Polytechnical UniversityXi’an 710072China

Identification of cancer driver genes plays an important role in precision oncology research,which is helpful to understand cancer initiation and progression.However,most existing computational methods mainly used the protein–protein interaction(PPI)networks,or treated the directed gene regulatory networks(GRNs)as the undirected gene–gene association networks to identify the cancer driver genes,which will lose the unique structure regulatory information in the directed GRNs,and then affect the outcome of the cancer driver gene identification.Here,based on the multi-omics pan-cancer data(i.e.,gene expression,mutation,copy number variation,and DNA methylation),we propose a novel method(called DGMP)to identify cancer driver genes by jointing directed graph convolutional network(DGCN)and multilayer perceptron(MLP).DGMP learns the multi-omics features of genes as well as the topological structure features in GRN with the DGCN model and uses MLP to weigh more on gene features for mitigating the bias toward the graph topological features in the DGCN learning process.The results on three GRNs show that DGMP outperforms other existing state-of-the-art methods.The ablation experimental results on the Dawn Net network indicate that introducing MLP into DGCN can offset the performance degradation of DGCN,and jointing MLP and DGCN can effectively improve the performance of identifying cancer driver genes.DGMP can identify not only the highly mutated cancer driver genes but also the driver genes harboring other kinds of alterations(e.g.,differential expression and aberrant DNA methylation)or genes involved in GRNs with other cancer genes.The source code of DGMP can be freely downloaded from https://***/NWPU-903PR/DGMP.

关键词： Driver gene Directed graph convolutional network Multilayer perceptron Gene regulatory network Multi-omics data

Advancements in Humanoid Robots: A Comprehensive Review and Future Prospects

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 301-328页

作者： Yuchuang tong Haotian Liu Zhengtao zhang IEEE CAS Engineering Laboratory for Intelligent Industrial Vision Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China

This paper provides a comprehensive review of the current status, advancements, and future prospects of humanoid robots, highlighting their significance in driving the evolution of next-generation industries. By analyzing various research endeavors and key technologies, encompassing ontology structure,control and decision-making, and perception and interaction, a holistic overview of the current state of humanoid robot research is presented. Furthermore, emerging challenges in the field are identified, emphasizing the necessity for a deeper understanding of biological motion mechanisms, improved structural design,enhanced material applications, advanced drive and control methods, and efficient energy utilization. The integration of bionics, brain-inspired intelligence, mechanics, and control is underscored as a promising direction for the development of advanced humanoid robotic systems. This paper serves as an invaluable resource, offering insightful guidance to researchers in the field,while contributing to the ongoing evolution and potential of humanoid robots across diverse domains.

关键词： Future trends and challenges humanoid robots human-robot interaction key technologies potential applications

Proving Mutual Authentication Property of RCIA Protocol in RFID Based on Logic of Events

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Chinese Journal of Electronics 2022年第1期31卷 79-88页

作者： ZHONG Xiaomei XIAO Meihua ZHANG Tong YANG Ke LUO Yunxian School of Software East China Jiaotong University

The increasing commercialization and massive deployment of radio frequency identification(RFID) systems has raised many security related issues which in return evokes the need of security protocols. Logic of events theory(Lo ET) is a formal method for constructing and reasoning about distributed systems and protocols that involve concepts of security. We propose fresh ciphertext and ciphertext release lemmas to extend Lo ET for analyzing and proving the security of authentication protocols that use symmetric key cryptography more than just digital signature. Based on the extended Lo ET we formally analyze and prove the authentication property of RCIA protocol, which provides mutual authentication between Tag and Reader in RFID system.Our proof approach based on extended Lo ET could be applied to the design and analysis of such ultralightweight RFID mutual authentication protocols.

关键词： RFID Ultralightweight mutual authentication protocol RCIA protocol Logic of events Theorem proving