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STCF conceptual design report (Volume 1): Physics & detector

Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.chang K.T.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du L.M.Duan D.Epifanov Y.L.fan S.S.fang Z.J.fang G.Fedotovich C.Q.Feng X.Feng Y.T.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.B.He S.Q.He X.G.He Y.L.He Z.B.He Z.X.Heng B.L.Hou T.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.H.Li C.Li D.Y.Li F.Li G.Li G.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li Y.Li Y.Y.Li Z.J.Li H.Liang J.H.Liang Y.T.Liang G.R.Liao L.Z.Liao Y.Liao C.X.Lin D.X.Lin X.S.Lin B.J.Liu C.W.Liu D.Liu F.Liu G.M.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu Z.Q.Liu Z.Y.Liu Z.W.Liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker C.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

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Trends of Oral Cancer Mortality in China from 1990 to 2019 and a 15-Year Predictive Analysis Based on a Bayesian Age-Period-Cohort Model

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Biomedical and Environmental Sciences 2023年第6期36卷 553-556页

作者： GU Jian chang song Ji wu LIU Yun wang Xiao Lan XU Shuang Shuang zhang Liang Liang LIU Yun Xia DING Gang School of Stomatology Weifang Medical UniversityWeifang 261053ShandongChina Department of Stomatology Weifang People’s HospitalFirst Affiliated Hospital of Weifang Medical UniversityWeifang 261053ShandongChina Department of Dentistry Affiliated Hospital of Weifang Medical UniversityWeifang 261035ShandongChina

Oral cancer is the most common malignant tumor of the head and *** is characterized by high rates of recurrence and distant metastasis and usually has a poor *** advances in cancer diagnosis and treatment,the overall ... 详细信息

关键词： diagnosis cancer Cancer

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Association between choroidal thickness and anterior chamber segment in eyes with narrow or open-angle

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International Journal of Ophthalmology(English edition) 2016年第8期9卷 1143-1147页

作者： song-Feng Li Ge-Wei wu chang-Xi Chen Ling Shen Zhi-Bao zhang Fei Gao Ning-Li wang Beijing Ophthalmology and Visual Science Key Laboratory Beijing Tongren Eye Center Beijing Institute of Ophthalmology Beijing Tongren Hospital Capital Medical University Department of Ophthalmology Beijing Shi Jing Shan Hospital Department of Ophthalmology The 2~(nd) Affiliated Hospital of Harbin Medical University

AIM: To investigate the relationship between choroidal thickness and anterior chamber segment in subjects with eyes with narrow or open-angle. METHODS: The subfoveal choroidal thickness was measured with enhanced depth -imaging optical coherence tomography and anterior chamber parameters were measured with ultrasound biomicroscopy in one eye of 23 subjects with open-angle eyes and 38 subjects with narrow-angle eyes. The mean age was 59.52 +/- 7.04y for narrow-angle subjects and 60.76 +/- 7.23y for open angle subjects (P=0.514). Multivariate linear regression analysis was performed to assess the association between choroidal thickness and narrow -angle parameters. RESULTS: There were no differences in subfoveal choroidal thickness between open - and narrow-angle subjects (P=0.231). Anterior chamber parameters, including central anterior chamber depth, trabecular iris angle, iris thickness 500 mu m from the scleral spur (IT500), and ciliary body thickness at 1 mm and 2 mm from the sclera! spur (CBT1, CBT2) showed significant differences between the two groups (P<0.05). Subfoveal choroidal thickness showed negative correlation (beta=-0.496, P=0.016) only with anterior chamber depth in the open angle group and with age (beta=-0.442, P=0.003) and 11500 (beta=-0.399, P=0.008) in the narrow-angle group. However, subfoveal choroidal thickness was not correlated with trabecular iris angle, anterior chamber depth, ciliary body thickness, or central corneal thickness in the narrow-angle group. CONCLUSION: Choroidal thickness does not differ in the two groups and has not correlated with anterior chamber parameters in narrow-angle subjects, suggesting a lack of relationship between choroidal thickness and primary angle-closure glaucoma.

关键词： choroidal thickness narrow-angle eye optical coherence tomography primary angle-closure glaucoma

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Solar-driven high-temperature steam generation at ambient pressure

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Progress in Natural Science:Materials International 2019年第1期29卷 10-15页

作者： Xinyu wang Yanming Liu Rui Feng Yao zhang Chao chang Benwei Fu Tian Luan Peng Tao Wen Shang Jianbo wu Chengyi song Tao Deng State Key Laboratory of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University

This paper demonstrates a facile solar steam generator for the generation of high-temperature steam at ambient pressure. The steam generator consists of a coiled copper tube(CCT) that serves as both solar collector and vapor heater. Both the inner and outer surfaces of the CCT are coated with black superhydrophobic copper oxide layer to improve the solar absorption, and such superhydrophobic layer prevents the condensation and clogging of water vapor during the heating process. Solar vapor is generated at the inlet of CCT through interfacial evaporation and subsequently heated inside the CCT as the vapor travels from the inlet to the outlet. By employing this approach, steam temperature that exceeds 100℃ under 1-sun illumination is demonstrated. Furthermore,steam temperature could reach as high as 250℃ under 10-sun illumination at ambient pressure. Successful sterilization experiment was also performed in this work to demonstrate the potential application of the high temperature steam generated. Such demonstrated approach helps open up the potential usage of solar-driven interfacial evaporation in applications that involve high-temperature steam, including medical sterilization,chemical manufacturing and food processing.

关键词： High-temperature steam Photothermal conversion materials Solar steam generation Sterilization Vapor heating

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Identification and fine mapping of rtms1-D,a gene responsible for reverse thermosensitive genic male sterility from Diannong S-1X

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Plant Diversity 2022年第2期44卷 213-221页

作者： Xiao zhang Guimei chang Zihao wu Jinpeng Wan Jun Yang Feijun wang fang wang Diqiu Yu Peng Xu CAS Key Laboratory of Tropical Plant Resources and Sustainable Use Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglunMenglaYunnan 666303China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China Center of Economic Botany Core Botanical GardensChinese Academy of SciencesMenglunMenglaYunnan 666303China The Innovative Academy of Seed Design Chinese Academy of SciencesMenglunMenglaYunnan 666303China

Thermosensitive genic male sterility(TGMS)has been widely used in two-line hybrid rice *** to hybrid seed production being highly affected by changeable environments,its application scope is limited to some ***,it is of great importance to identify potential TGMS genes in specific rice ***,Diannong S-1 xuan(DNS-1 X),a reverse TGMS(RTGMS)japonica male sterile line,was identified from Diannong *** analysis showed that male sterility was tightly controlled by a single recessive gene,which was supported by the phenotype of the F;and F;populations derived from the cross between DNS-1 X and Yunjing 26(YJ26).Combining simple sequence repeat(SSR)markers and bulked segregation analysis(BSA),we identified a 215 kb region on chromosome 10 as a candidate reverse TGMS region,which was designated as *** was narrower than the previously reported RTGMS genes rtmsl and tms6(t).The fertility conversion detected in the natural environment showed that DNS-1 X was sterile below 28-30℃;otherwise,it was *** analysis further indicated that the pollen abortion was occurred in the young microspore *** study will provide new resources for two-line hybrid rice and pave the way for molecular breeding of RTGMS lines.

关键词： Rice(Oryza sativa L) Reverse thermosensitive genic male sterile (RTGMS) rtmsl-D Fertility transition

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Mice 3D testicular organoid system as a novel tool to study Zika virus pathogenesis

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Virologica Sinica 2023年第1期38卷 66-74页

作者： Wei Yang Chen zhang Yan-Hua wu Li-Bo Liu Zi-Da Zhen Dong-Ying fan Zheng-Ran song Jia-Tong chang Pei-Gang wang Jing An Department of Microbiology School of Basic Medical SciencesCapital Medical UniversityBeijing100069China Department of Neurosurgery Capital Medical University Sanbo Brain HospitalBeijing100093China Center of Epilepsy Beijing Institute for Brain DisordersBeijing100093China

Zika virus(ZIKV)poses a serious threat to global public health due to its close relationship with neurological and male reproductive ***,deficiency of human testicular samples hinders the in-depth research on ZIKV-induced male reproductive system *** are relatively simple in vitro models,which could mimic the pathological changes of corresponding *** this study,we constructed a 3D testicular organoid model using primary testicular cells from adult BALB/c *** to the testis,this organoid system has a blood-testis barrier(BTB)-like structure and could synthesize *** tropism of testicular cells and ZIKV-induced pathological changes in testicular organoid was also similar to that in mammalian ***,our results provide a simple and reproducible in vitro testicular model for the investigations of ZIKV-induced testicular injury.

关键词： Organoid 3D cell culture Testicular organoid model Zika virus(ZIKV)

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Fluorescent co-localization of PTS1 and PTS2 and its application in analysis of the gene function and the peroxisomal dynamic in Magnaporthe oryzae

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第10期9卷 802-810页

作者： Jiao-yu wang Xiao-yan wu Zhen zhang Xin-fa DU Rong-yao CHAI Xiao-hong LIU Xue-qin MAO Hai-ping QIU Yan-li wang Fu-cheng LIN Guo-chang SUN Zhejiang Academy ofa gricultural Sciences Hangzhou 310021 China College of Plant Protection Northwest Agriculture and Forest University Yangling 712100 China State Key Laboratory for Rice Biology College of Agriculture and Biotechnology Zhejiang University Hangzhou 310029 China

The peroxisomal matrix proteins involved in many important biological metabolism pathways in eukaryotic cells are encoded by nucleal genes, synthesized in the cytoplasm and then transported into the organelles. Targeting and import of these proteins depend on their two peroxisomal targeting signals （PTS 1 and PTS2） in sequence as we have known so far. The vectors of the fluorescent fusions with PTS, i.e., green fluorescence protein （GFP）-PTS1, GFP-PTS2 and red fluorescence protein （RFP）-PTS1, were constructed and introduced into Magnaporthe oryzae Guy ll cells. Transformants containing these fusions emitted fluorescence in a punctate pattern, and the locations of the red and green fluorescence overlapped exactly in RFP-PTS 1 and GFP-PTS2 co-transformed strains. These data indicated that both PTS1 and PTS2 fusions were imported into peroxisomes. A probable higher efficiency of PTS1 machinery was revealed by comparing the fluorescence backgrotmds in GFP-PTS1 and GFP-PTS2 transformants. By introducing both RFP-PTS1 and GFP-PTS2 into Amgpex6 mutants, the involvement of MGPEX6 gene in both PTS1 and PTS2 pathways was proved. In addition, using these transformants, the inducement ofperoxisomes and the dynamic of peroxisomal number during the pre-penetration processes were investigated as well. In summary, by the localization and co-localization of PTS1 and PTS2, we provided a useful tool to evaluate the biological roles of the peroxisomes and the related genes.

关键词： Peroxisomal targeting signal (PTS) Peroxisomal localization MGPEX6 gene Magnaporthe oryzae

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电位调控快速浮选技术在铅锌矿中的应用实践

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矿冶 2024年第2期33卷 217-224页

作者：王洋赵彦杰左可胜张志范松吴丽丽王晨陕西西北有色铅锌集团有限公司陕西宝鸡721000 长安大学地球科学与资源学院西安710000 宝鸡市高新技术产业开发区管理委员会陕西宝鸡721000

电位调控快速浮选技术主要是通过调节矿浆电位,改变不同矿物的可浮性,提高选矿药剂的活性,提高浮选速度,缩短浮选时间,实现有用矿物与脉石矿物的快速分离浮选。以陕西东塘子铅锌矿工业应用为例进行阐述。该矿应用电位调控快速浮选技术前... 详细信息

电位调控快速浮选技术主要是通过调节矿浆电位,改变不同矿物的可浮性,提高选矿药剂的活性,提高浮选速度,缩短浮选时间,实现有用矿物与脉石矿物的快速分离浮选。以陕西东塘子铅锌矿工业应用为例进行阐述。该矿应用电位调控快速浮选技术前,处理能力为1000 t/d的选矿厂采用两个独立的磨浮系列进行生产,选矿成本较高;药剂制度采用重拉重压的方式,铅精矿质量不好、铅锌回收率尚有提升空间。为有效降低选矿成本、提高铅精矿质量及铅锌回收率,该矿引进电位调控快速浮选技术,对其中一个浮选系列进行了设备改造,提高该浮选系列的过浆能力;将石灰添加进球磨机,通过石灰将矿浆pH值调节为12.5,使矿浆电位降低并稳定在-170 mV;同时,应用乙硫氮、Z-1浮选剂等浮选药剂,并对相应的药剂制度进行调整优化后进行了工业应用。工业应用非常成功,实现了铅锌快速分离浮选,在产能不变的情况下,浮选作业由两个系列改为单系列运行,浮选时间由77.91 min缩短到47.66 min;取得的效果也非常明显,铅精矿主品位由56%提高到65%,铅锌回收率分别提高了0.16和0.64个百分点;停用一个浮选系列,减少装机容量400 kW,减少浮选岗位人员8名;降低药剂成本2.19元/t;年产生经济效益500余万元,经济效益和社会效益可观。

关键词：铅锌矿电位调控电化学浮选快速浮选矿浆pH值矿浆电位药剂制度浮选时间

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Plasma exosomal hsa_circ_0079439 as a novel biomarker for early detection of gastric cancer

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World Journal of Gastroenterology 2023年第22期29卷 3482-3496页

作者： Xiao Li Yan-Li Lin Jia-Kang Shao Xiao-Jie wu Xiang Li He Yao fa-Liang Shi Long-song Li Wen-Gang zhang Zheng-Yao chang Ning-Li Chai You-Liang wang En-Qiang Linghu Department of Gastroenterology The First Medical Center of Chinese PLA General HospitalBeijing 100853China Medical School of Chinese PLA Beijing 100853China Beijing Institute of Biotechnology Beijing 100071China

BACKGROUND Due to the poor prognosis of gastric cancer(GC),early detection methods are urgently *** exosomal circular RNAs(circRNAs)have been suggested as novel biomarkers for *** To identify a novel biomarker for early detection of *** Healthy donors(HDs)and GC patients diagnosed by pathology were *** GC patients and three HDs were selected for exosomal whole-transcriptome RNA *** expression profiles of circRNAs were analyzed by bioinformatics methods and validated by droplet digital polymerase chain *** expression levels and area under receiver operating characteristic curve values of plasma exosomal circRNAs and standard serum biomarkers were used to compare their diagnostic *** There were 303 participants,including 240 GC patients and 63 HDs,involved in the *** expression levels of exosomal hsa_circ_0079439 were significantly higher in GC patients than in HDs(P<0.0001).However,the levels of standard serum biomarkers were similar between the two *** area under the curve value of exosomal hsa_circ_0079439 was higher than those of standard biomarkers,including carcinoembryonic antigen,carbohydrate antigen(CA)19-9,CA72-4,alpha-fetoprotein,and CA125(0.8595 vs 0.5862,0.5660,0.5360,0.5082,and 0.5018,respectively).The expression levels of exosomal hsa_circ_0079439 were significantly decreased after treatment(P<0.05).Moreover,the expression levels of exosomal hsa_circ_0079439 were obviously higher in early GC(EGC)patients than in HDs(P<0.0001).CONCLUSION Our results suggest that plasma exosomal hsa_circ_0079439 is upregulated in GC ***,the levels of exosomal hsa_circ_0079439 could distinguish EGC and advanced GC patients from ***,plasma exosomal hsa_circ_0079439 might be a potential biomarker for the diagnosis of GC during both the early and late stages.

关键词： Gastric cancer Exosomes Circular RNA Droplet digital polymerase chain reaction Biomarker

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Interaction of radiation-induced defects with tungsten grain boundaries at across scales: a short review

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Tungsten 2020年第1期2卷 15-33页

作者： Xiang‑Yan Li Yan‑Ge zhang Yi‑Chun Xu Xue‑Bang wu Xiang‑Shan Kong Xian‑Ping wang Qian‑Feng fang chang‑song Liu Key Laboratory of Materials Physics Institute of Solid State PhysicsChinese Academy of SciencesHefei 230031China Key Laboratory for Liquid‑Solid Structural Evolution and Processing of Materials(Ministry of Education) Shandong UniversityJinan 250061China

As promising candidates for plasma-facing materials,tungsten-based materials suffer the irradiation of high-energy neutrons in addition to the hydrogen isotopes and helium irradiation and the high-thermal ***-produced defects,***-interstitial atoms(SIAs)and vacancies(Vs),can induce the hardening and embrittlement of tungsten,meanwhile enhancing the retention of hydrogen isotopes and helium in *** the grain size of materials to introduce a high density of defect sinks,e.g.,grain boundaries(GBs)prevalent in nano-/ultrafine-crystalline materials,was demonstrated to be an effective approach for mitigating irradiation damage in *** this paper,we reviewed the theoretical advances in exploring radiation-resistance of nano-structured tungsten at across *** was concentrated on the results of molecular dynamics,molecular statics,and the object kinetic Monte Carlo simulations on the fundamental interaction of the radiation-created Vs and SIAs with the *** mechanisms include GB-promoted V/SIA migration and SIA-V recombination,interstitial-emission induced annihilation,coupling of the V migration close to the GB with the SIA motion within the GB,and interstitial reflection by the locally dense GB *** proposed the remaining scientific issues on the defect-GB interactions at across scales and their relation to experimental *** prospected the possible trends for simulating the radiation damage accumulation and healing processes in nano-structured tungsten in terms of the development of the across-scale computational techniques and efficiency of the GB-enhanced tolerance of tungsten to irradiation under complex in-service conditions.

关键词： Nano-crystalline Grain boundary Radiation-resistance Self-healing Radiation damage Tungsten

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