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Acta Pharmaceutica Sinica B 2022年第1期12卷 326-338页

作者： Hongyu Sun Siyu He Li wu Zeying Cao Xian Sun Mingwei Xu Shan Lu Mingdi Xu Baoming Ning Huimin Sun Tiqiao Xiao Peter york Xu Xu Xianzhen Yin Jiwen zhang School of Chemical and Environmental Engineering Shanghai Institute of TechnologyShanghai 201418China Center for Drug Delivery System Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201210China university of Chinese Academy of Sciences Beijing 100049China School of Materials Science and Engineering Center for Supramolecular Chemistry and CatalysisDepartment of ChemistryShanghai UniversityShanghai 200444China NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients National Institutes for Food and Drug ControlBeijing 100050China National Institutes for Food and Drug Control Beijing 100050China Shanghai Synchrotron Radiation Facility/zhangjiang Lab Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Center for MOST and Image Fusion Analysis Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201210China

Changes in structure of oral solid dosage forms(OSDF) elementally determine the drug release and its therapeutic *** this research,synchrotron radiation X-ray micro-computed tomography was utilized to visualize the 3 D structure of enteric coated pellets recovered from the gastrointestinal tract of *** structures of pellets in solid state and in vitro compendium media were *** in vivo underwent morphological and structural changes which differed significantly from those in vitro compendium ***,optimizations of the dissolution media were performed to mimic the appropriate in vivo conditions by introducing pepsin and glass microspheres in *** sphericity,pellet volume,pore volume and porosity of the in vivo esomeprazole magnesium pellets in stomach for2 h were recorded 0.47,1.55 × 10^(8)μm^(3),0.44 × 10^(8)μm^(3)and 27.6%,*** adding pepsin and glass microspheres,the above parameters in vitro reached to 0.44,1.64 × 10^(8)μm^(3)0.38 × 10^(8)μm^(3)and 23.0%,*** magnesium pellets behaved *** structural features of pellets between in vitro media and in vivo condition were bridged successfully in terms of 3 D structures to ensure better design,characterization and quality control of advanced OSDF.

关键词： Internal 3D structure 3D reconstruction Structural parameter Enteric coated pellets Synchrotron radiation X-ray micro computed tomography In vivo and in vitro structure correlation Esomeprazole magnesium Omeprazole magnesium

Nanophotonic catalytic combustion enlightens mid-infrared light source

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Nano Research 2023年第9期16卷 11564-11570页

作者： Zhenhua wu Zhimao wu Haoran Lv Wenbin zhang Zekun Liu Shuai zhang Erzhen Mu Hengxin Lin Qing zhang Daxiang Cui Thomas Thundat Zhiyu Hu National Key Laboratory of Advanced Micro and Nano Manufacture Technology Shanghai Jiao Tong UniversityShanghai 200240China department of Micro/Nano Electronics Shanghai Jiao Tong UniversityShanghai 200240China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Institute of NanoMicroEnergy School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China School of Physics University of Electronic Science and Technology of ChinaChengdu 611731China School of Materials Science and Engineering Henan Polytechnic UniversityJiaozuo 454000China department of Instrument Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China department of Chemical and Biological Engineering University at Buffalothe State University of New YorkNew York 14260USA

The tunable mid-infrared source in a broad-spectrum heralds great scientific implications and remains a *** catalytic combustion facilitates access to customizable infrared light ***,we report on fabricating platinumalumina bilayer nano-cylinder arrays for methanol catalytic combustion,which enables them to act as an array of infrared point light sources,with wavelength tunable by controlling the flow rate of methanol/air *** then propose a technique of integrating nanophotonic structures with catalytic combustion to engineer infrared light *** demonstrate a prototype of a topological photonic crystal catalyst array in which infrared emission can be enhanced significantly with highly vertical *** work establishes a framework of nanophotonic catalytic combustion for infrared light sources.

关键词： nanophotonics catalytic combustion nano-array catalyst infrared light source

Endoscopic ultrasound features of autoimmune pancreatitis: The typical findings and chronic pancreatitis changes

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World Journal of Gastroenterology 2021年第42期27卷 7376-7386页

作者： Sheng-Yu zhang Yun-Lu Feng Long Zou Xi wu Tao Guo Qing-Wei Jiang Qiang Wang Ya-Min Lai shou-Jiang Tang Ai-Ming Yang department of Gastroenterology Peking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Division of Digestive Disease Department of MedicineUniversity of Mississippi Medical CenterJacksonMS 39216United States

BACKGROUND Few studies have fully described endoscopic ultrasound(EUS)features of newly diagnosed autoimmune pancreatitis(AIP)involving both typical findings and chronic pancreatitis(CP)*** typical EUS findings are prevalent in the diffuse type AIP but may not be as common for the focal type,and the differences between the diffuse and focal AIP need to be *** To demonstrate the EUS features of newly diagnosed AIP and the difference between diffuse and focal *** This retrospective single center study included 285 patients of newly diagnosed type 1 AIP following the international consensus diagnostic criteria,with the EUS procedures accomplished before corticosteroid *** explored the EUS features and compared the typical AIP and CP features between the diffuse and focal AIP *** Rosemont criteria were employed for CP features definition and CP change level *** For the typical AIP features,there were significantly more patients in the diffuse group with bile duct wall thickening(158 of 214 cases,73.4%vs 37 of 71 cases,52.1%,P=0.001)and peripancreatic hypoechoic margin(76 of 214 cases,35.5%vs 5 of 71 cases,7.0%,Pnewly diagnosed AIP cases in both *** This study demonstrated the difference in the typical AIP and CP features between diffuse and focal AIP and indicated the limited CP change level in newly diagnosed AIP.

关键词： Endoscopic ultrasound Autoimmune pancreatitis Rosemont criteria Chronic pancreatitis

Interlayer expansion of the layered zeolite precursor COK-5 with Sn(acac)_2Cl_2

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Journal of Energy Chemistry 2015年第5期24卷 642-645页

作者： Chaoqun Bian Qinming wu Jian zhang Shuxiang Pan Liang Wang Xiangju Meng Feng-shou Xiao department of Chemistry Key Lab of Applied Chemistry of Zhejiang Province Zhejiang University

In the interlayer expansion of the layered zeolite precursor COK-5, a Sn, salt, bis（2,4-pentanedionate）- dichlorotin [Sn（acac）2CL2], instead of a silylating agent was used to link the layers at 180 ℃. The obtained material, which is designed as Sn-COE-5, shows a shift of the first XRD reflection, which is very similar to that of COK-5 interlayer expanded with dichlorodimethylsilane （DCDMS）, indicating an increase in interlayer distance. X-ray diffraction （XRD）, N2 sorption isotherms, inductively coupled plasma （ICP）, and X-ray photo- electron spectroscopy （XPS） support the incorporation of isolated Sn sites in the sample. In the conversion of glucose to levulinic acid. Sn-COE-5 exhibits much higher activity than COK-5, which is due to the presence of Lewis acidic sites in the Sn-COE-5.

关键词： Interlayer expansion COK-5 Isolated tin species Sn(acac)2Cl2 COE-5

Arabidopsis ENOR3 regulates RNAi-mediated antiviral defense

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Journal of Genetics and Genomics 2018年第1期45卷 33-40页

作者： Hua Gao Mai Yang Haitao Yang Yue Qin Biyun Zhu Gang Xu Chengyuan Xie Dewei wu Xiaolin zhang Wanxiang Li Jianbin Yan Susheng Song Tiancong Qi shou-Wei Ding Daoxin Xie Tsinghua-Peking Joint Center for Life Sciences and MOE Key Laboratory of Bioinformatics School of Life Sciences Tsinghua University Beijing 100084 China department of Microbiology and Plant Pathology University of California Riverside CA 92521 USA Beijing Key Laboratory of Plant Gene Resources and Biotechnology for Carbon Reduction and Environmental Improvement College of Life Sciences Capital Normal University Beijing 100048 China

Viruses can infect host plants to cause severe diseases and substantial agricultural loss, while plants have evolved RNA interference （RNAi） strategy to defend against viral infection. Despite enormous efforts, only a few host proteins in RNAi pathway were shown to mediate antiviral defense, including RNA-dependent RNA polymerase I （RDRI）, RDR6, DICER-LIKE 2 （DCL2） and DCL4. In this study, we carried out a genetic screen for antiviral factors of RNAi pathway in Arabidopsis rdr6 background via inoculation with a 2b- deficient Cucumber Mosaic Virus （CMV-△2b）. We identified a mutant susceptible to CMV-△2h, referred to as enhancer o ojrdr6 （enor） 3-1 rdr6, and found that ENOR3 encodes a functionally unknown protein with high homology to the mammalian Non Imprinted in Prader-Willi/Angelman （NIPA） magnesium transporters. ENOR3 inhibits accumulation of CMV-△2b and acts additively with RDR1, RDR6, DCL2 and DCL4 in antivira/ defense. These results uncover that ENOR3 is a key component in antiviral RNAi Dathwav, and provide new insights into antiviral immunity.

关键词： Antiviral defense CMV-△2b DCL2/4 ENOR3 RDRI/6 RNAi

Hybrid N-order Lagrangian Interpolation Eulerian-Lagrangian Method for Salinity Calculation

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China Ocean Engineering 2016年第2期30卷 283-295页

作者：吴炎成朱首贤周林游小宝张文静 Institute of Meteorology and Oceanography PLA University of Science and TechnologyNanjing 211101China College of Oceanography Hohai UniversityNanjing 210098China China Satellite Marine Tracking and Control department Jiangyin 214431China Institute of Atmospheric Environment PLA General StaffBeijing 100029China

The Eulerian？Lagrangian method（ELM） has been used by many ocean models as the solution of the advection equation,but the numerical error caused by interpolation imposes restriction on its *** the present study,hybrid N-order Lagrangian interpolation ELM（Li ELM） is put forward in which the N-order Lagrangian interpolation is used at first,then the lower order Lagrangian interpolation is applied in the points where the interpolation results are abnormally higher or *** calculation results of a step-shaped salinity advection model are analyzed,which show that higher order（N=3？8） Li ELM can reduce the mean numerical error of salinity calculation,but the numerical oscillation error is still *** number order Li ELM makes larger numerical oscillation error than its adjacent odd number order Li *** N-order Li ELM can remove numerical oscillation,and it significantly reduces the mean numerical error when N is even and the current is in fixed direction,while it makes less effect on mean numerical error when N is odd or the current direction changes *** odd number order Li ELM makes less mean numerical error than its adjacent even number order Li ELM when the current is in the fixed direction,while the mean numerical error decreases as N increases when the current direction changes periodically,so odd number of N may be better for *** various types of Hybrid N-order Li ELM,the scheme reducing N-order directly to 1st-order may be the optimal for synthetic selection of accuracy and computational efficiency.

关键词： Eulerian?Lagrangian method Hybrid N-order Lagrangian interpolation numerical oscillation salinity calculation

Effects of water discharge on river-dominated delta growth

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Petroleum Science 2021年第6期18卷 1630-1649页

作者： Yan-Bao zhang Yi-Ke Liu Jia Yi Xue-Jian Liu Institute of Geophysics China Earthquake AdministrationBeijing100081China Key Laboratory of Petroleum Resources Research Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China China Earthquake Disaster Prevention Center China Earthquake AdministrationBeijing100029China The Pennsylvania State university Department of GeosciencesUniversity ParkPA16802USA

River-dominated deltas are commonly developed at modern bays and lakes and ancient petroliferous *** discharge is an important variable at pay zone scales in river-dominated delta reservoirs,which affects deltaic sand distributions and ***,it's unclear how it influences riverdominated delta *** paper integrates Delft3 D simulations and modern analogs to analyze the effects of water discharge,considering growth time,sediment supply,and coupled effects of sediment *** water discharges lead to the formation of lobate deltas,and the water discharge of 1,000 m~3/s is a referenced threshold ***-grained,highly-cohesive sediments increase the threshold values of water discharge at which the deltas become lobate from digitate,and vice *** the same simulation time,high water discharges favor more rugose shorelines,more distributary channels(especially secondary distributaries),and longer and wider deltas with more land ***,for the same sediment supply,high water discharges have few effects on shoreline roughness and the number of distributary channels.

关键词： River-dominated delta Water discharge Morphology Distributary channel Hydrocarbon exploration

Energy storage materials derived from Prussian blue analogues

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Science Bulletin 2017年第5期62卷 358-368页

作者： Feng Ma Qing Li Tanyuan Wang Hanguang zhang Gang wu State Key Laboratory of Material Processing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China department of Chemical and Biological Engineering University at Buffalo The State University of New York Buffalo NY 14260 USA

Prussian blue analogues(PBAs) with open frameworks have drawn much attention in energy storage fields due to their tridimensional ionic diffusion path, easy preparation, and low cost. This review summarizes the recent progress of using PBAs and their derivatives as energy storage materials in alkali ions,multi-valent ions, and metal-air batteries. The key factors to improve the electrochemical performance of PBAs as cathode materials in rechargeable batteries were firstly discussed. Several approaches for performance enhancement such as controlling the amounts of vacancies and coordinated water, optimizing morphologies, and depositing carbon coating are described in details. Then, we highlighted the significance of their diverse architectures and morphologies in anode materials for lithium/sodium ion batteries. Finally, the applications of Prussian blue derivatives as catalysts in metal-air batteries are also reviewed, providing insights into the origin of favorable morphologies and structures of catalyst for the optimal performance.

关键词： Prussian blue analogues Energy storage Rechargeable battery Open frameworks Cathode materials Anode materials Catalysts

^(18)F-FDG PET/CT findings of paratesticular alveolar rhabdomyosarcoma

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Cancer Innovation 2024年第2期3卷 68-71页

作者： Xueqi Chen Jiayin shou Shanshi Li Yan Fan Jianhua zhang department of Nuclear Medicine Peking University First HospitalBeijingChina department of Radiation Oncology Peking University First HospitalBeijingChina

Rhabdomyosarcoma(RMS)originates from primitive mesenchymal cells and is the most common soft tissue tumor in childhood.^(18)F-fluoro-deoxyglucose(^(18)F-FDG)positron emission tomography(PET)/computed tomography(CT)has been reported to be valuable in RMS staging and risk *** RMS is a relatively uncommon form of RMS,most of which are of the embryonal histologic *** alveolar RMS is associated with aggressive behavior,high metastatic potential,and poor *** the best of our knowledge,^(18)F-FDG PET/CT imaging findings of paratesticular alveolar RMS have never been ***,we report on a 16-year-old boy's rare paratesticular alveolar RMS with multiple metastases and its findings on^(18)F-FDG PET/*** case also demonstrates the potential value of^(18)F-FDG PET/CT in RMS staging and treatment decisions,and may aid in the differential diagnosis.

关键词： ^(18)F-FDG paratesticular alveolar rhabdomyosarcoma PET/CT