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Sedimentary Expressions of the Early Jurassic Jenkyns Event in an Inland Lacustrine System in the Yin'gen–Ejinaqi Basin, North China

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Acta Geologica Sinica(English Edition) 2024年第5期98卷 1359-1375页

作者： YANG Bing XU Guozhen HUI Guangji WEI Yi zhang Xinzhi YI Jinjun SUN Siyuan zhang sujiang Cores and Samples Center of Natural Resources Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences North China Institute of Science and Technology

The Jenkyns Event, more widely known as the Toarcian Oceanic Anoxic Event(T-OAE), is marked by globally distributed negative carbon-isotope excursions, widespread oxygen depletion, and large-scale organic carbon burial, which indicate major climate/environmental perturbations in Earth's surface systems during the Early Jurassic. Although extensive research has been conducted in European continental settings, particularly in the western peri-Tethys regions, the impacts of this event beyond Europe remains largely unexplored. Here, a multiapproach study including investigations into the sporepollen assemblages, pyrite framboids, clay minerals, total organic carbon(TOC) levels, and organic carbon isotope(δ13Corg) levels in a lacustrine borehole section(MED1) from the Yin'gen–Ejinaqi Basin, North China, provides evidence of the occurrence of the Jenkyns Event and its extensive sedimentary responses in the eastern Tethys terrestrial systems. Two distinct spore-pollen assemblages have been identified in MED1(drilling depth: 982.4 m to 1267.5 m), with the Cycadopites–Protopinus–Osmundacidites assemblage in the lower part(1267.5 m to 1132.9 m) indicating a middle Early Jurassic age and the Classopollis assemblage in the upper part(1132.9 m to 985.7 m) suggesting a Toarcian age. Framboidal pyrite data suggest more anoxic conditions during the deposition of black mudstone and shale intercalations in the lower part of the Classopollis assemblage(1132.9 m to 1066.9 m), which combined with organic carbon enrichment and negative δ13Corg excursions, are considered the paleoenvironmental response to the Jenkyns Event in the study area. Furthermore, the evolution of vegetation groups changed from plant groups characterized by bisaccate and cycad pollen, as well as fern spores, to vegetation groups represented by Cheirolepidiaceae pollen across the Jenkyns Event, as evidenced by sporepollen data, together with the clay mineral assemblage change characterized by a notable increase in i

关键词： clay minerals Jenkyns event organic carbon isotope pyrite framboids spore-pollen assemblages

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复方中草药添加剂对青年海兰褐蛋鸡生产性能、血清生化及肠道菌群的影响

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中国饲料 2024年第17期 110-116页

作者：马艳孙禹任道全张苏江塔里木大学动物科学与技术学院新疆阿拉尔843300 塔里木大学生命科学与技术学院新疆阿拉尔843300 塔里木畜牧科技兵团重点实验室新疆阿拉尔843300

为研究复方中草药添加剂对青年海兰褐蛋鸡生产性能、产蛋初期性能、抗氧化能力以及肠道菌群的影响,本试验选取12周龄健康青年海兰褐蛋鸡600只,随机分为3组,对照组饲喂基础饲粮,试验Ⅰ组和试验Ⅱ组分别在基础饲粮中添加0.2%和0.4%复方中... 详细信息

为研究复方中草药添加剂对青年海兰褐蛋鸡生产性能、产蛋初期性能、抗氧化能力以及肠道菌群的影响,本试验选取12周龄健康青年海兰褐蛋鸡600只,随机分为3组,对照组饲喂基础饲粮,试验Ⅰ组和试验Ⅱ组分别在基础饲粮中添加0.2%和0.4%复方中草药添加剂,每组4个重复,每个重复50只鸡。预饲期2周,正饲期8周。结果表明:(1)饲粮中添加0.4%复方中草药可有效提高青年海兰褐蛋鸡的日增重、日均采食量,降低料重比(P 0.05)。综上所述,在饲粮中添加0.4%的甘草、沙枣、石榴皮、枸杞(1:1:1:1)复方中草药添加剂能够提高青年海兰褐蛋鸡的生产性能、抗氧化能力,改善肠道菌群结构。

关键词：中草药海兰褐蛋鸡生产性能抗氧化指标肠道菌群

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不同青贮饲料对奶牛瘤胃液微生物多样性的影响

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家畜生态学报 2024年第1期45卷 22-28页

作者：周斐然赵龙飞张梦圆张苏江哈密市畜牧工作站新疆哈密839000 塔里木大学动物科学与技术学院新疆阿拉尔843300

为了更好地开发利用甜高粱青贮饲料,采用Illumina MiSeq 2×250系统,对细菌16S rDNA V3~V4区进行高通量测序,分析了分别饲喂高糖甜高粱青贮(HSS)、低糖甜高粱青贮(LSS)和玉米青贮(MZS)3种青贮饲料奶牛瘤胃液样本中的细菌多样性及群落结... 详细信息

为了更好地开发利用甜高粱青贮饲料,采用Illumina MiSeq 2×250系统,对细菌16S rDNA V3~V4区进行高通量测序,分析了分别饲喂高糖甜高粱青贮(HSS)、低糖甜高粱青贮(LSS)和玉米青贮(MZS)3种青贮饲料奶牛瘤胃液样本中的细菌多样性及群落结构。结果表明:HSS组和MZS组瘤胃液样品中菌类丰富度相近且高于LSS组;HSS组、MZS组中拟杆菌门(Bacteroidetes)所占比例最大,极显著高于LSS组(P<0.05),分别占39.65%和40.51%;其次是厚壁菌门(Firmicutes),分别占29.67%和32.87%,低于LSS组;通过菌属的分析,普雷沃菌属(Prevotella)和瘤胃球菌属(Ruminococcus)在3种瘤胃液中都是优势菌群,HSS组与MZS组瘤胃液中的细菌菌群有许多共性,且菌属丰富度高于LSS组。结果提示HSS可代替MZS用于饲喂奶牛。

关键词：高通量测序瘤胃微生物甜高粱多样性奶牛

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全球锗资源分布供需与产业链发展现状思考

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矿产综合利用 2024年第4期45卷 11-20页

作者：张苏江张新智邓文兵中国地质调查局自然资源实物地质资料中心河北廊坊065201

这是一篇矿业工程领域的论文。锗已成为信息通讯、现代航空、现代军事与新能源等诸多高新技术领域不可或缺的战略性稀有金属资源。世界锗资源较为匮乏且分布不均,近96%的锗探明储量集中在美国、中国和俄罗斯等少数国家。作为中国最为重... 详细信息

这是一篇矿业工程领域的论文。锗已成为信息通讯、现代航空、现代军事与新能源等诸多高新技术领域不可或缺的战略性稀有金属资源。世界锗资源较为匮乏且分布不均,近96%的锗探明储量集中在美国、中国和俄罗斯等少数国家。作为中国最为重要的战略性优势矿产资源之一,锗在全国14个省(区)均有分布,矿床类型以煤层型和碳酸盐岩容矿型为主,集中分布于大兴安岭、西南三江、川滇黔、长江中下游和南岭等5个成锗区(带)。本文通过分析国内外锗资源禀赋、分布与开发利用情况,研判世界和中国锗产业链的消费形势与供需格局,提出需加大国内重点锗成矿区(带)勘查、开展锗高端材料和应用技术研发,加强锗产业结构优化升级、推动锗二次回收绿色健康良性循环发展等建议。

关键词：矿业工程锗战略性矿产分布供需产业链

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Gene mutations in a patient with chronic myelomonocytic leukemia and changes upon progression to acute myeloid leukemia and during treatment

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Oncology and Translational Medicine 2019年第1期5卷 30-32页

作者： Jiaming Li sujiang zhang Department of Hematology Ruijin Hospital North Affiliated with Shanghai Jiao Tong University School of Medicine

Objective Chronic myelomonocytic leukemia(CMML) has been categorized as an uncommon hematological malignancy with overlapping features of myelodysplastic syndromes(MDS) and myeloproliferative neoplasms that have an inherent risk of progressing to acute myeloid leukemia(AML). Methods This study presents a case of confirmed CMML combined with M protein, in which the molecular changes upon progression to AML and under decitabine(DAC) plus bortezomib therapy were reported by tracking variant allele frequency(VAF) of mutations in a series of bone marrow samples. Results First, variable sensitivity of clones was observed during DAC treatment, and incomplete mutation clearance may be associated with low overall response rate and unsustained response. Secondly, DAC cannot prevent the new genetic alterations and accumulation of genetic progression on treatment, leading to acute transformation. Finally, autoimmunity was found to have acted as an important pathogenetic factor, increasing the additive mutations that further drive the clonal evolution in CMML. Conclusion Overall, changes in mutations and clonal architecture during CMML progression or treatment are predictive of an early evaluation of therapeutic strategies in CMML.

关键词： chronic myelomonocytic leukemia acute myeloid leukemia mutation decitabine bortezomib platelets SETD2 LILRB4

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Clinical manifestation of the SRSF2 gene mutation in Chinese patients with chronic myelomonocytic leukemia

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Chinese Medical Journal 2014年第24期127卷 4215-4219页

作者： Sun Chao zhang sujiang Qiao Chun Yang Xiangchou Li Jianyong Department of Hematology Wuxi People's Hospital Affiliated to Nanjing Medical University Wuxi Jiangsu 214023 China Department of Hematology the First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital Nanjing Jiangsu 210029 China

Background Spliceosome mutations have been recently identified and associated with hematological malignancies. SRSF2, one of components of the splicing machinery, has a high mutation frequency during chronic myelomonocytic leukemia, according to previous reports. However, the relevance of this finding in Chinese populations remains unknown. Methods We recruited 50 Chinese patients with chronic myelomonocytic leukemia to analyze the state of SRSF2 and to assess the corresponding clinical features by polymerase chain reaction followed by direct sequencing. Results Ten of 50 patients （20%） harbored SRSF2 mutations, including five P95R, two 95H, and three P95L point mutations. The patient group was older than the wild type group （P 〈0.01）. No significant statistical differences were observed with regard to the other clinical characteristics （sex, peripheral blood count, serum lactate dehydrogenase, karyotype, World Health Organization classification, etc.） between these two groups. Two of the patients showed an early evolution to acute myeloid leukemia. Conclusions SRSF2 mutations are frequent in chronic myelomonocytic leukemia patients, but show a relatively lower incidence in Chinese patients. Moreover, the mutation can be related to old age and an unfavorable prognosis. Our results provide valuable insights for the development of a diagnostic marker, or for the identification of a therapeutic target for chronic myelomonocytic leukemia.

关键词： SRSF2 gene mutation chronic myelomonocytic leukemia

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DNA crosslinking and recombination-activating genes 1/2(RAG1/2)are required for oncogenic splicing in acute lymphoblastic leukemia

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Cancer Communications 2021年第11期41卷 1116-1136页

作者： Hao zhang Nuo Cheng Zhihui Li Ling Bai Chengli Fang Yuwen Li Weina zhang Xue Dong Minghao Jiang Yang Liang sujiang zhang Jianqing Mi Jiang Zhu Yu zhang Sai-Juan Chen Yajie Zhao Xiang-Qin Weng Weiguo Hu Zhu Chen Jinyan Huang Guoyu Meng Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational MedicineRui-Jin HospitalSchool of Medicine and School of Life Sciences and BiotechnologyShanghai JiaoTong UniversityShanghai 200025P.R.China Key Laboratory of Synthetic Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 200032P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China Department of Hematologic Oncology State key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Geriatrics Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025P.R.China Medical Center on Aging of Ruijin Hospital Shanghai Jiao Tong University School of MedicineShanghai 200025P.R.China Department of Laboratory Medicine West China HospitalSichuan UniversityChengduSichuan 610044P.R.China Biomedical Big Data Center the First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310000P.R.China Cancer Center Zhejiang UniversityHangzhouZhejiang 310000P.R.China

Background:Abnormal alternative splicing is frequently associated with *** B-cell acute lymphoblastic leukemia(B-ALL),double homeobox 4 fused with immunoglobulin heavy chain(DUX4/IGH)can lead to the aberrant production of E-26 transformation-specific family related gene abnormal transcript(ERGalt)and other splicing ***,the molecular mechanism underpinning this process remains ***,we aimed to know how DUX4/IGH triggers abnormal splicing in ***:The differential intron retention analysis was conducted to identify novel DUX4/IGH-driven splicing in B-ALL patients.X-ray crystallography,small angle X-ray scattering(SAXS),and analytical ultracentrifugation were used to investigate how DUX4/IGH recognize double DUX4 responsive element(DRE)-DRE *** ERGalt biogenesis and B-cell differentiation assays were performed to characterize the DUX4/IGH crosslinking *** check whether recombination-activating gene 1/2(RAG1/2)was required for DUX4/IGH-driven splicing,the proximity ligation assay,co-immunoprecipitation,mammalian two hybrid characterizations,in vitro RAG1/2 cleavage,and shRNA knock-down assays were ***:We reported previously unrecognized intron retention events in Ctype lectin domain family 12,member A abnormal transcript(CLEC12Aalt)and chromosome 6 open reading frame 89 abnormal transcript(C6orf89alt),where also harbored repetitive DRE-DRE ***,X-ray crystallography and SAXS characterization revealed that DUX4 homeobox domain(HD)1-HD2 might dimerize into a dumbbell-shape trans configuration to crosslink two adjacent DRE *** DUX4/IGH-mediated crosslinking abolishes ERGalt,CLEC12Aalt,and C6orf89alt biogenesis,resulting in marked alleviation of its inhibitory effect on B-cell ***,we also observed a rare RAG1/2-mediated recombination signal sequence-like DNA edition in DUX4/IGH target ***,shRNA knock-down of RAG1/2 in leukemic Reh cells c

关键词： Acute lymphoblastic leukemia alternative splicing DUX4/IGH ERG_(alt) RAG1/2

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精准治疗有希望治愈肿瘤吗?

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上海交通大学学报 2021年第S1期55卷 55-57页

作者：张苏江陈赛娟上海交通大学医学院附属瑞金医院国家转化医学中心上海200025

以肿瘤靶向药物为代表的精准治疗正在给肿瘤治疗带来变革性的突破.急性早幼粒细胞白血病(APL)以往属于高致死性恶性血液肿瘤,如今,基于分子机制的精准诊断和精准治疗使APL成为第一个可被基本治愈的急性髓系白血病.近年来,前瞻性的全国... 详细信息

以肿瘤靶向药物为代表的精准治疗正在给肿瘤治疗带来变革性的突破.急性早幼粒细胞白血病(APL)以往属于高致死性恶性血液肿瘤,如今,基于分子机制的精准诊断和精准治疗使APL成为第一个可被基本治愈的急性髓系白血病.近年来,前瞻性的全国多中心随机对照临床试验的优化治疗、诊断分层体系优化、APL致癌蛋白PML-RARa协同靶向治疗调控图谱的阐明,为高危患者提供更多的治愈机遇.协同靶向精准治疗APL的思路将进一步拓展至其他类型白血病,甚至实体瘤.

关键词：肿瘤精准治疗急性早幼粒细胞白血病

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以色列的奶牛养殖业

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安徽农业科学 2006年第3期34卷 456-457,467页

作者：张苏江塔里木大学兵团畜牧科技重点实验室新疆阿拉尔843300

以色列气候干旱少雨,国土面积只有21 500 km2,饲草料资源有限,这些因素从客观上限制了以色列的奶牛养业。然而,以色列通过使用TMR饲料、控制牛场规模、改善牛舍环境以及完备的社会化服务体系,使得以色列奶牛年单产奶量位居世界首位,牛... 详细信息

以色列气候干旱少雨,国土面积只有21 500 km2,饲草料资源有限,这些因素从客观上限制了以色列的奶牛养业。然而,以色列通过使用TMR饲料、控制牛场规模、改善牛舍环境以及完备的社会化服务体系,使得以色列奶牛年单产奶量位居世界首位,牛奶年创商业总产值16亿美元,占国内总产值16.5%的佳绩。近年来,虽然我国奶牛养殖业发展迅速,但面临的困难十分严峻。以色列奶牛的饲养、管理模式值得我们思考和借鉴。

关键词：以色列奶牛养殖

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Efficacy and safety of combined decitabine and ruxolitinib in the treatment of chronic myelomonocytic leukemia

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Oncology and Translational Medicine 2019年第5期5卷 237-241页

作者： Jiaming Li sujiang zhang Yubao Chen Zeying Yan Ying Wang Zhiyin Liu Haimin Sun Yu Chen Department of Hematology Ruijin Hospital North affiliated to Shanghai Jiao Tong University School of Medicine

Objective The aim of the study was to evaluate the clinical efficacy of decitabine(DEC)combined with ruxolitinib(RUX)in the treatment of chronic myelomonocytic leukemia(CMML).Methods The clinical characteristics of 12 patients with CMML were analyzed retrospectively and subsequent target sequencing was performed to investigate the efficacy of the combined treatment with DEC and RUX and the molecular signatures *** Among the 12 cases,clinical improvement was observed in all patients(100%),spleen reduction was observed in six patients(67%),and hematologic improvement was observed in four patients(33%).In the CMML-1 group,the overall response was 50%(3/6),one case achieved complete response,one achieved bone marrow remission,and one achieved hematological *** the CMML-2 group,the overall response was 17%(1/6),one case achieved complete response,four showed disease progression(PD),and one exhibited no *** expected,ASXL1 mutation was predictive for the outcome of CMML(hazard ratio of 2.97,95%confidence interval of 1.21–7.06;P=0.02).Conclusion The use of DEC combined with RUX in the treatment of CMML effectively improved the clinical response and quality of life,especially for CMML-1 *** clinical trials will further evaluate the safety and efficacy of this novel therapeutic approach.

关键词： decitabine(DEC) ruxolitinib(RUX) chronic myelomonocytic leukemia(CMML)

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