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A sustainable synthesis of 3,3-disubstituted oxindoles via CuBr-catalysed capture of carboxylic oxonium ylides with isatylidene malononitrile

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Green Synthesis and Catalysis

Green Synthesis and Catalysis 2024年第3期5卷 180-185页

作者： Mengchu zhang Yukai Li Yuwei Wang Jirong shu Tianyuan zhang Dan zhang Song Cai Taoda Shi Wenhao Hu Guangdong Chiral Drug Engineering Laboratory School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou510000China Shenzhen University Health Science Center Shenzhen518060China

We herein reported a sustainable synthesis of 3,3-disubstituted oxindoles via a Michael-type reaction based on the CuBr-catalysed capture of carboxylic oxonium ylides with isatylidene *** reaction is characterized by a high atom economy and low economic *** catalyst CuBr could be conveniently *** products of the reaction were found to be inhibitory against Na ion *** expect the reaction to shed the light on synthesis of biologically interesting molecules directed by principles of green chemistry.

关键词： Copper catalysis Carboxylic oxonium ylide Sustainable synthesis

Characterization of Free Cutting Phase in Free Cutting Stainless Steel Containing High Copper

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Journal of Iron and Steel Research International 2009年第1期16卷 54-57页

作者： GENG Hong-ming WU Xiao-chun WANG Hong-bin min Yong-an zhang Hong-kui College of Materials Science and Engineering Shanghai University Shanghai 200072 China Baoshan Iron and Steel Co Ltd Shanghai 200940 China

The machinability of 4Cr13 steel was improved obviously by adding Cu and S. The effect of copper addition on the machinability of 4Cr13 was similar to that of sulphur addition. By means of SEM, EBSD, and HREM, the distribution and size of the free cutting phase in the steel 4Crl3Cu were studied. The results showed that the free cutting phase was copper-rich phase. The copper-rich phases dispersed in the steel and were determined to have about 10 nm in diameter. The content of copper in the copper-rich phase was over 70%.

关键词： machinability copper-rich phase EBSD HREM

Effect of Dendrobium nobile powder combined with conventional therapy on mild to moderate fatty liver

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World Journal of Gastroenterology 2024年第45期30卷 4791-4800页

作者： Xi Le Yin zhang Mei Yang Jie Li Hao Wang Jin-Lin Wu Juan Deng Hong-min zhang Department of Endocrinology People’s Hospital of Chongqing Liang Jiang New AreaChongqing 400000China The Key Laboratory of Laboratory Medical Diagnostics in the ministry of Education and Department of Clinical Biochemistry College of Laboratory MedicineChongqing Medical UniversityChongqing 400000China Department of Endocrinology The Second Affiliated HospitalChongqing Medical UniversityChongqing 400000China Department of Endocrinology Chongqing Traditional Chinese Medicine HospitalChongqing 400000China

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)encompasses a variety of liver conditions impacting individuals who consume minimal or no ***,traditional Chinese medicine has been gradually used to treat mild to moderate fatty liver,among which Dendrobium nobile *** has been affirmed by many doctors and patients to be ***,there is limited research on combining this treatment with standard therapies for mild to moderate *** To survey the effect of combining Dendrobium nobile *** with standard treatment on liver function and lipid metabolism disorder in patients with mild to moderate *** Eighty patients with mild to moderate NAFLD participated in this retrospective study,classified into two groups:The observation group(n=40)and the control group(n=40).In November 2020 and November 2022,the study was conducted at People’s Hospital of Chongqing Liang Jiang New *** control group received standard treatment,while the observation group received Dendrobium nobile *** based on the control *** study compared differences in traditional Chinese medicine clinical syndrome scores,liver fibrosis treatment,liver function indicators,lipid levels,and serum inflammatory factor levels before and after treatment,and we calculated the incidence of adverse reactions for both *** The total effective rate was 97.50%in the observation group and 72.5%in the control *** 8 weeks of treatment,the main and secondary symptom scores remarkably decreased,especially in the observation group(Pminin(LN),human rocollagen III(PC III),and collagen type IV(CIV).The levels of HA,LN,PC III,and CIV were significantly lower in the observation group(P<0.05).After 8 weeks,both groups indicated remarkable improvements in liver function and blood lipid levels,with the observation group having even lower levels(P<0.05).Serum l

关键词： Dendrobium nobile Lindl.powder Nonalcoholic fatty liver disease Combination treatment Mild to moderate fatty liver Liver function Lipid metabolism disorder

有机染料敏化太阳电池中激发态弛豫和电子注入的超快光谱研究（英文）

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物理化学学报 2016年第1期32卷 329-336页

作者：杨林李阳陈淑张静张敏王鹏中国科学院长春应用化学研究所高分子物理与化学国家重点实验室长春130022 中国科学院大学北京100049

为了实现窄能隙有机光敏剂的理性设计,有必要全面理解发生在二氧化钛/染料/电解质复杂界面的激发态演化动力学。本文通过构建分别以苯并噻二唑-苯甲酸(BTBA)和吡啶并噻二唑-苯甲酸(PTBA)为电子受体的有机给受体染料,借助超快瞬态吸收光... 详细信息

为了实现窄能隙有机光敏剂的理性设计,有必要全面理解发生在二氧化钛/染料/电解质复杂界面的激发态演化动力学。本文通过构建分别以苯并噻二唑-苯甲酸(BTBA)和吡啶并噻二唑-苯甲酸(PTBA)为电子受体的有机给受体染料,借助超快瞬态吸收光谱测量与理论模拟,我们发现在实际的二氧化钛/染料/电解质界面存在激发态多步弛豫与多态电子注入的过程。密度泛函理论及含时密度泛函理论计算表明,二氧化钛表面的光激发产生的"热"激发态染料分子会通过分子片段间的扭转运动发生显著的多步结构弛豫,最终形成共轭骨架具有醌式结构、更加平面化的平衡构型。通过对飞秒瞬态吸收光谱进行目标分析,我们发现相对于以苯并噻二唑-苯甲酸为电子受体的染料,以吡啶并噻二唑-苯甲酸为电子受体的染料呈现出较慢的电子注入速率与较短的激发态寿命,导致总的电子注入产率较低,给出了基于该染料所制备的太阳电池的外量子产率峰值低的原因。

关键词：太阳电池有机染料界面激发态电荷转移

Pangolin HKU4-related coronaviruses found in greater bamboo bats from southern China

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Virologica Sinica 2023年第6期38卷 868-876页

作者： min Guo Kai Zhao Xingwen Peng Xiangyang He Jin Deng Bo Wang Xinglou Yang Libiao zhang Guangdong Key Laboratory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationInstitute of ZoologyGuangdong Academy of SciencesGuangzhou510260China Yunnan Key Laboratory of Biodiversity Information Kunming Institute of ZoologyChinese Academy of SciencesKunming650023China Department of Biomedical Sciences and Pathobiology Virginia Polytechnic Institute and State UniversityBlacksburgVA24060USA Hubei Jiangxia Lab Wuhan430071China

Coronavirus(CoV)spillover originating from game animals,particularly pangolins,is currently a significant ***,vigilance is urgently needed for coronaviruses carried by bats,which are known as natural reservoirs of many *** this study,we collected 729 anal swabs of 20 different bat species from nine locations in Yunnan and Guangdong provinces,southern China,in 2016 and 2017,and described the molecular characteristics and genetic diversity of alphacoronaviruses(αCoVs)and betacoronaviruses(βCoVs)found in these *** RT-PCR,we identified 58(8.0%)bat CoVs in nine bat species from six ***,using the Illumina platform,we obtained two representative full-length genomes of the bat CoVs,namely TyRo-CoV-162275 and *** analysis showed that TyRo-CoV-162275 shared the highest identity with Malayan pangolin(Manis javanica)HKU4-related coronaviruses(MjHKU4r-CoVs)from Guangxi Province,whereas TyRo-CoV-162269 was closely related to HKU33-CoV discovered in a greater bamboo bat(Tylonycteris robustula)from Guizhou ***,TyRo-CoV-162275 has a putative furin protease cleavage site in its S protein and is likely to utilize human dipeptidyl peptidase-4(hDPP4)as a cell-entry receptor,similar to MERS*** the best of our knowledge,this is the first report of a bat HKU4r-CoV strain containing a furin protease cleavage *** findings expand our understanding of coronavirus geographic and host distributions.

关键词： Coronavirus Pangolin HKU4r-CoV Bat HKU4r-CoV Tylonycteris robustula Spillover risk

Pt(110)表面自吸附原子能量和力的改进分析型嵌入原子法分析

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物理学报 2006年第8期55卷 4103-4110页

作者：舒瑜张建民徐可为陕西师范大学物理学与信息技术学院西安710062 西安交通大学金属材料强度国家重点实验室西安710049

采用改进分析型嵌入原子法计算了Pt(110)表面自吸附原子的能量和法向力.当Pt吸附原子位于Pt(110)表面第一层原子的二重对称洞位上0.11nm时最稳定.Pt吸附原子的最佳迁移路径是由一个二重对称洞位沿密排方向迁移到最近邻的另一个二重对称... 详细信息

采用改进分析型嵌入原子法计算了Pt(110)表面自吸附原子的能量和法向力.当Pt吸附原子位于Pt(110)表面第一层原子的二重对称洞位上0.11nm时最稳定.Pt吸附原子的最佳迁移路径是由一个二重对称洞位沿密排方向迁移到最近邻的另一个二重对称洞位.在吸附原子远离表面的过程中,将依次经过排斥、过渡和吸引等三个区域.在排斥区和过渡区,由于吸附原子与表面原子间强的相互作用势,吸附原子的能量和法向力的形貌图均为(110)面原子排列的复形,与对势理论和嵌入原子法得到的结果一致.在吸引区,由于多体相互作用及晶体中原子电子密度的非球型对称分布影响的相对增强,使吸附原子的能量和法向力的形貌图更加复杂.

关键词：金属表面自吸附能量力

O-GlcNAcylation Coordinates Glutaminolysis by Regulating the Stability and Membrane Trafficking of ASCT2 in Hepatic Stellate Cells

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1107-1116页

作者： Feixia Wang Li Chen Biyun zhang zhanghao Li min Shen Li Tang Zili zhang Jiangjuan Shao Feng zhang Shizhong Zheng Shanzhong Tan Department of Integrated TCM and Western Medicine Nanjing Hospital Affiliated to Nanjing University of Chinese MedicineNanjingJiangsuChina Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica Nan-jing University of Chinese MedicineNanjingJiangsuChina Department of Nuclear Medicine Jiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineNanjingJiangsuChina

Background and Aims:Recognition of excessive activa-tion of hepatic stellate cells(HSCs)in liver fibrosis prompt-ed us to investigate the regulatory mechanisms of *** aimed to examine the role of O-GlcNAcylation modifica-tion of alanine,serine,cysteine transporter 2(ASCT2)in HSCs and liver ***:The expression of O-Glc-NAcylation modification in fibrotic mice livers and activated HSCs was analyzed by western ***-tion was used to assess the interaction of ASCT2 and O-Glc-NAc transferase(OGT).In addition,ASCT2 protein stability was assayed after cycloheximide(CHX)*** O-GlcNAcylation site of ASCT2 was predicted and mutated by site-directed ***-time PCR,immunofluores-cence,kit determinations and Seahorse assays were used to clarify the effect of ASCT2 O-GlcNAcylation on HSC glu-taminolysis and HSC *** blotting,immuno-chemistry,and immunohistofluorescence were used to ana-lyze the effect of ASCT2 O-GlcNAcylation in ***:We observed significantly increased O-GlcNAcylation modi-fication of ***2 was found to interact with OGT to regulate ASCT2 *** predicted and confirmed that O-GlcNAcylation of ASCT2 at Thr122 site resulted in HSCs *** found Thr122 O-GlcNAcylation of ASCT2 me-diated membrane trafficking of glutamine transport and attenuated HSC ***,we validated the expression and function of ASCT2 O-GlcNAcylation after in-jection of AAV8-ASCT2 shRNA in CCl4-induced liver fibrosis mice in ***:Thr122 O-GlcNAcylation regu-lation of ASCT2 resulted in stability and membrane traf-ficking-mediated glutaminolysis in HSCs and liver *** studies are required to assess its role as a putative therapeutic target.

关键词： ASCT2 O-GlcNacylation Stability Trafficking Liver fibrosis

Assessing Dual Rh/Ru Cascade Catalysts in One-Pot Homogeneous Synthesis of Ethanol from Syngas and Methanol

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CCS Chemistry 2023年第7期5卷 1549-1560页

作者： Ji-shu zhang Ya-Fei Jiang Fanfu Guan Shaoke zhang Cong-Qiao Xu Shao-Tao Bai Jialin Wen Jun Li Xumu zhang Department of Chemistry Southern University of Science and TechnologyShenzhen 518055 Guangdong Provincial Key Laboratory of Catalysis Southern University of Science and TechnologyShenzhen 518055 Academy for Advanced Interdisciplinary Studies Southern University of Science and TechnologyShenzhen 518055 Department of Chemistry Key Laboratory of Organic Optoelectronics and Molecular Engineering of Ministry of EducationTsinghua UniversityBeijing 100084

The direct conversion of cheap syngas into value-added ethanol at an industrial scale is in high *** we disclose a one-pot homogeneous homologation of methanol to ethanol with syngas via a rhodium/ruthenium bimetallic catalytic *** introducing a catalytic amount of methyl iodide,methanol can be converted to ethanol with high selectivity(>91%ethanol).A syngas ratio of H_(2)/CO=4:1 was found to be *** various phosphine ligands tested,Rh-dppp catalyst gave the highest aldehyde pathway selectivity,thus providing an effective route for the synthesis of ethanol upon coupling with a Ru hydrogenation *** bite angle of the bisphosphine ligands dramatically influences the selectivity of the dual Rh/Ru metallic cascade *** line with the experimental findings,theoretical calculations predicted a rational trend of the selectivity of different bisphosphine ligands via varying bite angle properties.

关键词： methanol homologation ethanol rhodium ruthenium syngas

Combination of renoportal anastomosis and inferior mesenteric vein-portal anastomosis in liver transplantation:A new portal reconstruction technique

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 182-185页

作者： Guo-Ling Lin min Xiao Li Zhuang Yu Yang Qi-Yong Li Jian-Fang Lu Meng-Xia Li shu-Sen Zheng Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryShulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhouChina Division of Hepatobiliary and Pancreatic Surgery Department of NursingShulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhouChina Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryZhejiang University School of MedicineHangzhouChina Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhouChina

Liver transplantation (LT) is the only way to cure end-stage liver disease with or without tumors in the last few decades [1].However,critical issues such as how to rebuild portal flow in patients with portal vein thrombosis (PVT) or superior mesenteric vein (SMV) thrombosis have been challenging for *** portal flow is critical in LT because more than 75%of the liver’s blood supply comes from the portal vein and the rest comes from the hepatic *** is a universal problem in LT.

关键词： anastomosis portal Liver