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Business Process Dynamic Reengineering Technology Based on Mode

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Journal of Beijing Institute of Technology 2019年第2期28卷 344-355页

作者： Ming Ding shuling zhang Chen zhang School of Information and Technology Northwest UniversityXi'an 710127China Xi'an Aeronautics Computing Technique Research Institute Xi'an 710119China School of Computer Science and Technology Xidian UniversityXi’an 710071China

To ensure the efficiency and quality of complex business process design,a mode-based dynamic business process reengineering approach is proposed in this ***,the composition of business process is divided into five *** process modes from three levels of mission,content and resource are defined,and the transition relationships between modes are ***,the architecture model of business process is defined based on the architecture analysis and design language(AADL).The dynamic reengineering framework and implementation procedure are ***,the AADL architecture models are analyzed and verified to evaluate the business process performance,and a blueprint for reengineering is *** the guidance of the blueprint,the detailed design and development of attributes such as business processes,activities,resources and cost are *** studies are presented to validate that the mode analysis and dynamic reengineering approach based on the AADL architecture is able to improve the efficiency,reliability and reusability of business process design.

关键词： business process mode architecture analysis and design language dynamic reengineering

Application of spline wavelet transform in differential of electroanalytical signal

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Chinese Science Bulletin 2001年第7期46卷 550-555页

作者： zhang shuling ZHENG Jianbin GU Wenliang zhang Hongquan HOU Xun GAO Hong Institute of Electroanalytical Chemistry Northwest UniversityXi’an 710069China State Key Laboratory of Transient Optics Technology Xi’an Institute of Optics and Precision MechanicsXi’an 710068China

Investigating characteristics of spline wavelet, we found that if the two-order spline function, the derivative function of the three-order B spline function, is used as the wavelet base function, the spline wavelet transform has both the property of denoising and that of differential. As a result, the relation between the spline wavelet transform and the differential was studied in theory. Experimental results show that the spline wavelet transform can well be applied to the differential of the electroanalytical signal. Compared with other kinds of wavelet transform, the spline wavelet transform has a characteristic of differential. Compared with the digital differentia] and simulative differential with electronic circuit, the spline wavelet transform not only can carry out denoising and differential for a signal, but also has the advantages of simple operation and small quantity of calculation, because step length, RC constant and other kinds of parameters need not be selected. Compared with

关键词： chemometrics signal processing wavelet transform differential.

ClC-3 chloride channel in hippocampal neuronal apoptosis

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Neural Regeneration Research 2013年第32期8卷 3047-3054页

作者： Lijuan Xu shuling zhang Hongling Fan Zhichao Zhong Xi Li Xiaoxiao Jin Quanzhong Chang Department of Physiology Zhuhai Campus of Zunyi Medical College First Hospital of Putian City Department of Pediatrics Zhuhai Campus of Zunyi Medical College

Over-production of nitric oxide is pathogenic for neuronal apoptosis around the ischemic area fol- lowing ischemic brain injury. In this study, an apoptotic model in rat hippocampal neurons was es- tablished by 0.5 mmol/L 3-morpholinosyndnomine （SIN-l）, a nitric oxide donor. The models were then cultured with 0.1 mmol/L of 4,4＇-diisothiocyanostilbene-2,2＇-disulfonic acid （DIDS; the chloride channel blocker）for 18 hours. Neuronal survival was detected using the 3-（4,5-dimethylthiazol- 2-yl）-2,5-diphenyltetrazolium bromide （MTT） assay, and apoptosis was assayed by Hoechst 33342-labeled neuronal DNA fluorescence staining. Western blot analysis and immunochemilumi- nescence staining were applied to determine the changes of activated caspase-3 and CIC-3 channel proteins. Real-time PCR was used to detect the mRNA expression of CIC-3. The results showed that SIN-1 reduced the neuronal survival rate, induced neuronal apoptosis, and promoted CIC-3 chloride channel protein and mRNA expression in the apoptotic neurons. DIDS reversed the effect of SIN-I. Our findings indicate that the increased activities of the CIC-3 chloride channel may be involved in hippocampal neuronal apoptosis induced by nitric oxide.

关键词： neural regeneration brain injury nitric oxide CIC-3 chloride channel 3-morpholinosyndnomine 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid hippocampal neurons apoptosis grants-supportedpaper neuroregeneration

Excision of Head and Neck Tumors Combined with Carotid Artery Resection without Arterial Blood Vessel Reconstruction

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Clinical oncology and cancer researeh 2009年第4期6卷 286-289页

作者： Yan zhang Ming Gao shuling Li No. 2 Department ot Head and Neck Surgery Tianjin Medical University Cancer Instituteand Hospital Tianjin 300060 China.

OBJECTIVE To summarize our clinical experience in treating 31 patients with neck masses undergoing carotid artery resection without arterial anastomosis （vascular reconstruction） in Tianjin Cancer Hospital during a period from 1979 to 2002. METHODS Preoperatively, patients were instructed to apply pressure to the carotid artery. Tumor excision combined with carotid artery resection （TECCAR） was conducted after an accurate testing of valid cerebral blood supply and compensation. RESULTS Among the study patients, 17 were male and 14 female, with the age ranging from 14 to 58 years. Of the 31 cases, 23 were carotid body tumors （8 malignant）, 2 vagal body tumors （1 malignant）, 4 carotid aneurysms, and 2 were metastatic tumors from the cervix involving carotid artery. Of the patients, a subtotal resection of the head and neck masses was conducted in 22 cases. Intraoperative death did not cerebrovascular complications occur, and postoperative CNS or （CVC） were not found. CONCLUSION TECCAR without arterial anastomosis is a safe and feasible procedure. In addition, this method of surgery has more advantages in comparison to an arterial anastomosis： i） Tumor resection was more complete, ii） Complications such as thrombus, infection, and lethal hemorrhage etc., were rare after surgery; iii） Postoperative radiotherapy, if needed, would be safe and acceptable; iv） It was a more simplified operational procedure.

关键词： tumor carotid artery resection without arterialblood-vessel reconstruction.

Characteristics of vascular lesions in patients with posterior circulation infarction according to age and region of infarct

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Neural Regeneration Research 2012年第32期7卷 2536-2541页

作者： Daopei zhang shuling zhang Hongtao zhang Yuming Xu Third Department of Neurology Zhengzhou People's Hospital Zhengzhou 450003 Henan Province China Third Department of Neurology First Affiliated Hospital Zhengzhou University Zhengzhou 450052 Henan Province China

Patients with posterior circulation infarction underwent CT angiography and magnetic resonance angiography. Intracranial and extracranial vasculopathy was evaluated according to age group and location of stroke. Patients aged 〉 60 years and 〈 60 years had similar rates of vertebral artery dominance and vertebrobasilar artery developmental or origin anomalies. Vertebrobasilar artery stenosis or occlusion and tortuosity occurred more frequently in patients aged 〉 60 years than 〈 60 years. The rates of vertebrobasilar artery anomalies and tortuosity were high in patients with posterior circulation infarction. Vertebrobasilar artery tortuosity occurred more frequently in patients aged 〉 60 years, whereas vertebrobasilar artery developmental anomalies occurred with similar frequency in patients aged 〈 60 years and 〉 60 years. Patients with infarction of the brainstem or cerebellum were more ~ikely to have vertebral artery stenosis or occlusion, basi^ar artery stenosis or occlusion, vertebral artery dominance or tortuosity, and basilar artery tortuosity, and patients with infarction of the thalamus, medial temporal, or occipital lobes were more likely to have stenosis or occlusion of the vertebral or basilar arteries. Vertebrobasilar artery tortuosity, vertebral artery dominance （hypoplasia）, and congenital variations of the vertebrobasilar system may lead to posterior circulation infarction at different locations in different age groups.

关键词： vertebrobasilar artery vertebral artery acute cerebral infarction artery tortuosity magnetic resonance angiography CT angiography neuroimaging neural regeneration

Dendritic mesoporous silica nanoparticles for enzyme immobilization

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Green Chemical Engineering 2024年第2期5卷 173-186页

作者： shuling zhang Jing Bai Weixi Kong Haolei Song Yunting Liu Guanhua Liu Li Ma Liya Zhou Yanjun Jiang School of Chemical Engineering and Technology Hebei University of TechnologyTianjin300130China College of Food Science and Biology Hebei University of Science&TechnologyShijiazhuang050018China Hebei Yanuo Bioscience Co. Ltd.Shijiazhuang052165China

Dendritic mesoporous silica nanoparticles(DMSNs)are a new class of solid porous materials used for enzyme immobilization support due to their intrinsic characteristics,including their unique open central-radial structures with large pore channels and their excellent *** this review,we review the recent progress in research on enzyme immobilization using DMSNs with different structures,namely,flower-like DMSNs and tree-branch-like *** DMSN synthesis methods are briefly compared,and the distinct characteristics of the two DMSN types and their effects on the catalytic performance of immobilized enzymes are comprehensively *** directions for future research on enzyme immobilization using DMSNs are also proposed.

关键词： Dendritic mesoporous silica nanoparticles Enzyme immobilization Flower-like Tree-branch-like Central-radial structure

Effect of aerobic exercise on GRP78 and ATF6 expressions in mice with non-alcoholic fatty liver disease

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Sports Medicine and Health Science 2023年第2期5卷 112-119页

作者： Junhan Li Lei Huang Wei Xiong Chun Gu shuling zhang Xiali Xue School of Sports Medicine and Health Chengdu Sport UniversityChengduSichuan ProvinceChina Department of Exercise Rehabilitation Sichuan Provincial Orthopedic HospitalChengduSichuan ProvinceChina Department of Hepatobiliary Surgery Sichuan Provincial People's HospitalChengduSichuan ProvinceChina

Nonalcoholic fatty liver disease(NAFLD)is a prevalent medical condition with an ever-growing *** multiple intracellular mechanisms are involved,endoplasmic reticulum(ER)stress has been demonstrated to play a significant role in the genesis and *** of the research supports the advantages of exercise for ***,little is known about the molecular mechanism(s)that underpin the effectiveness of exercise training in *** study aimed to identify how aerobic exercise affected hepatic ER stress in a mouse NAFLD *** this study,the mice were fed either a standard diet(SD)or a high-fat diet(HFD)for 17 *** mice were trained on a treadmill during the last eight *** animals were tested for serum levels of biochemical assays,protein expression,and gene *** hematoxylin and eosin,Oil red O,and immunohistochemistry staining were also *** results indicated that a high-fat diet generated NAFLD,with serum lipid disruption and hepatic function impairment,and increased GRP78 and ATF6 ***,aerobic training reversed the majority of these *** is concluded that NAFLD appears to be associated with hepatic ER stress response,and aerobic exercise mitigates NAFLD via lowering ER stress proteins GRP78 and ATF6.

关键词： Endoplasmic reticulum stress Exercise GRP78 ATF6 Nonalcoholic fatty liver disease

Role of chloride channels in nitric oxide-induced rat hippocampal neuronal apoptosis in vitro

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Neural Regeneration Research 2010年第9期5卷 690-694页

作者： Quanzhong Chang shuling zhang Jinbao Yin Department of Physiology Zhuhai Campus of Zunyi Medical College Zhuhai 519041 Guangdong Province China

BACKGROUND：Chloride channels participate in non-neuronal ***,it remains unclear whether chloride channels are involved in ischemic neuronal ***：To explore the effects of 4-acetamido-4＇-isothiocyanatostilbene-2,2＇-disulfonic acid （SITS） and 4,4＇-diisothiocyanostilbene-2,2＇-disulfonic acid （DIDS）,two chloride channel blockers,on the hippocampal neuronal apoptosis induced by 3-morpholinosydnonimine （SIN-1） based on the nitric oxide toxicity theory of neuronal apoptosis following ischemic brain ***,TIME AND SETTING：Comparative observation and in vitro experiments were performed at the laboratory of Zhuhai Campus of Zunyi Medical College from January to May ***：SIN-1,SITS,and DIDS were purchased from Sigma,***：Hippocampal neurons from Sprague-Dawley rats,aged 1 day,were cultured In vitro for 12 days and randomly assigned to control,SIN-1,or chloride channel blocker ***-1 group neurons were induced by SIN-1 for 18 hours to establish a model of ischemic neuronal *** in chloride channel blocker groups were treated with SITS or DIDS plus SIN-1 for 18 *** controls were cultured in DMEM/Ham＇s F12 complete medium *** OUTCOME MEASURES：The apoptotic neurons and nuclear appearance were detected by Hoechst 33258 fluorescence staining; neuronal viability was quantitatively determined by 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide ***-3 activity was analyzed by Western ***：SIN-1 （1 mmol/L） dramatically induced apoptosis （50%-60%）.SITS and DIDS inhibited nitric oxide-induced neuronal injury in a dose-dependent manner,suppressed caspase-3 activation,reduced neuronal apoptosis,and improved neuronal ***：Chloride channel blockers can protect against neuronal injury induced by *** channels might be involved in neuronal apoptosis following cerebral ischemia.

关键词： chloride channel nitric oxide hippocampal neuron rats cerebral ischemia neural regeneration

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调速给水泵组机械密封的改进设计

农业机械学报 2006年第9期37卷 184-185,173页

作者：张曙灵焦作大学机电工程系

对41/4″T8BID型机械密封频繁泄漏、使用寿命过短问题进行了故障分析,发现主要是动静环材质组合不当和冷却方式不合理造成。通过选择适合的动静环材料和改进机械密封,使问题得以解决。

关键词：调速给水泵组机械密封前置泵设计