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The Hankel Matrix Solution to a System of Quaternion Matrix Equations

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The Hankel Matrix Solution to a System of Quaternion Matrix ...

第32届中国控制与决策会议

作者： Yun Wang Jingpin Huang Hao Xiong shanshan zhang College of Science Guangxi University for Nationalities

The solution of matrix equations and the optimal approximation problem play an important role in linear optimal control,parameter identification,structural vibration,aviation and other *** matrix is kind of matrix with special structure and wide *** this paper,the problem of Hankel constraint solution to the system [AXB CXD]=[E F] over quaternion field is *** using the representation of vectors of a Hankel matrix and Kronecker product of matrices,a constrained problem will be transformed into an unconstrained *** the necessary and sufficient conditions for the equations with Hankel solution as well as the expression of general solution are ***,when the solution set is nonempty,by using invariance of Frobenius norm of orthogonal matrix product,the optimal approximation solution with minimal Frobenius norm for a given Hankel matrix is ***,two numerical examples is provided to verify the algorism.

关键词： Quaternion Field Quaternion Matrix Equations Hankel Matrix Kronecker Product Optimal Approximation

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权力感对社会排斥下自我关注的影响

心理科学 2015年第4期38卷 960-965页

作者：张野张珊珊崔璐沈阳师范大学教育科学学院沈阳110034 抚顺师范高等专科学校抚顺113122

采用实验法探讨在回忆和现实排斥情境下,不同社会排斥类型对大学生外显和内隐自我关注的影响及权力感的调节作用。实验1初步证实在两种排斥情境下,与拒绝型相比,忽视型被试的外显和内隐自我关注水平较高。实验2进一步证实权力感在忽视... 详细信息

采用实验法探讨在回忆和现实排斥情境下,不同社会排斥类型对大学生外显和内隐自我关注的影响及权力感的调节作用。实验1初步证实在两种排斥情境下,与拒绝型相比,忽视型被试的外显和内隐自我关注水平较高。实验2进一步证实权力感在忽视型排斥下对外显自我关注的影响中具有调节作用。结果表明,忽视型社会排斥威胁功效需要进而引发个体提高自我关注水平;情境因素对社会排斥产生的影响相同。

关键词：权力感排斥情境排斥类型自我关注

应用大剂量胰岛素血糖控制不达标后加用司美格鲁肽治疗的肥胖2型糖尿病1例

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中华糖尿病杂志 2022年第S01期14卷 207-209页

作者：张芳张珊珊山东中医药大学第一临床医学院内分泌科济南250013

分析1例在山东中医药大学第一临床医学院内分泌科治疗的肥胖2型糖尿病患者,在使用大剂量胰岛素治疗后血糖控制仍不达标,加用司美格鲁肽序贯治疗的诊治过程,并进行相关资料复习。患者为58岁男性,因“发现血糖升高3年”入院,入院后完善相... 详细信息

分析1例在山东中医药大学第一临床医学院内分泌科治疗的肥胖2型糖尿病患者,在使用大剂量胰岛素治疗后血糖控制仍不达标,加用司美格鲁肽序贯治疗的诊治过程,并进行相关资料复习。患者为58岁男性,因“发现血糖升高3年”入院,入院后完善相关检查,糖尿病分型诊断为2型糖尿病。既往长期使用胰岛素每日1次皮下注射联合口服降糖药物控制血糖,胰岛素最大剂量用至42 U/d,血糖控制仍不达标。入院后调整降糖方案,司美格鲁肽起始0.5 mg(1次/周)皮下注射,后逐渐加量至1.0 mg(1次/周),联合胰岛素睡前16 U(1次/d)、阿卡波糖50 mg(3次/d)、达格列净片10 mg(1次/d)、西格列汀100 mg(1次/d),血糖控制良好,患者满意。

关键词：糖尿病,2型肥胖联合治疗胰高糖素样肽-1受体激动剂

洋葱螺旋藻苷对超负荷运动骨骼肌损伤的保护作用及机制

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分子植物育种 2023年第15期21卷 5088-5094页

作者：张珊珊郑州工商学院郑州451400

本研究旨在探究洋葱中的活性成分螺旋藻苷在超负荷运动引起的骨骼肌损伤中的保护作用及其作用机制。通过建立超负荷运动引起的骨骼肌损伤大鼠模型,给予不同剂量的螺旋藻苷干预,并进行多项实验指标的检测。研究结果显示,螺旋藻苷剂量依... 详细信息

本研究旨在探究洋葱中的活性成分螺旋藻苷在超负荷运动引起的骨骼肌损伤中的保护作用及其作用机制。通过建立超负荷运动引起的骨骼肌损伤大鼠模型,给予不同剂量的螺旋藻苷干预,并进行多项实验指标的检测。研究结果显示,螺旋藻苷剂量依赖性地降低了大鼠血清LDH和CK水平,改善了骨骼肌形态,有效减轻了超负荷运动引起的骨骼肌损伤。此外,螺旋藻苷还抑制了超负荷运动诱导的骨骼肌细胞凋亡,并通过改善骨骼肌的氧化-抗氧化平衡来减轻氧化应激反应。研究还发现,螺旋藻苷激活了骨骼肌Nrf2途径,提高了抗氧化基因的表达,并降低了Keap1蛋白的表达。进一步的实验验证了螺旋藻苷通过激活Nrf2途径缓解超负荷运动引起的骨骼肌损伤。综上所述,螺旋藻苷可能是洋葱中发挥骨骼肌保护作用的关键成分,通过激活Nrf2途径和减轻氧化应激来保护骨骼肌免受超负荷运动引起的损伤。

关键词：洋葱(Allium cepa L.) 螺旋藻苷超负荷运动骨骼肌损伤氧化应激

委以重任还是排斥打压?明星员工与团队领导的人际互动后果

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心理学报 2024年第5期56卷 630-649页

作者：赵锴俞溪张山杉中国人民大学劳动人事学院北京100872 罗格斯大学管理与劳动关系学院美国新布朗斯维克08854 西南财经大学国际商学院成都611130

通过整合社会相互依赖理论及支配补偿理论,文章构建了一个被调节的间接效应模型,以阐释明星员工与团队领导的人际互动后果。通过开展1项情境实验和1项问卷调查研究,结果揭示:(1)下属明星员工身份通过增强团队领导对下属的信任促进领导... 详细信息

通过整合社会相互依赖理论及支配补偿理论,文章构建了一个被调节的间接效应模型,以阐释明星员工与团队领导的人际互动后果。通过开展1项情境实验和1项问卷调查研究,结果揭示:(1)下属明星员工身份通过增强团队领导对下属的信任促进领导授权行为,抑制领导排斥行为;下属明星员工身份通过增强领导地位威胁感知促进领导排斥行为;(2)下属的支配性强化了其明星员工身份与团队领导地位威胁感知之间的正向关系,并进一步促进了领导排斥行为。研究结果不仅验证了明星员工与团队领导人际互动的“双刃剑”效应及其边界条件,启发人们进一步思考如何构建有利于发挥明星员工价值的工作情境,还丰富了领导授权与排斥行为的前因研究。

关键词：明星员工团队领导人际互动领导授权领导排斥

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Dynamic human retinal pigment epithelium(RPE)and choroid architecture based on single-cell transcriptomic landscape analysis

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Genes & Diseases 2023年第6期10卷 2540-2556页

作者： Lulin Huang Lin Ye Runze Li shanshan zhang Chao Qu Shujin Li Jie Li Mu Yang Biao Wu Ran Chen Guo Huang Bo Gong Zheng Li Hongjie Yang Man Yu Yi Shi Changguan Wang Wei Chen Zhenglin Yang Sichuan Provincial Key Laboratory for Human Disease Gene Study Center for Medical GeneticsSichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026) Sichuan Academy of Medical SciencesChengduSichuan 610072China Department of Ophthalmology Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China School of Ophthalmology and Optometry Wenzhou Medical CollegeWenzhouZhejiang 325035China Department of Organ Transplant Center Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Department of Ophthalmology Peking University Third HospitalBeijing 100730China

The retinal pigment epithelium(RPE)and choroid are located behind the human retina and have multiple functions in the human visual *** of the RPE and choroid cells and their gene expression profiles are fundamental for understanding retinal disease mechanisms and therapeutic ***,we sequenced the RNA of about 0.3 million single cells from human RPE and choroids across two regions and seven ages,revealing regional and age differences within the human RPE and ***–cell interactions highlight the broad connectivity networks between the RPE and different choroid cell ***,the transcription factors and their target genes change during *** coding of somatic variations increases during aging in the human RPE and choroid at the single-cell ***,we identified ELN as a candidate for improving RPE degeneration and choroidal structure during *** mapping of the molecular architecture of the human RPE and choroid improves our understanding of the human vision support system and offers potential insights into the intervention targets for retinal diseases.

关键词： Aging Choroid ELN Human RPE scRNA-seq

One Stage Reconstruction of Esophageal Atresia and Distal Tracheoesophageal Fistula in a 3250-gm Neonate: A Case Report

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Open Journal of Pediatrics 2015年第2期5卷 147-150页

作者： Bijay Upadhyay Xuedong Wu Jun Li Ning Wang shanshan zhang Na Li Department of Pediatric Surgery Affiliated Hospital of Dali University Dali China

Esophageal atresia (EA) occurs when the upper part of the esophagus does not connect with the lower part of esophagus and stomach. Tracheoesophageal fistula (TEF) is an abnormal connection between the upper part of the esophagus and the trachea. Treatment for esophageal atresia has advanced over several decades due to improvements in surgical techniques and neonatal intensive care. The aim is to share our experience regarding the treatment of esophageal atresia with tracheoesophageal fistula. A 4-day-old neonate suffering from esophageal atresia with type IIIB tracheoesophageal fistula underwent one stage esophageal reconstruction and obtained good outcome without any complications. In this paper, a simple intra-operative technique for tracheal fistula repair and end to end esophageal anastomosis is discussed. We used a simple technique that we have found useful for ligation of tracheal fistula. Anastomosis of lower and upper esophagus without any complication like anastomotic leakage or stricture/stenosis of the neonate with EA/TEF (type IIIB), was proved to be safe and effective.

关键词： Esophageal Atresia Tracheoesophageal Fistula Esophageal Reconstruction End to End Anastamosis

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融入科研管理过程的机构知识库建设策略研究

现代情报 2018年第7期38卷 128-134页

作者：张闪闪中国科学技术信息研究所北京100038

构建融入科研管理过程的机构知识库平台,形成由科研项目管理系统、科研人员管理系统、科研成果管理系统、科研奖励管理系统构成的新型机构知识库平台,是实现机构知识资产积累传承、资源痕迹化管理的重要方法。针对所构建的新型知识库平... 详细信息

构建融入科研管理过程的机构知识库平台,形成由科研项目管理系统、科研人员管理系统、科研成果管理系统、科研奖励管理系统构成的新型机构知识库平台,是实现机构知识资产积累传承、资源痕迹化管理的重要方法。针对所构建的新型知识库平台,本文提出资源的获取流程,并提出通过强化管理意识、规范资源建设标准、重视成果痕迹化管理、强化知识组织体系、重视服务功能、建立权益保障机制6个方面,来共同推进融入科研管理过程的机构知识库的建设。

关键词：科研管理过程机构知识库系统架构科研机构

A new generation M^(pro)inhibitor with potent activity against SARS-CoV-2 Omicron variants

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1970-1982页

作者： Chong Huang Huiping Shuai Jingxin Qiao Yuxin Hou Rui Zeng Anjie Xia Lingwan Xie Zhen Fang Yueyue Li Chaemin Yoon Qiao Huang Bingjie Hu Jing You Baoxue Quan Xiu Zhao Nihong Guo Shiyu zhang Ronggang Ma Jiahao zhang Yifei Wang Ruicheng Yang shanshan zhang Jinshan Nan Haixing Xu Falu Wang Jian Lei Hin Chu Shengyong Yang State Key Laboratory of Biotherapy and Cancer Center and National Clinical Research Center for Geriatrics West China HospitalSichuan UniversityChengduSichuan 610041China State Key Laboratory of Emerging Infectious Diseases Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong Special Administrative RegionChina Department of Microbiology Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulamHong Kong Special Administrative RegionChina Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of EducationWest China School of PharmacySichuan UniversityChengduSichuan 610041China

Emerging SARS-CoV-2 variants, particularly the Omicron variant and its sublineages, continually threaten the global public *** molecule antivirals are an effective treatment strategy to fight against the virus. However, the first-generation antivirals eithershow limited clinical efficacy and/or have some defects in pharmacokinetic (PK) properties. Moreover, with increased use of thesedrugs across the globe, they face great pressure of drug resistance. We herein present the discovery and characterization of a newgeneration antiviral drug candidate (SY110), which is a potent and selective inhibitor of SARS-CoV-2 main protease (Mpro). Thiscompound displayed potent in vitro antiviral activity against not only the predominant SARS-CoV-2 Omicron sublineage BA.5, butalso other highly pathogenic human coronaviruses including SARS-CoV-1 and MERS-CoV. In the Omicron-infected K18-hACE2mouse model, oral treatment with SY110 significantly lowered the viral burdens in lung and alleviated the virus-induced ***, SY110 possesses favorable PK properties with high oral drug exposure and oral bioavailability, and also an outstandingsafety profile. Furthermore, SY110 exhibited sensitivity to several drug-resistance Mpro mutations. Collectively, this investigationprovides a promising new drug candidate against Omicron and other variants of SARS-CoV-2.

关键词： treatment predominant potent