检索结果-南通市图书馆

Targeting the COP9 signalosome for cancer therapy

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2022年第5期19卷 573-590页

作者： Wenqi Du ruicheng zhang Bilal Muhammad Dongsheng Pei Department of Pathology Xuzhou Medical UniversityXuzhou 221004China Department of Human Anatomy Xuzhou Medical UniversityXuzhou 221004China Department of Neurology Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221006China

The COP9 signalosome(CSN)is a highly conserved protein complex composed of 8 subunits(CSN1 to CSN8).The individual subunits of the CSN play essential roles in cell proliferation,tumorigenesis,cell cycle regulation,DNA damage repair,angiogenesis,and microenvironmental *** CSN complex has an intrinsic metalloprotease that removes the ubiquitin-like activator NEDD8 from cullin-RING ligases(CRLs).Binding of neddylated CRLs to CSN is sensed by CSN4 and communicated to CSN5 with the assistance of CSN6,thus leading to the activation of ***,CSN is a crucial regulator at the intersection between neddylation and ubiquitination in cancer ***,we summarize current understanding of the roles of individual CSN subunits in cancer ***,we explain how the CSN affects tumorigenesis through regulating transcription factors and the cell ***,we discuss individual CSN subunits as potential therapeutic targets to provide new directions and strategies for cancer therapy.

关键词： COP9 signalosome ubiquitin cullin-RING ligases cell proliferation tumorigenesis

Analysis of the Haze Weather Process in the East of China from January 21 to 28, 2021

在线全文

学校读者我要写书评

暂无评论

Journal of Geoscience and Environment Protection 2024年第7期12卷 130-138页

作者： ruicheng zhang School of Atmospheric Science Nanjing University of Information Science and Technology Nanjing China

Haze is a pollution weather phenomenon that has been widely concerned by people in recent years. It has a significant impact on people’s production, life, and health. This study focuses on large-scale haze weather that happened in eastern China in late January 2021. The research uses multi-party data and synoptic analysis methods to analyze the occurrence, evolution, and end of the haze weather. The polar vortex, the change of the atmospheric circulation, the change of the cold air force, the temperature and humidity, and the rain and snow weather are the important reasons for this weathering process. It can be used for reference in future research on haze weather.

关键词： Haze Forming Atmospheric Diffusion Conditions Eastern China

ODISSEE Test of ABS Anti-lock Braking System

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

ODISSEE Test of ABS Anti-lock Braking System

具有不确定性参数的轧机主传动系统自抗扰控制器设计

2018中国汽车工程学会年会

作者： zhang ruicheng Dongfeng Peugeot Citroen Automobile Co. Ltd.

The hardware composition and software testing principle of ODISSEE communication equipment for ABS anti-lock braking system of car are *** to the function test requirement of ABS,ABS initialization test and ABS start test are carried out in *** static test,ABS dynamic test,ABS stop test,ABS write process,ABS result test,WSS wheel speed sensor test,*** to the value of ABS dynamic test,the braking force of the four wheels is calculated to meet the requirements of the regulations;the operator interface during the testing process shows the test steps,the operation of the test requirements and the test results in time,which is convenient for the operator to operate the test This paper can be used as reference for equipment maintenance technicians and automobile testing technicians.

关键词： ODISSEEN ABS

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

电工技术学报 2005年第12期20卷 86-90,110页

作者：张瑞成童朝南北京科技大学信息工程学院北京100083

轧机主传动系统通常由直流电机驱动,其性能好坏直接影响板带材的产量和质量。针对轧机主传动系统存在不确定性负荷扰动和未建模动态的特点,首先建立了轧机主传动系统的模型,将不确定性负荷扰动和未建模动态视为一个综合扰动项,然后利用... 详细信息

轧机主传动系统通常由直流电机驱动,其性能好坏直接影响板带材的产量和质量。针对轧机主传动系统存在不确定性负荷扰动和未建模动态的特点,首先建立了轧机主传动系统的模型,将不确定性负荷扰动和未建模动态视为一个综合扰动项,然后利用扩张状态观测器对综合扰动项进行观测和补偿,基于自抗扰控制技术设计了一个不依赖于对象模型的轧机速度鲁棒控制器。仿真结果表明:该控制器不仅有效地抑制了不确定负荷扰动的影响,同时对系统内部参数如电机转动惯量、电枢电阻等的摄动也具有较强的鲁棒性。

关键词：轧机速度控制系统不确定性参数自抗扰控制器鲁棒性

基于转子感应电流影响的轧机主传动机电耦合系统参激振动机理研究

在线全文

学校读者我要写书评

暂无评论

振动与冲击 2016年第17期35卷 1-6页

作者：张瑞成卓丛林华北理工大学电气工程学院河北唐山063000

针对交流传动机电耦合模型往往忽略转子磁电转化问题,考虑交流电机转子复杂多变的磁电转化,根据交流电机电磁转矩机械特性,并引入交流电机内部空气摩擦阻力这一非线性因素,建立交流异步电机-轧机主传动系统机电耦合模型。采用多尺度法... 详细信息

针对交流传动机电耦合模型往往忽略转子磁电转化问题,考虑交流电机转子复杂多变的磁电转化,根据交流电机电磁转矩机械特性,并引入交流电机内部空气摩擦阻力这一非线性因素,建立交流异步电机-轧机主传动系统机电耦合模型。采用多尺度法求解该机电耦合模型在主参数共振情况下的近似解,并利用数值方法研究了定常解的稳定性,同时用Poinacre映射方法分析了转子感应电流频率对于轧机主传动机电耦合系统非线性参数共振的影响。研究结果表明转子感应电流频率是导致系统振动的一个重要因素,当转子感应电流频率变化时,轧机系统的运动形式从混沌运动到周期运动交替变化,最终变为混沌运动。给出了从生产工艺的角度利用变频技术稳定转子感应电机的频率可以有效的避免轧机的混沌运动,为进一步研究、控制轧机主传动系统提供了新思路。

关键词：轧机主传动系统机电耦合转子感应电流振动混沌

基于交流传动的轧机机电耦合系统振动特性分析

在线全文

学校读者我要写书评

暂无评论

机械强度 2006年第3期28卷 336-340页

作者：张瑞成童朝南北京科技大学信息工程学院北京100083

建立恰当的轧机系统模型,对其动态特性进行正确完备的描述是进行轧机系统设计、控制、状态监测和故障诊断的关键。随着交流调速技术的发展,交流电机已广泛用于轧机传动系统中。通过考虑驱动电机的影响,建立异步电机—轧机主传动系统的... 详细信息

建立恰当的轧机系统模型,对其动态特性进行正确完备的描述是进行轧机系统设计、控制、状态监测和故障诊断的关键。随着交流调速技术的发展,交流电机已广泛用于轧机传动系统中。通过考虑驱动电机的影响,建立异步电机—轧机主传动系统的机电耦合模型,并利用该模型对轧机系统由串联补偿电容、摩擦、间隙和负载扰动等因素引起的机电耦合动态过程进行数值研究。研究结果表明,建立的机电耦合模型可以方便地分析轧机系统机电耦合动力学规律,为进一步控制轧机振动特性奠定基础。

关键词：轧机交流传动机电耦合模型振动仿真

The Research On Load Balance Controller of Single Roller Transmission System of Rolling Mill Based on Load Observer

在线全文

学校读者我要写书评

暂无评论

The Research On Load Balance Controller of Single Roller Tra...

The Research on Load Balance Controller of Roller Single Roller Drive System Based on Fuzzy PID

第三十九届中国控制会议

作者： Liang Weizheng Shang ying Zhao Ming zhang ruicheng College of Electrical Engineering

In the aspect of steel rolling, in view of the slow speed response and poor synchronization performance of the upper and lower roller drag motors in the single-roller drive system of rolling mill, a control strategy combining load balance controller and load observer based on single neuron adaptive PID neural network is designed. In this control strategy, the actual load of the upper and lower rolls observed by the load observer is used as the input of the load balance controller, and the addition of feedforward compensation can suppress the speed fluctuation of the motor. The simulation results show that the speed response time and synchronization error of the motor are improved obviously by adding load observer, and the response time of the motor to steady state before rolling is decreased by nearly 26.5%. When rolling, the response time of motor returns to steady state is decreased by 16.5%, the maximum absolute value of synchronization error is reduced by 78%, and the synchronization performance is effectively improved.

关键词： Rolling Mill Single Roll Drive Synchronous Control Load Observer Cross-coupling Structure Load Balance Controller

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

The Research on Load Balance Controller of Roller Single Rol...

Analysis of Risk Factors of Postoperative Neurological Complications in Patients with Stanford Type A Aortic Dissection Undergoing Sun’s Procedure

第32届中国控制与决策会议

作者： Liang Weizheng Zhao Ming zhang ruicheng Shang Ying College of Electrical Engineering North China University of Science and Technology

In order to solve the load imbalance problem of the single-roller transmission system of the rolling mill,this paper adopts a cross-coupling method to achieve synchronous control between the two motors.A fuzzy proportional-integral-derivative（PID） load balance controller is designed to solve the load balance controller input Unbalanced rolling mill load caused by single factor and improper control *** the same time,in order to improve the synchronization performance of the motor,a PI tracking controller was ***,Simulink simulation tools are used to verify the effect of the load balancing controller on the effect of synchronous control of dual *** simulation results show that compared with the control strategy of traditional PID as the controller algorithm,fuzzy PID as the controller can reduce the overshoot and speed up the response,ensure the output of the upper and lower rollers is balanced,and also keep the motor within a safe ***.

关键词： Rolling Mill Single Roll Transmission Synchronous Control Cross-coupling Structure Load Balance Controller Fuzzy PID

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of Clinical and Nursing Research 2021年第6期5卷 93-101页

作者： Hui zhang ruicheng zhang Hua zhang Feng Li Jianming Zhao Shen Ma Rujun Zhu Pingfan Wang Department of Cardiac Surgery Henan Provincial Chest HospitalZhengzhou 450000Henan ProvinceChina

Objective:This study analyzed the risk factors of neurological complications in patients with Stanford type A aortic dissection after Sun’s procedure in a single-center with the purpose of improving the ***:From January 2019 to December 2020,the clinical data of 480 patients with Stanford type A aortic dissection,who were treated by Sun’s procedure in our center were retrospectively *** and multivariate logistic regression analyses were used to determine the risk factors of postoperative neurological *** to whether there were neurological complications after surgery,they were divided into two groups:the group with complications(n=70)and the group without complications(n=410).The clinical data of the two groups were collected and ***:There were 70 cases of patients with postoperative neurological complications in 480 *** incidence rates of temporary neurological dysfunction(TND)and permanent neurological dysfunction(PND)was 11.5%(55/480)and 3.1%(15/480),*** analysis showed that the age(≥70 years),stroke history,femoral artery intubation and cardiopulmonary bypass(CPB)time were associated with postoperative PND(p<0.05).Renal dysfunction,emergency surgery,postoperative hypernatremia,postoperative hyperglycemia,postoperative hypoxemia,postoperative low cardiac output syndrome,and assisted time of suction influenced the occurrence of postoperative TND(p<0.05).Multivariate logistic regression analysis showed that age(≥70 years),stroke history,femoral artery intubation and CPB time were independent risk factors for *** dysfunction,emergency surgery,postoperative hypernatremia,postoperative hyperglycemia,postoperative hypoxemia,postoperative low cardiac output syndrome,and aspiration time were independent risk factors for *** with the two groups,the hospitalization time and ICU time of the patients in the neurological complications group were significantly prolonged,and the

关键词： Aortic dissection Neurological complications Sun’s procedure Risk factors