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Chinese Medical Sciences Journal 2008年第3期23卷 162-165页

作者： Chun-yan zhang rong rong Xiao-ying Wang Department of Radiology Peking University First Hospital Functional Imaging Center Advanced Academy of Interdisciplinary Sciences Peking University Beijing 100034

Objective To investigate the signal intensity and apparent diffusion coefficient (ADC) of bone marrow of normal adult man on diffusion weighted imaging (DWI). Methods Fifteen healthy volunteers and thirty-eight patients with benign prostatic hyperplasia or normal prostate were enrolled in this study, with age range 28-82 years old (mean 55.26 ± 18.05 years). All people were examined with large field DWI on a 3.0T magnetic resonance scanner, which ranges from the top of head to the lower limb. The signal-to-noise ratio (SNR) on the DWI and ADC of lumber vertebra at renal hilum level, left ilium and superior segment of left femur were measured. The measured SNR and ADC value of the above sites were compared by one way analysis of variance and their correlations with age were investigated by Pearson's correlation analysis. Results The SNR of lumber vertebra, left ilium and left femur showed no significant difference (F = 0.271, P = 0.763). The SNR of lumber vertebra (r = 0.309, P = 0.024) and left ilium (r = 0.359, P = 0.008) showed positive correlation with age, while the SNR of left femur showed no correlation with age (r = -0.163, P = 0.283). The ADC of lumber vertebra [(0.617 ± 0.177) ×10-3 mm2/s] was significantly higher than that of left ilium [(0.404 ± 0.112) ×10-3 mm2/s, P < 0.001] and left femur [(0.362 ± 0.092) ×10-3 mm2/s, P < 0.001], while the ADC of left ilium and left femur had no significant difference. The ADC of lumber vertebra, left ilium and left femur showed no correlation with age. Conclusion Understanding of age-related changes of normal adult bone marrow on DWI is very important to differentiate the normal bone marrow and abnormal lesions.

关键词： diffusion weighted imaging magnetic resonance imaging bone marrow

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Benefit-Risk Assessment of Chinese Medicine Injections for Primary Liver Cancer Based on Multi-criteria Decision Analysis

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Chinese Journal of Integrative Medicine 2024年第6期30卷 559-564页

作者： zhang rong-rong SHAO Ming-yi FU Yu ZHAO Rui-xia WANG Jing-wen FANG Yu-xuan The First Clinical Medical College of Henan University of Traditional Chinese Medicine Zhengzhou450046China Personal Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Scientific Research Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Digestive Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China

ObjectiveTo evaluate the benefit-risk of 3 commonly used Chinese medicine injections, Aidi Injection (ADI), Cinobufagin Injection (CINI) and Compound Kushen Injection (CKI), in the treatment of primary liver cancer (PLC), so as to provide a reference for clinical *** controlled trials (RCTs) of ADI, CINI and CKI in the treatment of PLC published in the databases of China National Knowledge Infrastructure, Wanfang, China Science and Technology Journal Database, SinoMed, PubMed, Cochrane Library, and Web of Science were retrieved from January 2020 to October 2022. The data of benefit and risk indicators were combined to obtain the effect value. The multi-criteria decision analysis (MCDA) model was applied to build the decision tree. The benefit value, risk value and benefit risk value of the 3 injections in PLC treatment were calculated. Monte Carlo simulation was carried out to calculate the 95% confidence interval and probability of differences among the 3 injections, so as to optimize the evaluation *** total of 71 RCTs were included. The benefit values of ADI, CINI and CKI combined with transcatheter arterial chemoembolization (TACE) were 42, 38 and 36, respectively. The risk values were 42, 25 and 37, respectively. The benefit risk values were 42, 31 and 37, respectively. The benefit risk differences of ADI vs. CINI, ADI vs. CKI, and CKI vs. CINI were 11 (−0.86, 17.75), 5 (−5.01, 11.09), and 6 (−1.87, 12.63), respectively. The probability that ADI superior to CINI, ADI superior to CKI, and CKI superior to CINI was 96.26%, 77.27%, and 92.62%, *** on the results of MCDA model, CINI combined with TACE has the greatest risk in the treatment of the PLC. Considering the efficacy and safety, the possible priority of the 3 Chinese medicine injections combined with TACE in the treatment of PLC is ADI, CKI and CINI.

关键词： multi-criteria decision analysis benefit-risk assessment Chinese medicine injections primary livercancer

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Two cardenolide glycosides from the seed fairs of Asclepias curassavica and their cytotoxic activities

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Chinese Journal of Natural Medicines 2022年第3期20卷 202-209页

作者： JI Ai-Jia MA Qing KONG Mu-Yan LI Le-Yan CHEN Xin-Lian LIU Zhong-Qiu WU Jin-Jun zhang rong-rong Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People’s Republic of China School of Pharmaceutical SciencesGuangzhou University of Chinese MedicineGuangzhou 510006China China Resources Sanjiu Medical&Pharmaceutical Co. Ltd.Shenzhen 518110China School of Pharmaceutical Sciences Sun Yat-Sen UniversityGuangzhou 510006China

Two cardenolide glycosides,corotoxigenin 3-0-[β-D-glucopyranosyl-(l→4)-6-deoxy-β-D-glucopyranoside](1)and coroglaucigenin 3-0-[β-D-glucopyranosyl-(l→4)-6-deoxy-β-D-glucopyranoside](2),were isolated from the seed fairs of Asclepias *** structures of 1-2 were determined based on the combination of the analysis of their MS,NMR spectroscopic data and acid *** inhibitory effects of compounds 1 and 2 on human colorectal carcinoma cells(HCT116),non-small cell lung carcinoma cells(A549)and hepatic cancer cells(SMMC-7721)were *** results showed that both compounds 1 and 2 significantly inhibited the viability,proliferation,and migration of A549,HCT116 and SMMC-7721 cells,suggesting that compounds 1 and 2 can be applied in the treatment of lung,colon and liver cancers in clinical *** study may not only provide a scientific basis for clarifying the active ingredients in ***,but also help to understand its antitumor activity,which can promote the application of *** in clinical treatment of various cancers.

关键词： Asclepias curassavica Cardenolide glycosides Structure identification Cytotoxic activity

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Cloning and Expression of Actinobacillus pleuropneumoniae Gene Coding for TbpA and Development of an Indirect TbpA-ELISA

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Agricultural Sciences in China 2008年第10期7卷 1267-1273页

作者： LIANG Wang-wang HE Qi-gai CHEN Huan-chun XU Di-ping WU Rui zhang rong-rong National Key Laboratory of Agricultural Microbiology Huazhong Agricultural University Wuhan 430070 P.R.China Institute of Animal Husbandry and Veterinary Hubei Academy of Agricultural Sciences Wuhan 430064 P.R.China

This study presents the cloning and expression of gene encoding transferrin-binding protein A from Actinobacillus pleuropneurnoniae in Escherichia coli expression system and the development of an indirect TbpA-ELISA. The gene coding TbpA was amplified from the A. pleuropneumoniae serotype 2 genome using polymerase chain reaction and cloned to pET-28b expression vector under the control of strong, inducible T7 promoter. The recombinant plasmid was expressed in E. coli BL21 （DE3）. The expressed fusion protein was analyzed using SDS-PAGE and Western blotting. The diagnostic potential of recombinant TbpA （rTbpA） was evaluated through an antibody-detection indirect ELISA based on the purified rTbpA. The TbpA antibodies were detectable in mice on day 7 after vaccination with purified rTbpA protein or infection with A. pleuropneumoniae serotype 10 with the TbpA-based ELISA. In addition, the TbpA-ELISA was able to detect 12 serotyping rabbit antisera postinoculation （PI） with A. pleuropneumoniae 12 serotypes experimentally. The comparable result was obtained by detecting the 117 clinical serum samples using, respectively, the TbpA-ELISA and indirect hemagglutination test （IHA） based on multiplex antigen. The result indicates that the TbpA-ELISA was the more sensitive method compared with the Mix-IHA method because of its consistent presence in A. pleuropneumoniae serotypes. In conclusion, the conserved TbpA of A. pleuropneumoniae can be used for the development of a cross-serotype diagnostic method for the detection of antibodies against A. pleuropneurnoniae.

关键词： Actinobacillus pleuropneumoniae transferrin-binding protein diagnose

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High-throughput screening of CO_(2) cycloaddition MOF catalyst with an explainable machine learning model

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Green Energy & Environment 2025年第1期10卷 132-138页

作者： Xuefeng Bai Yi Li Yabo Xie Qiancheng Chen Xin zhang Jian-rong Li Beijing Key Laboratory for Green Catalysis and Separation and Department of Chemical Engineering College of Materials Science&EngineeringBeijing University of TechnologyBeijing100124China

The high porosity and tunable chemical functionality of metal-organic frameworks(MOFs)make it a promising catalyst design ***-throughput screening of catalytic performance is feasible since the large MOF structure database is *** this study,we report a machine learning model for high-throughput screening of MOF catalysts for the CO_(2) cycloaddition *** descriptors for model training were judiciously chosen according to the reaction mechanism,which leads to high accuracy up to 97%for the 75%quantile of the training set as the classification *** feature contribution was further evaluated with SHAP and PDP analysis to provide a certain physical understanding.12,415 hypothetical MOF structures and 100 reported MOFs were evaluated under 100℃ and 1 bar within one day using the model,and 239 potentially efficient catalysts were *** them,MOF-76(Y)achieved the top performance experimentally among reported MOFs,in good agreement with the prediction.

关键词： Metal-organic frameworks High-throughput screening Machine learning Explainable model CO_(2)cycloaddition

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基于信息量的不完备信息系统属性约简

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系统工程理论与实践 2005年第4期25卷 55-60页

作者：黄兵周献中张蓉蓉南京审计学院计算机科学与技术系江苏南京210029 南京大学工程管理学院江苏南京210093 合肥烟草专卖局安徽合肥230031

　通过引入信息量和条件信息量,对不完备信息系统中属性的重要性进行了定义;针对不完备数据表和不完备决策表提出了一种基于信息量和条件信息量的属性约简启发式算法,该算法的时间复杂度是多项式的.通过实例说明,该算法能得到信息表的... 详细信息

　通过引入信息量和条件信息量,对不完备信息系统中属性的重要性进行了定义;针对不完备数据表和不完备决策表提出了一种基于信息量和条件信息量的属性约简启发式算法,该算法的时间复杂度是多项式的.通过实例说明,该算法能得到信息表的约简和决策表的相对约简.

关键词：粗糙集不完备信息系统信息量属性约简

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Recent Advances in Artificial Sensory Neurons:Biological Fundamentals,Devices,Applications,and Challenges

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Nano-Micro Letters 2025年第3期17卷 168-216页

作者： Shuai Zhong Lirou Su Mingkun Xu Desmond Loke Bin Yu Yishu zhang rong Zhao Guangdong Institute of Intelligence Science and Technology HengqinZhuhai 519031People’s Republic of China College of Integrated Circuits Zhejiang UniversityHangzhou 3112000People’s Republic of China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 310027People’s Republic of China Department of Science Mathematics and TechnologySingapore University of Technology and DesignSingapore 487372Singapore Department of Precision Instruments Tsinghua UniversityBeijing 100084People’s Republic of China Center for Brain‑Inspired Computing Research Tsinghua UniversityBeijing 100084People’s Republic of China IDG/McGovern Institute for Brain Research Tsinghua UniversityBeijing 100084People’s Republic of China

Spike-based neural networks,which use spikes or action potentialsto represent information,have gained a lot of attention because of their high energyefficiency and low power *** fully leverage its advantages,convertingthe external analog signals to spikes is an essential *** including analog-to-digital converters or ring oscillators,and sensorssuffer from high power and area *** efforts are devoted to constructingartificial sensory neurons based on emerging devices inspired by the biologicalsensory *** can simultaneously perform sensing and spike conversion,overcoming the deficiencies of traditional sensory *** review summarizesand benchmarks the recent progress of artificial sensory *** starts with thepresentation of various mechanisms of biological signal transduction,followed bythe systematic introduction of the emerging devices employed for artificial ***,the implementations with different perceptual capabilitiesare briefly outlined and the key metrics and potential applications are also ***,we highlight the challenges and perspectives for the future development of artificial sensory neurons.

关键词： Artificial intelligence Emerging devices Artificial sensory neurons Spiking neural networks Neuromorphic sensing

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pH值对好氧颗粒污泥同步硝化反硝化过程的影响

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中国环境科学 2005年第6期25卷 650-654页

作者：张志任洪强张蓉蓉魏翔王晓蓉南京大学环境学院污染控制与资源化研究国家重点实验室江苏南京210093

从反应器脱氮性能和好氧颗粒污泥理化性状方面研究了pH值对好氧颗粒污泥同步硝化反硝化脱氮过程的影响.结果表明,好氧颗粒污泥微生态环境的形成,大大增强其耐酸碱冲击负荷能力,在pH值8～9范围内氨氮去除率均达到95%以上.在pH值6～9范围... 详细信息

从反应器脱氮性能和好氧颗粒污泥理化性状方面研究了pH值对好氧颗粒污泥同步硝化反硝化脱氮过程的影响.结果表明,好氧颗粒污泥微生态环境的形成,大大增强其耐酸碱冲击负荷能力,在pH值8～9范围内氨氮去除率均达到95%以上.在pH值6～9范围内,好氧颗粒污泥理化性状稳定,没有发生解体现象.

关键词：好氧颗粒污泥 pH值同步硝化反硝化

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教育与文化传承:贵州少数民族教育存在的两个问题

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贵州民族研究 2006年第4期26卷 157-160页

作者：张蓉蓉贵州大学贵州贵阳550025

忽视少数民族语言和文化是贵州少数民族教育存在的两个问题。有选择的文化传承成为现代学校教育的重要特征之一,也是阻碍少数民族文化传承的主要根源。贵州文化的多元性与现代学校教育的排他性之间的矛盾关系根源于:文化中心主义、高度... 详细信息

忽视少数民族语言和文化是贵州少数民族教育存在的两个问题。有选择的文化传承成为现代学校教育的重要特征之一,也是阻碍少数民族文化传承的主要根源。贵州文化的多元性与现代学校教育的排他性之间的矛盾关系根源于:文化中心主义、高度集中的教育管理制度、文化商业功利性和少数民族话语权缺失。

关键词：少数民族教育少数民族语言少数民族文化

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Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming zhang Bin Liu Limin rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

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