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Ocular surface changes in moderate-to-severe acne vulgaris

International Journal of Ophthalmology(English edition) 2024年第6期17卷 1049-1057页

作者： Ci-Yi Pan Dong-Jie Sun Han-ling Li Li Ma Min zhang Song-Yuan Tang Hui zhang Department of Ophthalmology First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina Department of Dermatology First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina Department of Stomatology the First People’s Hospital of Yunnan ProvinceKunming 650100Yunnan ProvinceChina Institute of Health Studies School of Public HealthKunming Medical UniversityKunming 650500Yunnan ProvinceChina

AIM:To investigate ocular surface disorders and tear function changes in patients with acne vulgaris and explore the potential relationship between acne vulgaris and dry ***:This cross-sectional study included right eyes of 53 patients with acne vulgaris and 54 healthy *** participants completed the Ocular Surface Disease Index(OSDI)*** following ocular surface-related parameters were measured:tear meniscus height(TMH),noninvasive tear breakup time(NIBUT),Schirmer I test(SIT),lipid layer thickness(LLT)score of the tear film,meibum score,meibomian gland orifice obstruction score,the ratio of meibomian gland loss,conjunctival hyperemia score,and corneal fluorescein staining(CFS)***:The stability of the tear film decreased in acne vulgaris *** the acne group,the TMH and NIBUT were lower,whereas the OSDI,meibum score,meibomian gland orifice obstruction score,ratio of meibomian gland loss,and conjunctival hyperemia score were higher compared with controls(P0.05).In two dry eye groups,the TMH,NIBUT,and LLT score were lower in the acne with dry eye(acne-DE)group,and the meibum score,meibomian gland orifice obstruction score,ratio of meibomian gland loss and conjunctival hyperemia score in the acne-DE group were higher(P0.05).CONCLUSION:Patients with moderate-to-severe acne vulgaris are more likely to experience dry eye than those without acne *** tear film stability and meibomian gland structure dysfunction are more pronounced in patients with moderate-to-severe acne and dry eye.

关键词： acne vulgaris meibomian gland dysfunction dry eye tear film

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Highly Hydrolysis-Resistant Polyimide Fibers Prepared by Thermal Crosslinking with Inherent Carboxyl Groups

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Chinese Journal of Polymer Science 2024年第2期42卷 247-255,I0010页

作者： Can-Can zhang Jun-Long Yang Ya-Jiang Huang Guang-Xian Li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering of ChinaSichuan UniversityChengdu610065China

Easy hydrolysis in alkaline environments limits the use of polyimide fibers in environmental protection. The hydrolysis resistance levels of polyimide fibers can be improved by crosslinking of the macromolecular chains. In this work, crosslinked polyimide fibers(CPI fibers) were produced by intrinsic carboxyl decarboxylation for the first time. The thermal stability of the polyimide fibers containing the intrinsic carboxyl groups(PIC fibers) was studied, and the temperature of the decarboxylation-crosslinking reaction was determined to be 450 ℃. The PIC fibers were hotdrawn to initiate thermal crosslinking of the carboxyl groups and molecular chain orientation at high temperature. The CPI fibers had high tensile strengths(0.72-1.46 GPa) and compressive strengths(401-604 MPa). The oriented macromolecules and chemically crosslinked structure improved the tightness of the molecular chains and endowed the CPI fibers with excellent hydrolytic resistance. The CPI-50 fiber did not dissolve in a 0.5 wt% NaOH solution during heating at 90 ℃ for 10 h, and the tensile strength retention reached 87% when treated in 0.5 wt% NaOH solutions at 90 ℃ for 1 h, providing a guarantee for its application in alkaline corrosive environments.

关键词： Polyimide Carboxyl group Crosslinking Hydrolysis-resistance

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Drug-eluting bead transarterial chemoembolization as neoadjuvant therapy pre-liver transplantation for advanced-stage hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2476-2486页

作者： Zhao-Dan Ye Li Zhuang Meng-Chen Song Zhe Yang Wu zhang Jing-Feng zhang Guo-Hong Cao Department of Radiology Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310022Zhejiang ProvinceChina Diagnostic and Therapeutic Center for Difficult Diseases Hwa Mei HospitalUniversity of Chinese Academy of SciencesNingbo 315010Zhejiang ProvinceChina

BACKGROUND The objectives of this study were to assess the safety and efficacy of drug-eluting bead transarterial chemoembolization(DEB-TACE)as neoadjuvant therapy before liver transplantation(LT)for advanced-stage hepatocellular carcinoma(HCC)and to analyze the prognostic *** To determine whether DEB-TACE before LT is superior to LT for advanced-stage *** A total of 99 individuals diagnosed with advanced HCC were studied *** participants were categorized into the following two groups based on whether they had received DEB-TACE before LT:DEB-TACE group(n=45)and control group(n=54).The participants were further divided into two subgroups based on the presence or absence of segmental portal vein tumor thrombus(PVTT).The DEB-TACE group consisted of two subgroups:Group A(n=31)without PVTT and group B(n=14)with *** control group also had two subgroups:Group C(n=37)without PVTT and group D(n=17)with *** on patient demographics,disease characteristics,therapy response,and adverse events(AEs)were *** overall survival(OS)and recurrence-free survival(RFS)rates were assessed using Kaplan-Meier *** and multivariate Cox regression analyses were conducted to determine the parameters that were independently related to OS and *** The DEB-TACE group exhibited an overall response rate of 86.6%.Following therapy,there was a significant decrease in the median alpha-fetoprotein(AFP)level(275.1 ng/mL vs 41.7 ng/mL,P<0.001).The main AE was post-embolization *** 2-year rates of RFS and OS were significantly higher in the DEB-TACE group than in the control group(68.9%vs 38.9%,P=0.003;86.7%vs 63.0%,P=0.008).Within the subgroups,group A had higher 2-year rates of RFS and OS compared to group C(71.0%vs 45.9%,P=0.038;83.8%vs 62.2%,P=0.047).The 2-year RFS rate of group B was markedly superior to that of group D(64.3%vs 23.5%,P=0.002).Results from multivariate analyses showed that pre-LT DEB-TACE[hazard ratio(HR)=

关键词： Hepatocellular carcinoma Liver transplantation Portal vein tumor thrombus Drug-eluting bead transarterial chemoembolization Neoadjuvant treatment

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Knockdown of fibrillin-1 suppresses retina-blood barrier dysfunction by inhibiting vascular endothelial apoptosis under diabetic conditions

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1403-1410页

作者： Yue zhang Xiao-Jing Liu Xin-Ran Zhai Yao Yao Bin Shao Yu-Han Zhen Xin zhang Zhe Xiao Li-Fang Wang Ming-Lian zhang Zhi-Min Chen Hebei Eye Hospital Provincial Key Laboratory of OphthalmologyHebei Provincial Clinical Research Center for Eye DiseasesXingtai 054001Hebei ProvinceChina Department of Ophthalmology Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

AIM:To investigate the effects of fibrillin-1(FBN1)deletion on the integrity of retina-blood barrier function and the apoptosis of vascular endothelial cells under diabetic ***:Streptozotocin(STZ)-induced diabetic mice were used to simulate the diabetic conditions of diabetic retinopathy(DR)patients,and FBN1 expression was detected in retinas from STZ-diabetic mice and *** the Gene Expression Omnibus(GEO)database,the GSE60436 dataset was selected to analyze FBN1 expressions in fibrovascular membranes from DR *** lentivirus to knock down FBN1 levels,vascular leakage and endothelial barrier integrity were detected by Evans blue vascular permeability assay,fluorescein fundus angiography(FFA)and immunofluorescence labeled with tight junction marker in *** glucose-induced monkey retinal vascular endothelial cells(RF/6A)were used to investigate effects of FBN1 on the cells in *** vascular endothelial barrier integrity and apoptosis were detected by trans-endothelial electrical resistance(TEER)assay and flow cytometry,***:FBN1 mRNA expression was increased in retinas of STZ-induced diabetic mice and fibrovascular membranes of DR patients(GSE60436 datasets)using RNA-seq ***,knocking down of FBN1 by lentivirus intravitreal injection significantly inhibited the vascular leakage compared to STZ-DR group by Evans blue vascular permeability assay and FFA *** of tight junction markers in STZ-DR mouse retinas were lower than those in the control group,and knocking down of FBN1 increased the tight junction *** vitro,30 mmol/L glucose could significantly inhibit viability of RF/6A cells,and FBN1 mRNA expression was increased under 30 mmol/L glucose ***-regulation of FBN1 reduced high glucose(HG)-stimulated retinal microvascular endothelial cell permeability,increased TEER,and inhibited RF/6A cell apoptosis in ***:The expression level of FBN1 increases in reti

关键词： diabetic retinopathy fibrillin-1 retinablood barrier vascular leakage vascular permeability apoptosis retinal vascular endothelial cells

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Free Products of Trialgebras

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Algebra Colloquium 2024年第1期31卷 25-40页

作者： Juwei Huang Yuqun Chen Zerui zhang School of Mathematics and Statistics Huizhou University HuizhouGuangdong 516007China School of Mathematical Sciences South China Normal University Guangzhou 510631China

We apply the method of Grobner-Shirshov bases for replicated algebras devel-oped by Kolesnikov to offer a general approach for constructing free products of associative trialgebras(or trioids).In particular,the open p... 详细信息

关键词： Grobner-Shirshov basis trialgebra trioid dimonoid free product

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银额盆地构造单元划分与油气勘探方向

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天然气工业 2024年第7期44卷 89-96页

作者：崔海峰韩小锋白晓寅黄元溢张成富林霖中国地质调查局西安地质调查中心陕西延长石油(集团)有限责任公司研究院中国石油东方地球物理公司中国石化中原油田分公司中国石油吐哈油田公司勘探开发研究院

银额盆地是中国陆上油气勘探程度较低的含油气盆地之一,近年来其油气勘探取得明显进展,但复杂的地质结构在一定程度上制约了对盆地内构造单元的认识,导致油气勘探方向不明。为明确下一步油气勘探方向,结合该盆地钻井、地震和重力勘探等... 详细信息

银额盆地是中国陆上油气勘探程度较低的含油气盆地之一,近年来其油气勘探取得明显进展,但复杂的地质结构在一定程度上制约了对盆地内构造单元的认识,导致油气勘探方向不明。为明确下一步油气勘探方向,结合该盆地钻井、地震和重力勘探等资料,落实了盆地内主要断裂的分布,划分了中生代构造单元,编制了中生界底界埋深图,明确了中生代凹陷的分布特征,最后指出了盆地油气勘探方向。研究结果表明:①银额盆地中生界与前中生界的不整合特征明显,上、下层在岩性组合和构造样式上明显不同,下构造层发育一系列复式褶皱和冲断构造,上构造层则由一系列近东西向、北东向断陷群构成;②盆地主要被红石山断裂带、阿尔金断裂带(或分支)、恩格尔乌苏断裂带和查干础鲁断裂带分隔,形成多个隆起和坳陷,坳陷又由多个凹陷和凸起构成;③油气主要在中生代箕状断陷的缓坡下部聚集,早期成藏后遭受抬升、调整,现今埋深相对较浅的凹陷值得关注,油气有利勘探面积超过5×10^(4) km^(2);④针对以粒间纳米级孔为主的微孔隙厚层泥岩,可以按照非常规油气藏勘探思路系统评价,探索泥岩的油气勘探潜力。结论认为,研究成果对深化认识银额盆地基础构造特征,进一步促进银额盆地油气勘探方向认识和推动盆地的油气勘探开发进程具有重要意义。

关键词：银额盆地中生界前中生界构造单元凹陷分布油气勘探方向

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The Educational Adaptive-optics Solar Telescope at the Shanghai Astronomy Museum

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Astronomical Techniques and Instruments 2024年第3期1卷 171-178页

作者： Zhimao Du Qing lin Xuejun Rao Yue Zhong Jiawen Yao Hua Bao Libo Zhong Yu Liang Hui zhang Shanghai Astronomy Museum Shanghai 201306China National Laboratory on Adaptive Optics Chengdu 610209China The Laboratory on Adaptive Optics Institute of Optics and ElectronicsChinese Academy of SciencesChengdu 610209China Yunnan Observatories Chinese Academy of SciencesKunming 650216China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China

The Educational Adaptive-optics Solar Telescope(EAST)at the Shanghai Astronomy Museum has been running routine astronomical observations since *** is a 65-cm-aperture Gregorian solar telescope for scientific education,outreach,and *** telescope system is designed in an“open”format so that the solar tower architecture can be integrated with it,and visitors can watch the observations live from inside the *** with adaptive optics,a high-resolution imaging system,and an integral field unit spectro-imaging system,this telescope can obtain high-resolution solar images in the TiO and Hαbands,and perform spectral image reconstruction using 400 optical fibers at selected *** can be used not only in public education and scientific outreach but also in solar physics research.

关键词： Astronomy museum Sun observation Adaptive optics Integral field unit

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Generation and characterization of nanobodies targeting GPCR

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Biophysics Reports 2024年第1期10卷 22-30页

作者： Shenglan zhang Zhiran Fan Jianfeng Liu Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory) Cellular Signaling laboratory International Research Center for Sensory Biology and Technology of MOST Key Laboratory of Molecular Biophysics of MOE College of Life Science and Technology Huazhong University of Science and Technology

G protein-coupled receptors(GPCRs) are a large family of cell membrane proteins that are important targets for drug discovery. Nanobodies, also known as VHH(variable domains of heavy chain-only antibodies, HcAbs) antibodies, are small antibody fragments derived from camelids that have gained significant attention as potential therapeutics for targeting GPCRs due to their advantages over conventional antibodies. However, there are challenges in developing nanobodies targeting GPCRs, among which epitope accessibility is the most significant because the cell membrane partially shields the GPCR surface. We developed a universal protocol for making nanobodies targeting GPCRs using the cell membrane extract of GPCR-overexpressing HEK293 cells as the llama/alpaca immunization antigen. We constructed an immune VHH library and identified nanobodies by phage display bio-panning. The monoclonal nanobodies were recombinantly expressed in Escherichia coli(E. coli) and purified to characterize their binding potency.

关键词： Nanobody Single domain antibody Heavy chain-only antibody GPCR G protein-coupled receptor

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陕西略阳南部何家垭镍钴含矿岩体铂族元素特征——对硫化物熔离过程的约束

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地质通报 2024年第8期43卷 1406-1416页

作者：舒子辉夏明哲张小明夏昭德张海东长安大学地球科学与资源学院陕西西安710054 新能源矿产与资源信息工程技术创新中心陕西西安710054 陕西省矿产地质调查中心陕西西安7100681

陕西何家垭镍钴含矿岩体位于南秦岭碧口地块,是近年来秦岭造山带中镍、钴战略性矿产找矿取得的重要新发现之一。该岩体由辉长岩、辉长闪长岩和少量辉石岩、角闪石岩组成,矿(化)体主要赋存在蚀变辉长岩中。基于对不同结构类型矿石铂族元... 详细信息

陕西何家垭镍钴含矿岩体位于南秦岭碧口地块,是近年来秦岭造山带中镍、钴战略性矿产找矿取得的重要新发现之一。该岩体由辉长岩、辉长闪长岩和少量辉石岩、角闪石岩组成,矿(化)体主要赋存在蚀变辉长岩中。基于对不同结构类型矿石铂族元素地球化学和硫化物原位硫同位素分析,探讨了岩浆性质和硫化物熔离过程。结果表明,各类矿石铂族元素(PGE)丰度均较低(3.93×10^(-9)~87.85×10^(-9),平均为27.88×10^(-9))。铂族元素地球化学特征反映,岩体母岩浆为高镁玄武质岩浆,受后期热液作用影响较弱。铂族元素和原位硫同位素特征显示,镁铁质矿物分离结晶是引起矿床中硫演化至饱和并发生深部硫化物熔离的重要因素。矿石中Pt元素的显著亏损可能是含Pt矿物结晶导致。南秦岭略阳何家垭岩体具有较好的镍钴成矿条件和找矿潜力,有望在秦岭造山带岩浆型铜镍硫化物矿床勘查评价方面取得重大突破。

关键词：成矿作用铂族元素铜镍矿何家垭陕西

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表面增强拉曼光谱技术在流行性病毒检测领域的研究进展

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中国激光 2024年第9期51卷 86-113页

作者：刘艺王楠何绍华张竣冯尚源林多福建师范大学光电与信息工程学院医学光电科学与技术教育部重点实验室福建福州350007

近几年新型冠状病毒COVID-19的迅速传播,引起了全球对传染病防控和快速病毒检测技术的高度关注。表面增强拉曼光谱(SERS)作为一种光学分析技术,凭借其独特的分子指纹特性和高检测灵敏度的特点,成为生物医学检测领域的有力工具,对可能大... 详细信息

近几年新型冠状病毒COVID-19的迅速传播,引起了全球对传染病防控和快速病毒检测技术的高度关注。表面增强拉曼光谱(SERS)作为一种光学分析技术,凭借其独特的分子指纹特性和高检测灵敏度的特点,成为生物医学检测领域的有力工具,对可能大规模暴发的流行性病毒灵敏迅速的检测以及监控提供新颖、高效的光学解决方案。本文对从2021年以来开展的DNA、RNA病毒,尤其是威胁人类生命健康的流行性病毒检测工作当中使用的标记、非标记SERS技术进行梳理,从SERS基底结构建构及功能化修饰,分子探针的设计,高速响应、高灵敏度检测模型构建,生物技术、机器学习方法的联合使用等方面,特别是基于便携式、手持式拉曼光谱仪的研究,对SERS技术在病毒检测领域的应用进展进行了总结和展望。

关键词：医用光学表面增强拉曼光谱病毒检测生物传感器纳米光子学纳米医学

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