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Clustering of Cardiovascular Risk Factors and Diabetes： A Prospective Cohort Study on the Inner Mongolian Population in China

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Biomedical and Environmental Sciences 2018年第10期31卷 749-756页

作者： WANG Ting Ting LIN Bo CUI Wen Xiu zhang Ming Zhi zhang Yong Hong zhang shao yan Department of Epidemiology School of Public Health andJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases Medical College of Soochow University Suzhou 215123 Jiangsu China Harbin Center for Disease Control and Prevention Harbin 150000 Heilongjiang China

Objective To evaluate the effect of clustering of cardiovascular risk factors（CVRFs） on type 2 diabetes mellitus（T2 DM） incidence and identify some high predictive clusters in the Inner Mongolian population in China. Methods A total of 1,884 Mongolian individuals aged 20 years or above were followed up from 2002 to 2013 and included in the final analysis. We categorized the participants into two subgroups according to the study outcome event. A Cox proportional hazards model was used to evaluate the effect of clustering of CVRFs on the incidence of T2 DM. Areas under the curve were used to compare the effect of every cluster on T2 DM and identify those having higher predictive value. Results We found 203 persons with T2 DM. Subjects with incident T2 DM tended to be older, had a higher prevalence of drinking, had higher systolic and diastolic pressures; total cholesterol, triglyceride, low-density lipoprotein cholesterol, and C-reactive protein levels; waist circumference; body mass index; and heart rate and lower HDL-C level than did those without T2 DM. The multivariable adjusted hazard ratio（95% confidence interval） of T2 DM was calculated based on comparisons with subjects with 0 CVRFs; in participants with 2 and ≥ 3 factors, the adjusted hazard ratios were 2.257（1.448, 3.518） and 3.316（2.119, 5.188）, respectively. Conclusion The clustering of CVRFs increased the risk of T2 DM. On the basis of fast heart rate, the cluster of abdominal obesity and other CVRFs had higher predictive value for T2 DM than the other three CVRF clusters.

关键词： Type 2 diabetes Cardiovascular risk factors Abdominal obesity Heart rate

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Combined Influence of Insulin Resistance and Inflammatory Biomarkers on Type 2 Diabetes:A Population-based Prospective Cohort Study of Inner Mongolians in China

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Biomedical and Environmental Sciences 2018年第4期31卷 300-305页

作者： QIU Qiao yan zhang Bei Lei zhang Ming Zhi WU Jia Hui ZHOU Jing Wen LIANG Zhu zhang Yong Hong zhang shao yan Department of Epidemiology School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases Medical College of Soochow University Suzhou 215123 Jiangsu China The Second Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310000 Zhejiang China Wujin District Center for Disease Control and Prevention Changzhou 213159 Jiangsu China Nanjing Brain Hospital Nanjing 210029 JiangsuChina Kunshan Center for Disease Control and Prevention Suzhou 215123 Jiangsu China

This prospective study was designed to examine the combined influence of insulin resistance（IR）and inflammatory biomarker levels on type 2 diabetes mellitus（T2DM）among 1,903Inner Mongolians.

关键词： CRP DM Combined Influence of Insulin Resistance and Inflammatory Biomarkers on Type 2 Diabetes A Population-based Prospective Cohort Study of Inner Mongolians in China IR

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Efficacy and Safety of Bufei Jiedu Granules in Treating Multidrug-Resistant Pulmonary Tuberculosis:A Multi-center,Double-Blinded and Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第7期30卷 579-587页

作者： zhang shao-yan QIU Lei zhang Shun-xian XIAO He-ping CHU Nai-hui zhang Xia zhang Hui-qiang ZHENG Pei-yong zhang Hui-yong LU Zhen-hui Institute of Respiratory Diseases Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai200032China Clinical Research Center Shanghai University of Traditional Chinese MedicineShanghai200032China Department of Tuberculosis Shanghai Pulmonary HospitalTongji UniversityShanghai200433China Department of Tuberculosis Beijing Chest HospitalCapital Medical UniversityBeijing101100China Department of Tuberculosis the Second Hospital of NanjingNanjing210003China Department of Tuberculosis the First Hospital Affiliated to Xinxiang Medical CollegeXinxiangHenan Province453100China

Objective: To assess the efficacy and safety of Bufei Jiedu(BFJD) Granules as adjuvant therapy for patients with multidrug-resistant pulmonary tuberculosis(MDR-PTB). Methods: A large-scale, multi-center, double-blinded, and randomized controlled trial was conducted in 18 sentinel hospitals in China from December 2012 to December 2016. A total of 312 MDR-PTB patients were randomly assigned to BFJD Granules or placebo groups(1:1) using a stratified randomization method, which both received the long-course chemotherapy regimen for 18 months(6 Am-Lfx-P-Z-Pto, 12 Lfx-P-Z-Pto). Meanwhile, patients in both groups also received BFJD Granules or placebo twice a day for a total of 18 months, respectively. The primary outcome was cure rate. The secondary outcomes included time to sputum-culture conversion, changes in lung cavities and quality of life(QoL) of patients. Adverse reactions were monitored during and after the trial. Results: A total of 216 cases completed the trial, 111 in the BFJD Granules group and 105 in the placebo group. BFJD Granules, as adjuvant treatment, increased the cure rate by 13.6% at the end of treatment, compared with the placebo(58.4% vs. 44.8%, P=0.02), and accelerated the median time to sputum-culture conversion(5 months vs. 11 months). The cavity closure rate of the BFJD Granules group(50.6%, 43/85) was higher than that of the placebo group(32.1%, 26/81;P=0.02) in patients who completed the treatment. At the end of the intensive treatment, according to the 36-item Short Form, the BFJD Granules significantly improved physical functioning, general health, and vitality of patients relative to the placebo group(all P<0.01). Overall, the death rates in the two groups were not significantly different;5.1%(8/156) in the BFJD Granules group and 2.6%(4/156) in the placebo group. Conclusions: Supplementing BFJD Granules with the long-course chemotherapy regimen significantly increased the cure rate and cavity closure rate, and rapidly improved QoL of pati

关键词： alternative medicine Chinese herbal formula Bufei Jiedu Granules multidrug-resistant tuberculosis long-course chemotherapy regimen randomized controlled trial

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Altered miR-143 and miR-150 expressions in peripheral blood mononuclear cells for diagnosis of non-small cell lung cancer

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Chinese Medical Journal 2013年第23期126卷 4510-4516页

作者： ZENG Xiao-li zhang shao-yan ZHENG Jun-fang YUAN Hui WANG yan Department of Clinical Laboratory Beijing Anzhen Hospital Capital Medical University Beijing 100029 China Department of Thoracic Surgery Beijing Anzhen Hospital Capital Medical University Beijing 100029 China Department of Biochemistry and Molecular Biology Capital Medical University Beijing 100069 China

Background Sensitive and specific biomarkers for identifying early stage of non-small cell lung cancer （NSCLC） are urgently needed to improve the therapeutic outcome and reduce the *** non-coding microRNAs （miRNAs） are key components of cancer development and are considered as potential biomarkers for cancer diagnosis and for monitoring *** aim of this study was to determine whether aberrant miRNA expression can be used as a marker in peripheral blood mononuclear cells （PBMC） for the diagnosis of *** The levels of two mature miRNAs （miR-143 and miR-150） were detected by probe-based stem-loop quantitative reverse-transcriptase PCR （RT-qPCR） in PBMC of 64 patients with NSCLC and 26 healthy individuals,and the relationship between miR-143 and miR-150 levels and clinical and pathological factors was *** All endogenous miRNAs were present in peripheral blood in a remarkably stable form and detected by ***-143 expression in the PBMC specimens was significantly lower in NSCLC patients than in healthy individuals （P ＜0.0001）.MiR-150 expression in the PBMC specimens was not significantly different between NSCLC patients and healthy individuals （P=0.260）.MiR-150 expression was significantly higher in lung adenocarcinoma patients than in healthy individuals （P=0.001）.There was a very strong difference in the expression level of miR-150 between lung adenocarcinoma patients and lung squamous cell caminoma patients （P ＜0.0001）.In receiver operating characteristic curve （ROC） analysis,low expression of miR-143 showed the area under the ROC （AUC） of 0.885 for distinguishing cancer patients from healthy *** expression of miR-150 had an AUC of 0.834 for distinguishing lung adenocarcinoma patients from healthy *** expression of miR-150 had an AUC of 0.951 for distinguishing lung adenocarcinoma from lung squamous cell *** miR-150 level was significantly associated with distant metastasis （P=0.014）.Conclu

关键词： microRNA carcinoma,non-small cell lung diagnosis

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Alcohol Drinking, Dyslipidemia, and Diabetes： A Population-based Prospective Cohort Study among Inner Mongolians in China

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Biomedical and Environmental Sciences 2016年第8期29卷 555-562页

作者： LIANG Zhu QIU Qiao yan WU Jia Hui ZHOU Jing Wen XU Tian zhang Ming Zhi zhang Yong Hong zhang shao yan Department of Epidemiology School of Public Health Medical College of Soochow University Suzhou 215123 Jiangsu China Jiangsu Key Laboratoty of Preventive and Translational Medicine for Geriatric Diseases School of Public Health Soochow University Suzhou 215123 Jiangsu China KunShan Center for Disease Control And Prevention KunShan 215300 Jiangsu China

Objective No previous studies have evaluated the association between dyslipidemia, alcohol drinking, and diabetes in an Inner Mongolian population. We aimed to evaluate the co-effects of drinking and dyslipidemia on diabetes incidence in this population. Methods The present study was based on 1880 participants from a population-based prospective cohort study among Inner Mongolians living in China. Participants were classified into four subgroups according to their drinking status and dyslipidemia. Multivariate logistic regression analysis and receiver operating characteristic （ROC） curves were used to evaluate the association between alcohol drinking, dyslipidemia, and diabetes. Results During the follow-up period, 203 participants were found to have developed diabetes. The multiva riable-adjusted odds ratios （95% confidence interval） for the incidence of non-dyslipidemia/drinkers, dyslipidemia/non-drinkers, and dyslipidemia/drinkers in diabetic patients were 1.40 （0.82-2.37）, 1.73 （1.17-2.55）, and 2.31 （1.38-3.87）, respectively, when compared with non-dyslipidemia/non-drinkers. The area under the ROC curve for a model containing dyslipidemia and drinking status along with conventional factors （AUC=0.746） was significantly （P=O.003） larger than the one containing only conventional factors （AUC=0.711）. Conclusion The present study showed that dyslipidemia was an independent risk factor for diabetes, and that drinkers with dyslipidemia had the highest risk of diabetes in the Mongolian population. These findings suggest that dyslipidemia and drinkin8 status may be valuable in predicting diabetes incidence.

关键词： Diabetes Dyslipidemia, Drinking, Prospective Cohort study

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钒酸铜空心纳米结构的制备及电化学性能

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人工晶体学报 2013年第12期42卷 2675-2679页

作者：张绍岩时伟石家庄学院化工学院石家庄050035 石家庄学院科研处石家庄050035

以CuSO4·5H2O和NH4VO3为原料,聚苯乙烯(PS)微球为模板,采用模板法制备了具有空心结构Cu3V2O7(OH)2·2H2O材料。采用X射线衍射(XRD)和场发射扫描电子显微镜(FE-SEM)对不同结构的Cu3V2O7(OH)2·2H2O的组成和形貌进行了表征。实验发现通... 详细信息

以CuSO4·5H2O和NH4VO3为原料,聚苯乙烯(PS)微球为模板,采用模板法制备了具有空心结构Cu3V2O7(OH)2·2H2O材料。采用X射线衍射(XRD)和场发射扫描电子显微镜(FE-SEM)对不同结构的Cu3V2O7(OH)2·2H2O的组成和形貌进行了表征。实验发现通过控制反应温度及反应体系的pH值可实现对Cu3V2O7(OH)2·2H2O材料微观结构及形貌的良好控制。电化学性能测试表明:不同结构的Cu3V2O7(OH)2·2H2O材料其放电性能存在着明显的差异,具有蜂窝状结构的Cu3V2O7(OH)2·2H2O展现出较高的放电比容量,25℃条件下其首次放电容量可达到489 mAh/g。

关键词：钒酸铜空心结构电化学锂一次电池

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劳动教养的轨迹及去向

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法学论坛 2008年第4期23卷 40-46页

作者：张绍彦中国社会科学院法学研究所北京100720

从劳动教养的产生和发展来看,它以不恰当地牺牲个人权利为代价来维护社会秩序,始终是一种具有一定任意性的治理工具。从法治角度考察,劳动教养是具有刑事性的处罚措施,是典型的"中国式"轻刑。劳动教养的去向是,废除制度,保留功能。即,... 详细信息

从劳动教养的产生和发展来看,它以不恰当地牺牲个人权利为代价来维护社会秩序,始终是一种具有一定任意性的治理工具。从法治角度考察,劳动教养是具有刑事性的处罚措施,是典型的"中国式"轻刑。劳动教养的去向是,废除制度,保留功能。即,与中国《刑法》犯罪定量因素决定的实为较重犯罪和较重刑罚相对应,建立相应的对轻罪的轻刑制度。

关键词：劳动教养轻罪轻刑开放式执行方式

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恐怖主义本原辨析——基于事实的本体性认识

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现代法学 2013年第5期35卷 33-42页

作者：张绍彦中国社会科学院法学研究所北京100720

人们对待恐怖主义的态度和立场,与恐怖主义本身,是人类文明与发展面临的两个同等重要和危险的难题,克服现代性的局限有助于认识和应对恐怖主义。哲学上的普遍主义及与之对应的国际霸权和国内强权是恐怖主义产生的两个重要根源。同时,弄... 详细信息

人们对待恐怖主义的态度和立场,与恐怖主义本身,是人类文明与发展面临的两个同等重要和危险的难题,克服现代性的局限有助于认识和应对恐怖主义。哲学上的普遍主义及与之对应的国际霸权和国内强权是恐怖主义产生的两个重要根源。同时,弄清恐怖和恐怖主义作为事实的界限,对于把握恐怖主义实质及制定恰当的对策也是必要的。

关键词：恐怖恐怖主义霸权主义

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产业升级、战略性贸易政策与发展中国家的目标产业选择

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中国流通经济 2007年第1期21卷 27-30页

作者：张绍焱张皓华中师范大学经济学院湖北武汉430079 武汉大学经济与管理学院湖北武汉430072

本文认为,产业升级理论指出了产业结构演变的方向,对政府制定产业规划具有重要指导意义,但由于它是从大的历史跨度进行分析,在具体实践中不容易应用。而战略性贸易政策为不完全竞争条件下政府的贸易干预提供了新的依据。但战略性贸易政... 详细信息

本文认为,产业升级理论指出了产业结构演变的方向,对政府制定产业规划具有重要指导意义,但由于它是从大的历史跨度进行分析,在具体实践中不容易应用。而战略性贸易政策为不完全竞争条件下政府的贸易干预提供了新的依据。但战略性贸易政策要在发展中国家取得良好的效果,必须满足一定的基本条件,其中目标产业选择最为关键。文章提出,发展中国家在"合适技术"产业上更具有比较优势,能更好地满足战略性贸易政策实施的约束条件,是现阶段发展中国家战略性贸易政策目标产业的明智选择。

关键词：产业升级战略性贸易政策发展中国家目标产业

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Overexpression of catalytic subunit M2 in patients with ovarian cancer

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Chinese Medical Journal 2012年第12期125卷 2151-2156页

作者： WANG Li-ming LU Fei-fei zhang shao-yan YAO Ru-yong XING Xiao-ming WEI Zhi-min Department of Obstetrics and Gynecology Department of Central Laboratory AffiliatedHospital of Medical College of Qingdao University QingdaoShandong 266003 China Department of Pathology AffiliatedHospital of Medical College of Qingdao University QingdaoShandong 266003 China

Background The formation and growth of tumors are related to the synthesis of the DNA. The enzyme ribonucleotide reductase （RR） is an enzyme that regulates the total rate of DNA synthesis and thus plays a pivotal role in cell growth. Catalytic subunit M2 （RRM2） is the main unit modulating the ribonucleotide reductase enzymatic activity. This study aimed to investigate the expression of RRM2 mRNA and protein in patients with ovarian cancer and its relevance to diagnosis and clinical outcome of the patients. Methods RRM2 mRNA levels and protein expression were detected in 98 ovarian specimens with immunohistochemistry and real-time quantitative polymerase chain reaction （PCR）. Expression of the RRM2 protein and correlation of the RRM2 gene expression with clinical pathological features were analyzed. The Kaplan-Meier test was used for evaluating RRM2 expression and time to progression and survival. The Cox proportional model was used to analyze the risk factors in prognosis of patients. Results Positive RRM2 immunostaining was found in 43 of 62 （69.4%） patients with epithelial ovarian cancer, 10 of 15 （66.7%） patients with borderline neoplasm, 4 of 15 （26.7%） patients with benign growths, and none of the normal group. The RRM2 mRNA levels were significantly over expressed in epithelial ovarian cancer （1.722＋0.639） and borderline ovarian neoplasms （1.365＋0.615）, compared to the normal group （0.678＋0.446） and benign group （0.828_＋0.545）. Patients with ovarian caner in clinical FIGO-stages Ill-IV presented higher RRM2 gene expression than those in clinical FIGO-stages I-I1. Furthermore, the survival of patients with low RRM2 mRNA level was significantly better than patients with high levels （P 〈0.05）. By Cox proportional risk model analysis, the risk of mortality of patients with high level expression of RRM2 mRNA was 2.553 times greater than those with low expression. Conclusion RRM2 expression closely correlates with the development of ovarian tumor and may serve as a

关键词： ovarian neoplasms ribonucleotide reductase M2 real-time quantitative polymerase chain reaction immunohistochemistry diagnosis prognosis

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