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miR‑423 sponged by lncRNA NORHA inhibits granulosa cell apoptosis

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Journal of Animal Science and Biotechnology 2024年第2期15卷 632-644页

作者： Yuqi Li Zhuofan zhang siqi Wang Xing Du Qifa Li College of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210095China

Background Atresia and degeneration,a follicular developmental fate that reduces female fertility and is triggered by granulosa cell(GC)apoptosis,have been induced by dozens of miRNAs.Here,we report a miRNA,miR-423,that inhibits the initiation of follicular atresia(FA),and early apoptosis of GCs.Results We showed that miR-423 was down-regulated during sow FA,and its levels in follicles were negatively correlated with the GC density and the P4/E2 ratio in the follicular fluid in vivo.The in vitro gain-of-function experiments revealed that miR-423 suppresses cell apoptosis,especially early apoptosis in GCs.Mechanically speaking,the miR-423 targets and interacts with the 3’-UTR of the porcine SMAD7 gene,which encodes an apoptosis-inducing factor in GCs,and represses its expression and pro-apoptotic function.Interestingly,FA and the GC apoptosis-related lncRNA NORHA was demonstrated as a ceRNA of miR-423.Additionally,we showed that a single base deletion/insertion in the miR-423 promoter is significantly associated with the number of stillbirths(NSB)trait of sows.Conclusion These results demonstrate that miR-423 is a small molecule for inhibiting FA initiation and GC early apoptosis,suggesting that treating with miR-423 may be a novel approach for inhibiting FA initiation and improving female fertility.

关键词： Granulosa cell apoptosis miR-423 NORHA SMAD7 Sow fertility traits

Biomarkers for neuromyelitis optica:a visual analysis of emerging research trends

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Neural Regeneration Research 2024年第12期19卷 2735-2749页

作者： Xiangjun Li Jiandong zhang siqi zhang Shengling Shi Yi’an Lu Ying Leng Chunyan Li Department of Ophthalmology Affiliated Hospital of Beihua UniversityJilinJilin ProvinceChina Department of Ophthalmology Changchun Bright Eye HospitalChangchunJilin ProvinceChina Departemt of Endocrinology Affiliated Hospital of Beihua UniversityJilinJilin ProvinceChina

Neuromyelitis optica is an inflammatory demyelinating disease of the central nervous system that differs from multiple sclerosis.Over the past 20 years,the search for biomarke rs for neuromyelitis optica has been ongoing.Here,we used a bibliometric approach to analyze the main research focus in the field of biomarkers for neuromyelitis optica.Research in this area is consistently increasing,with China and the United States leading the way on the number of studies conducted.The Mayo Clinic is a highly reputable institution in the United States,and was identified as the most authoritative institution in this field.Furthermore,Professor Wingerchuk from the Mayo Clinic was the most authoritative expe rt in this field.Keyword analysis revealed that the terms "neuro myelitis optica"(261 times), "multiple sclerosis"(220 times), "neuromyelitis optica spectrum disorder"(132 times), "aquaporin4"(99 times),and "optical neuritis"(87 times) were the most frequently used keywords in literature related to this field.Comprehensive analysis of the classical literature showed that the majority of publications provide conclusive research evidence supporting the use of aquaporin-4-IgG and neuromyelitis optica-IgG to effectively diagnose and differentiate neuromyelitis optica from multiple sclerosis.Furthermore,aquaporin-4-IgG has emerged as a highly specific diagnostic biomarker for neuromyelitis optica spectrum disorder.Myelin oligodendrocyte glycoprotein-IgG is a diagnostic biomarke r for myelin oligodendrocyte glycoprotein antibody-associated disease.Recent biomarkers for neuromyelitis optica in clude cerebrospinal fluid immunological biomarkers such as glial fibrillary acidic protein,serum astrocyte damage biomarkers like FAM19A5,serum albumin,and gammaaminobutyric acid.The latest prospective clinical trials are exploring the potential of these biomarkers.Preliminary results indicate that glial fibrillary acidic protein is emerging as a promising candidate biomarker for neuromyelitis optica spectrum disorder.The ultimate goal of

关键词： aquaporin-4 autoantibody multiple sclerosis myelin oligodendrocyte glycoprotein antibody-associated disease neuromyelitis optica neuromyelitis optica spectrum disorder optical coherence tomography

Efficient and reversible separation of NH_(3) by deep eutectic solvents with multiple active sites and low viscosities

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Chinese Journal of Chemical Engineering 2024年第3期67卷 97-105页

作者： Jiayin zhang Lu Zheng siqi Fang Hongwei zhang Zhenping Cai Kuan Huang Lilong Jiang National Engineering Research Center of Chemical Fertilizer Catalyst(NERC-CFC) College of Chemical EngineeringFuzhou UniversityFuzhou 350002China Qingyuan Innovation Laboratory Quanzhou 362801China

The efficient separation and collection of ammonia(NH_(3))during NH_(3) synthesis process is essential to improve the economic efficiency and protect the environment.In this work,ethanolammonium hydrochloride(EtOHACl)and phenol(PhOH)were used to prepare a novel class of deep eutectic solvents(DESs)with multiple active sites and low viscosities.The NH_(3) separation performance of EtOHACl+PhOH DESs was analyzed completely.It is figured out that the NH_(3) absorption rates in EtOHACl+PhOH DESs are very fast.The NH_(3) absorption capacities are very high and reach up to 5.52 and 10.74 mol·kg1 at 11.2 and 100.4 kPa under 298.2 K,respectively.In addition,the EtOHACl+PhOH DESs present highly selective absorption of NH_(3) over N_(2) and H_(2) and good regenerative properties after seven cycles of absorption/desorption.The intrinsic separation mechanism of NH_(3) by EtOHACl+PhOH DESs was further revealed by spectroscopic analysis and quantum chemistry calculations.

关键词： Separation Absorption Ionic liquid Deep eutectic solvent Multiple active site Low viscosity

Fundamental Understanding of Hydrogen Evolution Reaction on Zinc Anode Surface:A First‑Principles Study

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Nano-Micro Letters 2024年第6期16卷 180-191页

作者： Xiaoyu Liu Yiming Guo Fanghua Ning Yuyu Liu siqi Shi Qian Li Jiujun zhang Shigang Lu Jin Yi Institute for Sustainable Energy&Department of Chemistry Shanghai UniversityShanghai 200444People’s Republic of China School of Materials Science and Engineering Shanghai UniversityShanghai 200444People’s Republic of China College of Materials Science and Engineering National Engineering Research Center for Magnesium AlloysChongqing UniversityChongqing 400044People’s Republic of China

Hydrogen evolution reaction(HER)has become a key factor affecting the cycling stability of aqueous Zn-ion batteries,while the corresponding fundamental issues involving HER are still unclear.Herein,the reaction mechanisms of HER on various crystalline surfaces have been investigated by first-principle calculations based on density functional theory.It is found that the Volmer step is the ratelimiting step of HER on the Zn(002)and(100)surfaces,while,the reaction rates of HER on the Zn(101),(102)and(103)surfaces are determined by the Tafel step.Moreover,the correlation between HER activity and the generalized coordination number(CN)of Zn at the surfaces has been revealed.The relatively weaker HER activity on Zn(002)surface can be attributed to the higher CN of surface Zn atom.The atomically uneven Zn(002)surface shows significantly higher HER activity than the flat Zn(002)surface as the CN of the surface Zn atom is lowered.The CN of surface Zn atom is proposed as a key descriptor of HER activity.Tuning the CN of surface Zn atom would be a vital strategy to inhibit HER on the Zn anode surface based on the presented theoretical studies.Furthermore,this work provides a theoretical basis for the in-depth understanding of HER on the Zn surface.

关键词： Aqueous Zn-ion battery Zn anode Hydrogen evolution reaction Coordination number First-principles calculation

Expression and Characterization of a Novelλ-Carrageenase Cgl150A_Wa from Wenyingzhuangia aestuarii

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Journal of Ocean University of China 2024年第1期23卷 209-215页

作者： SUN Yuhao CAO siqi zhang Yuying XUE Changhu XIAO Hang CHANG Yaoguang College of Food Science and Engineering Ocean University of ChinaQingdao 266003China Marine Life Research Center Laoshan National LaboratoryQingdao 266237China Department of Food Science University of Massachusetts AmherstMA 01003United States

λ-Carrageenan is a highly sulfated polysaccharide alternating of 1,4-O-α-D-galactopyranose-2,6-sulfate(D2S,6S)and 1,3-O-β-D-galactopyranose-2-sulfate(G2S).λ-Carrageenases are desirable tools forλ-carrageenan degradation.Based on the genome mining,a novelλ-carrageenase Cgl150A_Wa was cloned from the bacterium Wenyingzhuangia aestuarii and expressed in Escherichia coli.Cgl150A_Wa was an endo-acting enzyme and exhibited its maximum activity at 30℃and pH 8.0.By employing a glycomics strategy that combined ultra-performance liquid chromatography-mass spectrometry analysis and glycoinformatics,Cgl150A_Wa was proven to degradeλ-carrageenan octaose and hexaose,and the major hydrolysis product of Cgl150A_Wa wasλ-carrageenan tetrose.In addition to the typicalλ-carrageenan motifs,the active center of Cgl150A_Wa might tolerate desulfatedλ-carrageenan motifs.Cgl150A_Wa is a potential biotechnological tool for preparingλ-carrageenan oligosaccharides and structural investigation.

关键词： carrageenan λ-carrageenase LC-MS oligosaccharide GH150

Juvenile cardiomyopathy with dystrophin deficiency

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Genes & Diseases 2024年第3期11卷 30-33页

作者： Yuhui Luo Qinglan Shu Yi Wang Min Gu Hao zhang siqi Hong Rui Wang Lixue Yin Department of Cardiology Chongqing General HospitalChongqing 401147China Department of Cardiovascular Ultrasound and Noninvasive Cardiology Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of China(UESTC)ChengduSichuan 610072China Department of RadiologyChongqing General HospitalChongqing 401147China Department of Neurology Children's Hospital of Chongqing Medical UniversityChongqing 400014China School of Medicine Zunyi Medical UniversityZunyiGuizhou 563000China

Pseudohypertrophic muscular dystrophy is a lethal X-linked recessive neuromuscular disorder caused by mutations in the dystrophin gene.This gene encodes a cytoskeletal protein that is extensively expressed in muscle cells and that enables the strength,stability,and functionality of myofibers.Muscular dystrophy can be grouped into two different categories based on the mutational rate and clinical severity,Duchenne muscular dystrophy(DMD)and Becker muscular dystrophy(BMD).DMD is the most common and the more severe type of dystrophy.DMD patients usually become wheelchair-bound by the age of 12 years and die in their late teens to early twenties.^(1)In contrast,BMD is relatively less severe and the patients can potentially have alonger lifeexpectancy.

关键词： dystrophin dystrophy Becker

Enhanced photocatalytic ammonia oxidation activity and nitrogen selectivity over Ag/AgCl/N-TiO_(2) photocatalyst

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Journal of Environmental Sciences 2024年第4期138卷 395-405页

作者： Jiaojiao Guan Daorong Li Jiahui Feng Peng Xu Zhaonian Li siqi Ge Hongxia Chen Kunfeng zhang College of Environmental Engineering Henan University of TechnologyZhengzhou 450001China CAS Key Laboratory of Standardization and Measurement for Nanotechnology National Center for Nanoscience and TechnologyBeijing 100190China Department of Chemistry Tsinghua UniversityBeijing 100084China

The removal of ammonia(NH_(3))emitted from agricultural and industrial activities is of great significance to protect human health and ecological environment.Photocatalytic NH_(3)oxidation to N2under mild conditions is a promising strategy.However,developing visible light photocatalysts for NH_(3)oxidation is still in its infancy.Here,we fabricate N-TiO_(2)and Ag/AgCl/N-TiO_(2)photocatalysts by sol-gel and photodeposition methods,respectively.The introduction of N not only endows TiO_(2)with visible light response(absorption edge at460 nm)but also results in the formation of heterophase junction(anatase and rutile).Thus,N-TiO_(2)shows 2.0 and 1.8 times higher than those over anatase TiO_(2)and commercial TiO_(2)for NH_(3)oxidation under full spectrum irradiation.Meanwhile,surface modification of Ag can simultaneously enhance visible light absorption(generating localized surface plasmon resonance effect)and charge separation efficiency.Therefore,the photocatalytic activity of Ag/AgCl/N-TiO_(2)is further improved.Furthermore,the presence of N and Ag also enhances the selectivity of N2product owing to the change of reaction pathway.This work simultaneously regulates photocatalytic conversion efficiency and product selectivity,providing some guidance for developing highly efficient photocatalysts for NH_(3)elimination.

关键词： TiO_(2) Doping Surface modification Photocatalysis NH_(3)elimination

Boosting reversible charging of Li-ion batteries at low temperatures by a synergy of propylene carbonate-based electrolyte and defective graphite

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Nano Research 2024年第3期17卷 1491-1499页

作者： Yingqiang Wu Jiao zhang Jinli Liu Li Sheng Bo zhang Limin Wang siqi Shi Li Wang Hong Xu Xiangming He Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of Sciences(CAS)Changchun 130022China China National Quality Supervision and Inspection Center for Industrial Explosive Materials Nanjing University of Science and TechnologyNanjing 210094China School of Materials Science and Engineering Materials Genome InstituteShanghai UniversityShanghai 200444China

Propylene carbonate(PC)-based electrolytes have exhibited significant advantages in boosting the low-temperature discharging of graphite-based Li-ion batteries.However,it is still unclear whether they can improve the charging property and suppress lithium plating.Studying this topic is challenging due to the problem of electrochemical compatibility.To overcome this issue,we introduced graphite with phase defects.The results show that the pouch-type full batteries using PC-based electrolyte exhibit steady performance over 500 cycles and can be reversibly charged over 30 times at-20℃ with an average Coulombic efficiency of 99.95%,while the corresponding value for the conventional ethylene carbonate(EC)-based electrolyte sample is only 31.20%.This indicates that the use of PC-based electrolyte significantly suppresses lithium plating during low-temperature charging.We further demonstrate that the improved performance is mainly attributed to the unique solvation structure,where PF-6more anions participate in solvation,leading to the formation of a stable F-rich solid state electrolyte interface on the graphite surface and a lower reduction tendency of Li+ions.This work inspires new ideas for the design of PC-based electrolytes for low-temperature charging and fast-charging batteries.

关键词： lithium-ion batteries graphite propylene carbonate low-temperature charging

Thermal characteristic evolution of lithium-ion batteries during the whole lifecycle

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Journal of Energy Chemistry 2024年第5期92卷 534-547页

作者： Guangxu zhang Xuezhe Wei Donghai Chen Xueyuan Wang siqi Chen Jiangong Zhu Haifeng Dai School of Materials Science and Engineering Tongji UniversityShanghai 201804China Clean Energy Automotive Engineering Center Tongji UniversityShanghai 201804China School of Automotive Studies Tongji UniversityShanghai 201804China

This work extensively investigates the thermal characteristic evolution of lithium-ion batteries under different degradation paths,and the evolution mechanism through multi-angle characterization is revealed.Under different degradation paths,the evolution trend of temperature rise rate remains unchanged with respect to depth of discharge during the adiabatic discharge process,albeit to varying degrees of alteration.The temperature rise rate changes significantly with aging during the adiabatic discharge process under low-temperature cycling and high-rate cycling paths.The total heat generation rate,irreversible heat generation rate,and reversible heat generation rate exhibit similar evolution behavior with aging under different degradation paths.The interval range of endothermic process of reversible electrochemical reactions increases and the contribution of irreversible heat to the total heat increases with aging.To further standardize the assessment of different degradation paths on the thermal characteristics,this work introduces the innovative concept of“Ampere-hour temperature rise”.In low-temperature cycling and high-rate cycling paths,the ampere-hour temperature rise increases significantly with aging,particularly accentuated with higher discharge rates.Conversely,in high-temperature cycling and high-temperature storage paths,the ampere-hour temperature rise remains relatively stable during the initial stages of aging,yet undergoes a notable increase in the later stages of aging.The multi-angle characterization reveals distinct thermal evolution behavior under different degradation paths primarily attributed to different behavior changes of severe side reactions,such as lithium plating.The findings provide crucial insights for the safe utilization and management of lithium–ion batteries throughout the whole lifecycle.

关键词： Lithium-ion batteries Adiabatic discharge Thermal characteristics Ampere-hour temperaturerise Degradation